Weight loss in obese older adults increases serum sclerostin and impairs hip geometry but both are prevented by exercise training

Armamento-Villareal, Reina; Sadler, Corinn; Napoli, Nicola; Shah, Krupa; Chode, Suresh; Sinacore, David R; Qualls, Clifford; Villareal, Dennis T

doi:10.1002/jbmr.1560

Cited by 158Bone health and osteoporosis researchNutrition and Health in AgingBone Metabolism and Diseases

Weight loss in obese older adults increases serum sclerostin and impairs hip geometry but both are prevented by exercise training

Open access

Armamento-Villareal, Reina, Sadler, Corinn, Napoli, Nicola, Shah, Krupa, Chode, Suresh, Sinacore, David R, Qualls, Clifford, Villareal, Dennis T·2012·Journal of Bone and Mineral Research

DOI 10.1002/jbmr.1560PMC PMC3361603

Open this paper in CoChat — free account

Abstract

We reported that weight loss induces bone loss which is prevented by exercise training; however, the mechanism for this observation remains unclear. Sclerostin, an inhibitor of bone formation, has been found to increase in states of unloading and may mediate the changes in bone metabolism associated with weight loss and exercise. The objective of the study was to determine the effect of lifestyle intervention in obese older adults on sclerostin levels, and on hip geometry parameters. A total of 107 obese (body mass index [BMI] ≥ 30 kg/m2) older (≥65 years) adults were randomly assigned to control, diet, exercise, and combined diet-exercise for 1 year. Sclerostin levels were measured by ELISA at baseline, 6 months, and 12 months, while hip geometry parameters were obtained from bone mineral density (BMD) images done by dual-energy X-ray absorptiometry using hip structure analysis at baseline and 12 months. Both the diet and diet-exercise groups had significant decreases in body weight (−9.6% and −9.4%, respectively), whereas weight was stable in the exercise and control groups. Sclerostin levels increased significantly and progressively in the diet group (6.6% ± 1.7% and 10.5% ± 1.9% at 6 and 12 months, respectively, all p < 0.05), whereas they were unchanged in the other groups; in particular, they were stable in the diet-exercise group (0.7% ± 1.6% and 0.4% ± 1.7% at 6 and 12 months, respectively, all p = 0.05). Hip geometry parameters showed significant decreases in cross-sectional area, cortical thickness, and BMD; and increases in buckling ratio at the narrow neck, intertrochanter, and femoral shaft. These negative changes on bone geometry were not observed in the diet-exercise group. Significant correlations between changes in sclerostin and changes in certain hip geometry parameters were also observed (p < 0.05). In conclusion, the increase in sclerostin levels with weight loss that was prevented by exercise may partly mediate the negative effects of weight loss on bone metabolism and the osteoprotective effect of exercise training. © 2012 American Society for Bone and Mineral Research.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/jbmr.1560

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Exercise training during calorie restriction prevents increases in bone turnover and serum sclerostin, thereby minimizing bone loss.
“Studies emphasize exercise training during calorie restriction to prevent an increase in bone turn-over327 and an increase in serum levels of sclerostin328, thus minimizing bone loss.”
From Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies (2018) · cites this paper as [328]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Bone Quality — The Material and Structural Basis of Bone Strength and Fragility
Seeman, E., & Delmas, P. D. (2006) · New England Journal of Medicine · doi:10.1056/nejmra053077 · Cited by 2,108 · see citing works
Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin
Robling, A. G., Niziolek, P. J., Baldridge, L. A., Condon, K. W., Allen, M. R., Alam, I., Mantila, S. M., Gluhak-Heinrich, J., Bellido, T. M., Harris, S. E., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705092200 · Cited by 1,350 · see citing works
Weight loss, exercise, or both and physical function in obese older adults
Villareal, D. T., Chode, S., Parimi, N., Sinacore, D. R., Hilton, T., Armamento-Villareal, R., Napoli, N., Qualls, C., & Shah, K. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1008234 · Cited by 1,096 · see citing works
Self-citation
Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society
Villareal, D. T., Apovian, C. M., Kushner, R. F., & Klein, S. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.5.923 · Cited by 880 · see citing works
Self-citation
SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor
Semënov, M., Tamai, K., & He, X. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504308200 · Cited by 771 · see citing works
Relationships among body mass, its components, and bone11Published simultaneously at BoneKEy-Osteovision (http://www.bonekey-ibms.org), a Web site sponsored by the International Bone and Mineral Society.
Reid, I. R. (2002) · Bone · doi:10.1016/s8756-3282(02)00864-5 · Cited by 625 · see citing works
Structural Trends in the Aging Femoral Neck and Proximal Shaft: Analysis of the Third National Health and Nutrition Examination Survey Dual-Energy X-Ray Absorptiometry Data
Beck, T., Looker, A. C., Ruff, C. B., Sievänen, H. T., & Wahner, H. W. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.12.2297 · Cited by 419 · see citing works
Increased Sclerostin Serum Levels Associated with Bone Formation and Resorption Markers in Patients with Immobilization-Induced Bone Loss
Gaudio, A., Pennisi, P., Bratengeier, C., Torrisi, V., Lindner, B., Mangiafico, R. A., Pulvirenti, I., Hawa, G., Tringali, G., & Fiore, C. E. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0067 · Cited by 315 · see citing works
Prediction of Incident Hip Fracture Risk by Femur Geometry Variables Measured by Hip Structural Analysis in the Study of Osteoporotic Fractures
Kaptoge, S., Beck, T. J., Reeve, J., Stone, K. L., Hillier, T. A., Cauley, J. A., & Cummings, S. R. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080802 · Cited by 283 · see citing works
Effects of Parathyroid Hormone Treatment on Circulating Sclerostin Levels in Postmenopausal Women
Drake, M. T., Srinivasan, B., Mödder, U. I., Peterson, J. M., McCready, L. K., Riggs, B. L., Dwyer, D., Stolina, M., Kostenuik, P. J., & Khosla, S. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0720 · Cited by 251 · see citing works
Bone, Body Weight, and Weight Reduction: What Are the Concerns?
Shapses, S. A., & Riedt, C. S. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.6.1453 · Cited by 247 · see citing works
Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation
Sutherland, M. K., Geoghegan, J. C., Yu, C., Turcott, E., Skonier, J. E., Winkler, D. G., & Latham, J. A. (2004) · Bone · doi:10.1016/j.bone.2004.05.023 · Cited by 238 · see citing works
Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss
Weiss, E. P., Racette, S. B., Villareal, D. T., Fontana, L., Steger-May, K., Schechtman, K. B., Klein, S., Ehsani, A. A., Holloszy, J. O., & Washington University School of Medicine CALERIE Group (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00853.2006 · Cited by 218 · see citing works
Self-citation
Extending DXA beyond bone mineral density: Understanding hip structure analysis
Beck, T. (2007) · Current Osteoporosis Reports · doi:10.1007/s11914-007-0002-4 · Cited by 215 · see citing works
Bone Mineral Changes in Obese Women During a Moderate Weight Loss With and Without Calcium Supplementation
Jensen, L. B., Kollerup, G., QUAADE, F., & Sørensen, O. H. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.1.141 · Cited by 201 · see citing works
Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones
Shah, K., Armamento-Villareal, R., Parimi, N., Chode, S., Sinacore, D. R., Hilton, T. N., Napoli, N., Qualls, C., & Villareal, D. T. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.475 · Cited by 173 · see citing works
Self-citation
Hip structural geometry and incidence of hip fracture in postmenopausal women: what does it add to conventional bone mineral density?
LaCroix, A. Z., Beck, T., Cauley, J. A., Lewis, C. E., Bassford, T. L., Jackson, R. D., Wu, G., & Chen, Z. (2009) · Osteoporosis International · doi:10.1007/s00198-009-1056-1 · Cited by 163 · see citing works
Bone loss accompanying voluntary weight loss in obese humans
Jensen, L. B., QUAADE, F., & Sørensen, O. H. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090404 · Cited by 151 · see citing works
In vivo short-term precision of hip structure analysis variables in comparison with bone mineral density using paired dual-energy X-ray absorptiometry scans from multi-center clinical trials
Khoo, B. C. C., Beck, T., Qiao, Q.-H., Parakh, P. K., Semanick, L. M., Prince, R. L., Singer, K. P., & Price, R. I. (2005) · Bone · doi:10.1016/j.bone.2005.03.007 · Cited by 147 · see citing works
Wnt signaling and the regulation of bone mass
Baron, R., & Rawadi, G. (2007) · Current Osteoporosis Reports · doi:10.1007/s11914-007-0006-0 · Cited by 127 · see citing works
Serum sclerostin levels positively correlate with lumbar spinal bone mineral density in postmenopausal women—the six-month effect of risedronate and teriparatide
Pοlyzos, S. A., Anastasilakis, A. D., Bratengeier, C., Woloszczuk, W., Παπαθεοδώρου, Α., & Terpos, E. (2011) · Osteoporosis International · doi:10.1007/s00198-010-1525-6 · Cited by 126 · see citing works
Femoral bone structural geometry adapts to mechanical loading and is influenced by sex steroids: The Penn State Young Women's Health Study
Petit, M. A., Beck, T., Lin, H.-M., Bentley, C. M., Legro, R. S., & Lloyd, T. (2004) · Bone · doi:10.1016/j.bone.2004.05.008 · Cited by 124 · see citing works
Physical activity and femoral neck bone strength during childhood: The Iowa Bone Development Study
Janz, K. F., Gilmore, J. M. E., Levy, S. M., Letuchy, E. M., Burns, T. L., & Beck, T. (2007) · Bone · doi:10.1016/j.bone.2007.05.001 · Cited by 118 · see citing works
Mechanobiology of the SkeletonA presentation from the Keystone Symposium Mechanotransduction in Physiology and Disease in Taos, New Mexico, 18 to 23 January 2009.
Turner, C. H., Warden, S. J., Bellido, T., Plotkin, L. I., Kumar, N. C., Jasiuk, I., Danzig, J., & Robling, A. G. (2009) · Science Signaling · doi:10.1126/scisignal.268pt3 · Cited by 112 · see citing works
Bone loss accompanying diet-induced or exercise-induced weight loss: a randomised controlled study.
Pritchard, J. E., Nowson, C. A., & Wark, J. D. (1996) · PubMed · Cited by 110 · see citing works
HSA: Beyond BMD with DXA
LOUBONNICK, S. (2007) · Bone · doi:10.1016/j.bone.2007.03.007 · Cited by 94 · see citing works
Technology Insight: noninvasive assessment of bone strength in osteoporosis
Bouxsein, M. (2008) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0798 · Cited by 82 · see citing works
Nutrition-Related Peptides and Bone Homeostasis
Reid, I. R., Cornish, J., & Baldock, P. A. J. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.051105 · Cited by 79 · see citing works
Prediction of hip and other osteoporotic fractures from hip geometry in a large clinical cohort
Program, F. T. M. B. D., Leslie, W. D., Pahlavan, P. S., Tsang, J. F., & Lix, L. M. (2009) · Osteoporosis International · doi:10.1007/s00198-009-0874-5 · Cited by 76 · see citing works
Weight loss and calcium intake influence calcium absorption in overweight postmenopausal women
Cifuentes, M., Riedt, C. S., Brolin, R. E., Field, M. P., Sherrell, R. M., & Shapses, S. A. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.1.123 · Cited by 68 · see citing works
Long-term treatment with raloxifene, but not bisphosphonates, reduces circulating sclerostin levels in postmenopausal women
Chung, Y., Lee, S. H., Lee, S.-Y., Kim, S.-Y., Kim, H.-H., Mirza, F., Lee, S.-K., Lorenzo, J. A., Kim, G. S., & Koh, J. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1675-1 · Cited by 67 · see citing works
Physical training increases osteoprotegerin in postmenopausal women
Bergström, I. B., Parini, P., Gustafsson, S. A., Andersson, G., & Brinck, J. W. (2011) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-011-0304-6 · Cited by 58 · see citing works
Bone cross-sectional geometry in male runners, gymnasts, swimmers and non-athletic controls: a hip-structural analysis study
Hind, K., Gannon, L., Whatley, E., Cooke, C. B., & Truscott, J. G. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2008-y · Cited by 49 · see citing works
Comparison of DXA Hip Structural Analysis with Volumetric QCT
Prevrhal, S., Shepherd, J., Faulkner, K. G., Gaither, K. W., Black, D. M., & Lang, T. (2008) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2007.12.001 · Cited by 44 · see citing works
Identification of Wnt family inhibitors: A pituitary tumor directed whole genome approach
Elston, M. S., & Clifton-Bligh, R. J. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.02.039 · Cited by 21 · see citing works
Positive Influence of Long-Lasting and Intensive Weight-Bearing Physical Activity on Hip Structure of Young Adults
Bréban, S., Chappard, C., Jaffré, C., Khacef, F., Briot, K., & Benhamou, C.-L. (2011) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2011.02.001 · Cited by 10 · see citing works
Long-term treatment with raloxifene, but not bisphosphonates, reduces circulating sclerostin levels in postmenopausal women
Bae, S. J., Chung, Y. E., Lee, S. H., Lee, S. Y., Kim, S. Y., Kim, H. H., Kim, H. K., Kim, G. S., & Koh, J. (2011) · Bone · doi:10.1016/j.bone.2011.03.550 · Cited by 7 · see citing works
Bone Mineral Density Response to Caloric Restriction–Induced Weight Loss or Exercise-Induced Weight Loss: A Randomized Controlled Trial
Villareal, D. T. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.22.2502 · Cited by 1 · see citing works
Self-citation

Flagged first, then by citations

Research works printed but not linked: 1

[15]Shah K Armamento-Villareal R Parimi N Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones J Bone Miner Res 2011 26 2851 2859 21786319 PMC3206995

Sorted by citations

Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies
Batsis, J. A., & Villareal, D. T. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0062-9 · Cited by 1,382 · see citing works
Self-citation
Mechanisms of diabetes mellitus-induced bone fragility
On behalf of the IOF Bone and Diabetes Working Group, Napoli, N., Chandran, M., Pierroz, D. D., Abrahamsen, B., Schwartz, A. V., & Ferrari, S. L. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.153 · Cited by 1,107 · see citing works
Self-citation
Bone fragility in diabetes: novel concepts and clinical implications
Hofbauer, L. C., Busse, B., Eastell, R., Ferrari, S., Frost, M., Müller, R., Burden, A. M., Rivadeneira, F., Napoli, N., & Rauner, M. (2022) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(21)00347-8 · Cited by 452 · see citing works
Self-citation
Evidence on physical activity and osteoporosis prevention for people aged 65+ years: a systematic review to inform the WHO guidelines on physical activity and sedentary behaviour
Pinheiro, M. B., Oliveira, J. S., Bauman, A. E., Fairhall, N., Kwok, W. S., & Sherrington, C. (2020) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-020-01040-4 · Cited by 435 · see citing works
Diagnosis and management of bone fragility in diabetes: an emerging challenge
Ferrari, S., Abrahamsen, B., Napoli, N., Åkesson, K., Chandran, M., Eastell, R., Fuleihan, G. E., Josse, R. G., Kendler, D. L., Kraenzlin, M., et al. (2018) · Osteoporosis International · doi:10.1007/s00198-018-4650-2 · Cited by 400 · see citing works
Self-citation
Muscle and bone, two interconnected tissues
Tagliaferri, C., Wittrant, Y., Davicco, M.-J., Walrand, S., & Coxam, V. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.03.002 · Cited by 394 · see citing works
The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro
Spatz, J., Wein, M. N., Gooi, J. H., Qu, Y., Garr, J., Liu, X. S., Barry, K. J., Uda, Y., Lai, F., Dedic, C., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.628313 · Cited by 294 · see citing works
Obesity and Bone: A Complex Relationship
Rinonapoli, G., Pace, V., Ruggiero, C., Ceccarini, P., Bisaccia, M., Meccariello, L., & Caraffa, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413662 · Cited by 271 · see citing works
Aging, obesity, sarcopenia and the effect of diet and exercise intervention
Colleluori, G., & Villareal, D. T. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111561 · Cited by 207 · see citing works
Self-citation
Interaction between Muscle and Bone
Kaji, H. (2014) · Journal of Bone Metabolism · doi:10.11005/jbm.2014.21.1.29 · Cited by 199 · see citing works
BMI and BMD: the potential interplay between obesity and bone fragility
Palermo, A., Tuccinardi, D., Defeudis, G., Watanabe, M., D’Onofrio, L., Lauria Pantano, A., Napoli, N., Pozzilli, P., & Manfrini, S. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13060544 · Cited by 197 · see citing works
Self-citation
Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: A Randomized Clinical Trial
Villareal, D. T., Fontana, L., Das, S. K., Redman, L., Smith, S. R., Saltzman, E., Bales, C., Rochon, J., Pieper, C., Huang, M., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2701 · Cited by 191 · see citing works
Self-citation
Weight loss in obese adults 65years and older: A review of the controversy
Waters, D. L., Ward, A. L., & Villareal, D. T. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.005 · Cited by 177 · see citing works
Self-citation
Effects of myokines on bone
Kaji, H. (2016) · BoneKEy Reports · doi:10.1038/bonekey.2016.48 · Cited by 162 · see citing works
DXA parameters, Trabecular Bone Score (TBS) and Bone Mineral Density (BMD), in fracture risk prediction in endocrine-mediated secondary osteoporosis
Shevroja, E., Cafarelli, F. P., Guglielmi, G., & Hans, D. B. (2021) · Endocrine · doi:10.1007/s12020-021-02806-x · Cited by 162 · see citing works
Weight Loss Interventions in Older Adults with Obesity: A Systematic Review of Randomized Controlled Trials Since 2005
Batsis, J. A., Gill, L. E., Masutani, R. K., Adachi‐Mejia, A. M., Blunt, H. B., Bagley, P. J., Lopez‐Jimenez, F., & Bartels, S. J. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14514 · Cited by 160 · see citing works
Effects of reduced energy availability on bone metabolism in women and men
Papageorgiou, M., Elliott-Sale, K. J., Parsons, A., Tang, J. C. Y., Greeves, J. P., Fraser, W. D., & Sale, C. (2017) · Bone · doi:10.1016/j.bone.2017.08.019 · Cited by 159 · see citing works
Does Diet-Induced Weight Loss Lead to Bone Loss in Overweight or Obese Adults? A Systematic Review and Meta-Analysis of Clinical Trials
Zibellini, J., Seimon, R. V., Lee, C. M., Gibson, A. A., Hsu, M. S., Shapses, S. A., Nguyen, T. V., & Sainsbury, A. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2564 · Cited by 157 · see citing works
Bone Health After Exercise Alone, GLP-1 Receptor Agonist Treatment, or Combination Treatment: A Secondary Analysis of a Randomized Clinical Trial
Jensen, S. B. K., Sørensen, V., Sandsdal, R. M., Lehmann, E. W., Lundgren, J. R., Juhl, C. R., Janus, C., Ternhamar, T., Stallknecht, B. M., Holst, J. J., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.16775 · Cited by 155 · see citing works
Implications of exercise-induced adipo-myokines in bone metabolism
Lombardi, G., Sanchis‐Gomar, F., Perego, S., Sansoni, V., & Banfi, G. (2015) · Endocrine · doi:10.1007/s12020-015-0834-0 · Cited by 117 · see citing works
Molecular Mechanisms of Obesity-Induced Osteoporosis and Muscle Atrophy
Roy, B., Curtis, M. E., Fears, L., Nahashon, S. N., & Fentress, H. M. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00439 · Cited by 117 · see citing works
Effect of Aerobic or Resistance Exercise, or Both, on Bone Mineral Density and Bone Metabolism in Obese Older Adults While Dieting: A Randomized Controlled Trial
Armamento‐Villareal, R., Aguirre, L. E., Waters, D. L., Napoli, N., Qualls, C., & Villareal, D. T. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3905 · Cited by 109 · see citing works
Self-citation
The Alliance of Mesenchymal Stem Cells, Bone, and Diabetes
Napoli, N., Strollo, R., Paladini, A., Briganti, S., Pozzilli, P., & Epstein, S. (2014) · International Journal of Endocrinology · doi:10.1155/2014/690783 · Cited by 99 · see citing works
Self-citation
Linkage between muscle and bone
Kaji, H. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32835fe6a5 · Cited by 94 · see citing works
Bone and mineral metabolism in patients undergoing Roux-en-Y gastric bypass
Hage, M. P., & Fuleihan, G. E. (2013) · Osteoporosis International · doi:10.1007/s00198-013-2480-9 · Cited by 91 · see citing works
Excessive Body Weight in Older Adults
Starr, K. N. P., & Bales, C. W. (2015) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2015.04.001 · Cited by 90 · see citing works
Sclerostin Levels and Changes in Bone Metabolism After Bariatric Surgery
Muschitz, C., Kocijan, R., Marterer, C., Nia, A., Muschitz, G. K., Resch, H., & Pietschmann, P. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3367 · Cited by 90 · see citing works
The effects of weight loss approaches on bone mineral density in adults: a systematic review and meta-analysis of randomized controlled trials
Soltani, S., Hunter, G. R., Kazemi, A., & Shab-Bidar, S. (2016) · Osteoporosis International · doi:10.1007/s00198-016-3617-4 · Cited by 89 · see citing works
Treatment of obesity in older persons—A systematic review
Haywood, C., & Sumithran, P. (2019) · Obesity Reviews · doi:10.1111/obr.12815 · Cited by 84 · see citing works
Exercise Mitigates Bone Loss in Women With Severe Obesity After Roux-en-Y Gastric Bypass: A Randomized Controlled Trial
Murai, I. H., Roschel, H., Dantas, W. S., Gil, S. D. S., Merege-Filho, C. A. A., de Cleva, R., de Sá‐Pinto, A. L., Lima, F., Santo, M. A., Benatti, F. B., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00074 · Cited by 84 · see citing works
Consequences of obesity and weight loss: a devil's advocate position
Brown, R. E., & Kuk, J. L. (2014) · Obesity Reviews · doi:10.1111/obr.12232 · Cited by 79 · see citing works
Hormonal and systemic regulation of sclerostin
Drake, M. T., & Khosla, S. (2017) · Bone · doi:10.1016/j.bone.2016.12.004 · Cited by 77 · see citing works
Changes in thigh muscle volume predict bone mineral density response to lifestyle therapy in frail, obese older adults
Armamento‐Villareal, R., Aguirre, L. E., Napoli, N., Shah, K. N., Hilton, T. N., Sinacore, D. R., Qualls, C., & Villareal, D. T. (2013) · Osteoporosis International · doi:10.1007/s00198-013-2450-2 · Cited by 77 · see citing works
Self-citation
Diabetes mellitus and risk of low-energy fracture: a meta-analysis
Bai, J., Gao, Q., Wang, C., & Dai, J. (2019) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01417-x · Cited by 73 · see citing works
Saturation Effect of Body Mass Index on Bone Mineral Density in Adolescents of Different Ages: A Population-Based Study
Ouyang, Y., Quan, Y., Guo, C., Xie, S., Liu, C., Huang, X., Huang, X., Chen, Y., Xiao, X., Ma, N., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.922903 · Cited by 74 · see citing works
Osteoporosis and fracture risk are multifactorial in patients with inflammatory rheumatic diseases
Buttgereit, F., Palmowski, A., Bond, M., Adami, G., & Dejaco, C. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01120-w · Cited by 75 · see citing works
Effect of Exercise Modality During Weight Loss on Bone Health in Older Adults With Obesity and Cardiovascular Disease or Metabolic Syndrome: A Randomized Controlled Trial
Beavers, K. M., Walkup, M. P., Weaver, A. A., Lenchik, L., Kritchevsky, S. B., Nicklas, B. J., Ambrosius, W. T., Stitzel, J. D., Register, T. C., Shapses, S. A., et al. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3555 · Cited by 69 · see citing works
Obesity and Skeletal Fragility
Chen, R., & Armamento‐Villareal, R. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad415 · Cited by 67 · see citing works
Self-citation
Association of serum sclerostin levels with low skeletal muscle mass: The Korean Sarcopenic Obesity Study (KSOS)
Kim, J. A., Roh, E., Hong, S., Lee, Y., Kim, N. H., Yoo, H. J., Seo, J. A., Kim, N. H., Kim, S. G., Baik, S. H., et al. (2019) · Bone · doi:10.1016/j.bone.2019.115053 · Cited by 67 · see citing works
Circulating Sclerostin Associated With Vertebral Bone Marrow Fat in Older Men But Not Women
Ma, Y.-H. V., Schwartz, A. V., Sigurdsson, S. O., Hue, T. F., Lang, T., Harris, T. B., Rosen, C. J., Vittinghoff, E., Eiríksdóttir, G., Hauksdóttir, A. M., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4493 · Cited by 66 · see citing works
Self-citation
Calorie restriction reduces biomarkers of cellular senescence in humans
Aversa, Z., White, T. A., Heeren, A. A., Hulshizer, C. A., Saul, D., Zhang, X., Molina, A. J. A., Redman, L. M., Martin, C. K., Racette, S. B., et al. (2023) · Aging Cell · doi:10.1111/acel.14038 · Cited by 64 · see citing works
Maximal Strength Training Improves Bone Mineral Density and Neuromuscular Performance in Young Adult Women
Mosti, M. P., Carlsen, T., Aas, E., Hoff, J., Stunes, A. K., & Syversen, U. (2014) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000000493 · Cited by 63 · see citing works
Bone adaptation in response to treadmill exercise in young and adult mice
Gardinier, J. D., Rostami, N., Juliano, L., & Zhang, C. (2018) · Bone Reports · doi:10.1016/j.bonr.2018.01.003 · Cited by 58 · see citing works
The Look AHEAD Trial: Bone Loss at 4-Year Follow-up in Type 2 Diabetes
Lipkin, E. W., Schwartz, A. V., Anderson, A., Davis, C., Johnson, K., Gregg, E. W., Bray, G. A., Berkowitz, R. I., Peters, A. L., Hodges, A., et al. (2014) · Diabetes Care · doi:10.2337/dc14-0762 · Cited by 56 · see citing works
Calorie restriction in overweight older adults: Do benefits exceed potential risks?
Locher, J. L., Goldsby, T. U., Goss, A. M., Kilgore, M. L., Gower, B. A., & Ard, J. D. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.03.009 · Cited by 57 · see citing works
Clinical and endocrine correlates of circulating sclerostin levels in patients with type 1 diabetes mellitus
Neumann, T. E., Hofbauer, L. C., Rauner, M., Lodes, S., Kästner, B., Franke, S., Kiehntopf, M., Lehmann, T., Müller, U., Wolf, G., et al. (2013) · Clinical Endocrinology · doi:10.1111/cen.12364 · Cited by 53 · see citing works
Bone Health following Bariatric Surgery: Implications for Management Strategies to Attenuate Bone Loss
Ben‐Porat, T., Elazary, R., Dagan, S. S., Goldenshluger, A., Brodie, R., Mintz, Y., & Weiss, R. (2018) · Advances in Nutrition · doi:10.1093/advances/nmx024 · Cited by 53 · see citing works
Weight loss-induced reduction of bone mineral density in older adults with obesity
Jiang, B. C., & Villareal, D. T. (2019) · Journal of Nutrition in Gerontology and Geriatrics · doi:10.1080/21551197.2018.1564721 · Cited by 50 · see citing works
Self-citation
Moderate weight loss in obese and overweight men preserves bone quality
Pop, L. C., Sukumar, D., Tomaino, K., Schlussel, Y., Schneider, S. H., Gordon, C. L., Wang, X., & Shapses, S. A. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.088534 · Cited by 47 · see citing works
The mechanisms underlying the beneficial effects of exercise on bone remodeling: Roles of bone-derived cytokines and microRNAs
Qi, Z., Liu, W., & Lu, J. (2016) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2016.05.010 · Cited by 47 · see citing works
Is Weight Loss Harmful for Skeletal Health in Obese Older Adults?
Papageorgiou, M., Kerschan-Schindl, K., Sathyapalan, T., & Pietschmann, P. (2020) · Gerontology · doi:10.1159/000500779 · Cited by 45 · see citing works
Aromatase Inhibitors Plus Weight Loss Improves the Hormonal Profile of Obese Hypogonadal Men Without Causing Major Side Effects
Colleluori, G., Chen, R., Turin, C. G., Vigevano, F., Qualls, C., Johnson, B., Mediwala, S., Villareal, D. T., & Armamento-Villareal, R. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00277 · Cited by 43 · see citing works
Self-citation
Is Caloric Restriction Associated with Better Healthy Aging Outcomes? A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Caristia, S., Vito, M. D., Sarro, A., Leone, A., Pecere, A., Zibetti, A., Filigheddu, N., Zeppegno, P., Prodam, F., Faggiano, F., et al. (2020) · Nutrients · doi:10.3390/nu12082290 · Cited by 42 · see citing works
Serum sclerostin decreases following 12months of resistance- or jump-training in men with low bone mass
Hinton, P. S., Nigh, P., & Thyfault, J. P. (2016) · Bone · doi:10.1016/j.bone.2016.10.011 · Cited by 39 · see citing works
The Effects of Bariatric Surgery on Bone Metabolism
Gregory, N. S. (2016) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2016.09.011 · Cited by 38 · see citing works
Caloric restriction induces anabolic resistance to resistance exercise
Murphy, C., & Koehler, K. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04354-0 · Cited by 38 · see citing works
Circulating Sclerostin Levels and Markers of Bone Turnover in Chinese-American and White Women
Costa, A. G., Walker, M. D., Zhang, C. A., Cremers, S., Dworakowski, E., McMahon, D. J., Liu, C., & Bilezikian, J. P. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2106 · Cited by 32 · see citing works
‘Just because I’m old it doesn’t mean I have to be fat’: a qualitative study exploring older adults’ views and experiences of weight management
Jackson, S. E., Holter, L., & Beeken, R. J. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-025680 · Cited by 34 · see citing works
Myokine, a key cytokine for physical exercise to alleviate sarcopenic obesity
Zhang, L., Lv, J., Wang, C., Ren, Y., & Ming, Y. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07821-3 · Cited by 32 · see citing works
Sclerostin and Pref-1 have differential effects on bone mineral density and strength parameters in adolescent athletes compared with non-athletes
Fazeli, P. K., Ackerman, K. E., Pierce, L., Guereca, G., Bouxsein, M., & Misra, M. (2013) · Osteoporosis International · doi:10.1007/s00198-013-2353-2 · Cited by 30 · see citing works
Multilevel Approach of a 1-Year Program of Dietary and Exercise Interventions on Bone Mineral Content and Density in Metabolic Syndrome – the RESOLVE Randomized Controlled Trial
Courteix, D., Valente‐dos‐Santos, J., Ferry, B., Lac, G., Lesourd, B., Chapier, R., Naughton, G. A., Marceau, G., Coelho-e-Silva, M. J., Vinet, A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136491 · Cited by 29 · see citing works
Bone Response to Weight Loss Following Bariatric Surgery
Mele, C., Caputo, M., Ferrero, A., Daffara, T., Cavigiolo, B., Spadaccini, D., Nardone, A., Prodam, F., Aimaretti, G., & Marzullo, P. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.921353 · Cited by 30 · see citing works
Serum Sclerostin, Body Composition, and Sarcopenia in Hemodialysis Patients with Diabetes
de Medeiros, M. C. W. C., Rocha, N. D. A., Bandeira, E., Dantas, I., Chaves, C., Oliveira, M., & Bandeira, F. A. F. (2020) · International Journal of Nephrology · doi:10.1155/2020/4596920 · Cited by 28 · see citing works
Sclerostin measurement in human disease: Validity and current limitations
Costa, A. G., Cremers, S., & Bilezikian, J. P. (2016) · Bone · doi:10.1016/j.bone.2016.10.012 · Cited by 27 · see citing works
Bariatric Roux-En-Y Gastric Bypass Surgery: Adipocyte Proteins Involved in Increased Bone Remodeling in Humans
Biagioni, M., Mendes, A. L., Nogueira, C. R., Leite, C. V., Gollino, L., & Mazeto, G. M. F. D. S. (2017) · Obesity Surgery · doi:10.1007/s11695-017-2546-4 · Cited by 26 · see citing works
Relative influence of heritability, environment and genetics on serum sclerostin
Kuipers, A. L., Zhang, Y., Yu, S., Kammerer, C. M., Nestlerode, C. S., Chu, Y., Bunker, C. H., Patrick, A. L., Wheeler, V. W., Miljkovic, I., et al. (2013) · Osteoporosis International · doi:10.1007/s00198-013-2517-0 · Cited by 26 · see citing works
Effects of obesity treatments on bone mineral density, bone turnover and fracture risk in adults with overweight or obesity
Harper, C., Pattinson, A. L., Fernando, H. A., Zibellini, J., Seimon, R. V., & Sainsbury, A. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0025 · Cited by 26 · see citing works
Effect of testosterone treatment on bone remodelling markers and mineral density in obese dieting men in a randomized clinical trial
Fui, M. N. T., Hoermann, R., Nolan, B. J., Clarke, M., Zajac, J. D., & Grossmann, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-27481-3 · Cited by 26 · see citing works
Glucagon-like Peptide-1 Receptor Agonists and Diabetic Osteopathy: Another Positive Effect of Incretines? A 12 Months Longitudinal Study
Refaie, A. F. A., Baldassini, L., Mondillo, C., Ceccarelli, E., Tarquini, R., Gennari, L., Gonnelli, S., & Caffarelli, C. (2024) · Calcified Tissue International · doi:10.1007/s00223-024-01240-1 · Cited by 26 · see citing works
Mediterranean Diet, Physical Activity, and Bone Health in Older Adults
Vázquez‐Lorente, H., García-Gavilán, J. F., Shyam, S., Konieczna, J., Martínez, J. A., Martín, V., Fitó, M., Ruiz‐Canela, M., Paz‐Graniel, I., Curto, A., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.3710 · Cited by 25 · see citing works
Muscle-bone axis in children with chronic kidney disease: current knowledge and future perspectives
Karava, V., Dotis, J., Christoforidis, A., Kondou, A., & Printza, N. G. (2021) · Pediatric Nephrology · doi:10.1007/s00467-021-04936-w · Cited by 25 · see citing works
Bone Fragility in Diabetes and its Management: A Narrative Review
Leungsuwan, D. S., & Chandran, M. (2024) · Drugs · doi:10.1007/s40265-024-02078-5 · Cited by 24 · see citing works
Association between Adiposity and Bone Mineral Density in Adults: Insights from a National Survey Analysis
Jiao, Y., Sun, J., Li, Y., Zhao, J., & Shen, J. (2023) · Nutrients · doi:10.3390/nu15153492 · Cited by 27 · see citing works
Sclerostin as a biomarker of physical exercise in osteoporosis: A narrative review
Oniszczuk, A., Kaczmarek, A., Kaczmarek, M., Ciałowicz, M., Arslan, E., Silva, A. F., Clemente, F. M., & Murawska‐Ciałowicz, E. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.954895 · Cited by 23 · see citing works
Targeting Energy Intake and Circadian Biology to Engage Mechanisms of Aging in Older Adults With Obesity: Calorie Restriction and Time-Restricted Eating
Panda, S., Maier, G., & Villareal, D. T. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad069 · Cited by 25 · see citing works
Self-citation
Bone Response to High-Intensity Interval Training versus Moderate-Intensity Continuous Training in Adolescents with Obesity
Julian, V., Costa, D. C., O’Malley, G., Metz, L., Fillon, A., Miguet, M., Cardenoux, C., Dutheil, F., Boirie‌, Y., Duclos, M., et al. (2021) · Obesity Facts · doi:10.1159/000519271 · Cited by 22 · see citing works
The relationship between postmenopausal women’s sclerostin levels and their bone density, age, body mass index, hormonal status, and smoking and consumption of coffee and dairy products
Kalem, M. N., Kalem, Z., Akgün, N., & Bakırarar, B. (2017) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-017-4288-x · Cited by 21 · see citing works
Lifestyle Management of Diabetes: Implications for the Bone-Vascular Axis
Pieralice, S., Vigevano, F., Toro, R. D., Napoli, N., & Maddaloni, E. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1060-y · Cited by 21 · see citing works
Self-citation
The effects of popular diets on bone health in the past decade: a narrative review
Peng, Y., Zhong, Z., Huang, C., & Wang, W. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1287140 · Cited by 20 · see citing works
Normal bone density and trabecular bone score, but high serum sclerostin in congenital generalized lipodystrophy
Lima, J. G., Nóbrega, L. H. C., de Lima, N. N., dos Santos, M. C. F., Baracho, M. D. F. P., Winzenrieth, R., Bandeira, F. A. F., Mendes-Aguiar, C. D. O., Neto, F. P. F., Ferreira, L. C., et al. (2017) · Bone · doi:10.1016/j.bone.2017.03.053 · Cited by 20 · see citing works
CORRIGENDA
Gregson, C. L., Poole, K. E. S., McCloskey, E. V., Duncan, E. L., Rittweger, J., Fraser, W. D., Smith, G. D., & Tobias, J. H. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3958 · Cited by 17 · see citing works
Intermittent fasting and bone health: a bone of contention?
Clayton, D. J., Varley, I., & Papageorgiou, M. (2023) · British Journal Of Nutrition · doi:10.1017/s0007114523000545 · Cited by 16 · see citing works
Bone disease in anorexia nervosa
Dede, A. D., Lyritis, G. P., & Tournis, S. (2014) · HORMONES · doi:10.1007/bf03401319 · Cited by 16 · see citing works
Muscle–bone and fat–bone interactions in regulating bone mass: do PTH and PTHrP play any role?
Datta, N. S. (2014) · Endocrine · doi:10.1007/s12020-014-0273-3 · Cited by 16 · see citing works
Bone-adiposity cross-talk: implications for pediatric obesity
Chaplais, E., Thivel, D., Greene, D., Dutheil, F., Duché, P., Naughton, G. A., & Courteix, D. (2015) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-015-0654-6 · Cited by 16 · see citing works
Has sclerostin a true endocrine metabolic action complementary to osteocalcin in older men?
Confavreux, C. B., Casey, R., Varennes, A., Goudable, J., Chapurlat, R. D., & Szulc, P. (2016) · Osteoporosis International · doi:10.1007/s00198-016-3540-8 · Cited by 15 · see citing works
Effects of Biliopancreatic Diversion on Bone Turnover Markers and Association with Hormonal Factors in Patients with Severe Obesity
Turcotte, A., Grenier–Larouche, T., Ung, R., Simonyan, D., Carreau, A., Carpentier, A. C., Mac‐Way, F., Michou, L., Tchernof, A., Biertho, L. D., et al. (2018) · Obesity Surgery · doi:10.1007/s11695-018-3617-x · Cited by 14 · see citing works
The Effect of a Comprehensive Life-Style Intervention Program of Diet and Exercise on Four Bone-Derived Proteins, FGF-23, Osteopontin, NGAL and Sclerostin, in Overweight or Obese Children and Adolescents
Karampatsou, S., Paltoglou, G., Genitsaridi, S. M., Kassari, P., & Charmandari, E. (2022) · Nutrients · doi:10.3390/nu14183772 · Cited by 14 · see citing works
Circulating Levels of Sclerostin Predict Glycemic Improvement after Sleeve Gastrectomy
Carbone, F., Migliola, E. N., Bonaventura, A., Vecchié, A., VUONO, S. D., Ricci, M. A., Vaudo, G., Boni, M., Ministrini, S., Lupattelli, G., et al. (2021) · Nutrients · doi:10.3390/nu13020623 · Cited by 13 · see citing works
Design and rationale of re-energize fontan: Randomized exercise intervention designed to maximize fitness in fontan patients
Tierney, E. S. S., Palaniappan, L. P., Leonard, M. B., Long, J., MYERS, J. N., Dávila, T., Lui, M. C., Kogan, F., Olson, I. L., Punn, R., et al. (2023) · American Heart Journal · doi:10.1016/j.ahj.2023.02.006 · Cited by 14 · see citing works
The Effect of Caloric Restriction with and without n-3 PUFA Supplementation on Bone Turnover Markers in Blood of Subjects with Abdominal Obesity: A Randomized Placebo-Controlled Trial
Raźny, U., Góralska, J., Calder, P. C., Gruca, A., Childs, C. E., Kapusta, M., Słowińska-Solnica, K., Dembinska-Kiec, A., Solnica, B., & Malczewska-Malec, M. (2021) · Nutrients · doi:10.3390/nu13093096 · Cited by 13 · see citing works
Obesity-Related Inflammation: Implications for Older Adults
Ellis, A. C., Crowe, K. M., & Lawrence, J. C. (2013) · Journal of Nutrition in Gerontology and Geriatrics · doi:10.1080/21551197.2013.842199 · Cited by 13 · see citing works
Increased sclerostin and bone turnover after diet-induced weight loss in type 2 diabetes: a post hoc analysis of the MADIAB trial
Strollo, R., Soare, A., Khazrai, Y. M., Mauro, A. D., Palermo, A., Toro, R. D., Fallucca, S., Belluomo, M. G., Dugo, L., Pianesi, M., et al. (2016) · Endocrine · doi:10.1007/s12020-016-1171-7 · Cited by 12 · see citing works
Self-citation
The effect of weight loss on body composition, serum bone markers, and adipokines in prepubertal obese children after 1-year intervention
Gajewska, J., Ambroszkiewicz, J., Klemarczyk, W., Chełchowska, M., Weker, H., & Szamotulska, K. (2017) · Endocrine Research · doi:10.1080/07435800.2017.1403444 · Cited by 11 · see citing works
Effectiveness of Nutritional Advice for Community-Dwelling Obese Older Adults With Frailty: A Systematic Review and Meta-Analysis
Yin, Y., Liu, J. Y. W., Fan, T. M., Leung, K. M., Ng, M. W., Tsang, T. Y., Wong, K. P., & Valimaki, M. A. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.619903 · Cited by 10 · see citing works
The Impact of Diet on Bone and Fracture Risk in Diabetes
Faraj, M., & Napoli, N. (2022) · Current Osteoporosis Reports · doi:10.1007/s11914-022-00725-y · Cited by 10 · see citing works
Self-citation
Bariatric Surgery and Bone Loss: Do We Need to Be Concerned?
Brzozowska, M. M., Sainsbury, A., Eisman, J. A., & Baldock, P. A. J. (2014) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-014-9162-9 · Cited by 10 · see citing works
DObesity: Relationship between vitamin D deficiency, obesity and sclerostin as a novel biomarker of bone metabolism
Azzam, E., Atta, M. N. S., Younan, D. N. A., Salem, T. M., & Abdul-Aziz, A. A. (2019) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2019.100197 · Cited by 10 · see citing works
Bone inflammation in postmenopausal women with type 2 diabetes or obesity in relation to Wnt signaling and bone strength
Leanza, G., Faraj, M., Cannata, F., Viola, V., Pellegrini, N., Tramontana, F., Pedone, C., Vadalà, G., Piccoli, A., Strollo, R., et al. (2026) · Metabolism · doi:10.1016/j.metabol.2026.156492 · Cited by 9 · see citing works
Self-citation
Obesity and Bone Loss at Menopause: The Role of Sclerostin
Marzullo, P., Mele, C., Mai, S., Nardone, A., Scacchi, M., & Aimaretti, G. (2021) · Diagnostics · doi:10.3390/diagnostics11101914 · Cited by 9 · see citing works

Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones
Shah, K., Armamento-Villareal, R., Parimi, N., Chode, S., Sinacore, D. R., Hilton, T. N., Napoli, N., Qualls, C., & Villareal, D. T. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.475 · Cited by 173 · see citing works
Self-citation
Effect of Weight Loss and Exercise Therapy on Bone Metabolism and Mass in Obese Older Adults: A One-Year Randomized Controlled Trial
Villareal, D. T., Shah, K. N., Banks, M. R., Sinacore, D. R., & Klein, S. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1473 · Cited by 157 · see citing works
Self-citation
Effect of Exercise Modality During Weight Loss on Bone Health in Older Adults With Obesity and Cardiovascular Disease or Metabolic Syndrome: A Randomized Controlled Trial
Beavers, K. M., Walkup, M. P., Weaver, A. A., Lenchik, L., Kritchevsky, S. B., Nicklas, B. J., Ambrosius, W. T., Stitzel, J. D., Register, T. C., Shapses, S. A., et al. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3555 · Cited by 69 · see citing works
Effect of Aerobic or Resistance Exercise, or Both, on Bone Mineral Density and Bone Metabolism in Obese Older Adults While Dieting: A Randomized Controlled Trial
Armamento‐Villareal, R., Aguirre, L. E., Waters, D. L., Napoli, N., Qualls, C., & Villareal, D. T. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3905 · Cited by 109 · see citing works
Self-citation
Exercise Mitigates Bone Loss in Women With Severe Obesity After Roux-en-Y Gastric Bypass: A Randomized Controlled Trial
Murai, I. H., Roschel, H., Dantas, W. S., Gil, S. D. S., Merege-Filho, C. A. A., de Cleva, R., de Sá‐Pinto, A. L., Lima, F., Santo, M. A., Benatti, F. B., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00074 · Cited by 84 · see citing works

Authors: Armamento-Villareal, R., Sadler, C., Napoli, N., Shah, K., Chode, S., Sinacore, D. R., Qualls, C., & Villareal, D. T.
Affiliations: Sections of Geriatrics and Endocrinology, New Mexico VA Health Care System, Albuquerque, NM, USA
University of New Mexico (US)
Università Campus Bio-Medico (IT)
University of Rochester Medicine (US)
Washington University in St. Louis (US)
Corresponding author: Villareal, Dennis T
ORCID: Napoli, Nicola
Shah, Krupa
Sinacore, David R
Qualls, Clifford
Villareal, Dennis T
Venue: Journal of Bone and Mineral Research
Publisher: Oxford University Press (OUP)
Published: 2012-01-27
Volume: 27
Issue: 5
Pages: 1215-1221
ISSN: 0884-0431 (ISSN-L)
1523-4681
DOI: 10.1002/jbmr.1560
PMC: PMC3361603
OpenAlex: W2142685940
Cited by: 158
References: 38
Citations by year: 2026: 8 · 2025: 11 · 2024: 11 · 2023: 11 · 2022: 9 · 2021: 11 · 2020: 15 · 2019: 12 · 2018: 11 · 2017: 8 · 2016: 17 · 2015: 10 · 2014: 12 · 2013: 12
FWCI: 11.66
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Journal of Bone and Mineral Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Institute of Clinical and Translational Sciences
National Institutes of Health (UL1TR000041, 5p60dk020579-35, UL1TR001449, 7r01ag025501-06)
National Institute on Aging (R01-AG025501, R01AG031176)
National Institute of Diabetes and Digestive and Kidney Diseases (DK20579, P30-DK56341, P60-DK-020579, P30DK056341, P30DK020579)
National Center for Research Resources (UL1RR024992)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Keywords: sclerostin, weight loss, obesity, older adults, exercise training, hip geometry, bone loss, bone mineral density, bone metabolism, osteoporosis prevention, dietary intervention, lifestyle intervention, bone geometry
MeSH terms: Aged, Enzyme-Linked Immunosorbent Assay, Female, Genetic Markers, Hip, Humans, Male, Obesity, Osteoporosis, Weight Loss, Exercise, Absorptiometry, Photon, Bone Density, Up-Regulation, Bone Morphogenetic Proteins, Adaptor Proteins, Signal Transducing

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Weight loss in obese older adults increases serum sclerostin and impairs hip geometry but both are prevented by exercise training

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks