Gestational Diabetes and Future Risk of Diabetes
Open accessAbstract
BACKGROUND: In this study of women with gestational diabetes we attempted to (a) Determine the magnitude of the long term risk of progression to diabetes and (b) Identify factors that predict the development of diabetes. METHODS: All women diagnosed with gestational diabetes (GDM) at Worcestershire Royal Hospital, UK from 1995 to 2003 were included in this observational cohort study and followed up till 2009. Diabetes was diagnosed if fasting glucose ≥ 7.0 mmol/L, random/two-hour glucose following 75 gram oral glucose test (OGTT) ≥ 11.1 mmol/L or HbA1c ≥ 7.0%. RESULTS: The risk of developing diabetes was 6.9% at five years and 21.1% at ten years following the initial diagnosis of GDM. Fasting and post-prandial glucose levels in the oral glucose tolerance test during pregnancy were associated with future risk of diabetes. There was no association with age, gestational age at diagnosis of GDM, numbers of previous and subsequent pregnancies. CONCLUSION: Risk of progression to diabetes in a UK based cohort of women with GDM is estimated. Women with fasting antenatal glucose ≥ 7.0 mmol/L and/or an antenatal two-hour glucose ≥ 11.1 mmol/L are at higher risk and need close follow up.
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Evidence on whether early GDM diagnosis increases later diabetes risk is inconsistent.
“However, the evidence is inconsistent203.”
From A global view of hypertensive disorders and diabetes mellitus during pregnancy (2022) · cites this paper as [203]
The Introduction (page unavailable) says studies identifying which women with GDM are more likely to develop later glucose intolerance have produced inconsistent results. It does not say that evidence is inconsistent specifically for early GDM diagnosis; the Results (page unavailable) report no significant association between gestational age at diagnosis and later diabetes risk in this cohort. (LLM, conf=0.82)
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- Authors
- Sivaraman
- Venue
- Journal of Clinical Medicine Research
- Publisher
- Elmer Press, Inc.
- Published
- 2013
- Volume
- 5
- Issue
- 2
- Pages
- 92-6
- ISSN
- 1918-3003 (ISSN-L)
- PMC
- PMC3601506
- OpenAlex
- W2046108353
- Cited by
- 32
- References
- 23
- Citations by year
- 2023: 4 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 2
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Journal of Clinical Medicine Research (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- University of Warwick
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- gestational diabetes mellitus, type 2 diabetes risk, fasting blood glucose, postprandial blood glucose, risk prediction factors, women
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