Moderate weight loss in obese and overweight men preserves bone quality
Open accessAbstract
Background Weight loss (WL) negatively affects bone mineral density (BMD) in older populations and has specifically been shown in women.Objective In this prospective controlled trial, we examined variables of bone quality and endocrine changes after intentional WL in men.Design Thirty-eight overweight and obese [mean ± SD body mass index (in kg/m²): 31.9 ± 4.4; age: 58 ± 6 y] men were recruited to either WL through caloric restriction or weight maintenance (WM) for 6 mo.Results There was a -7.9 ± 4.4% and +0.2 ± 1.6% change in body weight in the WL and WM groups, respectively. There was a greater increase in femoral neck and total body BMD and bone mineral content (BMC) in the WM group than in the WL group (P-interaction effect < 0.05). In contrast, there was a trend for the tibia cortical thickness and area to decrease more in the WM group than in the WL group (P ≤ 0.08). There was a decrease in the periosteal circumference in both groups over time (P < 0.01) and no statistically significant changes in trabecular bone. Circulating total, free, and bioavailable estradiol decreased in the WL group compared with the WM group, and changes were different between groups (P < 0.05). Serum total and bioavailable testosterone increased in both groups (P < 0.01). Serum 25-hydroxyvitamin D increased to a similar extent in both groups (P < 0.05).Conclusions Moderate WL in overweight and obese men did not decrease BMD at any anatomical site or alter cortical and trabecular bone and geometry. Also, despite increased BMD at some sites when maintaining excess body weight, cortical bone showed a trend in the opposite direction.
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Calorie restriction has protective effects on bone quality.
“Furthermore, trabecular geometry, cortical geometry and strength were no different in individuals undergoing intentional weight loss through calorie restriction or weight maintenance for 6 months324, which suggests that calorie restriction has protective effects on bone quality.”
From Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies (2018) · cites this paper as [324]
Trabecular geometry, cortical geometry and strength did not differ between individuals undergoing intentional weight loss by calorie restriction and those on weight maintenance for six months.
“Furthermore, trabecular geometry, cortical geometry and strength were no different in individuals undergoing intentional weight loss through calorie restriction or weight maintenance for 6 months324, which suggests that calorie restriction has protective effects on bone quality.”
From Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies (2018) · cites this paper as [324]
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- Authors
- Pop, L. C., Sukumar, D., Tomaino, K., Schlussel, Y., Schneider, S. H., Gordon, C. L., Wang, X., & Shapses, S. A.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Shapses, Sue A
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 101
- Issue
- 3
- Pages
- 659-667
- ISSN
- 0002-9165 (ISSN-L)
- PMC
- PMC4340066
- OpenAlex
- W2100884683
- Cited by
- 47
- References
- 48
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 5
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (R01-AG12161)
- NJ Agricultural Experiment Station (0153866)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Keywords
- weight loss, obesity, overweight men, bone quality, bone mineral density, bone mineral content, caloric restriction, weight maintenance, cortical bone, trabecular bone, estradiol, testosterone, 25-hydroxyvitamin D, bone geometry
- MeSH terms
- Aged, Behavior Therapy, Bone Resorption, Combined Modality Therapy, Diet, Reducing, Humans, Male, Middle Aged, Motor Activity, New Jersey, Obesity, Patient Education as Topic, Risk, Tibia, Weight Loss, Absorptiometry, Photon, Bone Density, Body Mass Index, Caloric Restriction, Overweight, Nutritional Sciences
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