The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
The effects of dietary protein intake on appendicular lean mass and muscle function in elderly men: a 10-wk randomized controlled trial
Open accessAbstract
Background: The Recommended Daily Allowance (RDA) for protein intake in the adult population is widely promoted as 0.8 g · kg-1 · d-1 Aging may increase protein requirements, particularly to maintain muscle mass.Objective: We investigated whether controlled protein consumption at the current RDA or twice the RDA (2RDA) affects skeletal muscle mass and physical function in elderly men.Design: In this parallel-group randomized trial, 29 men aged >70 y [mean ± SD body mass index (in kg/m 2): 28.3 ± 4.2] were provided with a complete diet containing either 0.8 (RDA) or 1.6 (2RDA) g protein · kg-1 · d-1, aimed to balance energy needs. Before treatment and after 10 wk of intervention, whole-body and appendicular lean mass were measured by using dual-energy X-ray absorptiometry. Knee-extension peak power was measured with dynamometry.Results: Both groups were found to have been in a moderate negative energy balance (mean ± SD RDA: 209 ± 213 kcal/d; 2RDA 145 ± 214 kcal/d; P= 0.427 for difference between the groups). In comparison with RDA, whole-body lean mass increased in 2RDA (P = 0.001; 1.49 ± 1.30 kg, P < 0.001 compared with -0.55 ± 1.49 kg, P = 0.149). This difference was mostly accounted for by an increase in trunk lean mass found in 2RDA (+1.39 ± 1.09 kg, P < 0.001). Appendicular lean mass also decreased in RDA compared with 2RDA (P = 0.022), driven by a reduction in RDA (-0.64 ± 0.91 kg, P = 0.005 compared with 0.11 ± 0.57 kg, P = 0.592). Adjusting for energy imbalances did not alter these findings. Knee-extension peak power was also differently affected (P = 0.012; 26.6 ± 47.7 W, P = 0.015 in 2RDA compared with -11.7 ± 31.0 W, P = 0.180 in RDA).Conclusions: Consumption of a diet providing 2RDA for protein compared with the current guidelines was found to have beneficial effects on lean body mass and leg power in elderly men. These effects were not explained by differences in energy balance. This trial was registered at the Australia New Zealand Clinical Trial Registry (www.anzctr.org.au) as ACTRN12616000310460.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Timed “Up & Go”: A Test of Basic Functional Mobility for Frail Elderly Persons
Podsiadlo, D., & Richardson, S. (1991) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1991.tb01616.x · Cited by 14,418
Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601
Janssen, I., Heymsfield, S. B., & Ross, R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50216.x · Cited by 3,139
Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., Newman, A. B., et al. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1059 · Cited by 3,083
Walston, J., Hadley, E. C., Ferrucci, L., Guralnik, J. M., Newman, A. B., Studenski, S. A., Ershler, W. B., Harris, T., & Fried, L. P. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00745.x · Cited by 1,605
Morton, R. W., Murphy, K. T., McKellar, S. R., Schoenfeld, B. J., Henselmans, M., Helms, E., Aragon, A. A., Devries, M. C., Banfield, L., Krieger, J. W., et al. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2017-097608 · Cited by 1,269
Houston, D. K., Nicklas, B. J., Ding, J., Harris, T. B., Tylavsky, F. A., Newman, A. B., Lee, J. S., Sahyoun, N. R., Visser, M., & Kritchevsky, S. B. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.150 · Cited by 1,214
Skeletal Muscle Power: A Critical Determinant of Physical Functioning in Older Adults
Reid, K. F., & Fielding, R. A. (2012) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e31823b5f13 · Cited by 913
An overview of sarcopenia: facts and numbers on prevalence and clinical impact
von Haehling, S., Morley, J. E., & Anker, S. D. (2010) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1007/s13539-010-0014-2 · Cited by 888
The Harris Benedict equation reevaluated: resting energy requirements and the body cell mass
Roza, A. M., & Shizgal, H. M. (1984) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/40.1.168 · Cited by 824
Dietary protein recommendations and the prevention of sarcopenia
Paddon-Jones, D., & Rasmussen, B. B. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831cef8b · Cited by 823
Srikanthan, P., & Karlamangla, A. S. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0435 · Cited by 785
Moore, D. R., Churchward-Venne, T. A., Witard, O., Breen, L., Burd, N. A., Tipton, K. D., & Phillips, S. M. (2015) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glu103 · Cited by 770
Jančeková, K., Ruprich, J., de Vries, J. H. M., Jakubiková, M., & Veer, P. V. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509990602 · Cited by 728
The LIFE Study Investigators* [*See Appendix for List of LIFE Study Investigators] (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.11.1157 · Cited by 668
Nutritional recommendations for the management of sarcopenia
Morley, J. E., Argiles, J. M., Evans, W. J., Bhasin, S., Cella, D., Deutz, N. E. P., Doehner, W., Fearon, K. C. H., Ferrucci, L., Hellerstein, M. K., et al. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2010.04.014 · Cited by 664
Association of Muscle Power With Functional Status in Community-Dwelling Elderly Women
Foldvari, M., Clark, M., Laviolette, L. C., Bernstein, M. A., Kaliton, D., Castaneda, C., Pu, C. T., Hausdorff, J. M., Fielding, R. A., & Singh, M. A. F. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.4.m192 · Cited by 653
The Skeletal Muscle Anabolic Response to Plant- versus Animal-Based Protein Consumption
van Vliet, S., Burd, N. A., & van Loon, L. J. (2015) · The Journal of Nutrition · doi:10.3945/jn.114.204305 · Cited by 651
Resistance exercise load does not determine training-mediated hypertrophic gains in young men
Mitchell, C. J., Churchward-Venne, T. A., West, D. W. D., Burd, N. A., Breen, L., Baker, S. K., & Phillips, S. M. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00307.2012 · Cited by 627
Self-citationVillareal, D. T., Apovian, C. M., Kushner, R. F., & Klein, S. (2005) · Obesity Research · doi:10.1038/oby.2005.228 · Cited by 579
Ello-Martin, J. A., Ledikwe, J. H., & Rolls, B. J. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.1.236s · Cited by 513
Meta-analysis of nitrogen balance studies for estimating protein requirements in healthy adults
Rand, W. M., Pellett, P. L., & Young, V. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.1.109 · Cited by 506
Tieland, M., van de Rest, O., Dirks, M. L., van der Zwaluw, N., Mensink, M., van Loon, L. J. C., & de Groot, L. C. P. G. M. (2012) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2012.07.005 · Cited by 446
Dietary protein distribution positively influences 24-h muscle protein synthesis in healthy adults
Mamerow, M. M., Mettler, J. A., English, K. L., Casperson, S. L., Arentson-Lantz, E., Sheffield-Moore, M., Layman, D. K., & Paddon-Jones, D. (2014) · The Journal of Nutrition · doi:10.3945/jn.113.185280 · Cited by 438
Cawthon, P. M., Peters, K. W., Shardell, M. D., McLean, R. R., Dam, T.-T. L., Kenny, A. M., Fragala, M. S., Harris, T. B., Kiel, D. P., Guralnik, J. M., et al. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu023 · Cited by 388
Vasunilashorn, S. M., Coppin, A. K., Patel, K. V., Lauretani, F., Ferrucci, L., Bandinelli, S., & Guralnik, J. M. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln022 · Cited by 383
Aging is accompanied by a blunted muscle protein synthetic response to protein ingestion
Wall, B. T., Gorissen, S. H., Pennings, B., Koopman, R., Groen, B. B. L., Verdijk, L. B., & van Loon, L. J. C. (2015) · PLOS ONE · doi:10.1371/journal.pone.0140903 · Cited by 352
Elia, M., & Livesey, G. (2015) · World review of nutrition and dietetics · doi:10.1159/000421672 · Cited by 338
A Brief Review of Critical Processes in Exercise-Induced Muscular Hypertrophy
Phillips, S. M. (2014) · Sports Medicine · doi:10.1007/s40279-014-0152-3 · Cited by 281
Relation of muscle mass and fat mass to cardiovascular disease mortality
Srikanthan, P., Horwich, T. B., & Tseng, C. H. (2016) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2016.01.033 · Cited by 260
Reid, K. F., Pasha, E., Doros, G., Clark, D. J., Patten, C., Phillips, E. M., Frontera, W. R., & Fielding, R. A. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-013-2728-2 · Cited by 246
Dietary protein and muscle in older persons
Paddon‐Jones, D., & Leidy, H. J. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000011 · Cited by 209
Churchward-Venne, T. A., Burd, N. A., & Phillips, S. M. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-40 · Cited by 186
Kelley, D. S., Taylor, P. C., Nelson, G. J., & Mackey, B. E. (1998) · Lipids · doi:10.1007/s11745-998-0187-9 · Cited by 143
Fluharty, F. L., & McClure, K. E. (1997) · Journal of Animal Science · doi:10.2527/1997.753604x · Cited by 134
Bosy-Westphal, A., & Müller, M. J. (2015) · International Journal of Obesity · doi:10.1038/ijo.2014.161 · Cited by 133
Shad, B. J., Thompson, J. L., & Breen, L. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00213.2016 · Cited by 131
An easy approach to calculating estimated energy requirements.
Gerrior, S., Juan, W., & Peter, B. (2006) · PubMed · Cited by 129
Murphy, C. H., Churchward-Venne, T. A., Mitchell, C. J., Kolar, N. M., Kassis, A., Karagounis, L. G., Burke, L. M., Hawley, J. A., & Phillips, S. M. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00550.2014 · Cited by 124
Self-citationChowdhury, E. A., Western, M. J., Nightingale, T. E., Peacock, O. J., & Thompson, D. (2017) · PLOS ONE · doi:10.1371/journal.pone.0171720 · Cited by 118
The Effects of Increased Protein Intake on Kidney Size and Function
Hammond, K. A., & Janes, D. N. (1998) · Journal of Experimental Biology · doi:10.1242/jeb.201.13.2081 · Cited by 105
DIETARY PROTEIN TO MAINTAIN MUSCLE MASS IN AGING: A CASE FOR PER-MEAL PROTEIN RECOMMENDATIONS
Murphy, C. H., Oikawa, S. Y., & Phillips, S. M. (2016) · The Journal of Frailty & Aging · doi:10.14283/jfa.2016.80 · Cited by 105
Tang, M., McCabe, G. P., Elango, R., Pencharz, P. B., Ball, R. O., & Campbell, W. W. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.042325 · Cited by 92
Voluntary weight loss: systematic review of early phase body composition changes
Heymsfield, S. B., Thomas, D., Nguyen, A. M., Peng, J. Z., Martin, C., Shen, W., Strauss, B., Bosy‐Westphal, A., & Muller, M. J. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00767.x · Cited by 88
Rafii, M., Chapman, K., Elango, R., Campbell, W. W., Ball, R. O., Pencharz, P. B., & Courtney-Martin, G. (2016) · The Journal of Nutrition · doi:10.3945/jn.115.225631 · Cited by 87
Eating and activity guidelines for New Zealand adults
McIntyre, L., & Dutton, M. V. (2015) · Cited by 79
Protein requirements of elderly people.
Campbell, W. W., & Evans, W. J. (1996) · PubMed · Cited by 75
Mackenzie, T., Clark, N. G., Bistrian, B., Flatt, J., Hallowell, E., & Blackburn, G. (1985) · Journal of the American College of Nutrition · doi:10.1080/07315724.1985.10720100 · Cited by 61
Xu, Z., Tan, Z., Zhang, Q., Gui, Q., & Yang, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109141 · Cited by 60
Amigues, I., Schott, A., Amine, M., Gelas‐Dore, B., Veerabudun, K., Paillaud, É., Beauchet, O., Rolland, Y., Canouï‐Poitrine, F., & Bonnefoy, M. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2012.12.002 · Cited by 48
Possibility of leg muscle hypertrophy by ambulation in older adults: a brief review
Abe, T., Ozaki, Loenneke, Thiebaud, Stager, & Stager (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s43837 · Cited by 46
Accuracy of handsv. household measures as portion size estimation aids
Gibson, A. A., Hsu, M. S. H., Rangan, A., Seimon, R. V., Lee, C., Das, A., Finch, C. H., & Sainsbury, A. (2016) · Journal of Nutritional Science · doi:10.1017/jns.2016.22 · Cited by 44
Farooqi, N., Sandström, T., Slinde, F., Håglin, L., & Carlsson, M. (2015) · International Journal of COPD · doi:10.2147/copd.s80616 · Cited by 12
Research works printed but not linked: 3
- 2007, Protein and amino acid requirements in human nutrition. World Health Organ Tech Rep Ser 2007:1–265, back cover., Protein and amino acid requirements in human nutrition. World Health Organ Tech Rep Ser 2007:1–265, back cover., 1
- 2013, Food and nutrition guidelines for healthy older peoplea background paper, Wellington (New Zealand): Ministry of Health
- 2014, Annual update of key results 2013/14: New Zealand Health Survey., Annual update of key results 2013/14: New Zealand Health Survey.
Cited by
Sorted by citations
Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function
Hertzler, S. R., Lieblein-Boff, J. C., Weiler, M., & Allgeier, C. (2020) · Nutrients · doi:10.3390/nu12123704 · Cited by 594
Traylor, D. A., Gorissen, S. H. M., & Phillips, S. M. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy003 · Cited by 243
Dietary Protein and Muscle Mass: Translating Science to Application and Health Benefit
Carbone, J. W., & Pasiakos, S. M. (2019) · Nutrients · doi:10.3390/nu11051136 · Cited by 226
Strategies to Prevent Sarcopenia in the Aging Process: Role of Protein Intake and Exercise
Rogeri, P. S., Zanella, R., Martins, G. L., Garcia, M. D. A., Leite, G., Lugaresi, R., Gasparini, S. O., Sperandio, G. A., Ferreira, L. H. B., Souza-Junior, T. P., et al. (2021) · Nutrients · doi:10.3390/nu14010052 · Cited by 181
Strasser, B., Wolters, M., Weyh, C., Krüger, K., & Ticinesi, A. (2021) · Nutrients · doi:10.3390/nu13062045 · Cited by 192
Metadata
- Authors
- Mitchell, C. J., Milan, A. M., Mitchell, S. M., Zeng, N., Ramzan, F., Sharma, P., Knowles, S. O., Roy, N. C., Sjödin, A., Wagner, K.-H., & Cameron-Smith, D.
- Affiliations
- University of Auckland (NZ)
- AgResearch (NZ)
- University of Copenhagen (DK)
- University of Vienna (AT)
- ORCID
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 106
- Issue
- 6
- Pages
- 1375-1383
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2765197935
- Cited by
- 132
- References
- 53
- Citations by year
- 2026: 2 · 2025: 13 · 2024: 12 · 2023: 8 · 2022: 20 · 2021: 20 · 2020: 19 · 2019: 25 · 2018: 13
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Funders
- AgResearch
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- protein intake, protein requirements, recommended daily allowance, appendicular lean mass, skeletal muscle mass, muscle function, older men, sarcopenia, energy balance, aging, muscle strength, trunk lean mass, protein supplementation, physical function decline, muscle protein synthesis, muscle protein degradation, muscle fiber cross-sectional area, muscle fiber hypertrophy
- MeSH terms
- Aged, Aged, 80 and over, Aging, Body Composition, Body Fluid Compartments, Energy Intake, Diet, Dietary Proteins, Energy Metabolism, Feeding Behavior, Humans, Leg, Male, Nutritional Requirements, Organ Size, Absorptiometry, Photon, Body Mass Index, Muscle, Skeletal, Muscle Strength, Recommended Dietary Allowances
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
