The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Cutting Edge: TNF-Induced MicroRNAs Regulate TNF-Induced Expression of E-Selectin and Intercellular Adhesion Molecule-1 on Human Endothelial Cells: Feedback Control of Inflammation
Open accessAbstract
MicroRNAs (miRNAs) pair with target sequences in the 3′ untranslated region of mRNAs to posttranscriptionally repress gene expression. In this study, we report that TNF-mediated induction of endothelial adhesion molecules can be regulated by miRNAs that are induced by TNF. Specifically, E-selectin and ICAM-1 are targets of TNF-induced miRNAs miR-31 and miR-17-3p, respectively. Specific antagonism of these TNF-induced miRNAs increased neutrophil adhesion to cultured endothelial cells. Conversely, transfections with mimics of these miRNAs decreased neutrophil adhesion to endothelial cells. These data suggest that miRNAs provide negative feedback control of inflammation.
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Cites
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Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets
Di, X., Gao, X., Peng, L., Ai, J., Jin, X., Qi, S., Li, H., Wang, K., & Luo, D. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01501-9 · Cited by 622
Noncoding RNAs, cytokines, and inflammation-related diseases
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MicroRNA-181b regulates NF-κB–mediated vascular inflammation
Sun, X., Icli, B., Wara, A. K., Belkin, N., He, S., Kobzik, L., Hunninghake, G. M., Vera, M. P., Blackwell, T. S., Baron, R. M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61495 · Cited by 444
Micro RNA ‐146 represses endothelial activation by inhibiting pro‐inflammatory pathways
Cheng, H. S., Sivachandran, N., Lau, A., Boudreau, E., Zhao, J. L., Baltimore, D., Delgado‐Olguin, P., Cybulsky, M. I., & Fish, J. E. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202318 · Cited by 417
Metadata
- Authors
- Suárez, Y., Wang, C., Manes, T. D., & Pober, J. S.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-12-14
- Volume
- 184
- Issue
- 1
- Pages
- 21-25
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1535099129
- Cited by
- 320
- References
- 10
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cutting Edge: TNF-Induced MicroRNAs Regulate TNF-Induced Expression of E-Selectin and Intercellular Adhesion Molecule-1 on Human Endothelial Cells: Feedback Control of Inflammation. https://app.cochat.ai/papers/10.4049/jimmunol.0902369
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- Suárez, Y., Wang, C., Manes, T. D., & Pober, J. S. (2010). Cutting Edge: TNF-Induced MicroRNAs Regulate TNF-Induced Expression of E-Selectin and Intercellular Adhesion Molecule-1 on Human Endothelial Cells: Feedback Control of Inflammation. The Journal of Immunology. https://doi.org/10.4049/jimmunol.0902369
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