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A Mediterranean diet lowers blood pressure and improves endothelial function: results from the MedLey randomized intervention trial
Open accessAbstract
Background: The consumption of a Mediterranean diet (MedDiet) is associated with a lower risk of cardiovascular disease. However, its impact on blood pressure and endothelial function is not clear.Objective: We sought to determine the effects of adhering to the consumption of a MedDiet for 6 mo on blood pressure and endothelial function in older, healthy Australians.Design: A total of 166 men and women aged >64 y were allocated via minimization to consume either a MedDiet (n = 85) or their habitual diet (HabDiet; control: n = 81) for 6 mo. The MedDiet comprised mainly plant foods, abundant extra-virgin olive oil, and minimal red meat and processed foods. A total of 152 participants commenced the study, and 137 subjects completed the study. Home blood pressure was measured on 5 consecutive days at baseline (n = 149) and at 3 and 6 mo. Endothelial function (n = 82) was assessed by flow-meditated dilatation (FMD) at baseline and 6 mo. Dietary intake was monitored with the use of 3-d weighed food records. Data were analyzed with the use of linear mixed-effects models to determine adjusted between-group differences.Results: The MedDiet adherence score increased significantly in the MedDiet group but not in the HabDiet group (P < 0.001). The MedDiet, compared with the HabDiet, resulted in lower systolic blood pressure (P-diet × time interaction = 0.02) [mean: -1.3 mm Hg (95% CI: -2.2, -0.3 mm Hg; P = 0.008) at 3 mo and -1.1 mm Hg (95% CI: -2.0, -0.1 mm Hg; P = 0.03) at 6 mo]. At 6 mo, the percentage of FMD was higher by 1.3% (95% CI: 0.2%, 2.4%; P = 0.026) in the MedDiet group.Conclusion: Australian men and women who consumed a MedDiet for 6 mo had small but significantly lower systolic blood pressure and improved endothelial function. This trial was registered at www.anzctr.org.au as ACTRN12613000602729.
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“Accurate measurement of BP is fundamental to diagnosis and effective management of hypertension.210,211,228”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [211]
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Stradi, I., Diani, L., & Forchielli, M. L. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1842117
Precision nutrition and metabolic health: Integrating multi-omics for individualized prevention
Gu, W., Ning, H., Tian, Z., & Sun, C. (2026) · Metabolism and Diseases · doi:10.1016/j.metdis.2026.100040
Metadata
- Authors
- Davis, C. R., Hodgson, J. M., Woodman, R., Bryan, J., Wilson, C., & Murphy, K. J.
- Affiliations
- University of South Australia (AU)
- Edith Cowan University (AU)
- Flinders University (AU)
- Corresponding author
- Davis, Courtney R
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 105
- Issue
- 6
- Pages
- 1305-1313
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2607334803
- Cited by
- 191
- References
- 44
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 15 · 2023: 20 · 2022: 30 · 2021: 31 · 2020: 26 · 2019: 18 · 2018: 16 · 2017: 3
- FWCI
- 16.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Australasian Journal of Paramedicine (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- Medical Research Council
- National Health and Medical Research Council (1050949)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Keywords
- Mediterranean diet, blood pressure, endothelial function, flow-mediated dilation, older adults, extra virgin olive oil, dietary intervention, hypertension, cardiovascular disease prevention, dietary adherence, systolic blood pressure reduction, plant-based diet, home blood pressure monitoring, dietary monitoring
- MeSH terms
- Aged, Australia, Blood Pressure, Cardiovascular Diseases, Endothelium, Vascular, Feeding Behavior, Female, Humans, Male, Vasodilation, Diet Records, Diet, Mediterranean
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