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Cited by 194Lipoproteins and Cardiovascular HealthNutritional Studies and DietCholesterol and Lipid Metabolism

The DOI matches its Crossref record; 90 of the 94 references it cites were found in a registry or an index.

Soy Protein Reduces Serum Cholesterol by Both Intrinsic and Food Displacement Mechanisms

Open access
Jenkins, David J.A., Mirrahimi, Arash, Srichaikul, Korbua, Berryman, Claire E., Wang, Li, Carleton, Amanda, Abdulnour, Shahad, Sievenpiper, John L., Kendall, Cyril W.C., Kris-Etherton, Penny M.·2010·The Journal of Nutrition
DOI 10.3945/jn.110.124958
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Abstract

The apparently smaller LDL cholesterol (LDL-C)-lowering effect of soy in recent studies has prompted the U.S. FDA to reexamine the heart health claim previously allowed for soy products. We therefore attempted to estimate the intrinsic and extrinsic (displacement) potential of soy in reducing LDL-C to determine whether the heart health claim for soy continues to be justified. The intrinsic effect of soy was derived from a meta-analysis using soy studies (20-133 g/d soy protein) included in the recent AHA Soy Advisory. The extrinsic effect of soy in displacing foods higher in saturated fat and cholesterol was estimated using predictive equations for LDL-C and NHANES III population survey data with the substitution of 13-58 g/d soy protein for animal protein foods. The meta-analysis of the AHA Soy Advisory data gave a mean LDL-C reduction of 0.17 mmol/L (n = 22; P < 0.0001) or 4.3% for soy, which was confirmed in 11 studies reporting balanced macronutrient profiles. The estimated displacement value of soy (13-58 g/d) using NHANES III population survey data was a 3.6-6.0% reduction in LDL-C due to displacement of saturated fats and cholesterol from animal foods. The LDL-C reduction attributable to the combined intrinsic and extrinsic effects of soy protein foods ranged from 7.9 to 10.3%. Thus, soy remains one of a few food components that reduces serum cholesterol (>4%) when added to the diet.

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Research works printed but not linked: 2

  1. Mercer, 1987, Effects on human plasma lipids of substituting soybean protein isolate for milk protein in the diet, Nutr Rep Int., 35, 279
  2. Steel, 1992, The effect on serum cholesterol levels of substituting milk with a soya beverage, Aust J Nutr Diet., 49, 24

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Metadata

Authors
Jenkins, D. J. A., Mirrahimi, A., Srichaikul, K., Berryman, C. E., Wang, L., Carleton, A., Abdulnour, S., Sievenpiper, J. L., Kendall, C. W. C., & Kris-Etherton, P. M.
Affiliations
  • St. Michael's Hospital (CA)
  • University of Toronto (CA)
  • Pennsylvania State University (US)
  • McMaster University (CA)
Corresponding author
Jenkins, David J.A.
ORCID
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2010-12
Volume
140
Issue
12
Pages
2302S-2311S
ISSN
0022-3166 (ISSN-L)
DOI
10.3945/jn.110.124958
OpenAlex
W2167914776
Cited by
194
References
94
Citations by year
2026: 7 · 2025: 7 · 2024: 15 · 2023: 10 · 2022: 15 · 2021: 11 · 2020: 7 · 2019: 16 · 2018: 12 · 2017: 10 · 2016: 15 · 2015: 16 · 2014: 11 · 2013: 14 · 2012: 13
FWCI
14.24
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Pharmavite
  • Almond Board of California
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords
soy protein, LDL cholesterol, serum cholesterol, saturated fat, dietary cholesterol, dietary fat intake, NHANES III
MeSH terms
Cholesterol, Food, Health Surveys, Humans, Soybean Proteins

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