Cited by 173Phytochemicals and Antioxidant ActivitiesCardiovascular Health and Disease PreventionNitric Oxide and Endothelin Effects

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Grape Polyphenols Reduce Blood Pressure and Increase Flow-Mediated Vasodilation in Men with Metabolic Syndrome

Open access

Barona, Jacqueline, Aristizabal, Juan C., Blesso, Christopher N., Volek, Jeff S., Fernandez, Maria Luz·2012·The Journal of Nutrition

DOI 10.3945/jn.112.162743

Open this paper in CoChat — free account Open PDF

Abstract

We evaluated the effects of grape polyphenols in individuals classified with metabolic syndrome (MetS). Men (n = 24) aged 30-70 y were randomly assigned to consume either a freeze-dried grape polyphenol powder (GRAPE) or a placebo for 30 d in a double-blind, crossover design, separated by a 3-wk washout period. Participants were asked to maintain their usual diet and physical activity during the study and abstain from consuming polyphenol-rich foods. MetS criteria including blood pressure (BP) and markers of vascular endothelial function including brachial artery flow-mediated vasodilation (FMD), plasma total nitrite + nitrate (NOx) to estimate NO production, plasma soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured at the end of each dietary period. Systolic BP (P < 0.0025) and plasma sICAM-1 concentrations (P < 0.025) were lower, whereas the FMD response was higher (P < 0.0001), during the GRAPE compared with the placebo period. In addition, changes in sVCAM-1 concentrations between periods were positively correlated with changes in systolic BP (r = 0.45; P < 0.05). Although NOx concentrations did not differ between periods, changes in systolic BP were negatively correlated with changes in NOx concentrations (r = -0.44; P < 0.05), indicating the vasodilating properties of NO. Other MetS variables did not differ between the GRAPE and placebo periods. These results suggest that GRAPE polyphenols may potentiate vasorelaxation and reduce BP and circulating cell adhesion molecules, resulting in improvements in vascular function.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3945/jn.112.162743

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860
The metabolic syndrome—a new worldwide definition
Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67402-8 · Cited by 9,352
Prevalence of Overweight and Obesity in the United States, 1999-2004
Ogden, C. L., Carroll, M. D., Curtin, L. R., McDowell, M. A., Tabak, C. J., & Flegal, K. M. (2006) · JAMA · doi:10.1001/jama.295.13.1549 · Cited by 8,720
Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition
Grundy, S. M., Brewer, H. B., Cleeman, J. I., Smith, S. C., & Lenfant, C. (2004) · Circulation · doi:10.1161/01.cir.0000111245.75752.c6 · Cited by 5,982
Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery
Corretti, M. C., Anderson, T. J., Benjamin, E. J., Celermajer, D. S., Charbonneau, F., Creager, M. A., Deanfield, J. E., Drexler, H., Gerhard‐Herman, M. D., Herrington, D. M., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01746-6 · Cited by 4,606
Prevalence of Overweight and Obesity in the United States
Crespo, C. J., & Smit, E. (2003) · Human Kinetics eBooks · doi:10.5040/9781718206601.ch-001 · Cited by 4,382
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219

Show all 56 references

Sorted by citations

Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview
Samtiya, M., Aluko, R. E., Dhewa, T., & Moreno‐Rojas, J. M. (2021) · Foods · doi:10.3390/foods10040839 · Cited by 686
Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update
Rodriguez‐Mateos, A., Vauzour, D., Krueger, C. G., Shanmuganayagam, D., Reed, J. D., Calani, L., Mena, P. R., Rio, D. D., & Crozier, A. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1330-7 · Cited by 623
Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review
Amiot, M. J., Riva, C., & Vinet, A. (2016) · Obesity Reviews · doi:10.1111/obr.12409 · Cited by 468
Intake and time dependence of blueberry flavonoid–induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity
Rodriguez‐Mateos, A., Rendeiro, C., Bergillos-Meca, T., Tabatabaee, S., George, T. W., Heiß, C., & Spencer, J. P. E. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.066639 · Cited by 361
Fruit Polyphenols: A Review of Anti-inflammatory Effects in Humans
Joseph, S. V., Edirisinghe, I., & Burton‐Freeman, B. M. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.767221 · Cited by 296
Current evidence on the effect of dietary polyphenols intake on chronic diseases
Costa, C., Tsatsakis, A. M., Mamoulakis, C., Teodoro, M., Briguglio, G., Caruso, E., Tsoukalas, D., Margina, D. M., Dardiotis, E., Kouretas, D., et al. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.10.023 · Cited by 262
Grape Polyphenols’ Effects in Human Cardiovascular Diseases and Diabetes
Rasines-Perea, Z., & Teissèdre, P. (2017) · Molecules · doi:10.3390/molecules22010068 · Cited by 241
Fruit-Derived Polyphenol Supplementation for Athlete Recovery and Performance
Bowtell, J., & Kelly, V. (2019) · Sports Medicine · doi:10.1007/s40279-018-0998-x · Cited by 213
Effects of Polyphenol Intake on Metabolic Syndrome: Current Evidences from Human Trials
Chiva‐Blanch, G., & Badimón, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5812401 · Cited by 229
Plant Foods, Antioxidant Biomarkers, and the Risk of Cardiovascular Disease, Cancer, and Mortality: A Review of the Evidence
Aune, D. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz042 · Cited by 222
The Effects of Flavonoids on Cardiovascular Health: A Review of Human Intervention Trials and Implications for Cerebrovascular Function
Rees, A., Dodd, G. F., & Spencer, J. P. E. (2018) · Nutrients · doi:10.3390/nu10121852 · Cited by 205
Fruit and Vegetable Consumption and the Incidence of Hypertension in Three Prospective Cohort Studies
Borgi, L., Muraki, I., Satija, A., Willett, W. C., Rimm, E. B., & Forman, J. P. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.06497 · Cited by 178
Effect of resveratrol on blood pressure: A meta-analysis of randomized controlled trials
Liu, Y., Ma, W., Zhang, P., Shun-chuan, H., & Huang, D. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.03.009 · Cited by 161
Cranberry Juice Consumption Lowers Markers of Cardiometabolic Risk, Including Blood Pressure and Circulating C-Reactive Protein, Triglyceride, and Glucose Concentrations in Adults
Novotny, J. A., Baer, D. J., Khoo, C., Gebauer, S. K., & Charron, C. S. (2015) · Journal of Nutrition · doi:10.3945/jn.114.203190 · Cited by 163
Dietary strategies to reduce metabolic syndrome
Andersen, C. J., & Fernández, M. L. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9251-y · Cited by 149
Resveratrol, in its natural combination in whole grape, for health promotion and disease management
Singh, C. K., Liu, X., & Ahmad, N. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12798 · Cited by 133
The Effect of Anthocyanin-Rich Foods or Extracts on Vascular Function in Adults: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Fairlie‐Jones, L., Davison, K., Fromentin, E., & Hill, A. M. (2017) · Nutrients · doi:10.3390/nu9080908 · Cited by 134
A polyphenol-rich dietary pattern improves intestinal permeability, evaluated as serum zonulin levels, in older subjects: The MaPLE randomised controlled trial
Del Bo', C., Bernardi, S., Cherubini, A., Porrini, M., Gargari, G., Hidalgo-Liberona, N., González-Domínguez, R., Zamora-Ros, R., Peron, G., Marino, M., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2020.12.014 · Cited by 133
Polyphenol-based nutraceuticals for the prevention and treatment of cardiovascular disease: Review of human evidence
Tomé‐Carneiro, J., & Visioli, F. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.10.018 · Cited by 138
Phenolic compounds in fruits and beverages consumed as part of the mediterranean diet: their role in prevention of chronic diseases
Aguilera, Y., Martin-Cabrejas, M. A., & de Mejía, E. G. (2015) · Phytochemistry Reviews · doi:10.1007/s11101-015-9443-z · Cited by 137
Potential mechanisms underlying cardiovascular protection by polyphenols: Role of the endothelium
Oak, M., Auger, C., Belcastro, E., Park, S., Lee, H.-H., & Schini‐Kerth, V. B. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.03.018 · Cited by 132
Functional Food and Cardiovascular Disease Prevention and Treatment: A Review
Asgary, S., Rastqar, A., & Keshvari, M. (2018) · Journal of the American College of Nutrition · doi:10.1080/07315724.2017.1410867 · Cited by 142
Dietary flavonoids and nitrate: effects on nitric oxide and vascular function
Bondonno, C. P., Croft, K. D., Ward, N., Considine, M. J., & Hodgson, J. M. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuu014 · Cited by 150
The role of nutraceuticals in the prevention of cardiovascular disease
Sosnowska, B., Penson, P. E., & Banach, M. (2017) · Cardiovascular Diagnosis and Therapy · doi:10.21037/cdt.2017.03.20 · Cited by 117
High-nitrate vegetable diet increases plasma nitrate and nitrite concentrations and reduces blood pressure in healthy women
Ashworth, A., Mitchell, K., Blackwell, J. R., Vanhatalo, A., & Jones, A. M. (2015) · Public Health Nutrition · doi:10.1017/s1368980015000038 · Cited by 109
Encapsulation of natural active compounds, enzymes, and probiotics for fruit juice fortification, preservation, and processing: An overview
Ephrem, E., Najjar, A., Charcosset, C., & Greige‐Gerges, H. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.06.021 · Cited by 106
Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial
Park, E., Edirisinghe, I., Choy, Y. Y., Waterhouse, A. L., & Burton‐Freeman, B. M. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515004328 · Cited by 102
Consumption of a Polyphenol-Rich Grape-Wine Extract Lowers Ambulatory Blood Pressure in Mildly Hypertensive Subjects
Draijer, R., de Graaf, Y., Slettenaar, M., de Groot, E., & Wright, C. (2015) · Nutrients · doi:10.3390/nu7053138 · Cited by 95
Low-molecular procyanidin rich grape seed extract exerts antihypertensive effect in males spontaneously hypertensive rats
Quiñones, M., Guerrero, L., Suárez, M., Pons, Z., Aleixandre, A., Arola, L., & Muguerza, B. (2013) · Food Research International · doi:10.1016/j.foodres.2013.01.023 · Cited by 92
Effects of Grape Seed Proanthocyanidin Extract on Vascular Endothelial Function in Participants with Prehypertension: A Randomized, Double-Blind, Placebo-Controlled Study
Odai, T., Terauchi, M., Kato, K., Hirose, A., & Miyasaka, N. (2019) · Nutrients · doi:10.3390/nu11122844 · Cited by 100
Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cells
Warner, E. F., Zhang, Q., Raheem, S., O’Hagan, D., O'Connell, M. A., & Kay, C. D. (2016) · Journal of Nutrition · doi:10.3945/jn.115.217943 · Cited by 86
Effects of pomegranate supplementation on exercise performance and post-exercise recovery in healthy adults: A systematic review
Ammar, A., Bailey, S. J., Chtourou, H., Trabelsi, K., Turki, M., Hökelmann, A., & Souissi, N. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518002696 · Cited by 81
Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertension
Ras, R. T., Zock, P. L., Zebregs, Y. E. M. P., Johnston, N. R., Webb, D. J., & Draijer, R. (2013) · British Journal Of Nutrition · doi:10.1017/s000711451300161x · Cited by 84
Anthocyanins from fruit juices improve the antioxidant status of healthy young female volunteers without affecting anti-inflammatory parameters: results from the randomised, double-blind, placebo-controlled, cross-over ANTHONIA (ANTHOcyanins in Nutrition Investigation Alliance) study
Kuntz, S., Kunz, C., Herrmann, J., Borsch, C., Abel, G., Fröhling, B., Dietrich, H., & Rudloff, S. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514001482 · Cited by 84
Effect of grape and other berries on cardiovascular health
Wightman, J. D., & Heuberger, R. (2014) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6890 · Cited by 84
A combination of isolated phytochemicals and botanical extracts lowers diastolic blood pressure in a randomized controlled trial of hypertensive subjects
Biesinger, S., Michaels, H. A., Quadros, A., Qian, Y., Rabovsky, A. B., Badger, R. S., & Jalili, T. (2015) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.88 · Cited by 84
Potential health benefits of (poly)phenols derived from fruit and 100% fruit juice
Ho, K. K. H. Y., Ferruzzi, M. G., & Wightman, J. D. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz041 · Cited by 81
Antioxidant and Anti-Inflammatory Actions of Polyphenols from Red and White Grape Pomace in Ischemic Heart Diseases
Bocșan, I. C., Măgureanu, D. C., Pop, R. M., Levai, A. M., Macovei, Ș. O., Pătrașca, I. M., Chedea, V. S., & Buzoianu, A. D. (2022) · Biomedicines · doi:10.3390/biomedicines10102337 · Cited by 81
Important Food Sources of Fructose‐Containing Sugars and Incident Hypertension: A Systematic Review and Dose‐Response Meta‐Analysis of Prospective Cohort Studies
Liu, Q., Ayoub‐Charette, S., Khan, T. A., Au‐Yeung, F., Blanco Mejia, S., de Souza, R. J., Wolever, T. M. S., Leiter, L. A., Kendall, C. W. C., & Sievenpiper, J. L. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.118.010977 · Cited by 65
Dietary polyphenols and metabolic syndrome among Iranian adults
Sohrab, G., Hosseinpour‐Niazi, S., Hejazi, J., Yuzbashian, E., Mirmiran, P., & Azizi, F. (2013) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2013.787397 · Cited by 76
Dietary grape powder increases IL-1β and IL-6 production by lipopolysaccharide-activated monocytes and reduces plasma concentrations of large LDL and large LDL-cholesterol particles in obese humans
Zunino, S. J., Peerson, J. M., Freytag, T. L., Breksa, A. P., Bonnel, E. L., Woodhouse, L. R., & Storms, D. H. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514000890 · Cited by 76
Dietary Anthocyanins and Stroke: A Review of Pharmacokinetic and Pharmacodynamic Studies
Manolescu, B. N., Oprea, E., Mititelu, M., Ruta, L. L., & FARCASANU, I. C. (2019) · Nutrients · doi:10.3390/nu11071479 · Cited by 76
Daily consumption of red grape cell powder in a dietary dose improves cardiovascular parameters: a double blind, placebo-controlled, randomized study
Vaisman, N., & Niv, E. (2015) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2014.1000840 · Cited by 74
Randomized clinical trial on the efficacy of hesperidin 2S on validated cardiovascular biomarkers in healthy overweight individuals
Salden, B. N., Troost, F. J., de Groot, E., Stevens, Y., Garcés‐Rimón, M., Possemiers, S., Winkens, B., & Masclee, A. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.136960 · Cited by 73
Efficacy of Dietary Polyphenols from Whole Foods and Purified Food Polyphenol Extracts in Optimizing Cardiometabolic Health: A Meta-Analysis of Randomized Controlled Trials
Kiyimba, T., Yiga, P., Bamuwamye, M., Ogwok, P., der Schueren, B. V., & Matthys, C. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.01.002 · Cited by 82
Plant-derived seasonings as sodium salt replacers in food
Taladrid, D., Laguna, L., Bartolomé, B., & Moreno-Arribas, M. V. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.03.002 · Cited by 71
Grape Consumption Increases Anti-Inflammatory Markers and Upregulates Peripheral Nitric Oxide Synthase in the Absence of Dyslipidemias in Men with Metabolic Syndrome
Barona, J., Blesso, C. N., Andersen, C. J., Park, Y., Lee, J., & Fernández, M. L. (2012) · Nutrients · doi:10.3390/nu4121945 · Cited by 68
Self-citation
Virgin Coconut Oil Prevents Blood Pressure Elevation and Improves Endothelial Functions in Rats Fed with Repeatedly Heated Palm Oil
Nurul-Iman, B. S., Kamisah, Y., Jaarin, K., & Qodriyah, H. M. S. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/629329 · Cited by 72
Sweet Bing Cherries Lower Circulating Concentrations of Markers for Chronic Inflammatory Diseases in Healthy Humans
Kelley, D. S., Adkins, Y. C., Reddy, A., Woodhouse, L. R., Mackey, B. E., & Erickson, K. L. (2013) · Journal of Nutrition · doi:10.3945/jn.112.171371 · Cited by 65
Effects of chronic consumption of specific fruit (berries, citrus and cherries) on CVD risk factors: a systematic review and meta-analysis of randomised controlled trials
Wang, Y., Lara, J., Haskell‐Ramsay, C. F., & Lodge, J. K. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02299-w · Cited by 64
Carbonyl Stress in Aging Process: Role of Vitamins and Phytochemicals as Redox Regulators
Ergin, V. (2013) · Aging and Disease · doi:10.14336/ad.2013.0400276 · Cited by 59
Potential Factors Influencing the Effects of Anthocyanins on Blood Pressure Regulation in Humans: A Review
Vendrame, S., & Klimis‐Zacas, D. J. (2019) · Nutrients · doi:10.3390/nu11061431 · Cited by 63
Effect of Grape Polyphenols on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials
Li, S., Zhao, P., Tian, H., Chen, L., & Cui, L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137665 · Cited by 58
Effects of pomegranate extract on blood flow and running time to exhaustion
Trexler, E. T., Smith‐Ryan, A. E., Melvin, M. N., Roelofs, E. J., & Wingfield, H. L. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0137 · Cited by 56
A 6-week supplementation with grape pomace to subjects at cardiometabolic risk ameliorates insulin sensitivity, without affecting other metabolic syndrome markers
Martínez‐Maqueda, D., Zapatera, B., Gallego‐Narbón, A., Vaquero, M. P., Saura-Calixto, F. D., & Pérez‐Jiménez, J. (2018) · Food & Function · doi:10.1039/c8fo01323c · Cited by 55
Acute effects of flavonoid-rich blueberry on cognitive and vascular function in healthy older adults
Dodd, G. F., Williams, C. M., Butler, L. T., & Spencer, J. P. E. (2019) · Nutrition and Healthy Aging · doi:10.3233/nha-180056 · Cited by 55
Fine wine or sour grapes? A systematic review and meta-analysis of the impact of red wine polyphenols on vascular health
Weaver, S. R., Rendeiro, C., McGettrick, H. M., Philp, A., & Lucas, S. J. E. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02247-8 · Cited by 57
A single serving of blueberry (V. corymbosum) modulates peripheral arterial dysfunction induced by acute cigarette smoking in young volunteers: a randomized-controlled trial
Bo’, C. D., Porrini, M., Fracassetti, D., Campolo, J., Klimis‐Zacas, D. J., & Riso, P. (2014) · Food & Function · doi:10.1039/c4fo00570h · Cited by 52
Do grape polyphenols improve metabolic syndrome components? A systematic review
Woerdeman, J., van Poelgeest, E. M., Ket, J. C. F., Eringa, E. C., Serné, E. H., & Smulders, Y. M. (2017) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.227 · Cited by 50
A single dose of purple grape juice improves physical performance and antioxidant activity in runners: a randomized, crossover, double-blind, placebo study
Toscano, L. T., Silva, A. S., de França, A. C. L., de Sousa, B. R. V., Filho, É. J. B. D. A., Costa, M. D. S., Biasoto, A. C. T., da Silva, D. F., Sena, K. D. F., Cerqueira, G. S., et al. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02139-6 · Cited by 50
A Larger Body Mass Index is Associated with Increased Atherogenic Dyslipidemia, Insulin Resistance, and Low-Grade Inflammation in Individuals with Metabolic Syndrome
Ebron, K., Andersen, C. J., Aguilar, D., Blesso, C. N., Barona, J., Dugan, C. E., Jones, J. L., Al‐Sarraj, T., & Fernández, M. L. (2015) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2015.0053 · Cited by 49
Self-citation
Effects of pomegranate extract on blood flow and vessel diameter after high‐intensity exercise in young, healthy adults
Roelofs, E. J., Smith‐Ryan, A. E., Trexler, E. T., Hirsch, K. R., & Mock, M. G. (2016) · European Journal of Sport Science · doi:10.1080/17461391.2016.1230892 · Cited by 49
The impact of grape seed extract treatment on blood pressure changes
Zhang, H., Liu, S., Li, L., Liu, S., Liu, S., Mi, J., & Tian, G. (2016) · Medicine · doi:10.1097/md.0000000000004247 · Cited by 47
The Acute Effects of Grape Polyphenols Supplementation on Endothelial Function in Adults: Meta-Analyses of Controlled Trials
Li, S., Tian, H., Zhao, H., Chen, L., & Cui, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069818 · Cited by 45
Plant bioactive compounds from Mediterranean diet improve risk factors for metabolic syndrome
Farias‐Pereira, R., Zuk, J. B., & Khavaran, H. (2023) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2023.2232949 · Cited by 50
Polyphenolic bioactives as an emerging group of nutraceuticals for promotion of gut health: A review
Ashwin, K., Pattanaik, A. K., & Howarth, G. S. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101376 · Cited by 48
Acute Effects of Hesperidin in Oxidant/Antioxidant State Markers and Performance in Amateur Cyclists
Martínez-Noguera, F. J., Marín‐Pagán, C., Carlos‐Vivas, J., Rubio‐Arias, J. Á., & Alcaráz, P. E. (2019) · Nutrients · doi:10.3390/nu11081898 · Cited by 42
Plant polyphenols as natural bioactives for alleviating lipid metabolism disorder: Mechanisms and application challenges
Wei, H., Rui, J., Yan, X., Xu, R., Chen, S., Zhang, B., Wang, L., Zhang, Z., Zhu, C., Ma, M., et al. (2025) · Food Research International · doi:10.1016/j.foodres.2025.115682 · Cited by 46
Evaluation of Agraz Consumption on Adipocytokines, Inflammation, and Oxidative Stress Markers in Women with Metabolic Syndrome
Moncada, J. E., Marín-Echeverri, C., Galvis-Pérez, Y., Ciro-Gómez, G. L., Aristizábal, J. C., Blesso, C. N., Fernández, M. L., & Barona-Acevedo, J. (2018) · Nutrients · doi:10.3390/nu10111639 · Cited by 40
Self-citation
Pomegranate Extract Improves Maximal Performance of Trained Cyclists after an Exhausting Endurance Trial: A Randomised Controlled Trial
Torregrosa-García, A., Ávila-Gandía, V., Luque-Rubia, A. J., Abellán-Ruiz, M. S., Querol-Calderón, M., & López-Román, F. J. (2019) · Nutrients · doi:10.3390/nu11040721 · Cited by 40
The effect of grapefruits (Citrus paradisi) on body weight and cardiovascular risk factors: A systematic review and meta-analysis of randomized clinical trials
Onakpoya, I., O’Sullivan, J. W., Heneghan, C. J., & Thompson, M. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.901292 · Cited by 38
Effects of Blueberry Consumption on Cardiovascular Health in Healthy Adults: A Cross-Over Randomised Controlled Trial
Wang, Y., Lara, J., Haskell‐Ramsay, C. F., & Lodge, J. K. (2022) · Nutrients · doi:10.3390/nu14132562 · Cited by 36
The effect of acute pomegranate extract supplementation on oxygen uptake in highly-trained cyclists during high-intensity exercise in a high altitude environment
Crum, E. M., Muhamed, A. M. C., Barnes, M. J., & Stannard, S. R. (2017) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-017-0172-0 · Cited by 35
The Effects of Quercetin Supplementation on Blood Pressures and Endothelial Function Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Tamtaji, O. R., Milajerdi, A., Dadgostar, E., Kolahdooz, F., Chamani, M., Amirani, E., Mirzaei, H., & Asemi, Z. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190513095352 · Cited by 35
Clinical effects of an oral supplement rich in antioxidants on skin radiance in women
Dumoulin, M., Gaudout, D., & Lemaire, B. (2016) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s118920 · Cited by 32
Effects of grape consumption on biomarkers of inflammation, endothelial function, and PBMC gene expression in obese subjects
Bardagjy, A. S., Hu, Q., Giebler, K., Ford, A., & Steinberg, F. M. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.04.003 · Cited by 31
Dietary Flavanols: A Review of Select Effects on Vascular Function, Blood Pressure, and Exercise Performance
Al-Dashti, Y. A., Holt, R. R., Stebbins, C. L., Keen, C. L., & Hackman, R. M. (2018) · Journal of the American College of Nutrition · doi:10.1080/07315724.2018.1451788 · Cited by 35
Vascular Effects of the Polyphenolic Nutraceutical Supplement Taurisolo®: Focus on the Protection of the Endothelial Function
Martelli, A., Flori, L., Gorica, E., Piragine, E., Saviano, A., Annunziata, G., Minno, M. N. D. D., Ciampaglia, R., Calcaterra, I. L., Μaione, F., et al. (2021) · Nutrients · doi:10.3390/nu13051540 · Cited by 33
Natural pomegranate juice reduces inflammation, muscle damage and increase platelets blood levels in active healthy Tunisian aged men
Achraf, A., Chtourou, H., Turki, M., Abdelkarim, O., Ayadi, F. M., Höekelmann, A., Yaich, S., & Souissi, N. (2017) · Alexandria Journal of Medicine · doi:10.1016/j.ajme.2017.03.005 · Cited by 28
Changing to a Low-Polyphenol Diet Alters Vascular Biomarkers in Healthy Men after Only Two Weeks
Hurtado‐Barroso, S., Quifer‐Rada, P., de Alvarenga, J. F. R., Pérez-Fernández, S., Tresserra‐Rimbau, A., & Lamuela-Raventós, R. M. (2018) · Nutrients · doi:10.3390/nu10111766 · Cited by 32
Microbial Diversity and Abundance of Parabacteroides Mediate the Associations Between Higher Intake of Flavonoid-Rich Foods and Lower Blood Pressure
Jennings, A., Koch, M., Bang, C., Franke, A., Lieb, W., & Cassidy, A. (2021) · Hypertension · doi:10.1161/hypertensionaha.121.17441 · Cited by 27
Anthocyanin Effects on Vascular and Endothelial Health: Evidence from Clinical Trials and Role of Gut Microbiota Metabolites
Laudani, S., Godos, J., Domenico, F. M. D., Barbagallo, I. A., Randazzo, C. L., Leggio, G. M., Galvano, F., & Grosso, G. (2023) · Antioxidants · doi:10.3390/antiox12091773 · Cited by 34
Added Sugar Intake is Associated with Blood Pressure in Older Females
Mansoori, S., Kushner, N., Suminski, R. R., Jr., Farquhar, W. B., & Chai, S. C. (2019) · Nutrients · doi:10.3390/nu11092060 · Cited by 28
Effect of Agraz (Vaccinium meridionale Swartz) on High-Density Lipoprotein Function and Inflammation in Women with Metabolic Syndrome
Marín-Echeverri, C., Blesso, C. N., Fernández, M. L., Galvis-Pérez, Y., Ciro-Gómez, G. L., Núñez-Rangel, V., Aristizábal, J. C., & Barona-Acevedo, J. (2018) · Antioxidants · doi:10.3390/antiox7120185 · Cited by 27
Self-citation
Montmorency cherry supplementation attenuates vascular dysfunction induced by prolonged forearm occlusion in overweight, middle-aged men
Bakkar, Z. A., Fulford, J., Gates, P. E., Jackman, S. R., JONES, A. M., Bond, B., & Bowtell, J. L. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00804.2018 · Cited by 27
Pola Konsumsi dengan Terjadinya Sindrom Metabolik
Suhaema, S., & Masthalina, H. (2015) · Kesmas National Public Health Journal · doi:10.21109/kesmas.v9i4.741 · Cited by 23
Effects of Freeze-Dried Grape Powder on High-Density Lipoprotein Function in Adults with Metabolic Syndrome: A Randomized Controlled Pilot Study
Millar, C. L., Duclos, Q., Garcia, C., Norris, G. H., Lemos, B. S., DiMarco, D. M., Fernández, M. L., & Blesso, C. N. (2018) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2018.0052 · Cited by 24
Self-citation
The Role of Plant-Derived Bioactive Compounds in Mitigating Oxidative Stress
TUGEN, A., & Buruleanu, C. L. (2025) · Foods · doi:10.3390/foods15010108 · Cited by 23
The effect of grape products containing polyphenols on C-reactive protein levels: a systematic review and meta-analysis of randomised controlled trials
khorasani, S. S., & Hosseinzadeh, M. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520003591 · Cited by 20
The effect of grape (Vitis vinifera) seed extract supplementation on flow-mediated dilation, blood pressure, and heart rate: A systematic review and meta-analysis of controlled trials with duration- and dose-response analysis
Foshati, S., Nouripour, F., Sadeghi, E., & Amani, R. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105905 · Cited by 21
The effect of whole grape products on blood pressure and vascular function: A systematic review and meta-analysis of randomized controlled trials
Ashoori, M., Soltani, S., Kolahdouz‐Mohammadi, R., Moghtaderi, F., Clayton, Z. S., & Abdollahi, S. (2023) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2023.05.001 · Cited by 20
Winery by-products as a valuable source for natural antihypertensive agents
López‐Fernández‐Sobrino, R., Torres‐Fuentes, C., Bravo, F. I., & Muguerza, B. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2049202 · Cited by 22
Physico-chemical characterization and antioxidant capacity of the colombian berry (Vaccinium meridionale Swartz) with a high-polyphenol content: potential effects in people with metabolic syndrome
Quiroz, J. Q., Galvis-Pérez, Y., GALEANO-VÁSQUEZ, S., Marín-Echeverri, C., FRANCO-ESCOBAR, C., Ciro-Gómez, G. L., Núñez-Rangel, V., ARISTIZÁBAL-RIVERA, J. C., & Barona-Acevedo, J. (2019) · Food Science and Technology · doi:10.1590/fst.32817 · Cited by 19
Recent Advances in Extraction of Polyphenols by Advanced Extraction Methods
Yendurı, S., Venkatesh, K. V., & Prashant, K. N. (2025) · Phytochemical Analysis · doi:10.1002/pca.70012 · Cited by 20
Effect of Grape Seed Extract on Blood Pressure in Subjects with Pre-Hypertension
Robinson, Lu, B., Edirisinghe, I., & Kappagoda, C. T. (2012) · Journal of Pharmacy and Nutrition Sciences · doi:10.6000/1927-5951.2012.02.02.6 · Cited by 18
Bioactivities and mechanisms of dietary proanthocyanidins on blood pressure lowering: A critical review of in vivo and clinical studies
Fan, W., Zong, H., Zhao, T., Deng, J., & Yang, H. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2132375 · Cited by 18
Daily Consumption of Grapefruit for 6 Weeks Reduces Urine F2-Isoprostanes in Overweight Adults with High Baseline Values but Has No Effect on Plasma High-Sensitivity C-Reactive Protein or Soluble Vascular Cellular Adhesion Molecule
Dow, C. A., Wertheim, B. C., Patil, B. S., & Thomson, C. A. (2013) · Journal of Nutrition · doi:10.3945/jn.113.175166 · Cited by 15
Consumption of Aged White Wine under a Veil of Flor Reduces Blood Pressure-Increasing Plasma Nitric Oxide in Men at High Cardiovascular Risk
Roth, I., Casas, R. M., Ribó-Coll, M., & Estruch, R. (2019) · Nutrients · doi:10.3390/nu11061266 · Cited by 15
Chardonnay Marc as a New Model for Upcycled Co-products in the Food Industry: Concentration of Diverse Natural Products Chemistry for Consumer Health and Sensory Benefits
Holt, R. R., Barile, D., Wang, S. C., Munafo, J. P., Arvik, T. J., Li, X., Lee, F., Keen, C. L., Tagkopoulos, I., & Schmitz, H. H. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c04519 · Cited by 15
Fortification of orange juice with microencapsulated Kocuria flava Y4 towards a novel functional beverage: Biological and quality aspects
Barik, A., Pallavi, P., Sen, S. K., Rajhans, G., Bose, A., & Raut, S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17509 · Cited by 14

Authors: Barona, J., Aristizabal, J. C., Blesso, C. N., Volek, J. S., & Fernandez, M. L.
Affiliations: University of Connecticut (US)
ORCID: Blesso, Christopher N.
Volek, Jeff S.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2012-09
Volume: 142
Issue: 9
Pages: 1626-1632
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.112.162743
OpenAlex: W2128017243
Cited by: 173
References: 56
Citations by year: 2026: 5 · 2025: 16 · 2024: 6 · 2023: 11 · 2022: 10 · 2021: 11 · 2020: 10 · 2019: 17 · 2018: 19 · 2017: 11 · 2016: 11 · 2015: 19 · 2014: 8 · 2013: 15 · 2012: 4
FWCI: 10.29
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3811 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: grape polyphenols, metabolic syndrome, blood pressure, flow-mediated dilation, endothelial function, nitric oxide, soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, adhesion molecules, vasorelaxation, men
MeSH terms: Adult, Aged, Blood Pressure, Brachial Artery, Endothelium, Vascular, Freeze Drying, Humans, Male, Middle Aged, Nitrates, Nitrites, Placebos, Vasculitis, Vasodilation, Biomarkers, Cross-Over Studies, Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, Metabolic Syndrome, Vitis, Polyphenols

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Grape Polyphenols Reduce Blood Pressure and Increase Flow-Mediated Vasodilation in Men with Metabolic Syndrome

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks