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Cited by 289Nutritional Studies and DietCardiovascular Health and Risk FactorsNuts composition and effects

The DOI matches its Crossref record; 78 of the 79 references it cites were found in a registry or an index.

Egg consumption in relation to risk of cardiovascular disease and diabetes: a systematic review and meta-analysis

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Shin, Jang Yel, Xun, Pengcheng, Nakamura, Yasuyuki, He, Ka·2013·The American Journal of Clinical Nutrition
DOI 10.3945/ajcn.112.051318PMC PMC3683816
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Abstract

Background The associations of egg consumption with cardiovascular disease (CVD) and diabetes are still unclear.Objective We aimed to quantitatively summarize the literature on egg consumption and risk of CVD, cardiac mortality, and type 2 diabetes by conducting a meta-analysis of prospective cohort studies.Design A systematic literature review was conducted for published studies in PubMed and EMBASE through March 2012. Additional information was retrieved through Google or a hand review of the reference from relevant articles. Studies were included if they had a prospective study design, were published in English-language journals, and provided HRs and 95% CIs for the associations of interest. Data were independently extracted by 2 investigators, and the weighted HRs and 95% CIs for the associations of interest were estimated by using a random-effects model.Results A total of 22 independent cohorts from 16 studies were identified, including participants ranging in number from 1600 to 90,735 and in follow-up time from 5.8 to 20.0 y. Comparison of the highest category (≥1 egg/d) of egg consumption with the lowest (<1 egg/wk or never) resulted in a pooled HR (95% CI) of 0.96 (0.88, 1.05) for overall CVD, 0.97 (0.86, 1.09) for ischemic heart disease, 0.93 (0.81, 1.07) for stroke, 0.98 (0.77, 1.24) for ischemic heart disease mortality, 0.92 (0.56, 1.50) for stroke mortality, and 1.42 (1.09, 1.86) for type 2 diabetes. Of the studies conducted in diabetic patients, the pooled HR (95% CI) was 1.69 (1.09, 2.62) for overall CVD.Conclusions This meta-analysis suggests that egg consumption is not associated with the risk of CVD and cardiac mortality in the general population. However, egg consumption may be associated with an increased incidence of type 2 diabetes among the general population and CVD comorbidity among diabetic patients.

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Metadata

Authors
Shin, J. Y., Xun, P., Nakamura, Y., & He, K.
Affiliations
University of North Carolina at Chapel Hill (US)
Corresponding author
He, Ka
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2013-07
Volume
98
Issue
1
Pages
146-159
ISSN
0002-9165 (ISSN-L)
DOI
10.3945/ajcn.112.051318
PMC
PMC3683816
OpenAlex
W2150644041
Cited by
289
References
79
Citations by year
2026: 4 · 2025: 10 · 2024: 11 · 2023: 13 · 2022: 30 · 2021: 20 · 2020: 29 · 2019: 27 · 2018: 32 · 2017: 38 · 2016: 21 · 2015: 33 · 2014: 16 · 2013: 4
FWCI
3.53
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (R21DK073812)
  • National Institute of Neurological Disorders and Stroke (R21NS056445)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
  • Health Sciences › Nursing › Nutrition and Dietetics › Nuts composition and effects
Keywords
egg consumption, cardiovascular disease, type 2 diabetes, ischemic heart disease, stroke, cardiac mortality, diabetes comorbidity, dietary cholesterol, dietary fat
MeSH terms
Cardiovascular Diseases, Diabetes Mellitus, Type 2, Eggs, Humans, Risk Factors, Incidence, Randomized Controlled Trials as Topic, Databases, Factual

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