Associations of key diet-quality indexes with mortality in the Multiethnic Cohort: the Dietary Patterns Methods Project
Open accessAbstract
Background Healthy dietary patterns have been linked positively with health and longevity. However, prospective studies in diverse populations in the United States addressing dietary patterns and mortality are limited. Objective We assessed the ability of the following 4 diet-quality indexes [the Healthy Eating Index-2010 (HEI-2010), the Alternative HEI-2010 (AHEI-2010), the alternate Mediterranean diet score (aMED), and the Dietary Approaches to Stop Hypertension (DASH)] to predict the reduction in risk of mortality from all causes, cardiovascular disease (CVD), and cancer. Design White, African American, Native Hawaiian, Japanese American, and Latino adults (n = 215,782) from the Multiethnic Cohort completed a quantitative food-frequency questionnaire. Scores for each dietary index were computed and divided into quintiles for men and women. Mortality was documented over 13-18 y of follow-up. HRs and 95% CIs were computed by using adjusted Cox models. Results High HEI-2010, AHEI-2010, aMED, and DASH scores were all inversely associated with risk of mortality from all causes, CVD, and cancer in both men and women (P-trend < 0.0001 for all models). For men, the HEI-2010 was consistently associated with a reduction in risk of mortality for all causes (HR: 0.75; 95% CI: 0.71, 0.79), CVD (HR: 0.74; 95% CI: 0.69, 0.81), and cancer (HR: 0.76; 95% CI: 0.70, 0.83) when lowest and highest quintiles were compared. In women, the AHEI and aMED showed large reductions for all-cause mortality (HR: 0.78; 95% CI: 0.74, 0.82), the AHEI showed large reductions for CVD (HR: 0.76; 95% CI: 0.69, 0.83), and the aMED showed large reductions for cancer (HR: 0.84; 95% CI: 0.76, 0. 92). Conclusion These results, in a US multiethnic population, suggest that consuming a dietary pattern that achieves a high diet-quality index score is associated with lower risk of mortality from all causes, CVD, and cancer in adult men and women.
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In general, energy intakes of 1200 to 1500 kcal/day for women and 1500 to 1800 kcal/day for men have been recommended as safe during weight reduction.
“In general, energy intakes of 1200 to 1500 kcal/day for women and 1500 to 1800 kcal/day for men have been recommended as safe during weight reduction [54].”
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The Dietary assessment and calculation of dietary indexes and Participant characteristics sections discuss diet-quality scores and reported energy intakes, but not safe calorie targets for weight reduction. Searches for the stated kcal/day ranges and for weight-reduction recommendations found no passage addressing the claim; page numbers were unavailable in our copy. (LLM, conf=0.76)
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- Authors
- Harmon, B. E., Boushey, C. J., Shvetsov, Y. B., Ettienne, R., Reedy, J., Wilkens, L. R., Le Marchand, L., Henderson, B. E., & Kolonel, L. N.
- Affiliations
- University of Southern California (US)
- Corresponding author
- Boushey, Carol J
- ORCID
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 101
- Issue
- 3
- Pages
- 587-597
- ISSN
- 0002-9165 (ISSN-L)
- PMC
- PMC4340063
- OpenAlex
- W2152572619
- Cited by
- 364
- References
- 5
- Citations by year
- 2026: 15 · 2025: 23 · 2024: 14 · 2023: 29 · 2022: 27 · 2021: 41 · 2020: 45 · 2019: 35 · 2018: 45 · 2017: 36 · 2016: 37 · 2015: 17
- FWCI
- 48.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eSpace (Curtin University) (submittedVersion)
- Funders
- National Cancer Institute (HHSN261201200423P)
- NIH/NCI (P30 CA071789, 4R37 CA 54281)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Physical Sciences › Environmental Science › Ecology › Agriculture Sustainability and Environmental Impact
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- diet quality index, Healthy Eating Index-2010, Alternative Healthy Eating Index-2010, alternate Mediterranean diet score, DASH diet, all-cause mortality, cardiovascular mortality, cancer mortality, dietary habits, multi-ethnic cohort, ethnic diversity, sex differences, food frequency questionnaire, prospective cohort
- MeSH terms
- Aged, Asian, Black or African American, Cardiovascular Diseases, Diet, Female, Follow-Up Studies, Hawaii, Health Promotion, Hispanic or Latino, Humans, Japan, Male, Middle Aged, Mortality, Neoplasms, Patient Compliance, Prospective Studies, Los Angeles, Cohort Studies, Guidelines as Topic, White People, Native Hawaiian or Other Pacific Islander, Native Hawaiian or Pacific Islander
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