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Cited by 132Nutrition and Health in AgingMuscle metabolism and nutritionMuscle Physiology and Disorders

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

The effects of dietary protein intake on appendicular lean mass and muscle function in elderly men: a 10-wk randomized controlled trial

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Mitchell, Cameron J, Milan, Amber M, Mitchell, Sarah M, Zeng, Nina, Ramzan, Farha, Sharma, Pankaja, Knowles, Scott O, Roy, Nicole C, Sjödin, Anders, Wagner, Karl-Heinz, Cameron-Smith, David·2017·The American Journal of Clinical Nutrition
DOI 10.3945/ajcn.117.160325
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Abstract

Background: The Recommended Daily Allowance (RDA) for protein intake in the adult population is widely promoted as 0.8 g · kg-1 · d-1 Aging may increase protein requirements, particularly to maintain muscle mass.Objective: We investigated whether controlled protein consumption at the current RDA or twice the RDA (2RDA) affects skeletal muscle mass and physical function in elderly men.Design: In this parallel-group randomized trial, 29 men aged >70 y [mean ± SD body mass index (in kg/m 2): 28.3 ± 4.2] were provided with a complete diet containing either 0.8 (RDA) or 1.6 (2RDA) g protein · kg-1 · d-1, aimed to balance energy needs. Before treatment and after 10 wk of intervention, whole-body and appendicular lean mass were measured by using dual-energy X-ray absorptiometry. Knee-extension peak power was measured with dynamometry.Results: Both groups were found to have been in a moderate negative energy balance (mean ± SD RDA: 209 ± 213 kcal/d; 2RDA 145 ± 214 kcal/d; P= 0.427 for difference between the groups). In comparison with RDA, whole-body lean mass increased in 2RDA (P = 0.001; 1.49 ± 1.30 kg, P < 0.001 compared with -0.55 ± 1.49 kg, P = 0.149). This difference was mostly accounted for by an increase in trunk lean mass found in 2RDA (+1.39 ± 1.09 kg, P < 0.001). Appendicular lean mass also decreased in RDA compared with 2RDA (P = 0.022), driven by a reduction in RDA (-0.64 ± 0.91 kg, P = 0.005 compared with 0.11 ± 0.57 kg, P = 0.592). Adjusting for energy imbalances did not alter these findings. Knee-extension peak power was also differently affected (P = 0.012; 26.6 ± 47.7 W, P = 0.015 in 2RDA compared with -11.7 ± 31.0 W, P = 0.180 in RDA).Conclusions: Consumption of a diet providing 2RDA for protein compared with the current guidelines was found to have beneficial effects on lean body mass and leg power in elderly men. These effects were not explained by differences in energy balance. This trial was registered at the Australia New Zealand Clinical Trial Registry (www.anzctr.org.au) as ACTRN12616000310460.

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Research works printed but not linked: 3

  1. 2007, Protein and amino acid requirements in human nutrition. World Health Organ Tech Rep Ser 2007:1–265, back cover., Protein and amino acid requirements in human nutrition. World Health Organ Tech Rep Ser 2007:1–265, back cover., 1
  2. 2013, Food and nutrition guidelines for healthy older peoplea background paper, Wellington (New Zealand): Ministry of Health
  3. 2014, Annual update of key results 2013/14: New Zealand Health Survey., Annual update of key results 2013/14: New Zealand Health Survey.

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Metadata

Authors
Mitchell, C. J., Milan, A. M., Mitchell, S. M., Zeng, N., Ramzan, F., Sharma, P., Knowles, S. O., Roy, N. C., Sjödin, A., Wagner, K.-H., & Cameron-Smith, D.
Affiliations
  • University of Auckland (NZ)
  • AgResearch (NZ)
  • University of Copenhagen (DK)
  • University of Vienna (AT)
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2017-12
Volume
106
Issue
6
Pages
1375-1383
ISSN
0002-9165 (ISSN-L)
DOI
10.3945/ajcn.117.160325
OpenAlex
W2765197935
Cited by
132
References
53
Citations by year
2026: 2 · 2025: 13 · 2024: 12 · 2023: 8 · 2022: 20 · 2021: 20 · 2020: 19 · 2019: 25 · 2018: 13
FWCI
11.52
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
  • ResearchSpace (University of Auckland) (submittedVersion)
Funders
AgResearch
Topics
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
protein intake, protein requirements, recommended daily allowance, appendicular lean mass, skeletal muscle mass, muscle function, older men, sarcopenia, energy balance, aging, muscle strength, trunk lean mass, protein supplementation, physical function decline, muscle protein synthesis, muscle protein degradation, muscle fiber cross-sectional area, muscle fiber hypertrophy
MeSH terms
Aged, Aged, 80 and over, Aging, Body Composition, Body Fluid Compartments, Energy Intake, Diet, Dietary Proteins, Energy Metabolism, Feeding Behavior, Humans, Leg, Male, Nutritional Requirements, Organ Size, Absorptiometry, Photon, Body Mass Index, Muscle, Skeletal, Muscle Strength, Recommended Dietary Allowances

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