The assessment of vascular function during dietary intervention trials in human subjects

McCall, Damian O.; McKinley, Michelle C.; Noad, Rebecca; McKeown, Pascal P.; McCance, David R.; Young, Ian S.; Woodside, Jayne V.

doi:10.1017/s0007114511002996

Cited by 14Cardiovascular Health and Disease PreventionNutritional Studies and DietCardiovascular and exercise physiology

The assessment of vascular function during dietary intervention trials in human subjects

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McCall, Damian O., McKinley, Michelle C., Noad, Rebecca, McKeown, Pascal P., McCance, David R., Young, Ian S., Woodside, Jayne V.·2011·British Journal Of Nutrition

DOI 10.1017/s0007114511002996

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Abstract

The potential to reduce cardiovascular morbidity through dietary modification remains an area of intense clinical and scientific interest. Any putatively beneficial intervention should be tested within a randomised controlled trial which records appropriate endpoints, ideally incident CVD and death. However, the large sample sizes required for these endpoints and associated high costs mean that the majority of dietary intervention research is conducted over short periods among either healthy volunteers or those at only slightly increased risk, with investigators using a diverse range of surrogate measures to estimate arterial health in these studies. The present review identifies commonly employed techniques, discusses the relative merits of each and highlights emerging approaches.

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The clinical relevance of acute changes in endothelial function and arterial compliance following an intervention is unclear, particularly when simultaneous changes in blood pressure occur.
“The clinical relevance of acute changes in endothelial function and arterial compliance following an intervention is unclear, particularly when simultaneous changes in BP occur (Anderson, 2006;McCall et al., 2011).”
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Dark chocolate improves endothelial and platelet function: Figure 1
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EFFECTS OF DIETARY NITRATE FROM VEGETABLES ON BLOOD PRESSURE IN HEALTHY HUMANS
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Authors: McCall, D. O., McKinley, M. C., Noad, R., McKeown, P. P., McCance, D. R., Young, I. S., & Woodside, J. V.
Affiliations: Queen's University Belfast (GB)
Royal Victoria Hospital (GB)
Corresponding author: Woodside, Jayne V.
ORCID: McKinley, Michelle C.
McKeown, Pascal P.
McCance, David R.
Young, Ian S.
Woodside, Jayne V.
Venue: British Journal Of Nutrition
Publisher: Cambridge University Press (CUP)
Published: 2011-07-01
Volume: 106
Issue: 7
Pages: 981-994
ISSN: 0007-1145 (ISSN-L)
1475-2662
DOI: 10.1017/s0007114511002996
OpenAlex: W2320943522
Cited by: 14
References: 174
Citations by year: 2019: 1 · 2018: 2 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 1
FWCI: 0.21
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified)
Locations: British Journal Of Nutrition (publishedVersion)
PubMed (publishedVersion)
Research Portal (Queen's University Belfast) (publishedVersion, other-oa)
Funders: Public Health Agency (EAT/4195/09)
Economic and Social Research Council (ES/G007438/1)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: vascular function, dietary intervention, surrogate endpoints, arterial health, cardiovascular disease prevention, surrogate measures, cardiovascular risk, healthy volunteers
MeSH terms: Arteries, Cardiovascular Diseases, Elasticity, Endothelium, Vascular, Humans, Pulse, Research Design, Vasodilation, Biomarkers, Outcome Assessment, Health Care

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The assessment of vascular function during dietary intervention trials in human subjects

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