The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
IL-1RL2 and Its Ligands Contribute to the Cytokine Network in Psoriasis
Abstract
Psoriasis is a common immune-mediated disease in European populations; it is characterized by inflammation and altered epidermal differentiation leading to redness and scaling. T cells are thought to be the main driver, but there is also evidence for an epidermal contribution. In this article, we show that treatment of mouse skin overexpressing the IL-1 family member, IL-1F6, with phorbol ester leads to an inflammatory condition with macroscopic and histological similarities to human psoriasis. Inflammatory cytokines thought to be important in psoriasis, such as TNF-α, IL-17A, and IL-23, are upregulated in the mouse skin. These cytokines are induced by and can induce IL-1F6 and related IL-1 family cytokines. Inhibition of TNF or IL-23 inhibits the increased epidermal thickness, inflammation, and cytokine production. Blockade of IL-1F6 receptor also resolves the inflammatory changes in human psoriatic lesional skin transplanted onto immunodeficient mice. These data suggest a role for IL-1F family members in psoriasis.
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Cites
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Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
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Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
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β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
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Interleukin-23 drives innate and T cell–mediated intestinal inflammation
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The pathogenic role of tissue-resident immune cells in psoriasis
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Cited by
Teng, M. W. L., Bowman, E. P., McElwee, J. J., Smyth, M. J., Casanova, J.-L., Cooper, A. M., & Cua, D. J. (2015) · Nature Medicine · doi:10.1038/nm.3895 · Cited by 873
The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses
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Dinarello, C., Arend, W., Sims, J., Smith, D., Blumberg, H., O'Neill, L., Goldbach-Mansky, R., Pizarro, T., Hoffman, H., Bufler, P., et al. (2010) · Nature Immunology · doi:10.1038/ni1110-973 · Cited by 351
Self-citationInflammasome-independent regulation of IL-1-family cytokines
Netea, M. G., van de Veerdonk, F. L., van der Meer, J. W. M., Dinarello, C. A., & Joosten, L. A. B. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112306 · Cited by 326
Metadata
- Authors
- Blumberg, H., Dinh, H., Dean, C., Trueblood, E. S., Bailey, K., Shows, D., Bhagavathula, N., Aslam, M. N., Varani, J., Towne, J. E., & Sims, J. E.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-10-01
- Volume
- 185
- Issue
- 7
- Pages
- 4354-4362
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2099578672
- Cited by
- 161
- References
- 9
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: IL-1RL2 and Its Ligands Contribute to the Cytokine Network in Psoriasis. https://app.cochat.ai/papers/10.4049/jimmunol.1000313
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- Blumberg, H., Dinh, H., Dean, C., Trueblood, E. S., Bailey, K., Shows, D., Bhagavathula, N., Aslam, M. N., Varani, J., Towne, J. E., & Sims, J. E. (2010). IL-1RL2 and Its Ligands Contribute to the Cytokine Network in Psoriasis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1000313
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
