Fermented soy product intake is inversely associated with the development of high blood pressure: The Japan Public Health Center-Based Prospective Study
Open accessAbstract
Background: Randomized controlled studies have investigated the short-term effect of soy product intake on blood pressure (BP) in normotensive people. To our knowledge, no prospective studies exist on the effect of habitual intake of fermented soy products, separate from total soy products, on BP in the general population.Objective: We examined the association between the habitual intake of soy products, including fermented soy products, and the development of high BP during a 5-y period among participants in a population-based prospective cohort study in Japan.Methods: The study included normotensive participants aged 40-69 y at baseline (926 men and 3239 women) who completed 2 questionnaires and whose BP was measured at the baseline survey between 1993 and 1994 and the 5-y follow-up in the Japan Public Health Center-Based Prospective Study Cohort II. The intake of soy products was assessed with a food-frequency questionnaire. High BP was defined as systolic blood pressure ≥130 mm Hg, diastolic blood pressure ≥85 mm Hg, or antihypertensive medication use. ORs and 95% CIs of high BP by frequency of soy products (miso, natto, and tofu) consumption, intake of total and fermented soy products, and intake of isoflavones from total and fermented soy products were estimated with the use of multiple logistic regression analysis.Results: Multivariable-adjusted ORs of high BP for the highest compared with the lowest tertile of total and fermented soy product intake were 1.03 (95% CI: 0.84, 1.25; P-trend = 0.786) and 0.72 (95% CI: 0.56, 0.92; P-trend = 0.009), respectively. The frequency of nonfermented soy product (tofu) intake was not associated with the development of high BP (P-trend = 0.597).Conclusions: The intake of fermented soy products, but not total or nonfermented soy products, was inversely associated with developing high BP in men and women with normal BP.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Consumption of fermented soybeans (miso and natto) has been associated with a reduced risk of hypertension.
“The consumption of fermented soybeans (miso and natto) has been associated with a reduced risk of hypertension [204]”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [204]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860 · see citing works
Lozano, R., Naghavi, M., Foreman, K., Lim, S., Shibuya, K., Aboyans, V., Abraham, J., Adair, T., Aggarwal, R., Ahn, S. Y., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61728-0 · Cited by 14,070 · see citing works
2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,638 · see citing works
The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618 · see citing works
Global status report on noncommunicable diseases 2010.
Alwan, A. (2011) · Cited by 8,494 · see citing works
The Pathogenesis of Atherosclerosis — An Update
Ross, R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198602203140806 · Cited by 4,885 · see citing works
Total energy intake: implications for epidemiologic analyses.
WILLETT, W., & STAMPFER, M. J. (1986) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114366 · Cited by 2,751 · see citing works
RE: “TOTAL ENERGY INTAKE: IMPLICATIONS FOR EPIDEMIOLOGIC ANALYSES”
Palmgren, J., & Kushi, L. H. (1991) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115841 · Cited by 2,712 · see citing works
Impact of High-Normal Blood Pressure on the Risk of Cardiovascular Disease
Vasan, R. S., Larson, M. G., Leip, E. P., Evans, J. C., O’Donnell, C. J., Kannel, W. B., & Levy, D. A. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa003417 · Cited by 2,079 · see citing works
Appel, L. J., Brands, M. W., Daniels, S. R., Karanja, N., Elmer, P. J., & Sacks, F. M. (2006) · Hypertension · doi:10.1161/01.hyp.0000202568.01167.b6 · Cited by 1,304 · see citing works
Cardioprotection and lifespan extension by the natural polyamine spermidine
Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., Harger, A., Schipke, J., Zimmermann, A., Schmidt, A., et al. (2016) · Nature Medicine · doi:10.1038/nm.4222 · Cited by 1,168 · see citing works
Vasan, R. S., Larson, M. G., Leip, E. P., Kannel, W. B., & Levy, D. A. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06710-1 · Cited by 1,074 · see citing works
Isoflavone Content in Commercial Soybean Foods
Wang, H., & Murphy, P. A. (1994) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00044a016 · Cited by 1,004 · see citing works
Soy Isoflavone Aglycones Are Absorbed Faster and in Higher Amounts than Their Glucosides in Humans
Izumi, T., Osawa, S., Obata, A., Tobe, K., Saito, M., Kataoka, S., Kikuchi, M., Piskuła, M. K., & Kubota, Y. (2000) · Journal of Nutrition · doi:10.1093/jn/130.7.1695 · Cited by 959 · see citing works
Polyamines: Mysterious Modulators of Cellular Functions
Igarashi, K., & Kashiwagi, K. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2601 · Cited by 888 · see citing works
Standard tables of food composition in Japan
Kagawa, Y. (2008) · Medical Entomology and Zoology · Cited by 830 · see citing works
Arai, Y., Watanabe, S., Kimira, M., Shimoi, K., Mochizuki, R., & Kinae, N. (2000) · Journal of Nutrition · doi:10.1093/jn/130.9.2243 · Cited by 790 · see citing works
Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T., Cifkova, R., Backer, G. D., Dominiczak, A. F., et al. (2013) · Open Access CRIS of the University of Bern · doi:10.7892/boris.41664 · Cited by 742 · see citing works
Soy Protein and Cardiovascular Disease
Erdman, J. W. (2000) · Circulation · doi:10.1161/01.cir.102.20.2555 · Cited by 408 · see citing works
The JPHC Study: Design and Some Findings on the Typical Japanese Diet
Tsugane, S., & Sawada, N. (2014) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyu096 · Cited by 388 · see citing works
Self-citationSoy, phytoestrogens and metabolism: A review
Cederroth, C. R., & Nef, S. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.02.027 · Cited by 352 · see citing works
Japanese Intake of Flavonoids and Isoflavonoids from Foods
Kimira, M., Arai, Y., Shimoi, K., & Watanabe, S. (1998) · Journal of Epidemiology · doi:10.2188/jea.8.168 · Cited by 317 · see citing works
Hwang, C. S., Kwak, H.-S., Lim, H. J., Lee, S. H., Kang, Y. S., Choe, T. B., Hur, H. G., & Han, K. O. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.06.020 · Cited by 296 · see citing works
Decrease in Polyamines with Aging and Their Ingestion from Food and Drink
Nishimura, K., Shiina, R., Kashiwagi, K., & Igarashi, K. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj003 · Cited by 295 · see citing works
Physical Activity and Risk of Hypertension
Huai, P., Xun, H., Reilly, K. H., Wang, Y., Ma, W., & Xi, B. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01965 · Cited by 293 · see citing works
Kokubo, Y., Iso, H., Ishihara, J., Okada, K., Inoue, M., & Tsugane, S. (2007) · Circulation · doi:10.1161/circulationaha.106.683755 · Cited by 283 · see citing works
Self-citationIshihara, J., Sobue, T., Yamamoto, S., Yoshimi, I., Sasaki, S., Kobayashi, M., Takahashi, T., Iitoi, Y., Akabane, M., & Tsugane, S. (2003) · Journal of Epidemiology · doi:10.2188/jea.13.1sup_134 · Cited by 203 · see citing works
Self-citationMahn, K., Borrás, C., Knock, G., Taylor, P., Khan, I. Y., Sugden, D., Poston, L., Ward, J., Sharpe, R., Viña, J., et al. (2005) · The FASEB Journal · doi:10.1096/fj.05-4008fje · Cited by 201 · see citing works
Effect of soy isoflavones on blood pressure: A meta-analysis of randomized controlled trials
Liu, X. X., Li, S.-J., Chen, J. Z., Sun, K., Wang, X. J., Wang, X., & Hui, R. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.09.006 · Cited by 153 · see citing works
Long-Term Oral Polyamine Intake Increases Blood Polyamine Concentrations
Soda, K., Kano, Y., SAKURAGI, M., Takao, K., Lefor, A. K., & Konishi, F. (2009) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.55.361 · Cited by 153 · see citing works
Isoflavone intake in four different European countries: the VENUS approach
van Erp-Baart, M.-A. J., Brants, H. A. M., Kiely, M. E., Mulligan, A. A., Turrini, A., Sermoneta, C., Kilkkinen, A., & Valsta, L. M. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2002793 · Cited by 149 · see citing works
Nagata, C., Wada, K., Tamura, T., Konishi, K., Goto, Y., Koda, S., Kawachi, T., Tsuji, M., & Nakamura, K. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.137281 · Cited by 149 · see citing works
Guidelines for management of hypertension
Swales, J. D. (1994) · BMJ · doi:10.1136/bmj.308.6932.855a · Cited by 134 · see citing works
Longitudinal study of soy food intake and blood pressure among middle-aged and elderly Chinese women
Yang, G., Shu, X., Jin, F., Zhang, X., Li, H., Li, Q., Gao, Y., & Zheng, W. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.5.1012 · Cited by 103 · see citing works
Guidelines for the Management of Hypertension
Chobanian, A. V. (2016) · Medical Clinics of North America · doi:10.1016/j.mcna.2016.08.016 · Cited by 95 · see citing works
Pan, W., Ikeda, K., Takebe, M., et al. (2001) · Journal of Nutrition · doi:10.1093/jn/131.4.1154 · Cited by 92 · see citing works
Effect of soya protein on blood pressure: a meta-analysis of randomised controlled trials
Dong, J.-Y., Tong, X., Wu, Z., Xun, P., He, K., & Qin, L. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511000262 · Cited by 79 · see citing works
Pan, A., Franco, O. H., Ye, J., Demark‐Wahnefried, W., Ye, X., Yu, Z., Li, H., & Lin, X. (2008) · Journal of Nutrition · doi:10.3945/jn.108.097519 · Cited by 50 · see citing works
Dietary soy exerts an antihypertensive effect in spontaneously hypertensive female rats
Martin, D., Breitkopf, N. P., Eyster, K. M., et al. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.2.r553 · Cited by 47 · see citing works
Murakami, K., Yamanaka, N., Ohnishi, K., et al. (2012) · Food & Function · doi:10.1039/c2fo10245e · Cited by 43 · see citing works
Nagata, C., Shimizu, H., Takami, R., Hayashi, M., Takeda, N., & Yasuda, K. (2003) · Preventive Medicine · doi:10.1016/s0091-7435(03)00052-5 · Cited by 38 · see citing works
Decreased sensitivity of aorta from hypertensive rats to vasorelaxation by tyrphostin
Sauro, M. D., & Thomas, B. (1993) · Life Sciences · doi:10.1016/0024-3205(93)90212-l · Cited by 10 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, et al. Car- dioprotection and lifespan extension by the natural polyamine spermi- dine. Nat Med 2016;22:1428-38.
Cited by
Sorted by citations
Fermented Foods as a Dietary Source of Live Organisms
Rezac, S., Kok, C. R., Heermann, M., & Hutkins, R. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01785 · Cited by 540 · see citing works
The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties
Maftei, N.-M., Raileanu, C. R., Balta, A. A., Ambrose, L., Boev, M., Marin, D. B., & Lisa, E. L. (2024) · Microorganisms · doi:10.3390/microorganisms12020234 · Cited by 381 · see citing works
Yogurt and other fermented foods as sources of health-promoting bactéria
Kok, C. R., & Hutkins, R. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy056 · Cited by 317 · see citing works
The food-gut axis: lactic acid bacteria and their link to food, the gut microbiome and human health
De Filippis, F., Pasolli, E., & Ercolini, D. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa015 · Cited by 303 · see citing works
Sanders, M. E., Merenstein, D., Merrifield, C. A., & Hutkins, R. (2018) · Nutrition Bulletin · doi:10.1111/nbu.12334 · Cited by 278 · see citing works
Taylor, B. C., Lejzerowicz, F., Poirel, M., Shaffer, J. P., Jiang, L., Aksenov, A., Litwin, N., Humphrey, G., Martino, C., Miller-Montgomery, S., et al. (2020) · mSystems · doi:10.1128/msystems.00901-19 · Cited by 203 · see citing works
Nozue, M., Shimazu, T., Charvat, H., Mori, N., Mutoh, M., Sawada, N., Iwasaki, M., Yamaji, T., Inoue, M., Kokubo, Y., et al. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-020-00732-1 · Cited by 42 · see citing works
Self-citation
- Authors
- Nozue, M., Shimazu, T., Sasazuki, S., Charvat, H., Mori, N., Mutoh, M., Sawada, N., Iwasaki, M., Yamaji, T., Inoue, M., Kokubo, Y., Yamagishi, K., Iso, H., & Tsugane, S.
- Affiliations
- National Cancer Centre Japan (JP)
- National Cerebral and Cardiovascular Center (JP)
- University of Tsukuba (JP)
- The University of Osaka (JP)
- Corresponding author
- Shimazu, Taichi
- ORCID
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 147
- Issue
- 9
- Pages
- 1749-1756
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2742185215
- Cited by
- 66
- References
- 42
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 15 · 2021: 5 · 2020: 11 · 2019: 3 · 2018: 8
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Health, Labour and Welfare
- Ministry of Agriculture, Forestry and Fisheries (MAFF-CPS-2016-1-1)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- fermented soybean, hypertension, hypertension development, miso, natto, tofu, isoflavones, dietary factors, normotensive subjects, Japan Public Health Center-based Prospective Study
- MeSH terms
- Aged, Blood Pressure, Diet, Diet Surveys, Female, Fermentation, Follow-Up Studies, Humans, Hypertension, Isoflavones, Japan, Male, Middle Aged, Prospective Studies, Public Health, Surveys and Questionnaires, Glycine max, Logistic Models, Odds Ratio, Soy Foods
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
