Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk

Trammell, Samuel AJ; Yu, Liping; Redpath, Philip; Migaud, Marie E; Brenner, Charles

doi:10.3945/jn.116.230078

Cited by 112Sirtuins and Resveratrol in MedicineFolate and B Vitamins ResearchFood and Agricultural Sciences

Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk

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Trammell, Samuel AJ, Yu, Liping, Redpath, Philip, Migaud, Marie E, Brenner, Charles·2016·The Journal of Nutrition

DOI 10.3945/jn.116.230078PMC PMC6879052

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Abstract

Background Nicotinamide riboside (NR) is a recently discovered NAD(+) precursor vitamin with a unique biosynthetic pathway. Although the presence of NR in cow milk has been known for more than a decade, the concentration of NR with respect to the other NAD(+) precursors was unknown.Objective We aimed to determine NAD(+) precursor vitamin concentration in raw samples of milk from individual cows and from commercially available cow milk.Methods LC tandem mass spectrometry and isotope dilution technologies were used to quantify NAD(+) precursor vitamin concentration and to measure NR stability in raw and commercial milk. Nuclear magnetic resonance (NMR) spectroscopy was used to test for NR binding to substances in milk.Results Cow milk typically contained ∼12 μmol NAD(+) precursor vitamins/L, of which 60% was present as nicotinamide and 40% was present as NR. Nicotinic acid and other NAD(+) metabolites were below the limits of detection. Milk from samples testing positive for Staphylococcus aureus contained lower concentrations of NR (Spearman ρ = -0.58, P = 0.014), and NR was degraded by S. aureus Conventional milk contained more NR than milk sold as organic. Nonetheless, NR was stable in organic milk and exhibited an NMR spectrum consistent with association with a protein fraction in skim milk.Conclusions NR is a major NAD(+) precursor vitamin in cow milk. Control of S. aureus may be important to preserve the NAD(+) precursor vitamin concentration of milk.

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NR is stably associated with protein fractions in milk with a lifetime of weeks.
“Importantly, NR is stably associated with protein fractions in milk25 with a lifetime of weeks”
From NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells (2016) · cites this paper as [25]
The ‘NR concentration as a function of organic certification’ section reports NMR signals consistent with NR binding to proteins in milk fractions. The Results report that NR was stable in pasteurized milk, but the stability assays described in ‘Milk sample acquisition and preparations’ ran for only 8 hours; the paper does not establish a lifetime of weeks. Page numbers are unavailable in our copy. (LLM, conf=0.88)
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Authors: Trammell, S. A., Yu, L., Redpath, P., Migaud, M. E., & Brenner, C.
Affiliations: University of Iowa (US)
Queen's University Belfast (GB)
Corresponding author: Brenner, Charles
ORCID: Trammell, Samuel AJ
Yu, Liping
Redpath, Philip
Migaud, Marie E
Brenner, Charles
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2016-05
Volume: 146
Issue: 5
Pages: 957-963
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.116.230078
PMC: PMC6879052
OpenAlex: W2323596853
Cited by: 112
References: 39
Citations by year: 2026: 2 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 12 · 2021: 11 · 2020: 10 · 2019: 21 · 2018: 15 · 2017: 10 · 2016: 4
FWCI: 9.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2472 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
Research Portal (Queen's University Belfast) (submittedVersion)
Funders: Iowa State University
Biotechnology and Biological Sciences Research Council (BB/N001842/1)
National Institute of General Medical Sciences (T32GM008629)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
Life Sciences › Agricultural and Biological Sciences › Food Science › Food and Agricultural Sciences
Keywords: nicotinamide riboside, NAD+ precursors, cow's milk, nicotinamide, Staphylococcus aureus, milk quality, organic milk, vitamin stability, milk protein, vitamin biosynthesis
MeSH terms: Provitamins, Animals, Cattle, Commerce, Female, Food Microbiology, Milk, Milk Proteins, NAD, Niacin, Niacinamide, Magnetic Resonance Spectroscopy, Pyridinium Compounds, Staphylococcus aureus, Vitamin B Complex, Tandem Mass Spectrometry, Food, Organic

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Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk

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