The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Cutting Edge: The Foxp3 Target miR-155 Contributes to the Development of Regulatory T Cells
Open accessAbstract
Foxp3 is a transcription factor that is essential for the normal development of regulatory T cells (Tregs). In the absence of microRNAs (miRNAs), Foxp3+ Tregs develop but fail to maintain immune homeostasis, leading to a scurfy-like disease. Global analysis of the network of genes regulated by Foxp3 has identified the miRNA miR-155, which is highly expressed in Tregs, as a direct target of Foxp3. In this study we report that miR-155-deficient mice have reduced numbers of Tregs, both in the thymus and periphery, due to impaired development. However, we found no evidence for defective suppressor activity of miR-155-deficient Tregs, either in vitro or in vivo. Our results indicate that miR-155 contributes to Treg development, but that additional miRNAs control Treg function.
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Cites
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Self-citationRegulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
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Cited by
Bartel, D. P. (2018) · Cell · doi:10.1016/j.cell.2018.03.006 · Cited by 3,751
Physiological and pathological roles for microRNAs in the immune system
O'Connell, R. M., Rao, D. S., Chaudhuri, A. A., & Baltimore, D. (2010) · Nature Reviews Immunology · doi:10.1038/nri2708 · Cited by 1,378
MicroRNAs in Development and Disease
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MicroRNA-155 Promotes Autoimmune Inflammation by Enhancing Inflammatory T Cell Development
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Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses
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Metadata
- Authors
- Kohlhaas, S., Garden, O. A., Scudamore, C., Turner, M., Okkenhaug, K., & Vigorito, E.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-03-01
- Volume
- 182
- Issue
- 5
- Pages
- 2578-2582
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2152257387
- Cited by
- 379
- References
- 20
- FWCI
- 10.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kohlhaas, S., Garden, O. A., Scudamore, C., Turner, M., Okkenhaug, K., & Vigorito, E. (2009). Cutting Edge: The Foxp3 Target miR-155 Contributes to the Development of Regulatory T Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.0803162
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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