The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
IL-10–Producing Regulatory B Cells in the Pathogenesis of Chronic Hepatitis B Virus Infection
Open accessAbstract
A regulatory subset of B cells has been found to modulate immune responses in autoimmunity, infection, and cancer, but it has not been investigated in the setting of human persistent viral infection. IL-10 is elevated in patients with chronic hepatitis B virus infection (CHB), but its cellular sources and impact on antiviral T cells have not been addressed. We investigated the role of IL-10 and regulatory B cells in the pathogenesis of CHB. Serum IL-10 levels were studied longitudinally in patients with CHB undergoing spontaneous disease flares. There was a close temporal correlation between IL-10 levels and fluctuations in viral load or liver inflammation. Blockade of IL-10 in vitro rescued polyfunctional virus-specific CD8 T cell responses. To investigate the potential contribution of regulatory B cells, their frequency was measured directly ex vivo and after exposure to stimuli relevant to hepatitis B virus (HBV) (CpG or HBV Ags). IL-10–producing B cells were enriched in patients, and their frequency correlated temporally with hepatic flares, both after stimulation and directly ex vivo. Phenotypically, these cells were predominantly immature (CD19+CD24hiCD38hi) ex vivo; sorted CD19+CD24hiCD38hi cells suppressed HBV-specific CD8 T cell responses in an IL-10–dependent manner. In summary, these data reveal a novel IL-10–producing subset of B cells able to regulate T cell immunity in CHB.
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Cites
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Self-citationA global scientific strategy to cure hepatitis B
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Self-citationHepatitis B flares in chronic hepatitis B: Pathogenesis, natural course, and management
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Metadata
- Authors
- Das, A., Ellis, G., Pallant, C., Lopes, A. R., Khanna, P., Peppa, D., Chen, A., Blair, P., Dusheiko, G., Gill, U., Kennedy, P. T., Brunetto, M., Lampertico, P., Mauri, C., & Maini, M. K.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-10
- Volume
- 189
- Issue
- 8
- Pages
- 3925-3935
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2140430530
- Cited by
- 339
- References
- 53
- FWCI
- 18.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Das, A., Ellis, G., Pallant, C., Lopes, A. R., Khanna, P., Peppa, D., Chen, A., Blair, P., Dusheiko, G., Gill, U., Kennedy, P. T., Brunetto, M., Lampertico, P., Mauri, C., & Maini, M. K. (2012). IL-10–Producing Regulatory B Cells in the Pathogenesis of Chronic Hepatitis B Virus Infection. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1103139
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
