Cited by 32Gestational Diabetes Research and ManagementDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and Research

Gestational Diabetes and Future Risk of Diabetes

Open access
Sivaraman·2013·Journal of Clinical Medicine Research

Abstract

BACKGROUND: In this study of women with gestational diabetes we attempted to (a) Determine the magnitude of the long term risk of progression to diabetes and (b) Identify factors that predict the development of diabetes. METHODS: All women diagnosed with gestational diabetes (GDM) at Worcestershire Royal Hospital, UK from 1995 to 2003 were included in this observational cohort study and followed up till 2009. Diabetes was diagnosed if fasting glucose ≥ 7.0 mmol/L, random/two-hour glucose following 75 gram oral glucose test (OGTT) ≥ 11.1 mmol/L or HbA1c ≥ 7.0%. RESULTS: The risk of developing diabetes was 6.9% at five years and 21.1% at ten years following the initial diagnosis of GDM. Fasting and post-prandial glucose levels in the oral glucose tolerance test during pregnancy were associated with future risk of diabetes. There was no association with age, gestational age at diagnosis of GDM, numbers of previous and subsequent pregnancies. CONCLUSION: Risk of progression to diabetes in a UK based cohort of women with GDM is estimated. Women with fasting antenatal glucose ≥ 7.0 mmol/L and/or an antenatal two-hour glucose ≥ 11.1 mmol/L are at higher risk and need close follow up.

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  • Evidence on whether early GDM diagnosis increases later diabetes risk is inconsistent.

    “However, the evidence is inconsistent203.”

    From A global view of hypertensive disorders and diabetes mellitus during pregnancy (2022) · cites this paper as [203]

    The Introduction (page unavailable) says studies identifying which women with GDM are more likely to develop later glucose intolerance have produced inconsistent results. It does not say that evidence is inconsistent specifically for early GDM diagnosis; the Results (page unavailable) report no significant association between gestational age at diagnosis and later diabetes risk in this cohort. (LLM, conf=0.82)

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Research works printed but not linked: 1

  1. [5]In: Diabetes in Pregnancy: Management of diabetes and its complications from preconception to the postnatal period London 2008 21370515

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Authors
Sivaraman
Venue
Journal of Clinical Medicine Research
Published
2013
Volume
5
Issue
2
Pages
92-6
ISSN
1918-3003 (ISSN-L)
OpenAlex
W2046108353
Cited by
32
References
23
Citations by year
2023: 4 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 2
FWCI
3.74
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Journal of Clinical Medicine Research (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
University of Warwick
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
gestational diabetes mellitus, type 2 diabetes risk, fasting blood glucose, postprandial blood glucose, risk prediction factors, women

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