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Cited by 328Nutritional Studies and DietCancer Risks and FactorsPhytochemicals and Antioxidant Activities

Fruit, vegetable, and fiber intake in relation to cancer risk: Findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)

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Bradbury, Kathryn E, Appleby, Paul N, Key, Timothy J·2014·The American Journal of Clinical Nutrition
DOI 10.3945/ajcn.113.071357
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Abstract

Fruit, vegetables, and certain components of plant foods, such as fiber, have long been thought to protect against cancer. The European Prospective Investigation into Cancer and Nutrition (EPIC) is a prospective cohort that includes >500,000 participants from 10 European countries and has made a substantial contribution to knowledge in this research area. The purpose of this article is to summarize the findings published thus far from the EPIC study on the associations between fruit, vegetable, or fiber consumption and the risk of cancer at 14 different sites. The risk of cancers of the upper gastrointestinal tract was inversely associated with fruit intake but was not associated with vegetable intake. The risk of colorectal cancer was inversely associated with intakes of total fruit and vegetables and total fiber, and the risk of liver cancer was also inversely associated with the intake of total fiber. The risk of cancer of the lung was inversely associated with fruit intake but was not associated with vegetable intake; this association with fruit intake was restricted to smokers and might be influenced by residual confounding due to smoking. There was a borderline inverse association of fiber intake with breast cancer risk. For the other 9 cancer sites studied (stomach, biliary tract, pancreas, cervix, endometrium, prostate, kidney, bladder, and lymphoma) there were no reported significant associations of risk with intakes of total fruit, vegetables, or fiber.

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  • Bradbury et al. reported a large-scale study (>500,000 participants) of associations between fruit, vegetable, or fiber consumption and risk of cancer at 14 different sites.

    “Bradbury et al., reported a large-scale study (>500,000 participants) of the associations between fruit, vegetable, or fiber consumption and the risk of cancer at 14 different sites.”

    From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [145]

  • There was an inverse association between fruit intake and risk of upper gastrointestinal tract and lung cancer, as well as an inverse association between fiber intake and liver cancer.

    “They showed that there was an inverse association between fruit intake and the risk of upper gastrointestinal tract and lung cancer, as well as an inverse association between fiber intake and liver cancer.”

    From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [145]

  • Dietary intake of vegetables, fruits, and fiber was inversely associated with risk of colorectal cancer, suggesting little evidence that vegetable intake is associated with risk of any of the individual cancer sites reviewed.

    “The dietary intake of vegetables, as well as fruits and fiber, was inversely associated with the risk of colorectal cancer, suggesting that there is little evidence that vegetable intake is associated with the risk of any of the individual cancer sites reviewed [145].”

    From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [145]

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Authors
Bradbury, K. E., Appleby, P. N., & Key, T. J.
Affiliations
University of Oxford (GB)
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2014-07
Volume
100
Pages
394S-398S
ISSN
0002-9165 (ISSN-L)
DOI
10.3945/ajcn.113.071357
OpenAlex
W2003989043
Cited by
328
References
34
Citations by year
2026: 8 · 2025: 18 · 2024: 20 · 2023: 21 · 2022: 30 · 2021: 35 · 2020: 34 · 2019: 31 · 2018: 32 · 2017: 36 · 2016: 32 · 2015: 22 · 2014: 8 · 2013: 1
FWCI
5.14
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
Cancer Research UK
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
fruit consumption, vegetable consumption, dietary fiber, cancer risk, colorectal cancer, liver cancer, lung cancer, breast cancer, upper gastrointestinal cancer, smoking, residual confounding, EPIC cohort
MeSH terms
Diet, Dietary Fiber, Feeding Behavior, Fruit, Humans, Neoplasms, Vegetables

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