Cited by 173Phytochemicals and Antioxidant ActivitiesCardiovascular Health and Disease PreventionNitric Oxide and Endothelin Effects

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Grape Polyphenols Reduce Blood Pressure and Increase Flow-Mediated Vasodilation in Men with Metabolic Syndrome

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Barona, Jacqueline, Aristizabal, Juan C., Blesso, Christopher N., Volek, Jeff S., Fernandez, Maria Luz·2012·The Journal of Nutrition

DOI 10.3945/jn.112.162743

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Abstract

We evaluated the effects of grape polyphenols in individuals classified with metabolic syndrome (MetS). Men (n = 24) aged 30-70 y were randomly assigned to consume either a freeze-dried grape polyphenol powder (GRAPE) or a placebo for 30 d in a double-blind, crossover design, separated by a 3-wk washout period. Participants were asked to maintain their usual diet and physical activity during the study and abstain from consuming polyphenol-rich foods. MetS criteria including blood pressure (BP) and markers of vascular endothelial function including brachial artery flow-mediated vasodilation (FMD), plasma total nitrite + nitrate (NOx) to estimate NO production, plasma soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured at the end of each dietary period. Systolic BP (P < 0.0025) and plasma sICAM-1 concentrations (P < 0.025) were lower, whereas the FMD response was higher (P < 0.0001), during the GRAPE compared with the placebo period. In addition, changes in sVCAM-1 concentrations between periods were positively correlated with changes in systolic BP (r = 0.45; P < 0.05). Although NOx concentrations did not differ between periods, changes in systolic BP were negatively correlated with changes in NOx concentrations (r = -0.44; P < 0.05), indicating the vasodilating properties of NO. Other MetS variables did not differ between the GRAPE and placebo periods. These results suggest that GRAPE polyphenols may potentiate vasorelaxation and reduce BP and circulating cell adhesion molecules, resulting in improvements in vascular function.

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Authors: Barona, J., Aristizabal, J. C., Blesso, C. N., Volek, J. S., & Fernandez, M. L.
Affiliations: University of Connecticut (US)
ORCID: Blesso, Christopher N.
Volek, Jeff S.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2012-09
Volume: 142
Issue: 9
Pages: 1626-1632
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.112.162743
OpenAlex: W2128017243
Cited by: 173
References: 56
Citations by year: 2026: 5 · 2025: 16 · 2024: 6 · 2023: 11 · 2022: 10 · 2021: 11 · 2020: 10 · 2019: 17 · 2018: 19 · 2017: 11 · 2016: 11 · 2015: 19 · 2014: 8 · 2013: 15 · 2012: 4
FWCI: 10.29
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3811 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: grape polyphenols, metabolic syndrome, blood pressure, flow-mediated dilation, endothelial function, nitric oxide, soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, adhesion molecules, vasorelaxation, men
MeSH terms: Adult, Aged, Blood Pressure, Brachial Artery, Endothelium, Vascular, Freeze Drying, Humans, Male, Middle Aged, Nitrates, Nitrites, Placebos, Vasculitis, Vasodilation, Biomarkers, Cross-Over Studies, Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, Metabolic Syndrome, Vitis, Polyphenols

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Grape Polyphenols Reduce Blood Pressure and Increase Flow-Mediated Vasodilation in Men with Metabolic Syndrome

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