The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Grape Polyphenols Reduce Blood Pressure and Increase Flow-Mediated Vasodilation in Men with Metabolic Syndrome
Open accessAbstract
We evaluated the effects of grape polyphenols in individuals classified with metabolic syndrome (MetS). Men (n = 24) aged 30-70 y were randomly assigned to consume either a freeze-dried grape polyphenol powder (GRAPE) or a placebo for 30 d in a double-blind, crossover design, separated by a 3-wk washout period. Participants were asked to maintain their usual diet and physical activity during the study and abstain from consuming polyphenol-rich foods. MetS criteria including blood pressure (BP) and markers of vascular endothelial function including brachial artery flow-mediated vasodilation (FMD), plasma total nitrite + nitrate (NOx) to estimate NO production, plasma soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured at the end of each dietary period. Systolic BP (P < 0.0025) and plasma sICAM-1 concentrations (P < 0.025) were lower, whereas the FMD response was higher (P < 0.0001), during the GRAPE compared with the placebo period. In addition, changes in sVCAM-1 concentrations between periods were positively correlated with changes in systolic BP (r = 0.45; P < 0.05). Although NOx concentrations did not differ between periods, changes in systolic BP were negatively correlated with changes in NOx concentrations (r = -0.44; P < 0.05), indicating the vasodilating properties of NO. Other MetS variables did not differ between the GRAPE and placebo periods. These results suggest that GRAPE polyphenols may potentiate vasorelaxation and reduce BP and circulating cell adhesion molecules, resulting in improvements in vascular function.
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“However, this meant that the statistical power of the present data (64 %) was somewhat lower than that predicted (80 %) in the sample size calculation based on a previous study (n 20) (29) .”
From High-nitrate vegetable diet increases plasma nitrate and nitrite concentrations and reduces blood pressure in healthy women (2015) · cites this paper as [29]
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“our findings are consistent with previous studies showing significant elevations in plasma nitrite concentration and reductions in BP following nitrate ingestion (7,29) .”
From High-nitrate vegetable diet increases plasma nitrate and nitrite concentrations and reduces blood pressure in healthy women (2015) · cites this paper as [29]
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Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
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Prevalence of Overweight and Obesity in the United States
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Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219
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Metadata
- Authors
- Barona, J., Aristizabal, J. C., Blesso, C. N., Volek, J. S., & Fernandez, M. L.
- Affiliations
- University of Connecticut (US)
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 142
- Issue
- 9
- Pages
- 1626-1632
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2128017243
- Cited by
- 173
- References
- 56
- Citations by year
- 2026: 5 · 2025: 16 · 2024: 6 · 2023: 11 · 2022: 10 · 2021: 11 · 2020: 10 · 2019: 17 · 2018: 19 · 2017: 11 · 2016: 11 · 2015: 19 · 2014: 8 · 2013: 15 · 2012: 4
- FWCI
- 10.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- grape polyphenols, metabolic syndrome, blood pressure, flow-mediated dilation, endothelial function, nitric oxide, soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, adhesion molecules, vasorelaxation, men
- MeSH terms
- Adult, Aged, Blood Pressure, Brachial Artery, Endothelium, Vascular, Freeze Drying, Humans, Male, Middle Aged, Nitrates, Nitrites, Placebos, Vasculitis, Vasodilation, Biomarkers, Cross-Over Studies, Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, Metabolic Syndrome, Vitis, Polyphenols
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