Cited by 194Lipoproteins and Cardiovascular HealthNutritional Studies and DietCholesterol and Lipid Metabolism

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Soy Protein Reduces Serum Cholesterol by Both Intrinsic and Food Displacement Mechanisms

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Jenkins, David J.A., Mirrahimi, Arash, Srichaikul, Korbua, Berryman, Claire E., Wang, Li, Carleton, Amanda, Abdulnour, Shahad, Sievenpiper, John L., Kendall, Cyril W.C., Kris-Etherton, Penny M.·2010·The Journal of Nutrition

DOI 10.3945/jn.110.124958

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Abstract

The apparently smaller LDL cholesterol (LDL-C)-lowering effect of soy in recent studies has prompted the U.S. FDA to reexamine the heart health claim previously allowed for soy products. We therefore attempted to estimate the intrinsic and extrinsic (displacement) potential of soy in reducing LDL-C to determine whether the heart health claim for soy continues to be justified. The intrinsic effect of soy was derived from a meta-analysis using soy studies (20-133 g/d soy protein) included in the recent AHA Soy Advisory. The extrinsic effect of soy in displacing foods higher in saturated fat and cholesterol was estimated using predictive equations for LDL-C and NHANES III population survey data with the substitution of 13-58 g/d soy protein for animal protein foods. The meta-analysis of the AHA Soy Advisory data gave a mean LDL-C reduction of 0.17 mmol/L (n = 22; P < 0.0001) or 4.3% for soy, which was confirmed in 11 studies reporting balanced macronutrient profiles. The estimated displacement value of soy (13-58 g/d) using NHANES III population survey data was a 3.6-6.0% reduction in LDL-C due to displacement of saturated fats and cholesterol from animal foods. The LDL-C reduction attributable to the combined intrinsic and extrinsic effects of soy protein foods ranged from 7.9 to 10.3%. Thus, soy remains one of a few food components that reduces serum cholesterol (>4%) when added to the diet.

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Authors: Jenkins, D. J. A., Mirrahimi, A., Srichaikul, K., Berryman, C. E., Wang, L., Carleton, A., Abdulnour, S., Sievenpiper, J. L., Kendall, C. W. C., & Kris-Etherton, P. M.
Affiliations: St. Michael's Hospital (CA)
University of Toronto (CA)
Pennsylvania State University (US)
McMaster University (CA)
Corresponding author: Jenkins, David J.A.
ORCID: Jenkins, David J.A.
Mirrahimi, Arash
Berryman, Claire E.
Wang, Li
Sievenpiper, John L.
Kendall, Cyril W.C.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2010-12
Volume: 140
Issue: 12
Pages: 2302S-2311S
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.110.124958
OpenAlex: W2167914776
Cited by: 194
References: 94
Citations by year: 2026: 7 · 2025: 7 · 2024: 15 · 2023: 10 · 2022: 15 · 2021: 11 · 2020: 7 · 2019: 16 · 2018: 12 · 2017: 10 · 2016: 15 · 2015: 16 · 2014: 11 · 2013: 14 · 2012: 13
FWCI: 14.24
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4447 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: Pharmavite
Almond Board of California
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: soy protein, LDL cholesterol, serum cholesterol, saturated fat, dietary cholesterol, dietary fat intake, NHANES III
MeSH terms: Cholesterol, Food, Health Surveys, Humans, Soybean Proteins

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Soy Protein Reduces Serum Cholesterol by Both Intrinsic and Food Displacement Mechanisms

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