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Cited by 271Probiotics and Fermented FoodsGut microbiota and healthInfant Nutrition and Health

Guidance for Substantiating the Evidence for Beneficial Effects of Probiotics: Current Status and Recommendations for Future Research1–3

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Rijkers, Ger T., Bengmark, Stig, Enck, Paul, Haller, Dirk, Herz, Udo, Kalliomaki, Marko, Kudo, Satoshi, Lenoir-Wijnkoop, Irene +9 more·2010·The Journal of Nutrition
DOI 10.3945/jn.109.113779
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Abstract

Probiotic bacteria are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. There is a growing interest in probiotics within the scientific community, with consumers, and in the food industry. The interactions between the gut and intestinal microbiota and between resident and transient microbiota define a new arena in physiology, an understanding of which would shed light on the "cross-talk" between humans and microbes. The different beneficial effects of specific probiotic strains may be translated into different health claims. However, there is a need for comprehensive and harmonized guidelines on the assessment of the characteristics and efficacy of probiotics and of foods containing them. An international expert group of ILSI has evaluated the published evidence of the functionality of different probiotics in 4 areas of (human) application: 1) metabolism, 2) chronic intestinal inflammatory and functional disorders, 3) infections, and 4) allergy. Based on the existing evidence, concrete examples of demonstration of benefits and gaps are listed, and guidelines and recommendations are defined that should help design the next generation of probiotic studies.

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  • Confirmation of probiotic identity, viability, and number of organisms by quantitative culture and molecular methods was done in only eight trials.

    “Confirmation of probiotic identity, viability, and number of organisms by quantitative culture and molecular methods was done in only eight trials but should be standard in research studies (Rijkers 2010; Wolvers 2010).”

    From Probiotics for treating acute infectious diarrhoea (2020) · cites this paper as Rijkers 2010

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Authors
Rijkers, G. T., Bengmark, S., Enck, P., Haller, D., Herz, U., Kalliomaki, M., Kudo, S., Lenoir-Wijnkoop, I., Mercenier, A., Myllyluoma, E., Rabot, S., Rafter, J., Szajewska, H., Watzl, B., Wells, J., Wolvers, D., & Antoine, J.-M.
Affiliations
  • University Medical Center Utrecht (NL)
  • University College London (GB)
  • Universitätsklinikum Tübingen (DE)
  • Technical University of Munich (DE)
  • Mead Johnson (United States) (US)
  • Yakult (Netherlands) (NL)
  • Nestlé (Switzerland) (CH)
  • University of Helsinki (FI)
  • Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
  • Karolinska Institutet (SE)
  • Medical University of Warsaw (PL)
  • Max Rubner Institut (DE)
  • Wageningen University & Research (NL)
  • Danone (France) (FR)
ORCID
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2010-03
Volume
140
Issue
3
Pages
671S-676S
ISSN
0022-3166 (ISSN-L)
DOI
10.3945/jn.109.113779
OpenAlex
W2095749671
Cited by
271
References
2
Citations by year
2026: 5 · 2025: 7 · 2024: 8 · 2023: 13 · 2022: 14 · 2021: 21 · 2020: 15 · 2019: 17 · 2018: 17 · 2017: 24 · 2016: 16 · 2015: 25 · 2014: 19 · 2013: 13 · 2012: 22
FWCI
34.31
Type
journal article
Language
en
Update notices
erratum (2010-06-01)
Open access
Licence
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • OpenAgrar (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords
probiotics, health claim substantiation, gut microbiota, host-microbe interactions, probiotic functionality, functional gastrointestinal disorders, probiotic efficacy, probiotic foods, allergy, infection, metabolism, research guidelines
MeSH terms
Food Microbiology, Humans, Nutritional Physiological Phenomena, Research Design, Practice Guidelines as Topic, Probiotics

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