The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
A Mediterranean diet lowers blood pressure and improves endothelial function: results from the MedLey randomized intervention trial
Open accessAbstract
Background: The consumption of a Mediterranean diet (MedDiet) is associated with a lower risk of cardiovascular disease. However, its impact on blood pressure and endothelial function is not clear.Objective: We sought to determine the effects of adhering to the consumption of a MedDiet for 6 mo on blood pressure and endothelial function in older, healthy Australians.Design: A total of 166 men and women aged >64 y were allocated via minimization to consume either a MedDiet (n = 85) or their habitual diet (HabDiet; control: n = 81) for 6 mo. The MedDiet comprised mainly plant foods, abundant extra-virgin olive oil, and minimal red meat and processed foods. A total of 152 participants commenced the study, and 137 subjects completed the study. Home blood pressure was measured on 5 consecutive days at baseline (n = 149) and at 3 and 6 mo. Endothelial function (n = 82) was assessed by flow-meditated dilatation (FMD) at baseline and 6 mo. Dietary intake was monitored with the use of 3-d weighed food records. Data were analyzed with the use of linear mixed-effects models to determine adjusted between-group differences.Results: The MedDiet adherence score increased significantly in the MedDiet group but not in the HabDiet group (P < 0.001). The MedDiet, compared with the HabDiet, resulted in lower systolic blood pressure (P-diet × time interaction = 0.02) [mean: -1.3 mm Hg (95% CI: -2.2, -0.3 mm Hg; P = 0.008) at 3 mo and -1.1 mm Hg (95% CI: -2.0, -0.1 mm Hg; P = 0.03) at 6 mo]. At 6 mo, the percentage of FMD was higher by 1.3% (95% CI: 0.2%, 2.4%; P = 0.026) in the MedDiet group.Conclusion: Australian men and women who consumed a MedDiet for 6 mo had small but significantly lower systolic blood pressure and improved endothelial function. This trial was registered at www.anzctr.org.au as ACTRN12613000602729.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Accurate measurement of BP is fundamental to diagnosis and effective management of hypertension.210,211,228”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [211]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1200303 · Cited by 4,257
RetractedAtherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure
Appel, L. J., Moore, T. J., Obarzanek, E., Vollmer, W. M., Svetkey, L. P., Sacks, F. M., Bray, G. A., Vogt, T. M., Cutler, J. A., Windhauser, M. M., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361601 · Cited by 5,981
Sacks, F. M., Svetkey, L. P., Vollmer, W. M., Appel, L. J., Bray, G. A., Harsha, D., Obarzanek, E., Conlin, P. R., Miller, E. R., Simons-Morton, D. G., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200101043440101 · Cited by 5,638
Pickering, T. G., Hall, J. E., Appel, L. J., Falkner, B. E., Graves, J., Hill, M. N., Jones, D. W., Kurtz, T., Sheps, S. G., & Roccella, E. J. (2005) · Circulation · doi:10.1161/01.cir.0000154900.76284.f6 · Cited by 3,985
Mediterranean diet pyramid: a cultural model for healthy eating
Willett, W., Sacks, F., Trichopoulou, A., Drescher, G., Ferro-Luzzi, A., Helsing, E., & Trichopoulos, D. (1995) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.6.1402s · Cited by 2,461
Esposito, K., Marfella, R., Ciotola, M., Di Palo, C., Giugliano, F., Giugliano, G., D'Armiento, M., D'Andrea, F., & Giugliano, D. (2004) · JAMA · doi:10.1001/jama.292.12.1440 · Cited by 2,126
Pickering, T. G., Hall, J. E., Appel, L. J., Falkner, B. E., Graves, J., Hill, M. N., Jones, D. W., Kurtz, T., Sheps, S. G., & Roccella, E. J. (2005) · Hypertension · doi:10.1161/01.hyp.0000150859.47929.8e · Cited by 2,051
Potential Role of Carotenoids as Antioxidants in Human Health and Disease
Fiedor, J., & Burda, K. (2014) · Nutrients · doi:10.3390/nu6020466 · Cited by 1,420
Definition of the Mediterranean Diet; A Literature Review
Davis, C. R., Bryan, J., Hodgson, J. M., & Murphy, K. J. (2015) · Nutrients · doi:10.3390/nu7115459 · Cited by 1,272
Self-citationBrachial Flow-Mediated Dilation Predicts Incident Cardiovascular Events in Older Adults
Yeboah, J., Crouse, J. R., Hsu, F., Burke, G. L., & Herrington, D. M. (2007) · Circulation · doi:10.1161/circulationaha.106.678276 · Cited by 902
Benefits of the Mediterranean Diet: Insights From the PREDIMED Study
Martínez‐González, M. Á., Salas‐Salvadó, J., Estruch, R., Corella, D., Fitó, M., & Ros, E. (2015) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2015.04.003 · Cited by 836
Inaba, Y., Chen, J. A., & Bergmann, S. R. (2010) · The International Journal of Cardiovascular Imaging · doi:10.1007/s10554-010-9616-1 · Cited by 820
Behavioral and Dietary Risk Factors for Noncommunicable Diseases
Ezzati, M., & Ríboli, E. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1203528 · Cited by 775
Cohort Profile: Design and methods of the PREDIMED study
Martinez-Gonzalez, M. A., Corella, D., Salas-Salvado, J., Ros, E., Covas, M. I., Fiol, M., Warnberg, J., Aros, F., Ruiz-Gutierrez, V., Lamuela-Raventos, R. M., et al. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dyq250 · Cited by 671
Hodge, A. M., Patterson, A. J., Brown, W. J., Ireland, P. D., & Giles, G. G. (2000) · Australian and New Zealand Journal of Public Health · doi:10.1111/j.1467-842x.2000.tb00520.x · Cited by 632
Scientific Evidence of Interventions Using the Mediterranean Diet: A Systematic Review
Serra‐Majem, L., Román, B., & Estruch, R. (2006) · Nutrition Reviews · doi:10.1111/j.1753-4887.2006.tb00232.x · Cited by 583
Ψαλτοπούλου, Θ., Naska, A., Orfanos, P., Trichopoulos, D., Mountokalakis, T. D., & Trichopoulou, A. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.4.1012 · Cited by 524
Diet, nutrition and the prevention of hypertension and cardiovascular diseases
Reddy, K. S., & Katan, M. B. (2004) · Public Health Nutrition · doi:10.1079/phn2003587 · Cited by 487
A Walnut Diet Improves Endothelial Function in Hypercholesterolemic Subjects
Ros, E., Núñez, I., Pérez-Heras, A., Serra, M., Gilabert, R., Casals, E., & Deulofeu, R. (2004) · Circulation · doi:10.1161/01.cir.0000124477.91474.ff · Cited by 472
Accuracy of weighed dietary records in studies of diet and health.
Livingstone, M. B., Prentice, A. M., Strain, J. J., Coward, W. A., Black, A. E., Barker, M. E., McKenna, P. G., & Whitehead, R. G. (1990) · BMJ · doi:10.1136/bmj.300.6726.708 · Cited by 455
Ndanuko, R. N., Tapsell, L. C., Charlton, K. E., Neale, E. P., & Batterham, M. J. (2016) · Advances in Nutrition · doi:10.3945/an.115.009753 · Cited by 403
Assessment of atherosclerosis: the role of flow-mediated dilatation
Charakida, M., Masi, S., Lüscher, T. F., Kastelein, J. J. P., & Deanfield, J. E. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq340 · Cited by 292
Bonanome, A., Pagnan, A., Biffanti, S., Opportuno, A., Sorgato, F., Dorella, M., Maiorino, M., & Ursini, F. (1992) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.12.4.529 · Cited by 291
Toledo, E., Hu, F. B., Estruch, R., Buil-Cosiales, P., Corella, D., Salas-Salvadó, J., Covas, M. I., Arós, F., Gómez-Gracia, E., Fiol, M., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-207 · Cited by 289
The role of virgin olive oil components in the modulation of endothelial function
Perona, J. S., Cabello-Moruno, R., & Ruíz-Gutiérrez, V. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.11.007 · Cited by 282
Mediterranean and Low-Fat Diets Improve Endothelial Function in Hypercholesterolemic Men
Fuentes, F. J., López‐Miranda, J., Sánchez, E., Sánchez, F., Paez, J., Paz-Rojas, E., Marı́n, C., Gómez, P., Jiménez-Perepérez, J., Ordovás, J. M., et al. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-12-200106190-00011 · Cited by 260
Rallidis, L. S., Lekakis, J. P., Kolomvotsou, A., Zampelas, A., Vamvakou, G. D., Efstathiou, S. P., Dimitriadis, G., Raptis, S., & Kremastinos, D. T. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27290 · Cited by 201
The relative importance of vascular structure and function in predicting cardiovascular events
Fathi, R. B., Haluska, B. A., Isbel, N. M., Short, L., & Marwick, T. H. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.09.042 · Cited by 198
Zazpe, I., Sanchez-Tainta, A., Estruch, R., Lamuela-Raventos, R. M., Schröder, H., Salas-Salvado, J., Corella, D., Fiol, M., Gomez-Gracia, E., Aros, F., et al. (2008) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.04.011 · Cited by 193
Itsiopoulos, C., Brazionis, L., Kaimakamis, M., Cameron, M., Best, J. D., O’Dea, K., & Rowley, K. (2011) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.03.005 · Cited by 171
Mediterranean diet reduces endothelial damage and improves the regenerative capacity of endothelium
Marín, C., Ramírez, R., Delgado‐Lista, J., Yubero‐Serrano, E. M., Pérez‐Martínez, P., Carracedo, J., García‐Ríos, A., Rodríguez, F., Gutierrez-Mariscal, F. M., Gómez, P., et al. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.006866 · Cited by 165
The Effect of the Mediterranean Diet on Hypertension: A Systematic Review and Meta-Analysis
Nissensohn, M., Román‐Viñas, B., Sánchez‐Villegas, A., Piscopo, S., & Serra‐Majem, L. (2015) · Journal of Nutrition Education and Behavior · doi:10.1016/j.jneb.2015.08.023 · Cited by 157
Hargrove, R. L., Etherton, T. D., Pearson, T. A., Harrison, E. H., & Kris‐Etherton, P. M. (2001) · Journal of Nutrition · doi:10.1093/jn/131.6.1758 · Cited by 124
Marfella, R., Ciotola, M., Palo, C. D., Giugliano, F., Giugliano, G., & Giugliano, D. (2017) · Cited by 120
Tzima, N., Pitsavos, C. E., Panagiotakos, D. B., Skoumas, J., Zampelas, A., Chrysohoou, C. A., & Stefanadis, C. (2007) · Lipids in Health and Disease · doi:10.1186/1476-511x-6-22 · Cited by 107
Bonifacj, C., Gerber, M., Scali, J., & Daurès, J. (1997) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600387 · Cited by 101
Franzini, L., Ardigò, D., Valtueña, S., Pellegrini, N., Rio, D. D., Bianchi, M. A., Scazzina, F., Piatti, P. M., Brighenti, F., & Zavaroni, I. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.04.001 · Cited by 84
Søndergaard, E. V., Møller, J. E., & Egstrup, K. (2003) · American Heart Journal · doi:10.1016/s0002-8703(03)00078-4 · Cited by 61
Knight, A., Bryan, J., Wilson, C. J., Hodgson, J. M., & Murphy, K. J. (2015) · BMC Geriatrics · doi:10.1186/s12877-015-0054-8 · Cited by 56
Self-citationMcCall, D., McGartland, C. P., McKinley, M. C., Sharpe, P. C., McCance, D. R., Young, I. S., & Woodside, J. V. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.01.009 · Cited by 33
Moreno, J. A., López‐Miranda, J., Pérez‐Martínez, P., Marı́n, C., Moreno‐Luna, R., Gómez, P., Paniagua, J. A., & Pérez‐Jiménez, F. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508911508 · Cited by 31
Davis, C. R., Bryan, J., Hodgson, J. M., Wilson, C. J., Dhillon, V. S., & Murphy, K. J. (2015) · BMC Nutrition · doi:10.1186/s40795-015-0033-7 · Cited by 21
Self-citationDavis, C. R., Bryan, J., Hodgson, J. M., Wilson, C. J., & Murphy, K. J. (2015) · BMC Nutrition · doi:10.1186/s40795-015-0021-y · Cited by 16
Self-citation
Cited by
Sorted by citations
The Mediterranean diet and health: a comprehensive overview
Guasch‐Ferré, M., & Willett, W. C. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13333 · Cited by 940
Medina-Leyte, D. J., Zepeda-García, Ó., Domínguez‐Pérez, M., González-Garrido, A., Villarreal-Molina, M. T., & Jacobo‐Albavera, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083850 · Cited by 678
Blonde, L., Umpierrez, G. E., Reddy, S. S., McGill, J. B., Berga, S. L., Bush, M., Chandrasekaran, S., DeFronzo, R. A., Einhorn, D., Galindo, R. J., et al. (2022) · Endocrine Practice · doi:10.1016/j.eprac.2022.08.002 · Cited by 507
Samson, S. L., Vellanki, P., Blonde, L., Christofides, E. A., Galindo, R. J., Hirsch, I. B., Isaacs, S. D., Izuora, K. E., Low Wang, C. C., Twining, C. L., et al. (2023) · Endocrine Practice · doi:10.1016/j.eprac.2023.02.001 · Cited by 375
Lifestyle interventions for the prevention and treatment of hypertension
Valenzuela, P. L., Carrera‐Bastos, P., Gálvez, B. G., Ruiz‐Hurtado, G., Ordovás, J. M., Ruilope, L. M., & Lucía, A. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00437-9 · Cited by 400
Metadata
- Authors
- Davis, C. R., Hodgson, J. M., Woodman, R., Bryan, J., Wilson, C., & Murphy, K. J.
- Affiliations
- University of South Australia (AU)
- Edith Cowan University (AU)
- Flinders University (AU)
- Corresponding author
- Davis, Courtney R
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 105
- Issue
- 6
- Pages
- 1305-1313
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2607334803
- Cited by
- 191
- References
- 44
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 15 · 2023: 20 · 2022: 30 · 2021: 31 · 2020: 26 · 2019: 18 · 2018: 16 · 2017: 3
- FWCI
- 16.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Australasian Journal of Paramedicine (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- Medical Research Council
- National Health and Medical Research Council (1050949)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Keywords
- Mediterranean diet, blood pressure, endothelial function, flow-mediated dilation, older adults, extra virgin olive oil, dietary intervention, hypertension, cardiovascular disease prevention, dietary adherence, systolic blood pressure reduction, plant-based diet, home blood pressure monitoring, dietary monitoring
- MeSH terms
- Aged, Australia, Blood Pressure, Cardiovascular Diseases, Endothelium, Vascular, Feeding Behavior, Female, Humans, Male, Vasodilation, Diet Records, Diet, Mediterranean
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
