Cited by 191Nutritional Studies and DietCardiovascular Health and Disease PreventionSodium Intake and Health

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A Mediterranean diet lowers blood pressure and improves endothelial function: results from the MedLey randomized intervention trial

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Davis, Courtney R, Hodgson, Jonathan M, Woodman, Richard, Bryan, Janet, Wilson, Carlene, Murphy, Karen J·2017·The American Journal of Clinical Nutrition

DOI 10.3945/ajcn.116.146803

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Abstract

Background: The consumption of a Mediterranean diet (MedDiet) is associated with a lower risk of cardiovascular disease. However, its impact on blood pressure and endothelial function is not clear.Objective: We sought to determine the effects of adhering to the consumption of a MedDiet for 6 mo on blood pressure and endothelial function in older, healthy Australians.Design: A total of 166 men and women aged >64 y were allocated via minimization to consume either a MedDiet (n = 85) or their habitual diet (HabDiet; control: n = 81) for 6 mo. The MedDiet comprised mainly plant foods, abundant extra-virgin olive oil, and minimal red meat and processed foods. A total of 152 participants commenced the study, and 137 subjects completed the study. Home blood pressure was measured on 5 consecutive days at baseline (n = 149) and at 3 and 6 mo. Endothelial function (n = 82) was assessed by flow-meditated dilatation (FMD) at baseline and 6 mo. Dietary intake was monitored with the use of 3-d weighed food records. Data were analyzed with the use of linear mixed-effects models to determine adjusted between-group differences.Results: The MedDiet adherence score increased significantly in the MedDiet group but not in the HabDiet group (P < 0.001). The MedDiet, compared with the HabDiet, resulted in lower systolic blood pressure (P-diet × time interaction = 0.02) [mean: -1.3 mm Hg (95% CI: -2.2, -0.3 mm Hg; P = 0.008) at 3 mo and -1.1 mm Hg (95% CI: -2.0, -0.1 mm Hg; P = 0.03) at 6 mo]. At 6 mo, the percentage of FMD was higher by 1.3% (95% CI: 0.2%, 2.4%; P = 0.026) in the MedDiet group.Conclusion: Australian men and women who consumed a MedDiet for 6 mo had small but significantly lower systolic blood pressure and improved endothelial function. This trial was registered at www.anzctr.org.au as ACTRN12613000602729.

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Authors: Davis, C. R., Hodgson, J. M., Woodman, R., Bryan, J., Wilson, C., & Murphy, K. J.
Affiliations: University of South Australia (AU)
Edith Cowan University (AU)
Flinders University (AU)
Corresponding author: Davis, Courtney R
ORCID: Davis, Courtney R
Hodgson, Jonathan M
Woodman, Richard
Bryan, Janet
Wilson, Carlene
Murphy, Karen J
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2017-06
Volume: 105
Issue: 6
Pages: 1305-1313
ISSN: 0002-9165 (ISSN-L)
DOI: 10.3945/ajcn.116.146803
OpenAlex: W2607334803
Cited by: 191
References: 44
Citations by year: 2026: 12 · 2025: 19 · 2024: 15 · 2023: 20 · 2022: 30 · 2021: 31 · 2020: 26 · 2019: 18 · 2018: 16 · 2017: 3
FWCI: 16.15
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2080 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Australasian Journal of Paramedicine (submittedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders: Medical Research Council
National Health and Medical Research Council (1050949)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
Keywords: Mediterranean diet, blood pressure, endothelial function, flow-mediated dilation, older adults, extra virgin olive oil, dietary intervention, hypertension, cardiovascular disease prevention, dietary adherence, systolic blood pressure reduction, plant-based diet, home blood pressure monitoring, dietary monitoring
MeSH terms: Aged, Australia, Blood Pressure, Cardiovascular Diseases, Endothelium, Vascular, Feeding Behavior, Female, Humans, Male, Vasodilation, Diet Records, Diet, Mediterranean

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A Mediterranean diet lowers blood pressure and improves endothelial function: results from the MedLey randomized intervention trial

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