The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Plasticity and Heterogeneity in the Generation of Memory B Cells and Long-Lived Plasma Cells: The Influence of Germinal Center Interactions and Dynamics
Abstract
In the humoral response, short-lived plasmablasts generate an early burst of Ab that probably plays an initial protective role. Simultaneously, another arm of the response is often triggered that leads to delayed effector function but long-term protection. This arm comprises the germinal center response and its products: long-lived memory B (Bmem) cells and plasma cells (PCs). The factors that control the differentiation of PCs and Bmem cells, as well as the composition and function of the memory compartment—how it self-renews while generating rapid secondary effector function—are poorly understood. Recent work in mice and humans is beginning to illuminate these issues. We review this progress, with emphasis on events in the germinal center, especially B–T interactions, which influence the development of memory and PC compartments and on Bmem cell heterogeneity that may underlie flexibility and self-renewal of long-lived humoral immunity.
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Cites
Immunological memory and protective immunity: understanding their relation
Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775 · cited 1×
“Although we understand the basic features of a humoral response (1), we still do not know the signals that invoke Bmem cell formation or fully understand what regulates the quality and quantity of the memory and PC populations.”
BackgroundA Critical Role for IL-21 in Regulating Immunoglobulin Production
Ozaki, K., Spolski, R., Feng, C. G., Qi, C.-F., Cheng, J., Sher, A., Morse, H. C., Liu, C., Schwartzberg, P. L., & Leonard, W. J. (2002) · Science · doi:10.1126/science.1077002 · Cited by 978
SAP-controlled T–B cell interactions underlie germinal centre formation
Qi, H., Cannons, J. L., Klauschen, F., Schwartzberg, P. L., & Germain, R. N. (2008) · Nature · doi:10.1038/nature07345 · Cited by 637
Arrested differentiation, the self-renewing memory lymphocyte, and vaccination
Fearon, D. T., Manders, P., & Wagner, S. D. (2001) · Science · doi:10.1126/science.1062589 · Cited by 265
Cited by
Follicular Helper CD4 T Cells (T FH )
Crotty, S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101400 · Cited by 2,738
Victora, G. D., & Nussenzweig, M. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075032 · Cited by 1,878
A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells
Weisel, F. J., Zuccarino-Catania, G. V., Chikina, M., & Shlomchik, M. J. (2016) · Immunity · doi:10.1016/j.immuni.2015.12.004 · Cited by 524
Self-citationGerminal Center and Extrafollicular B Cell Responses in Vaccination, Immunity, and Autoimmunity
Elsner, R. A., & Shlomchik, M. J. (2020) · Immunity · doi:10.1016/j.immuni.2020.11.006 · Cited by 526
Self-citationBcl6 and Maf Cooperate To Instruct Human Follicular Helper CD4 T Cell Differentiation
Kroenke, M. A., Eto, D., Locci, M., Cho, M., Davidson, T., Haddad, E. K., & Crotty, S. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103246 · Cited by 355
Metadata
- Authors
- Good-Jacobson, K. L., & Shlomchik, M. J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-09
- Volume
- 185
- Issue
- 6
- Pages
- 3117-3125
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2122772587
- Cited by
- 221
- References
- 4
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- closed
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