Fish Oil Increases Muscle Protein Mass and Modulates Akt/FOXO, TLR4, and NOD Signaling in Weanling Piglets After Lipopolysaccharide Challenge1–3
Open accessAbstract
Proinflammatory cytokines play a key role in the pathophysiology of muscle atrophy. In addition, n3 polyunsaturated fatty acids (PUFAs) exert an inhibitory effect on proinflammatory cytokines affecting many inflammatory diseases. We hypothesized that dietary supplementation of fish oil could attenuate lipopolysaccharide (LPS)-induced muscle atrophy. Weanling pigs were used in a 2 × 2 factorial design and the main factors included diet (5% corn oil or 5% fish oil) and immunological challenge (LPS or saline). After 21 d of treatment with either fish oil or corn oil, pigs received an i.p. injection of either saline or LPS. At 4 h postinjection, blood and muscle samples were obtained. Fish oil led to enrichment of eicosapentaenoic acid, docosahexaenoic acid, and total n3 PUFAs in muscles. Fish oil increased muscle protein mass, indicated by a higher protein:DNA ratio in gastrocnemius and longissimus dorsi (LD) muscles. In addition, fish oil increased Akt1 mRNA abundance and decreased Forkhead Box O (FOXO) 1 and FOXO4 mRNA abundance. Fish oil also increased phosphorylation of Akt and FOXO1 in gastrocnemius and LD muscles. Fish oil decreased the mRNA abundance of muscle atrophy F-box (MAFbx) and muscle RING finger 1 in gastrocnemius and LD muscles. Moreover, fish oil reduced the plasma tumor necrosis factor (TNF) α, muscle TNFα, and prostaglandin E2 concentrations, and muscle TNFα and cyclooxygenase 2 (COX2) mRNA abundance. Finally, fish oil downregulated the mRNA abundance of muscle toll-like receptor (TLR4) and its downstream signaling molecules [myeloid differentiation factor 88 (MyD88), TNFα receptor-associated factor 6 (TRAF6), and NF-κB p65], and nucleotide-binding oligomerization domain protein (NOD1), NOD2, and their adaptor molecule [receptor-interacting serine/threonine-protein kinase 2 (RIPK2)]. These results indicate fish oil may suppress muscle proinflammatory cytokine production via regulation of TLR and NOD signaling pathways and therefore improve muscle protein mass, possibly through maintenance of Akt/FOXO signaling.
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Dietary supplementation of menhaden fish oil suppresses lipopolysaccharide-induced muscle atrophy in piglets through modulation of Akt/FoxO, Toll-like receptors and nucleotide-binding oligomerization domain protein signaling pathways.
“Dietary supplementation of menhaden fish oil, mainly containing omega-3 unsaturated fatty acids and docosahexaenoic acid, could suppress lipopolysaccharide-induced muscle atrophy in piglets through the modulation of Akt/FoxO, Toll-like receptors and nucleotide-binding oligomerization domain protein signaling pathways [76].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [76]
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Strategies to mitigate muscle mass loss in individuals with spinal cord injury
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Polyunsaturated Omega-3 Fatty Acids and Skeletal Muscle
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- Authors
- Liu, Y., Chen, F., Odle, J., Lin, X., Zhu, H., Shi, H., Hou, Y., & Yin, J.
- Affiliations
- Wuhan Polytechnic University (CN)
- North Carolina State University (US)
- State Key Laboratory of Animal Nutrition (CN)
- Corresponding author
- Liu, Yulan
- Yin, Jingdong
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 143
- Issue
- 8
- Pages
- 1331-1339
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2171004709
- Cited by
- 74
- References
- 47
- Citations by year
- 2025: 7 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 7 · 2020: 8 · 2019: 8 · 2018: 6 · 2017: 5 · 2016: 8 · 2015: 6 · 2014: 4 · 2013: 2
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (NCET-10, 2013CB127302)
- Natural Science Foundation of Hubei Province
- Program for New Century Excellent Talents in University (NCET-10)
- National Key Research and Development Program of China (2012CB126305, 2013CB127302)
- Wuhan Science and Technology Project
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Meat and Animal Product Quality
- Keywords
- omega-3 fatty acids, muscle atrophy, lipopolysaccharide challenge, TLR4 signaling, inflammatory cytokines, TNF-α, cyclooxygenase-2, atrogin-1, weaned piglets, gastrocnemius, longissimus dorsi, eicosapentaenoic acid, docosahexaenoic acid
- MeSH terms
- Animals, Docosahexaenoic Acids, Fish Oils, Lipopolysaccharides, Muscle Proteins, Swine, Tumor Necrosis Factor-alpha, Eicosapentaenoic Acid, Signal Transduction, NF-kappa B, Muscle, Skeletal, Proto-Oncogene Proteins c-akt, Toll-Like Receptor 4, Cyclooxygenase 2, Forkhead Transcription Factors, Nod1 Signaling Adaptor Protein, Myeloid Differentiation Factor 88
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