Effect of Protein Intake on Lean Body Mass in Functionally Limited Older Men: A Randomized Clinical Trial
Open accessAbstract
Importance: The Institute of Medicine set the recommended dietary allowance (RDA) for protein at 0.8 g/kg/d for the entire adult population. It remains controversial whether protein intake greater than the RDA is needed to maintain protein anabolism in older adults. Objective: To investigate whether increasing protein intake to 1.3 g/kg/d in older adults with physical function limitations and usual protein intake within the RDA improves lean body mass (LBM), muscle performance, physical function, fatigue, and well-being and augments LBM response to a muscle anabolic drug. Design, Setting, and Participants: This randomized clinical trial with a 2 × 2 factorial design was conducted in a research center. A modified intent-to-treat analytic strategy was used. Participants were 92 functionally limited men 65 years or older with usual protein intake less thanor equal to 0.83 g/kg/d within the RDA. The first participant was randomized on September 21, 2011, and the last participant completed the study on January 19, 2017. Interventions: Participants were randomized for 6 months to controlled diets with 0.8 g/kg/d of protein plus placebo, 1.3 g/kg/d of protein plus placebo, 0.8 g/kg/d of protein plus testosterone enanthate (100 mg weekly), or 1.3 g/kg/d of protein plus testosterone. Prespecified energy and protein contents were provided through custom-prepared meals and supplements. Main Outcomes and Measures: The primary outcome was change in LBM. Secondary outcomes were muscle strength, power, physical function, health-related quality of life, fatigue, affect balance, and well-being. Results: Among 92 men (mean [SD] age, 73.0 [5.8] years), the 4 study groups did not differ in baseline characteristics. Changes from baseline in LBM (0.31 kg; 95% CI, -0.46 to 1.08 kg; P = .43) and appendicular (0.04 kg; 95% CI, -0.48 to 0.55 kg; P = .89) and trunk (0.24 kg; 95% CI, -0.17 to 0.66 kg; P = .24) lean mass, as well as muscle strength and power, walking speed and stair-climbing power, health-related quality of life, fatigue, and well-being, did not differ between men assigned to 0.8 vs 1.3 g/kg/d of protein regardless of whether they received testosterone or placebo. Fat mass decreased in participants given higher protein but did not change in those given the RDA: between-group differences were significant (difference, -1.12 kg; 95% CI, -2.04 to -0.21; P = .02). Conclusions and Relevance: Protein intake exceeding the RDA did not increase LBM, muscle performance, physical function, or well-being measures or augment anabolic response to testosterone in older men with physical function limitations whose usual protein intakes were within the RDA. The RDA for protein is sufficient to maintain LBM, and protein intake exceeding the RDA does not promote LBM accretion or augment anabolic response to testosterone. Trial Registration: clinicaltrials.gov Identifier: NCT01275365.
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Higher protein doses have recently demonstrated no changes in lean mass.
“higher doses have recently demonstrated no changes in lean mass273”
From Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies (2018) · cites this paper as [273]
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Trumbo, P., Schlicker, S., Yates, A. A., & Poos, M. (2002) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(02)90346-9 · Cited by 5,993 · see citing works
Exercise training and nutritional supplementation for physical frailty in very elderly people
Fiatarone, M. A., O'Neill, E. F., Ryan, N. D., Clements, K. M., Solares, G. R., Nelson, M. E., Roberts, S. B., Kehayias, J. J., Lipsitz, L. A., & Evans, W. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302501 · Cited by 2,857 · see citing works
Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553 · see citing works
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2354 · Cited by 1,954 · see citing works
Self-citationDeutz, N. E. P., Bauer, J. M., Barazzoni, R., Biolo, G., Boirie, Y., Bosy-Westphal, A., Cederholm, T., Cruz-Jentoft, A., Krznariç, Z., Nair, K. S., et al. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.04.007 · Cited by 1,738 · see citing works
High-Intensity Strength Training in Nonagenarians: Effects on Skeletal Muscle
Fiatarone, M. A. (1990) · JAMA · doi:10.1001/jama.1990.03440220053029 · Cited by 1,593 · see citing works
Houston, D. K., Nicklas, B. J., Ding, J., Harris, T. B., Tylavsky, F. A., Newman, A. B., Lee, J. S., Sahyoun, N. R., Visser, M., & Kritchevsky, S. B. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.150 · Cited by 1,214 · see citing works
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., Wackerhage, H., Taylor, P. M., & Rennie, M. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2640fje · Cited by 1,211 · see citing works
Effects of Testosterone Treatment in Older Men
Snyder, P. J., Bhasin, S., Cunningham, G. R., Matsumoto, A. M., Stephens-Shields, A. J., Cauley, J. A., Gill, T. M., Barrett-Connor, E., Swerdloff, R. S., Wang, C., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1506119 · Cited by 890 · see citing works
Self-citationCella, D. F., Eton, D. T., Lai, J., Peterman, A. H., & Merkel, D. E. (2002) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(02)00529-8 · Cited by 808 · see citing works
Bauer, J. M., Verlaan, S., Bautmans, I., Brandt, K., Donini, L. M., Maggio, M., McMurdo, M. E. T., Mets, T., Seal, C., Wijers, S. L., et al. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.05.021 · Cited by 670 · see citing works
Muscle tissue changes with aging
Volpi, E., Nazemi, R., & Fujita, S. (2004) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/01.mco.0000134362.76653.b2 · Cited by 569 · see citing works
Bhasin, S., Woodhouse, L., Casaburi, R., Singh, A. B., Mac, R. P., Lee, M., Yarasheski, K. E., Sinha-Hikim, I., Dzekov, C., Dzekov, J., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1184 · Cited by 544 · see citing works
Self-citationMeta-analysis of nitrogen balance studies for estimating protein requirements in healthy adults
Rand, W. M., Pellett, P. L., & Young, V. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.1.109 · Cited by 506 · see citing works
Optimal protein intake in the elderly
Wolfe, R. R., Miller, S. L., & Miller, K. B. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.06.008 · Cited by 456 · see citing works
Tieland, M., van de Rest, O., Dirks, M. L., van der Zwaluw, N., Mensink, M., van Loon, L. J. C., & de Groot, L. C. P. G. M. (2012) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2012.07.005 · Cited by 446 · see citing works
Campbell, W. W., Trappe, T. A., Wolfe, R. R., & Evans, W. J. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.6.m373 · Cited by 397 · see citing works
Self-citationBhasin, S. (2000) · JAMA · doi:10.1001/jama.283.6.763 · Cited by 367 · see citing works
Self-citationCastaneda, C., Charnley, J., Evans, W., & Crim, M. (1995) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.1.30 · Cited by 290 · see citing works
Evaluation of protein requirements for trained strength athletes
Tarnopolsky, M. A., Atkinson, S. A., MacDougall, J. D., Chesley, A., Phillips, S., & Schwarcz, H. P. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.5.1986 · Cited by 289 · see citing works
Longland, T. M., Oikawa, S. Y., Mitchell, C. J., Devries, M. C., & Phillips, S. M. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.119339 · Cited by 271 · see citing works
Increased protein requirements in elderly people: new data and retrospective reassessments
Campbell, W. W., Crim, M. C., Dallal, G., Young, V. R., & Evans, W. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.4.501 · Cited by 267 · see citing works
Self-citationLemon, P. W., Tarnopolsky, M. A., MacDougall, J. D., & Atkinson, S. A. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.2.767 · Cited by 241 · see citing works
Kim, J. E., O’Connor, L. E., Sands, L. P., Slebodnik, M. B., & Campbell, W. W. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuv065 · Cited by 238 · see citing works
Self-citationKoopman, R., Verdijk, L. B., MANDERS, R. J. F., Gijsen, A. P., Gorselink, M., Pijpers, E., Wagenmakers, A. J. M., & van Loon, L. J. C. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.3.623 · Cited by 202 · see citing works
Gersovitz, M., Motil, K. J., Munro, H. N., Scrimshaw, N. S., & Young, V. R. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/35.1.6 · Cited by 174 · see citing works
Berner, L. A., Becker, G., Wise, M., & Doi, J. (2013) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2013.01.014 · Cited by 171 · see citing works
Effects of resistance training and dietary protein intake on protein metabolism in older adults
Campbell, W. W., Crim, M. C., Young, V. R., Joseph, L. J., & Evans, W. J. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.268.6.e1143 · Cited by 170 · see citing works
Self-citationBody Composition in Elderly Men: Effect of Dietary Modification during Strength Training
Meredith, C. N., Frontera, W. R., O’Reilly, K., & Evans, W. J. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb01937.x · Cited by 160 · see citing works
Maurya, S. K., Bal, N. C., Sopariwala, D. H., Pant, M., Rowland, L. A., Shaikh, S. A., & Periasamy, M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.636878 · Cited by 146 · see citing works
Gregório, L., Brindisi, J., Kleppinger, A., Sullivan, R., Mangano, K. M., Bihuniak, J., Kenny, A., Kerstetter, J., & Insogna, K. (2013) · The Journal of Nutrition, Health & Aging · doi:10.1007/s12603-013-0391-2 · Cited by 137 · see citing works
Rennie, M. J. (2009) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h09-012 · Cited by 135 · see citing works
Sahni, S., Mangano, K. M., Hannan, M., Kiel, D., & McLean, R. (2015) · Journal of NutriLife · doi:10.3945/jn.114.204925 · Cited by 133 · see citing works
Holm, L., Olesen, J. L., Matsumoto, K., Doi, T., Mizuno, M., Alsted, T. J., Mackey, A. L., Schwarz, P., & Kjær, M. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00935.2007 · Cited by 131 · see citing works
LeBrasseur, N. K., Bhasin, S., Miciek, R., & Storer, T. W. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.01953.x · Cited by 82 · see citing works
Self-citationHutchison, A. T., Piscitelli, D., Horowitz, M., Jones, K. L., Clifton, P. M., Standfield, S., Hausken, T., Feinle‐Bisset, C., & Luscombe‐Marsh, N. D. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.117556 · Cited by 74 · see citing works
Isanejad, M., Mursu, J., Sirola, J., Kröger, H., Rikkonen, T., Tuppurainen, M., & Erkkila, A. (2015) · Journal of Nutritional Science · doi:10.1017/jns.2015.31 · Cited by 68 · see citing works
Revicki, D. A., Leidy, N. K., & Howland, L. O. O. C. (1996) · Quality of Life Research · doi:10.1007/bf00449916 · Cited by 64 · see citing works
Xu, Z.-R., Tan, Z., Zhang, Q., Gui, Q.-F., & Yang, Y.-M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109141 · Cited by 61 · see citing works
Iglay, H. B., Apolzan, J. W., Gerrard, D. E., Eash, J. K., Anderson, J. C., & Campbell, W. W. (2009) · The journal of nutrition health & aging · doi:10.1007/s12603-009-0016-y · Cited by 56 · see citing works
Self-citationDietary protein intake is associated with lean body mass in community-dwelling older adults
Geirsdóttir, Ó. G., Arnarson, A., Ramel, A., Jónsson, P. V., & Þórsdóttir, I. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.05.014 · Cited by 53 · see citing works
The Total Specific Dynamic Action of High-Protein and High-Carbohydrate Diets on Human Subjects
Glickman, N., Mitchell, H. H., Lambert, E. H., & Keeton, R. W. (1948) · Journal of Nutrition · doi:10.1093/jn/36.1.41 · Cited by 53 · see citing works
McDonald, C. J., Ankarfeldt, M. Z., Capra, S. M., Bauer, J. D., Raymond, K., & Heitmann, B. L. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516000611 · Cited by 48 · see citing works
Protein requirements: methodologic controversy amid a call for change
Fukagawa, N. K. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.084772 · Cited by 32 · see citing works
Beasley, J. M., Deierlein, A. L., Morland, K. B., Granieri, E., & Spark, A. (2016) · The Journal of Nutrition, Health & Aging · doi:10.1007/s12603-015-0707-5 · Cited by 32 · see citing works
Nutrient database for the 2003 exchange lists for meal planning☆☆☆
Wheeler, M. L. (2003) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(03)00376-6 · Cited by 29 · see citing works
Campbell, W. W., Kim, J. E., Amankwaah, A. F., Gordon, S. L., & Weinheimer-Haus, E. M. (2015) · The Journal of Nutrition · doi:10.3945/jn.115.213595 · Cited by 28 · see citing works
Self-citationBhasin, S., Apovian, C. M., Travison, T. G., Pencina, K. M., Huang, G. T.-W., Moore, L. L., Campbell, W. W., Howland, A., Chen, R., Singer, M. R., et al. (2017) · Contemporary Clinical Trials · doi:10.1016/j.cct.2017.05.004 · Cited by 10 · see citing works
Self-citationApovian, C., Singer, M., Campbell, W. W., Bhasin, S., McCarthy, A. C., Shah, M. S., Basaria, S., & Moore, L. (2017) · The Journal of Nutrition, Health & Aging · doi:10.1007/s12603-017-0990-4 · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
2 of the 51 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [2]2. Rennie MJ. Anabolic resistance: the effects of aging, sexual dimorphism, and immobilization on human muscle protein turnover. Appl Physiol Nutr Metab. 2009;34(3):377-381.
Cited by
Sorted by citations
Cruz-Jentoft, A. J., & Sayer, A. A. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31138-9 · Cited by 3,905 · see citing works
Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies
Batsis, J. A., & Villareal, D. T. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0062-9 · Cited by 1,382 · see citing works
Sarcopenia in chronic kidney disease: what have we learned so far?
Sabatino, A., Cuppari, L., Stenvinkel, P., Lindholm, B., & Avesani, C. M. (2020) · Journal of Nephrology · doi:10.1007/s40620-020-00840-y · Cited by 524 · see citing works
Calorie Restriction and Aging in Humans
Flanagan, E. W., Most, J., Mey, J. T., & Redman, L. M. (2020) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-122319-034601 · Cited by 239 · see citing works
“Application of current clinical approaches like vitamin D supplementation and testosterone as adjuvant therapies to CR in elderly individuals may be warranted for those at high risk of developing sarcopenia and frailty (11).”
BackgroundInfluentialGender-Specific Impact of Sex Hormones on the Immune System
Sciarra, F., Campolo, F., Franceschini, E., Carlomagno, F., & Venneri, M. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076302 · Cited by 196 · see citing works
“Te replacement therapy in hypogonadal men is shown to increase the concentrations of circulating monocytes [52,53].”
BackgroundStrategies to Prevent Sarcopenia in the Aging Process: Role of Protein Intake and Exercise
Rogeri, P. S., Zanella, R., Martins, G. L., Garcia, M. D. A., Leite, G., Lugaresi, R., Gasparini, S. O., Sperandio, G. A., Ferreira, L. H. B., Souza-Junior, T. P., et al. (2021) · Nutrients · doi:10.3390/nu14010052 · Cited by 181 · see citing works
“3 g/kg/d of protein on markers of physical performance and lean body mass [128].”
BackgroundStrasser, B., Wolters, M., Weyh, C., Krüger, K., & Ticinesi, A. (2021) · Nutrients · doi:10.3390/nu13062045 · Cited by 181 · see citing works
Mitochondria as a Target for Mitigating Sarcopenia
Coen, P. M., Musci, R., Hinkley, J., & Miller, B. F. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01883 · Cited by 140 · see citing works
“However, recent studies examining increased protein intake in older individuals do not show increased lean body mass (LBM) accretion (Bhasin et al., 2018), and that the amount and quality of protein intake are not associated with muscle mass or strength in older adults (Gingrich et al.”
BackgroundCruz-Jentoft, A. J., Dawson Hughes, B., Scott, D., Sanders, K. M., & Rizzoli, R. (2020) · Maturitas · doi:10.1016/j.maturitas.2019.11.007 · Cited by 144 · see citing works
A word of caution against excessive protein intake
Mittendorfer, B., Klein, S., & Fontana, L. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0274-7 · Cited by 122 · see citing works
Sarcopenia definition: Does it really matter? Implications for resistance training
Smith, C., Woessner, M. N., Sim, M., & Levinger, I. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101617 · Cited by 107 · see citing works
Mertz, K. H., Reitelseder, S., Bechshoeft, R. L., Bülow, J., Højfeldt, G. W., Jensen, M., Schacht, S. R., Lind, M. V., Rasmussen, M. A., Mikkelsen, U. R., et al. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa372 · Cited by 91 · see citing works
“Increasing protein content in an iso-caloric diet has been shown to result in the loss of fat mass (18), but in the present study supplementation of any kind was associated with an increase in the fat percentage, with no marked change in LTM or body weight.”
BackgroundHruby, A., & Jacques, P. F. (2019) · Current Developments in Nutrition · doi:10.1093/cdn/nzz019 · Cited by 81 · see citing works
“Meeting protein needs in aging populations may therefore be important not just for maintenance of lean mass (7–9), strength (7, 8, 10), and physical function (9, 11, 12), but also for counteracting inflammation, oxidation, and their downstream catabolic effects”
BackgroundNasimi, N., Sohrabi, Z., Nunes, E. A., Sadeghi, E., Jamshidi, S., Gholami, Z., Akbarzadeh, M., Faghih, S., Akhlaghi, M., & Phillips, S. M. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.05.011 · Cited by 80 · see citing works
Benefits and Risks of Testosterone Treatment in Men with Age-Related Decline in Testosterone
dos Santos, M. R., & Bhasin, S. (2020) · Annual Review of Medicine · doi:10.1146/annurev-med-050219-034711 · Cited by 69 · see citing works
Self-citationProtein Intake and Functional Integrity in Aging: The Framingham Heart Study Offspring
Hruby, A., Sahni, S., Bolster, D. R., & Jacques, P. F. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly201 · Cited by 66 · see citing works
“These and other phenomena (25,40) potentially underlying observed differences are also supported by prior studies indicating that protein intake in men may have weaker associations with frailty (19), disability (25,26), and health-related quality of life, fatigue, or well-being (41).”
BackgroundResultOptimizing Adult Protein Intake During Catabolic Health Conditions
Phillips, S. M., Paddon-Jones, D., & Layman, D. K. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa047 · Cited by 65 · see citing works
“Given that a primary outcome was lean body mass measured by DXA (57) and given the recognized variability in the estimates of fat- and bone-free mass (i.e., lean body mass) from DXA measurements (58, 59), with only 21 participants per group this trial was not powered to detect differences in lean body mass due to prot…”
BackgroundInfluentialPhillips, S. M., & Martinson, W. (2018) · Nutrition reviews · doi:10.1093/nutrit/nuy062 · Cited by 64 · see citing works
Li, M.-L., Zhang, F., Luo, H.-Y., Quan, Z.-W., Wang, Y.-F., Huang, L.-T., & Wang, J.-H. (2024) · The Journal of nutrition, health and aging · doi:10.1016/j.jnha.2024.100184 · Cited by 62 · see citing works
Nutritional Interventions: Dietary Protein Needs and Influences on Skeletal Muscle of Older Adults
Campbell, W. W., Deutz, N. E. P., Volpi, E., & Apovian, C. M. (2023) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glad038 · Cited by 58 · see citing works
Self-citationBarazzoni, R., Bischoff, S. C., Busetto, L., Cederholm, T., Chourdakis, M., Cuerda, C., Delzenne, N. M., Genton, L., Schneider, S. M., Singer, P., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.05.006 · Cited by 59 · see citing works
“Similar to the estimation of energy needs, this approach may result in substantial overestimation of protein requirements in persons with obesity [83].”
Is It Time to Reconsider the U.S. Recommendations for Dietary Protein and Amino Acid Intake?
Weiler, M. D., Hertzler, S. R., & Dvoretskiy, S. (2023) · Nutrients · doi:10.3390/nu15040838 · Cited by 55 · see citing works
“…ancillary benefits of protein intakes above the RDA were reported, including lower body fat mass/better weight maintenance following weight loss [67–69], reductions in blood lipids (triacylglycerols, total-and LDL-cholesterol) when the additional protein source was whey [70], and improved…”
BackgroundMareschal, J., Genton, L., Collet, T., & Graf, C. E. (2020) · Nutrients · doi:10.3390/nu12092820 · Cited by 48 · see citing works
“2018 [47] Men Mobility limitations: SPPB 3–10 Daily protein intake < 0.”
BackgroundInfluentialBoutry, C., Vinyes-Parès, G., Breuillé, D., & Moritani, T. (2020) · Nutrients · doi:10.3390/nu12061866 · Cited by 46 · see citing works
“[12] demonstrated a beneficial effect of protein on physical performance in frail elderly adults but others did not demonstrate any long-term benefit [49].”
BackgroundESI Clinical Practice Guidelines for the Evaluation and Management of Obesity In India
Madhu, S., Kapoor, N., Das, S., Nishant, R., & Sanjay, K. (2022) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.356236 · Cited by 46 · see citing works
“8 g/kg per day protein is enough to maintain lean body mass and muscle function.[119,120] At present, there is inadequate data to support the use of pharmacotherapy and bariatric surgery in sarcopenic obesity.”
BackgroundLi, C., Meng, H., Wu, S., Fang, A., Liao, G., Tan, X., Chen, P., Wang, X., Chen, S., & Zhu, H. (2021) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2021.01.006 · Cited by 43 · see citing works
Hudson, J. L., Wang, Y., Bergia III, R. E., & Campbell, W. W. (2020) · Advances in Nutrition · doi:10.1093/advances/nmz106 · Cited by 41 · see citing works
“Protein intake as it relates to aging adults and skeletal muscle quantity and performance is particularly important (45, 53), but the varied experimental designs in the 5 articles resulted in 4 iterations of energy balance and RT, which precluded aggregating the articles separately.”
BackgroundSelf-citationGagliano‐Jucá, T., Pencina, K. M., Guo, W., Li, Z., Huang, G. T.-W., Basaria, S. S., & Bhasin, S. (2020) · Andrology · doi:10.1111/andr.12834 · Cited by 40 · see citing works
Self-citationHuang, W.-C., Huang, Y.-C., Lee, M., Chang, H., & Doong, J.-Y. (2021) · Nutrients · doi:10.3390/nu13020418 · Cited by 39 · see citing works
“Likewise, whether this association with protein-rich food applied to a frail older adults was still unclear [35].”
BackgroundManagement of sarcopenia in patients with rheumatoid arthritis
Torii, M., Itaya, T., Minamino, H., Katsushima, M., Fujita, Y., Tanaka, H., Oshima, Y., Watanabe, R., Ito, H., Arai, H., et al. (2022) · Modern Rheumatology · doi:10.1093/mr/roac095 · Cited by 38 · see citing works
Jang, Y. J. (2022) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2210.10014 · Cited by 39 · see citing works
“2 months did not increase lean body mass, muscle performance, nor physical function [13].”
BackgroundWei, M., Meng, D., Guo, H., He, S., Tian, Z., Wang, Z., Yang, G., & Wang, Z. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19169952 · Cited by 37 · see citing works
“8 g/kg/d for the entire adult population), there is no positive effect on the increase of LBM or the enhancement of the anabolic response to testosterone [22,23].”
BackgroundRus, G. E., Porter, J., Brunton, A., Crocker, M., Kotsimbos, Z., Percic, J., Polzella, L., Willet, N., & Huggins, C. (2020) · Nutrition & Dietetics · doi:10.1111/1747-0080.12608 · Cited by 29 · see citing works
“The lack of consistency reflects the absence of consensus for increasing protein intake in older adults.(5,40) As low protein intake is one of the underlying causes of sarcopenia(5) it is important for future research to determine the effective dose range.”
BackgroundNilsson, A. E., Rojas, D. M., & Kadi, F. (2018) · Nutrients · doi:10.3390/nu10091156 · Cited by 34 · see citing works
“3 g·kg−1 BW did not infer additional effects on muscle mass or enhance the testosterone-induced anabolic response [33].”
BackgroundHengeveld, L. M., de Goede, J., Afman, L. A., Bakker, S. J. L., Beulens, J. W. J., Blaak, E. E., Boersma, E. H., Geleijnse, J. M., van Goudoever, J. B., Hopman, M. T. E., et al. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab140 · Cited by 35 · see citing works
“2018 (46) Lean body mass, muscle strength, physical performance, serum lipids, kidney function Campbell et al.”
Perttila, N. M., Pitkälä, K. H., Kautiainen, H., Tilvis, R., & Strandberg, T. E. (2017) · The Journal of Frailty & Aging · doi:10.14283/jfa.2017.26 · Cited by 32 · see citing works
Dietary Protein, Exercise, and Frailty Domains
Schoufour, J. D., Overdevest, E., Weijs, P. J. M., & Tieland, M. (2019) · Nutrients · doi:10.3390/nu11102399 · Cited by 29 · see citing works
“Whereas some studies show a beneficial effect of dietary protein on muscle mass [16] or physical performance [17] in frail elderly people, other studies did not find an effect of increased dietary protein intake on muscle mass, strength or performance in elderly people that consume adequate daily protein [38,39].”
Mechanisms Regulating Muscle Protein Synthesis in Chronic Kidney Disease.
Zhang, L.-P., Chen, Q., Chen, Z.-H., Wang, Y., Gamboa, J., Ikizler, T., Garibotto, G., & Mitch, W. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2019121277 · Cited by 19 · see citing works
Protein Intake and Human Health: Implications of Units of Protein Intake
Hruby, A., & Jacques, P. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa097 · Cited by 26 · see citing works
“Only 4 of the 16 trials reported greater fat mass losses in high- compared with low-protein groups (24, 57, 71, 76); 3 trials reported higher or maintained lean or fat-free masses in high- v.”
ResultPossible Role of Nutrition in Prevention of Sarcopenia and Falls
Schneider, D., & Trence, D. (2019) · Endocrine Practice · doi:10.4158/ep-2019-0144 · Cited by 25 · see citing works
Huisingh-Scheetz, M. J., Martinchek, M., Becker, Y. T., Ferguson, M. K., & Thompson, K. (2019) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.12.002 · Cited by 24 · see citing works
Reinders, I., Wijnhoven, H. A. H., Jyväkorpi, S. K., Suominen, M. H., Niskanen, R. T., Bosmans, J. E., Brouwer, I. A., Fluitman, K. S., Klein, M. C. A., Kuijper, L. D. J., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-040637 · Cited by 24 · see citing works
Pikosky, M. A., Cifelli, C. J., Agarwal, S., & Fulgoni, V. L. I. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.873512 · Cited by 24 · see citing works
Rojas-Agurto, E., Leal-Witt, M. J., Arias, C., Cabello, J. F., Bunout, D. C., & Cornejo, V. (2023) · Nutrients · doi:10.3390/nu15132939 · Cited by 23 · see citing works
“3 g/kg/day do not modify muscle mass in patients with sarcopenia [37].”
BackgroundFuture foods symposium on alternative proteins: Workshop proceedings
Karmaus, A. L., & Jones, W. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.06.018 · Cited by 23 · see citing works
Reinders, I., Visser, M., Jyväkorpi, S. K., Niskanen, R. T., Bosmans, J. E., Ben, Â. J., Brouwer, I. A., Kuijper, L. D. J., Olthof, M. R., Pitkälä, K. H., et al. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02675-0 · Cited by 23 · see citing works
Matison, A. P., Milte, C. M., Shaw, J. E., Magliano, D. J., Daly, R. M., & Torres, S. J. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-02894-y · Cited by 21 · see citing works
Colon-Emeric, C. S., Whitson, H. E., Berry, S. D., Fielding, R. A., Houston, D. K., Kiel, D. P., Rosen, C. J., Seldeen, K. L., Volpi, E., White, J. P., et al. (2019) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16248 · Cited by 21 · see citing works
“However, protein’s effects on lean body mass and physical performance diminish with age.(38) The protein recommended daily allowance is based on nitrogen balance studies, an inadequate outcome for older adults at risk of sarcopenia.”
BackgroundBuratto, J., Kirk, B., Phu, S., Vogrin, S., & Duque, G. (2023) · Endocrine Practice · doi:10.1016/j.eprac.2023.04.013 · Cited by 20 · see citing works
Jungert, A., Eichner, G., & Neuhäuser‐Berthold, M. (2020) · Nutrients · doi:10.3390/nu12123626 · Cited by 19 · see citing works
Maleky, F., & Ahmadi, L. (2025) · RSC Advances · doi:10.1039/d4ra08221d · Cited by 18 · see citing works
Hawley, A., Liang, X., Børsheim, E., Wolfe, R., Salisbury, L., Hendy, E. B., Wu, H., Walker, S., Tacinelli, A. M., & Baum, J. (2022) · Meat Science · doi:10.1016/j.meatsci.2022.108830 · Cited by 17 · see citing works
Therapeutic and lifestyle approaches to obesity in older persons
Jiang, B. C., & Villareal, D. T. (2019) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000520 · Cited by 18 · see citing works
Gagliano‐Jucá, T., Li, Z., Pencina, K. M., Traustadóttir, T., Travison, T. G., Woodhouse, L. J., Basaria, S. S., Tsitouras, P. D., Harman, S. M., Bhasin, S., et al. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz167 · Cited by 19 · see citing works
Self-citationLandi, F., Sieber, C., Fielding, R., Rolland, Y., & Guralnik, J. M. (2018) · The Journal of frailty & aging · doi:10.14283/jfa.2018.26 · Cited by 30 · see citing works
“However, a significant reduction in intramuscular fat and increase in normal density muscle was observed with the nutritional supplement (29, 30).”
Protein-Restricted Diets and Their Impact on Metabolic Health and Aging
Kim, S. Q., Spann, R. A., Hill, C. M., Berryman, C. E., Berthoud, H., McDougal, D. H., He, Y., Münzberg, H., Yu, S., & Morrison, C. D. (2025) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-121624-114918 · Cited by 17 · see citing works
Kositsawat, J., Duque, G., & Kirk, B. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111521 · Cited by 16 · see citing works
Mena‐Montes, B., Hernández-Álvarez, D., Pedraza-Vázquez, G., Toledo-Pérez, R., Librado‐Osorio, R., García, J. A., Alarcón‐Aguilar, A., Lazzarini-Lechuga, R. C., Rosas‐Carrasco, Ó., Königsberg, M., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5526665 · Cited by 14 · see citing works
“Besides, various studies that have been conducted to determine protein intake effectiveness in the elderly population are biased, since they were performed recruiting healthy older adults without functional limitations and not individuals with protein intakes lower than the recommended daily dose [20].”
BackgroundThe medicalization of testosterone: reinventing the elixir of life
Gagliano‐Jucá, T., Álvarez, M., & Basaria, S. S. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09751-8 · Cited by 16 · see citing works
Self-citationAndrogens as the “old age stick” in skeletal muscle
Gentile, G., Stefano, F. D., Sorrentino, C., D’Angiolo, R., Lauretta, C., Giovannelli, P., Migliaccio, A., Castoria, G., & Donato, M. D. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02163-6 · Cited by 14 · see citing works
“…trials have consistently reported a significant improvement of the 6-minutes walking distance test, stair climb power, leg press strength and power on androgen treat-ment, once again indicating a dangerous liaison between the androgen decline and the loss of skeletal muscle tro-phism [127, 140].”
Optimizing Diagnostic Accuracy and Treatment Decisions in Men With Testosterone Deficiency
Bhasin, S., & Ozimek, N. (2021) · Endocrine Practice · doi:10.1016/j.eprac.2021.08.002 · Cited by 15 · see citing works
Self-citationFalqueto, H., dos Santos, M. R., & Manfredi, L. H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.838526 · Cited by 15 · see citing works
Huang, G. T.-W., Pencina, K. M., Li, Z., Apovian, C. M., Travison, T. G., Storer, T. W., Gagliano‐Jucá, T., Basaria, S. S., & Bhasin, S. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab007 · Cited by 15 · see citing works
“The adherence with dietary prescription (81%–86%) and testosterone/placebo injections (>99%) was high (14).”
BackgroundInfluentialSelf-citationFigueiredo, M. G., Gagliano‐Jucá, T., & Basaria, S. S. (2023) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2022.12.002 · Cited by 12 · see citing works
Self-citationNutritional approaches targeting mitochondria for the prevention of sarcopenia
Hahm, J., Nirmala, F. S., Ha, T. Y., & Ahn, J. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad084 · Cited by 12 · see citing works
Reinders, I., Visser, M., & Wijnhoven, H. A. H. (2020) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2020.02.020 · Cited by 12 · see citing works
Norouzi, M., Nadjarzadeh, A., Maleki, M., Khayyatzadeh, S. S., Hosseini, S., Yaseri, M., & Fattahi, H. (2022) · BMC Surgery · doi:10.1186/s12893-022-01495-1 · Cited by 12 · see citing works
“Also, the amount and type of protein intake has been studied [13]; although some studies indicated that taking protein from diet or supplements is associated with the prevention of excessive inflammatory responses [18, 19], some others reported conflicting results [20, 21].”
ResultSilva, T. R., Lago, S. C., Yavorivski, A., Ferreira, L. L., Fighera, T. M., & Spritzer, P. M. (2020) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001692 · Cited by 11 · see citing works
“As an integrated marker of protein anabolism, LBM can be measured precisely and is responsive to dietary interventions.(29) Secondary outcomes included appendicular lean mass (ALM), whole body and trunk fat mass and visceral adipose tissue (VAT).”
BackgroundStrasser, B., Grote, V., Bily, W., Nics, H., Riedl, P., Jira, I., & Fischer, M. J. (2023) · Healthcare · doi:10.3390/healthcare11162317 · Cited by 10 · see citing works
“5 g/kg per day may be too low for functionally limited older patients to successfully recover muscular strength and physical function, especially those with chronic diseases [26].”
BackgroundOgawa, M., Yoshida, N., Satomi‐Kobayashi, S., Tsuboi, Y., Komaki, K., Wakida, K., Gotake, Y., Inoue, T., Tanaka, H., Yamashita, T., et al. (2019) · Journal of Cardiology · doi:10.1016/j.jjcc.2019.03.011 · Cited by 10 · see citing works
O’Leary, F., Grech, A. L., Sui, Z., Cheng, H., Rangan, A., & Hirani, V. (2019) · European Journal of Clinical Nutrition · doi:10.1038/s41430-019-0478-x · Cited by 10 · see citing works
“There is some evidence that there may be benefits of higher protein intakes in protecting against the development of age-related syndromes including sarcopenia and frailty [15, 36–38]; however the evidence is mixed [39].”
BackgroundCheese: mere indulgence or part of a healthy diet?
Eugénio, A. T., Ramos, R., Barreto, I. R., Carriço, R., Marcos, J., Camelo, A., Santo, C. E., & Brandão, I. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1649432 · Cited by 9 · see citing works
Khanal, P., He, L., Degens, H., Stebbings, G. K., Onambélé-Pearson, G. L., Williams, A. G., Thomis, M. A., & Morse, C. I. (2021) · Nutrients · doi:10.3390/nu13093076 · Cited by 9 · see citing works
“Investigating the beneficial effect of protein and other nutrients on muscle phenotypes has utilized several approaches previously, with some studies identifying direct associations between nutrients and muscle phenotypes while some identified nutrients profiles of healthy elderly individuals [28–31].”
BackgroundIs Exercise Beneficial and Safe in Patients with Cirrhosis and Portal Hypertension?
Tapper, E. B., Martínez-Macías, R. F., & Duarte‐Rojo, A. (2018) · Current Hepatology Reports · doi:10.1007/s11901-018-0404-z · Cited by 9 · see citing works
Network pharmacology-based analysis of the effects of puerarin on sarcopenia
Chen, X., Wang, Y., Liu, M., Song, X., Wang, D., & Zhang, J. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-2360 · Cited by 7 · see citing works
“For some patients, exercise therapy is limited by advanced age and disease conditions, while evidence of the effectiveness of nutritional interventions alone has not yet been gathered by highquality studies (8,20).”
BackgroundThe anabolic applications of androgens in older adults with functional limitations
Gattu, A. K., Goldman, A. L., Guzelce, E. C., Galbiati, F., & Bhasin, S. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09766-1 · Cited by 8 · see citing works
Self-citationCorrea‐de‐Araujo, R., & Bhasin, S. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac181 · Cited by 7 · see citing works
Self-citationFraile‐Μartinez, O., Ortega, M. A., & Montero, C. G. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020692 · Cited by 9 · see citing works
Niskanen, R. T., Reinders, I., Wijnhoven, H. A. H., Hyvönen, A., Pols‐Vrijmoeth, M., Trommel‐Bout, M., Visser, M., Pitkälä, K. H., Suominen, M. H., Öhman, H., et al. (2023) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.13197 · Cited by 7 · see citing works
Overdevest, E., Dorhout, B. G., Nicolaou, M., van Valkengoed, I. G. M., Haveman‐Nies, A., Oztürk, H., de Groot, C. P. G. M., Tieland, M., & Weijs, P. J. M. (2021) · Nutrients · doi:10.3390/nu13010184 · Cited by 7 · see citing works
Molecular cloning, characterization, and functional analysis of the uncharacterized C11orf96 gene
Yang, H., Zhu, J., Guo, H., Tang, A., Chen, S., Zhang, D., Yuan, L., & Liu, G. (2022) · BMC Veterinary Research · doi:10.1186/s12917-022-03224-5 · Cited by 7 · see citing works
Sarcopenia in Aging: Pathogenesis, Diagnosis, and Emerging Therapeutic Frontiers
Jeyaraman, M., Jeyaraman, N., Nallakumarasamy, A., Ramasubramanian, S., Muthu, S., Murugan, S., Rajendran, S. N. S., Rajendran, R. L., Ahn, B., & Gangadaran, P. (2025) · Molecular Imaging and Biology · doi:10.1007/s11307-025-02071-8 · Cited by 6 · see citing works
Pharmacological targeting of age-related changes in skeletal muscle tissue
Leuchtmann, A. B., & Handschin, C. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.02.030 · Cited by 6 · see citing works
Optimizing the Design of Clinical Trials to Evaluate the Efficacy of Function-Promoting Therapies
Bhasin, S., Cawthon, P. M., Correa‐de‐Araujo, R., Storer, T. W., Volpi, E., Newman, A. B., Dioh, W., Tourette, C., Evans, W. J., & Fielding, R. A. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad024 · Cited by 6 · see citing works
Self-citationIgarashi, H., Uchino, H., Kanaguchi, M., Hisanaga, K., Sato, G., Yoshikawa, F., Furuta, M., Washizawa, N., Usui, S., Miyagi, M., et al. (2023) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-023-00990-6 · Cited by 5 · see citing works
“Increased total body muscle mass and higher total daily dose of insulin within the CRIC group, implicating increased anabolic demands due to the relatively high proportion of the protein intake [22, 23] Data from series of studies suggest that high protein intake could have detrimental metabolic effects; acute intrave…”
BackgroundApovian, C., Singer, M., Campbell, W. W., Bhasin, S., McCarthy, A. C., Shah, M. S., Basaria, S., & Moore, L. (2017) · The Journal of Nutrition, Health & Aging · doi:10.1007/s12603-017-0990-4 · Cited by 5 · see citing works
Self-citationWu, X., Lim, K. J., Ma, Y., Gu, J., Jiang, Y., Zhu, L., Chen, Y., & Sun, J. (2026) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70212 · Cited by 4 · see citing works
“However, another intervention trial done in nonsarcopenic patients with reduced mobility comparing the effects of normal versus increased protein intake on mobility showed no differences between these interventions [12].”
Kramer, C. S., Monsegue, A. P., Morwani‐Mangnani, J., Grootswagers, P., Beekman, M., Slagboom, P. E., Verdijk, L. B., & de Groot, C. P. G. M. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.112002 · Cited by 4 · see citing works
“Muscle mass, as measured by ALM, is estimated to require n = 25 in the mobility compromised group (Beaudart et al., 2020), n = 24 in the metabolically compromised group (Bhasin et al., 2018; Tieland et al., 2012b), and n = 55 in the TKR group (Liao et al., 2020).”
Dietary protein and muscle wasting in chronic kidney disease: new insights
Güngör, Ö., Kara, A. V., Hasbal, N. B., & Kalantar‐Zadeh, K. (2023) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000903 · Cited by 5 · see citing works
“[31] conducted a randomized controlled trial in elderly patients with physical function limitations.”
BackgroundNutritional requirements during ageing
Lecerf, J. (2019) · Object Constraint Language · doi:10.1051/ocl/2019015 · Cited by 3 · see citing works
Akazawa, N., Funai, K., Hino, T., Tsuji, R., Tamura, W., Tamura, K., Hioka, A., & Moriyama, H. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.09.922 · Cited by 2 · see citing works
Nagy, S.-R., Mititelu, M., Marin, R. C., Popovici, V., Pallag, A., & Jurca, T. (2025) · Sports · doi:10.3390/sports13060182 · Cited by 3 · see citing works
“Numerous studies investigated protein and amino acid supplementation associated with RT benefits in older people [12,18,20,23,61,74,81,84,101–111] Gender-related differences were evident in all exercises, with men consistently out-performing women.”
InfluentialBesoins nutritionnels au cours du vieillissement
Lecerf, J. (2019) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2019.06.002 · Cited by 2 · see citing works
Nagy, S.-R., Mititelu, M., Popovici, V., Marin, R.-C., Pallag, A., & Jurca, T. (2025) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk10030248 · Cited by 1 · see citing works
Differing dietary patterns according to body composition
Lee, Y.-C., Kim, H.-M., Lee, H. S., Jeon, S., Kwon, Y., & Lee, J. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1509620 · Cited by 1 · see citing works
High Protein Diets: What to Tell Our Patients.
Garibotto, G., Verzola, D., Picciotto, D., & Russo, E. (2026) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2026.01.023
Highlights from the 2019 International Congress on Frailty and Sarcopenia Research
Maltais, M. L., Aubertin‐Leheudre, M., Dray, C., Fielding, R. A., Rolland, Y., Cesari, M., & Vellas, B. J. (2019) · The Journal of Frailty & Aging · doi:10.14283/jfa.2019.13 · Cited by 1 · see citing works
“Dr Shalender Bashin presented preliminary results showing that protein intake higher than the recommended daily allowance (RDA) may not be always needed for improving muscle mass and function in older adults (24).”
Rooks, D. (2019) · Current Physical Medicine and Rehabilitation Reports · doi:10.1007/s40141-019-00236-5 · Cited by 1 · see citing works
Function Promoting Therapies Come of Age
Fielding, R. A. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz171
“3 g/kg/d for 6 months did not further increase lean body mass over and above the increases observed with testosterone therapy alone (14).”
Background
- Authors
- Bhasin, S., Apovian, C. M., Travison, T. G., Pencina, K., Moore, L. L., Huang, G., Campbell, W. W., Li, Z., Howland, A. S., Chen, R., Knapp, P. E., Singer, M. R., Shah, M., Secinaro, K., Eder, R. V., Hally, K., Schram, H., Bearup, R., Beleva, Y. M., McCarthy, A. C., Woodbury, E., McKinnon, J., Fleck, G., Storer, T. W., & Basaria, S.
- Affiliations
- Brigham and Women's Hospital (US)
- Boston Medical Center (US)
- Beth Israel Deaconess Medical Center (US)
- Boston University (US)
- Purdue University West Lafayette (US)
- Corresponding author
- Bhasin, Shalender
- ORCID
- Venue
- JAMA Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2018-04-01
- Volume
- 178
- Issue
- 4
- Pages
- 530
- ISSN
- 2168-6106 (ISSN-L)
- PMC
- PMC5885156
- OpenAlex
- W2790541301
- Cited by
- 113
- References
- 51
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 2 · 2023: 14 · 2022: 21 · 2021: 14 · 2020: 17 · 2019: 19 · 2018: 9 · 2017: 2
- FWCI
- 10.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Internal Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K08HL132122)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- protein intake, lean body mass, older men, functional limitations, high-protein diet, testosterone enanthate, muscle strength, muscle power, physical function, health-related quality of life, fatigue, well-being, sarcopenia, appendicular lean mass, walking speed, balance, protein supplementation
- MeSH terms
- Activities of Daily Living, Affect, Aged, Aged, 80 and over, Androgens, Body Composition, Dietary Proteins, Double-Blind Method, Fatigue, Health Status, Humans, Male, Mental Health, Quality of Life, Testosterone, Absorptiometry, Photon, Muscle Strength, Independent Living, Recommended Dietary Allowances
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