An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach
Open accessAbstract
BACKGROUND: Low-grade chronic inflammation in overweight subjects is thought to play an important role in disease development. OBJECTIVE: It was hypothesized that specific dietary components are able to reduce low-grade inflammation as well as metabolic and oxidative stress. DESIGN: Dietary products [resveratrol, green tea extract, alpha-tocopherol, vitamin C, n-3 (omega-3) polyunsaturated fatty acids, and tomato extract] selected for their evidence-based antiinflammatory properties were combined and given as supplements to 36 healthy overweight men with mildly elevated plasma C-reactive protein concentrations in a double-blind, placebo-controlled, crossover study with treatment periods of 5 wk. Inflammatory and oxidative stress defense markers were quantified in plasma and urine. Furthermore, 120 plasma proteins, 274 plasma metabolites (lipids, free fatty acids, and polar compounds), and the transcriptomes of peripheral blood mononuclear cells and adipose tissue were quantified. RESULTS: Plasma adiponectin concentrations increased by 7%, whereas C-reactive protein (principal inflammation marker) was unchanged. However, a multitude of subtle changes were detected by an integrated analysis of the "omics" data, which indicated modulated inflammation of adipose tissue, improved endothelial function, affected oxidative stress, and increased liver fatty acid oxidation. CONCLUSION: An intervention with selected dietary products affected inflammatory processes, oxidative stress, and metabolism in humans, as shown by large-scale profiling of genes, proteins, and metabolites in plasma, urine, and adipose tissue. This trial was registered at clinical trials.gov as NCT00655798.
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Different people respond differently to foods and nutrients, warranting personalized approaches to nutrition interventions and services.
“It is now understood that different people respond differently to foods and nutrients, warranting personalized approaches to nutrition interventions and services [3,17-21].”
From Wearable Technology to Quantify the Nutritional Intake of Adults: Validation Study (2020) · cites this paper as [21]
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A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies
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Wearable Technology to Quantify the Nutritional Intake of Adults: Validation Study
Dimitratos, S. M., German, J. B., & Schaefer, S. E. (2020) · JMIR mHealth and uHealth · doi:10.2196/16405 · Cited by 27 · see citing works
The assessment of vascular function during dietary intervention trials in human subjects
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- Authors
- Bakker, G. C., van Erk, M. J., Pellis, L., Wopereis, S., Rubingh, C. M., Cnubben, N. H., Kooistra, T., van Ommen, B., & Hendriks, H. F.
- Affiliations
- Netherlands Organisation for Applied Scientific Research (NL)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 91
- Issue
- 4
- Pages
- 1044-1059
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2112502488
- Cited by
- 252
- References
- 6
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 4 · 2023: 11 · 2022: 11 · 2021: 9 · 2020: 9 · 2019: 15 · 2018: 16 · 2017: 26 · 2016: 17 · 2015: 16 · 2014: 23 · 2013: 28 · 2012: 34
- FWCI
- 20.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- TNO Repository (submittedVersion)
- Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- anti-inflammatory diet, overweight men, low-grade inflammation, oxidative stress, metabolic stress, nutrigenomics, resveratrol, green tea extract, alpha-tocopherol, vitamin C, omega-3 fatty acids, tomato extract, C-reactive protein, adiponectin, adipose tissue inflammation, endothelial function, plasma metabolites, peripheral blood mononuclear cells, adipose tissue transcriptome
- MeSH terms
- Adipose Tissue, Adult, Anti-Inflammatory Agents, Antioxidants, C-Reactive Protein, Diet, Double-Blind Method, Endothelium, Vascular, Female, Humans, Inflammation, Leukocytes, Mononuclear, Liver, Male, Metabolic Diseases, Middle Aged, Oxidative Stress, Cross-Over Studies, Overweight, Lipid Metabolism, Adiponectin, Nutrigenomics, Young Adult
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