Activity energy expenditure and change in body composition in late life
Open accessAbstract
Background Change in body composition, specifically loss of fat-free mass and gain in fat mass, in older adults is a major pathway leading to the onset of functional decline and physical disability.Objective The objective was to determine the association of activity-related energy expenditure with change in body mass and composition among older men and women.Design Total energy expenditure (TEE) was assessed over 2 wk by using the doubly labeled water method in 302 community-dwelling older adults aged 70-82 y. Resting metabolic rate (RMR) was measured by using indirect calorimetry, and the thermic effect of meals was estimated at 10% of TEE. Activity energy expenditure (AEE) was calculated as [TEE(0.9) - RMR]. Total body mass, fat-free mass (FFM), and fat mass (FM) were assessed by dual-energy X-ray absorptiometry annually over a mean (+/-SD) of 4.9 +/- 1.3 y.Results In multivariate models adjusted for baseline age, smoking status, and race, men and women had a decline (in kg/y) in body mass (men: -0.34, 95% CI: -0.71, 0.02; women: -0.45, 95% CI: -0.71, -0.19) and FFM (men: -0.48, 95% CI: -0.67, -0.29; women: -0.14, 95% CI: -0.026, -0.03). No changes (in kg/y) were observed in FM (men: 0.14, 95% CI: -0.10, 0.38; women: -0.28, 95% CI: -0.49, -0.07). In men and women, higher AEE at baseline was associated with greater FFM. The average change in these outcomes (ie, slope), however, was similar across tertiles of AEE.Conclusions These data suggest that accumulated energy expenditure from all physical activities is associated with greater FFM, but the effect does not alter the trajectory of FFM change in late life.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Over five years, the rate of muscle loss in the most active older adults was similar to that in the least active third.
“The rate of muscle loss across the most active individuals over five years was similar to those in the lowest third of free-living activity.”
From Successful aging: Advancing the science of physical independence in older adults (2015) · cites this paper as Manini et al. 2009
In older adults, those in the highest third of daily activity energy expenditure had the greatest lean mass.
“individuals in the highest third of daily activity energy expenditure had the greatest amount of lean mass.”
From Successful aging: Advancing the science of physical independence in older adults (2015) · cites this paper as Manini et al. 2009
Cites
Random-Effects Models for Longitudinal Data
Laird, N. M., & Ware, J. H. (1982) · Biometrics · doi:10.2307/2529876 · Cited by 8,923 · see citing works
New methods for calculating metabolic rate with special reference to protein metabolism
Weir, J. B. D. V. (1949) · The Journal of Physiology · doi:10.1113/jphysiol.1949.sp004363 · Cited by 5,608 · see citing works
Exercise training and nutritional supplementation for physical frailty in very elderly people
Fiatarone, M. A., O'Neill, E. F., Ryan, N. D., Clements, K. M., Solares, G. R., Nelson, M. E., Roberts, S. B., Kehayias, J. J., Lipsitz, L. A., & Evans, W. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302501 · Cited by 2,857 · see citing works
High-Intensity Strength Training in Nonagenarians: Effects on Skeletal Muscle
Fiatarone, M. A. (1990) · JAMA · doi:10.1001/jama.1990.03440220053029 · Cited by 1,593 · see citing works
Strength conditioning in older men: skeletal muscle hypertrophy and improved function
Frontera, W. R., Meredith, C. N., O'Reilly, K. P., Knuttgen, H. G., & Evans, W. J. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.64.3.1038 · Cited by 1,386 · see citing works
Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber.
Ravussin, E., Lillioja, S., Anderson, T. E., Christin, L., & Bogardus, C. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112749 · Cited by 1,166 · see citing works
Hughes, V. A., Frontera, W. R., Roubenoff, R., Evans, W. J., & Singh, M. A. F. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.2.473 · Cited by 804 · see citing works
Energy expenditure by doubly labeled water: validation in humans and proposed calculation
Schoeller, D. A., Ravussin, É., Schutz, Y., Acheson, K. J., Baertschi, P., & Jéquier, E. (1986) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1986.250.5.r823 · Cited by 683 · see citing works
Self-citationDaily activity energy expenditure and mortality among older adults
Manini, T. M., Everhart, J. E., Patel, K. V., Schoeller, D. A., Colbert, L. H., Visser, M., Tylavsky, F., Bauer, D. C., Goodpaster, B. H., & Harris, T. B. (2006) · JAMA · doi:10.1001/jama.296.2.171 · Cited by 598 · see citing works
Self-citationMeasurement of energy expenditure in humans by doubly labeled water method
Schoeller, D. A., & van Santen, E. (1982) · Journal of Applied Physiology · doi:10.1152/jappl.1982.53.4.955 · Cited by 594 · see citing works
Self-citationWeight stability masks sarcopenia in elderly men and women
Gallagher, D., Ruts, E., Visser, M., Heshka, S., Baumgartner, R. N., Wang, J., Pierson, R. N., Pi-Sunyer, F. X., & Heymsfield, S. B. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.2.e366 · Cited by 466 · see citing works
Self-citationNewman, A. B., Lee, J. S., Visser, M., Goodpaster, B. H., Kritchevsky, S. B., Tylavsky, F. A., Nevitt, M., & Harris, T. B. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.4.872 · Cited by 445 · see citing works
Self-citationAnthropometric assessment of 10-y changes in body composition in the elderly
HUGHES, V. A., Roubenoff, R., Wood, M., Frontera, W. R., Evans, W. J., & Singh, M. A. F. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.2.475 · Cited by 394 · see citing works
Black, A., Prentice, A. M., & Coward, W. A. (1986) · PubMed · Cited by 389 · see citing works
Pattern and intensity of physical activity
Westerterp, K. R. (2001) · Nature · doi:10.1038/35069142 · Cited by 267 · see citing works
A 3-year longitudinal study on body composition changes in the elderly: Role of physical exercise
Raguso, C. A., Kyle, U. G., Kossovsky, M. P., Roynette, C. E., Paoloni‐Giacobino, A., Hans, D. B., Genton, L., & Pichard, C. (2005) · Clinical Nutrition · doi:10.1016/j.clnu.2005.10.013 · Cited by 234 · see citing works
Total energy expenditure in the elderly
Elia, M., Ritz, P., & Stubbs, R. J. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601030 · Cited by 223 · see citing works
Misra, A., Alappan, N. K., Vikram, N. K., Goel, K., Gupta, N., Mittal, K., Bhatt, S., & Luthra, K. (2008) · Diabetes Care · doi:10.2337/dc07-2316 · Cited by 214 · see citing works
Fantin, F., Francesco, V. D., Fontana, G., Zivelonghi, A., Bissoli, L., Zoico, E., Rossi, A. P., Micciolo, R., Bosello, O., & Zamboni, M. M. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.12.1375 · Cited by 159 · see citing works
Effects of birth cohort and age on body composition in a sample of community-based elderly
Ding, J., Kritchevsky, S. B., Newman, A. B., Taaffe, D. R., Nicklas, B. J., Visser, M., Lee, J. S., Nevitt, M. C., Tylavsky, F. A., Rubin, S. M., et al. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.405 · Cited by 148 · see citing works
Self-citationKoopman, R., MANDERS, R. J. F., Jonkers, R. A. M., Hul, G. B. J., Kuipers, H., & van Loon, L. J. C. (2005) · European Journal of Applied Physiology · doi:10.1007/s00421-005-0118-0 · Cited by 141 · see citing works
Thermic effect of food in humans: methods and results from use of a respiratory chamber
Tataranni, P., Larson, D., Snitker, S., & Ravussin, É. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.5.1013 · Cited by 135 · see citing works
Thermic effect of food in humans: methods and results from use of a respiratory chamber.
Tataranni, P. A., Larson, D. E., Snitker, S., et al. (1995) · PubMed · doi:10.1093/ajcn/61.4.1013 · Cited by 113 · see citing works
Energy requirements in the eighth decade of life
Blanc, S., Schoeller, D. A., Bauer, D. C., Danielson, M. E., Tylavsky, F. A., Simonsick, E. M., Harris, T. B., Kritchevsky, S. B., & Everhart, J. E. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.2.303 · Cited by 95 · see citing works
Self-citationQDR 4500A DXA overestimates fat-free mass compared with criterion methods
Tylavsky, F. A., Lohman, T. G., Blunt, B. A., Schoeller, D. A., Fuerst, T. P., Cauley, J. A., Nevitt, M. C., Visser, M., & Harris, T. B. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00732.2002 · Cited by 68 · see citing works
Self-citationBlanc, S., Colligan, A. S., Trabulsi, J., Harris, T. B., Everhart, J. E., Bauer, D. C., & Schoeller, D. A. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00743.2001 · Cited by 64 · see citing works
Self-citationThermogenic response to an oral glucose load in man: comparison between young and elderly subjects.
Bloesch, D., Schutz, Y., Breitenstein, E., Jéquier, E., & Felber, J. P. (1988) · Journal of the American College of Nutrition · doi:10.1080/07315724.1988.10720263 · Cited by 64 · see citing works
Ekelund, U., Brage, S., Franks, P. W., Hennings, S., Emms, S., Wong, M.-Y., & Wareham, N. J. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.5.964 · Cited by 62 · see citing works
Nonexercise movement in elderly compared with young people
Harris, A. M., Lanningham‐Foster, L., McCrady, S. K., & Levine, J. A. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00509.2006 · Cited by 56 · see citing works
Kant, A. K. (2002) · Journal of the American College of Nutrition · doi:10.1080/07315724.2002.10719229 · Cited by 51 · see citing works
Dziura, J. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh105 · Cited by 49 · see citing works
Flagged first, then by citations
1 of the 32 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Buford, T. W., Anton, S. D., Judge, A. R., Marzetti, E., Wohlgemuth, S. E., Carter, C. S., Leeuwenburgh, C., Pahor, M., & Manini, T. M. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.04.004 · Cited by 295 · see citing works
Self-citationSuccessful aging: Advancing the science of physical independence in older adults
Anton, S. D., Woods, A. J., Ashizawa, T., Barb, D., Buford, T. W., Carter, C. S., Clark, D. J., Cohen, R. A., Corbett, D. B., Cruz-Almeida, Y., et al. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.09.005 · Cited by 292 · see citing works
Self-citationLongitudinal changes in body composition associated with healthy ageing: men, aged 20–96 years
Jackson, A. S., Janssen, I., Sui, X., Church, T. S., & Blair, S. N. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511003886 · Cited by 189 · see citing works
Activity Energy Expenditure and Incident Cognitive Impairment in Older Adults
Middleton, L. E. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.277 · Cited by 160 · see citing works
Bann, D., Hire, D., Manini, T., Cooper, R., Botoseneanu, A., McDermott, M. M., Pahor, M., Glynn, N. W., Fielding, R., King, A. C., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0116058 · Cited by 134 · see citing works
Self-citationHamer, M., & Stamatakis, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066222 · Cited by 132 · see citing works
Bann, D., Kuh, D. J., Wills, A. K., Adams, J. E., Brage, S., & Cooper, R. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwu033 · Cited by 91 · see citing works
Longitudinal change in energy expenditure and effects on energy requirements of the elderly
study, F. T. H. A., Cooper, J. A., Manini, T. M., Paton, C. M., Yamada, Y., Everhart, J. E., Cummings, S., Mackey, D. C., Newman, A. B., Glynn, N. W., et al. (2013) · Nutrition Journal · doi:10.1186/1475-2891-12-73 · Cited by 61 · see citing works
Self-citationPhysical Activity and Adiposity Markers at Older Ages: Accelerometer Vs Questionnaire Data
Sabia, S., Cogranne, P., van Hees, V. T., Bell, J. A., Elbaz, A., Mika Kivimaki, B., & Singh‐Manoux, A. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.01.086 · Cited by 52 · see citing works
Obesity in the Elderly: Is Faulty Metabolism to Blame?
Johannsen, D. L., & Ravussin, É. (2010) · Aging Health · doi:10.2217/ahe.10.12 · Cited by 51 · see citing works
Physical activity and fat-free mass during growth and in later life
Westerterp, K. R., Yamada, Y., Sagayama, H., Ainslie, P. N., Andersen, L. F., Anderson, L. J., Arab, L., Baddou, I., Bedu-Addo, K., Blaak, E. E., et al. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab260 · Cited by 50 · see citing works
Self-citationBonnefoy, M., Boutitie, F., Mercier, C., Gueyffier, F., Carré, C., Guetemme, G., Ravis, B., Laville, M., & Cornu, C. (2011) · The Journal of Nutrition, Health & Aging · doi:10.1007/s12603-011-0352-6 · Cited by 52 · see citing works
Calabro, M. A., Kim, Y., Franke, W. D., Stewart, J. M., & Welk, G. J. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2014.241 · Cited by 44 · see citing works
Daily physical activity as determined by age, body mass and energy balance
Westerterp, K. R. (2015) · European Journal of Applied Physiology · doi:10.1007/s00421-015-3135-7 · Cited by 28 · see citing works
Berman, E. S. F., Melanson, E. L., Swibas, T., Snaith, S. P., & Speakman, J. R. (2015) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.10 · Cited by 25 · see citing works
Gitsi, E., Kokkinos, A. D., Konstantinidou, S. M., Livadas, S., & Argyrakopoulou, G. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13195862 · Cited by 24 · see citing works
Validity of predictive equations for resting metabolic rate in healthy older adults
Itoi, A., Yamada, Y., Yokoyama, K., Adachi, T., & Kimura, M. (2017) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2017.08.010 · Cited by 21 · see citing works
European ancestry and resting metabolic rate in older African Americans
Manini, T., Patel, K., Bauer, D., Ziv, E., Schoeller, D., Mackey, D., Li, R.-L., Newman, A., Nalls, M., Zmuda, J. M., et al. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.22 · Cited by 17 · see citing works
Self-citationPorter, J. A., Nguo, K., Gibson, S., Huggins, C. E., Collins, J., Kellow, N. J., & Truby, H. (2018) · Nutrition Journal · doi:10.1186/s12937-018-0348-8 · Cited by 16 · see citing works
Indirect calorimetry in obese female subjects: Factors influencing the resting metabolic rate
Hagedorn, T. (2012) · World Journal of Experimental Medicine · doi:10.5493/wjem.v2.i3.58 · Cited by 15 · see citing works
Villani, A. M., Miller, M., Cameron, I. D., Kurrle, S. E., Whitehead, C., & Crotty, M. (2013) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-013-0108-8 · Cited by 14 · see citing works
Dzien, A., Winner, H., Theurl, E., Dzien‐Bischinger, C., & Lechleitner, M. (2013) · Obesity Facts · doi:10.1159/000348573 · Cited by 10 · see citing works
Validity of the dietary reference intakes for determining energy requirements in older adults
Ndahimana, D., Go, N.-Y., Ishikawa-Takata, K., Park, J., & Kim, E.-K. (2019) · Nutrition Research and Practice · doi:10.4162/nrp.2019.13.3.256 · Cited by 7 · see citing works
Belury, M. A., Clark, B. C., McGrath, R. P., & Cawthon, P. M. (2022) · Advances in Geriatric Medicine and Research · doi:10.20900/agmr20220001 · Cited by 6 · see citing works
Effects of Organized Physical Activity on Selected Health Indices among Women Older than 55 Years
Żmijewski, P., Mazurek, K., Kozdroń, E., Szczypiorski, P., & Frysztak, A. (2015) · The Scientific World JOURNAL · doi:10.1155/2015/625032 · Cited by 4 · see citing works
Sadrollahi, A., Khalili, Z., Nazari, R., Mohammadi, M., Khatir, M. A., & Mossadegh, N. (2016) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.31455 · Cited by 3 · see citing works
Moczek, K., Gawlik, K., & Rosołek, B. (2018) · Advances in Rehabilitation · doi:10.5114/areh.2018.83392 · Cited by 3 · see citing works
Cai, Z., You, B., Yu, S., Fan, Y., Tian, H., Ainsworth, B. E., & Chen, P. (2026) · Nutrients · doi:10.3390/nu18020344 · Cited by 2 · see citing works
Lim, H.-J. (2016) · 대한지역사회영양학회지 · doi:10.5720/kjcn.2016.21.2.178 · Cited by 2 · see citing works
Can increasing physical activity prevent aging-related loss of skeletal muscle?
Heymsfield, S. B., & Fearnbach, N. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab283 · Cited by 2 · see citing works
Nutritional Guidelines, Energy Balance, and Weight Control: Issues for the Aging Active Female
Robert-McComb, J. J., Bustamante-Ara, N. E., & Marroquin, J. E. A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8884-2_32 · Cited by 1 · see citing works
Bedeutung der Ernährungs- und Bewegungstherapie für den geriatrischen Patienten
Lenzen-Großimlinghaus, R. (2022) · Aktuelle Ernãhrungsmedizin · doi:10.1055/a-1354-5428 · Cited by 1 · see citing works
Composition corporelle et activité physique chez le sujet âgé
Bonnefoy, M. (2009) · Les cahiers de l année gérontologique · doi:10.1007/s12612-009-0037-5 · Cited by 1 · see citing works
Body Weight, Body Composition, and Aging
Addison, O. R., & Ryan, A. S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.95817-3 · Cited by 1 · see citing works
Booth, W. J. (2012) · Scholarship@Western (Western University)
Weight Regain Following Intentional Weight Loss in Older Adults
Ryan, A. S. (2016) · Current Nutrition Reports · doi:10.1007/s13668-016-0160-z
Nutritional Guidelines, Energy Balance, and Weight Control: Issues for the Aging Active Female
Bustamante-Ara, N. E., Frost, S., & Robert-McComb, J. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-15485-0_22
Bann, D. (2013) · UCL Discovery (University College London)
Martins, A. D., Batalha, N. M. P., Fernandes, O., Oliveira, R. F. S., Gonçalves, B. V., & Brito, J. P. (2026) · Sport Sciences for Health · doi:10.1007/s11332-026-01715-8
- Authors
- Manini, T. M., Everhart, J. E., Anton, S. D., Schoeller, D. A., Cummings, S. R., Mackey, D. C., Delmonico, M. J., Bauer, D. C., Simonsick, E. M., Colbert, L. H., Visser, M., Tylavsky, F., Newman, A. B., & Harris, T. B.
- Affiliations
- University of Florida (US)
- Corresponding author
- Manini, Todd M
- ORCID
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 90
- Issue
- 5
- Pages
- 1336-1342
- ISSN
- 0002-9165 (ISSN-L)
- PMC
- PMC2762160
- OpenAlex
- W2166395334
- Cited by
- 40
- References
- 32
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 6 · 2014: 2 · 2013: 6 · 2012: 2
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (publishedVersion)
- Journal of Media Literacy Education (submittedVersion, cc-by)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Institute on Aging (N01‐AG‐6–2101, N01AG62106, N01-AG-62103, P30AG028740)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- physical activity energy expenditure, body composition, fat-free mass, fat mass, total energy expenditure, resting metabolic rate, older adults, aging, physical activity, functional decline, community-dwelling older adults
- MeSH terms
- Adipose Tissue, Aged, Aged, 80 and over, Aging, Basal Metabolism, Body Composition, Body Weight, Energy Metabolism, Female, Disabled Persons, Persons with Disabilities, Humans, Male, Rest, Smoking
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
