The DOI matches its Crossref record; 67 of the 68 references it cites were found in a registry or an index.
IL-10 Triggers Changes in Macrophage Phenotype That Promote Muscle Growth and Regeneration
Open accessAbstract
We examined the function of IL-10 in regulating changes in macrophage phenotype during muscle growth and regeneration following injury. Our findings showed that the Th1 cytokine response in inflamed muscle is characterized by high levels of expression of CD68, CCL-2, TNF-α, and IL-6 at 1 d postinjury. During transition to the Th2 cytokine response, expression of those transcripts declined, whereas CD163, IL-10, IL-10R1, and arginase-1 increased. Ablation of IL-10 amplified the Th1 response at 1 d postinjury, causing increases in IL-6 and CCL2, while preventing a subsequent increase in CD163 and arginase-1. Reductions in muscle fiber damage that normally occurred between 1 and 4 d postinjury did not occur in IL-10 mutants. In addition, muscle regeneration and growth were greatly slowed by loss of IL-10. Furthermore, myogenin expression increased in IL-10 mutant muscle at 1 d postinjury, suggesting that the mutation amplified the transition from the proliferative to the early differentiation stages of myogenesis. In vitro assays showed that stimulation of muscle cells with IL-10 had no effect on cell proliferation or expression of MyoD or myogenin. However, coculturing muscle cells with macrophages activated with IL-10 to the M2 phenotype increased myoblast proliferation without affecting MyoD or myogenin expression, showing that M2 macrophages promote the early, proliferative stage of myogenesis. Collectively, these data show that IL-10 plays a central role in regulating the switch of muscle macrophages from a M1 to M2 phenotype in injured muscle in vivo, and this transition is necessary for normal growth and regeneration of muscle.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In mouse skeletal muscle injury by chemical toxin or unloading/reloading, IL-4 mRNA, although detectable, does not rise above uninjured levels over the course of healing [73,74].”
From Macrophage phenotypes during tissue repair (2013) · cites this paper as [73]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534 · cited 1×
“4), all of which are cytokines that typify a Th1 cytokine response (27).”
BackgroundFadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166 · cited 2×
“Furthermore, phagocytosis of apoptotic neutrophils by M1 macrophages increased production of the Th2 cytokine TGF-b by the macrophages, while reducing expression of the Th1 cytokines IL-1b and TNF-a, reflecting a shift toward an M2 phenotype (52).”
BackgroundCellular and Molecular Regulation of Muscle Regeneration
CHARGÉ, S. B. P., & Rudnicki, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00019.2003 · Cited by 2,691 · cited 1×
“The transition during myogenesis to a stage at which myogenin expression is elevated is developmentally important, because it represents the transition from a proliferative population of myogenic cells that is unable to undergo terminal differentiation to a population that has permanently withdrawn from the cell cycle…”
BackgroundArnold, L., Henry, A., Poron, F., Baba-Amer, Y., van Rooijen, N., Plonquet, A., Gherardi, R. K., & Chazaud, B. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070075 · Cited by 2,002 · cited 3×
“These findings contrast with a previous report that showed that cocultures of muscle cells with macrophages that had been activated with the corticosteroid dexamethasone together with IL-10 caused no change in myoblast proliferation, but they increased myogenin expression (18).”
BackgroundResultInfluentialRegulatory interactions between muscle and the immune system during muscle regeneration
Tidball, J. G., & Villalta, S. A. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00735.2009 · Cited by 1,105 · cited 1×
“C hanges in muscle use or acute damage produce a rapid and highly structured inflammatory response that is dominated by successive waves of invasion of myeloid cells that can strongly influence both the magnitude of muscle damage and the rate at which repair occurs (1).”
BackgroundSelf-citationHeme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
Lee, T.-S., & Chau, L.-Y. (2002) · Nature Medicine · doi:10.1038/nm0302-240 · Cited by 1,019 · cited 5×
“However, expression of heme oxygenase-1 (HMOX-1), which can be activated by CD163 ligation (37), was not increased at 4 d (Fig.”
BackgroundInfluentialHindlimb unloading rodent model: technical aspects
Morey, E. R., & Globus, R. K. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00969.2001 · Cited by 998
Cornelison, D., & Wold, B. J. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8721 · Cited by 934 · cited 1×
“withdraw from the cell cycle, and the expression of myogenin, also a transcription factor, increases (20, 21).”
BackgroundInterleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy
Serrano, A. L., Baeza-Raja, B., Perdiguero, E., Jardí, M., & Muñoz-Cánoves, P. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.011 · Cited by 873 · cited 1×
“However, the relationships between IL-6 and myoblast proliferation and differentiation are complex; IL-6 is well established as a muscle mitogen (25) that plays a significant role in muscle fiber growth (42), but it can also induce muscle wasting (43).”
BackgroundAtrophy of the soleus muscle by hindlimb unweighting
Thomason, D. B., & Booth, F. W. (1990) · Journal of Applied Physiology · doi:10.1152/jappl.1990.68.1.1 · Cited by 631 · cited 1×
“The soleus muscle is most rapidly affected and can lose 30 to 40% of its mass in 10 d through mechanisms that resemble those that occur in the muscles of patients subjected to prolonged bedrest (34).”
Background
Cited by
Sorted by citations
Items 201–300 of 470
Martin, K. S., Kegelman, C. D., Virgilio, K. M., Passipieri, J. A., Christ, G., Blemker, S., & Peirce, S. (2017) · Annals of Biomedical Engineering · doi:10.1007/s10439-016-1707-2 · Cited by 23
Alvarez, P., Bogen, O., Green, P., & Levine, J. (2017) · Pain · doi:10.1097/j.pain.0000000000000936 · Cited by 30
All for One and One for All: Regenerating Skeletal MusclePreprint
Hindi, S. M., & Millay, D. P. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a040824 · Cited by 29
Choi, K. M., Gibbons, S. J., Sha, L., Beyder, A., Verhulst, P.-J., Cipriani, G., Phillips, J. E., Bauer, A. J., Ördög, T., Camp, J. J., et al. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.04.006 · Cited by 31
Welc, S. S., Wehling‐Henricks, M., Kuro‐o, M., Thomas, K. A., & Tidball, J. G. (2019) · Experimental Physiology · doi:10.1113/ep088142 · Cited by 31
“…following injury or disease through multiple mechanisms, including by removal of cellular debris to facilitate repair (Collins & Grounds, 2001; Deng et al., 2012; Mitchell, McGeachie, & Grounds, 1992) and participating in revascularization of the injured tissue (Shireman et al., 2007),…”
BackgroundBryson, K. J., Garrido, D., Esposito, M., McLachlan, G., Digard, P., Schouler, C., Guabiraba, R., Trapp, S., & Vervelde, L. (2020) · Veterinary Research · doi:10.1186/s13567-019-0733-0 · Cited by 31
Immunomodulatory nanodiamond aggregate-based platform for the treatment of rheumatoid arthritis
Pentecost, A., Kim, M. J., Jeon, S., Ko, Y. J., Kwon, I. C., Gogotsi, Y. G., Kim, K., & Spiller, K. L. (2019) · Regenerative Biomaterials · doi:10.1093/rb/rbz012 · Cited by 31
Zhou, Y., Xie, S., Tang, Y., Li, X., Cao, Y. B., Hu, J., & Lü, H. (2020) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2020.02.013 · Cited by 30
“M2 macrophages can reduce inflammation and promote tissue regeneration [37,38].”
BackgroundYu, S.-H., Huang, C.-Y., Lee, S.-D., Hsu, M.-F., Wang, R.-Y., Kao, C.-L., & Kuo, C.-H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114649 · Cited by 29
“IL-10 is highly expressed in M2 macrophages, which are known to promote muscle regeneration [33, 34].”
BackgroundStem cells and tissue niche: two faces of the same coin of muscle regeneration
Scicchitano, B. M., Sica, G., & Musarò, A. (2016) · European Journal of Translational Myology · doi:10.4081/ejtm.2016.6125 · Cited by 29
Xie, W., Strong, J. A., & Zhang, J. (2020) · Pain · doi:10.1097/j.pain.0000000000001887 · Cited by 29
Jung, S., Ahn, N., Kim, S.-H., Byun, J., Joo, Y., Kim, S.-W., Jung, Y., Park, S., Hwang, I., & Kim, K. (2015) · The Journal of Physiological Sciences · doi:10.1007/s12576-015-0388-1 · Cited by 29
Davies, O. G., Liu, Y., Player, D. J., Martin, N. R. W., Grover, L. M., & Lewis, M. P. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00194 · Cited by 29
“Lastly, IL-6 can stimulate transcription of the anti-inflammatory cytokine IL-10, which has a central role in regulating macrophage phenotype, promoting a switch to M2 macrophages that are required for normal muscle growth and regeneration (Deng et al., 2012).”
BackgroundChe, X., Park, K. C., Park, S. J., Kang, Y. H., Jin, H. A., Kim, J. W., Seo, D. H., Kim, D. K., Kim, T. I., Kim, W. H., et al. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00027.2018 · Cited by 28
“IL-10 itself can also promote the M1-to-M2 transition (10), and IL-10Rdependent signals increase IL-10 production in M2 macrophages (30).”
BackgroundAnoveros‐Barrera, A., Bhullar, A. S., Stretch, C., Dunichand‐Hoedl, A. R., Martins, K. J. B., Rieger, A. M., Bigam, D. L., McMullen, T. P. W., Bathe, O. F., Putman, C. T., et al. (2019) · Skeletal Muscle · doi:10.1186/s13395-019-0209-y · Cited by 28
“For instance, positive correlation of CD8A gene with IL-10 receptor suggests an involvement of CD8 T cells [64, 65] and other antiinflammatory immune cells (M2 macrophages) [66, 67] in the IL-10 pathway of the skeletal muscle which involves a reduction in the expression of pro-inflammatory mediators (IL-6, IL-1α, IL-β…”
BackgroundXin, Y., Gao, J., Hu, R., Li, H., Li, Q., Han, F., He, Z., Lai, L., & Su, M. (2020) · Immunology Letters · doi:10.1016/j.imlet.2020.05.005 · Cited by 28
Shifts in macrophage cytokine production drive muscle fibrosis
Tidball, J. G., & Wehling‐Henricks, M. (2015) · Nature Medicine · doi:10.1038/nm.3896 · Cited by 28
Meng, J., Zou, X., Wu, R., Zhong, R., Zhu, D., & Zhang, Y. (2014) · Protein & Cell · doi:10.1007/s13238-014-0025-4 · Cited by 28
“IL-10 plays an important role in muscle regeneration by regulating the transformation of macrophages from an M1 to an M2 phenotype (Deng et al., 2012).”
BackgroundYaghi, O., Hanna, B. S., Langston, P. K., Michelson, D. A., Jayewickreme, T., Marin-Rodero, M., Benoist, C. O., & Mathis, D. J. (2023) · Nature Immunology · doi:10.1038/s41590-023-01669-w · Cited by 25
“If key elements of this sequence are disrupted, muscle regeneration is compromised 9,13,14,17–20 .”
BackgroundPang, Q.-M., Yang, R., Zhang, M., Zou, W.-H., Qian, N.-N., Xu, Q.-J., Chen, H., Peng, J., Luo, X., Zhang, Q., et al. (2022) · Stem Cells International · doi:10.1155/2022/5181241 · Cited by 30
The Role of Supporting Cell Populations in Satellite Cell Mediated Muscle Repair
Johnson, A. L., Kamal, M. J., & Parise, G. (2023) · Cells · doi:10.3390/cells12151968 · Cited by 30
“The secretion of IL-10 and TGF-β by T regs helps to promote the expansion of satellite cells, whereas IL-4 release promotes myotube fusion [98,100,101].”
BackgroundInfluentialActivated dendritic cells modulate proliferation and differentiation of human myoblasts
Ladislau, L., Portilho, D. M., Courau, T., Solares-Pérez, A., Négroni, E., Lainé, J., Klatzmann, D., Bonomo, A. C., Allenbach, Y., Benvéniste, O., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0426-z · Cited by 26
Skiba, G. H., Andrade, S. F., & Rodacki, A. L. F. (2021) · Neurological Sciences · doi:10.1007/s10072-021-05307-x · Cited by 29
“Then, complex repair and growth processes are activated, which can persist for days [8, 59].”
BackgroundThe Phenotypic and Functional Features of Human M2 Macrophages Generated Under Low Serum Conditions
Sakhno, L. V., Shevela, Е. Y., Tikhonova, M. A., Ostanin, A. A., & Chernykh, E. R. (2015) · Scandinavian Journal of Immunology · doi:10.1111/sji.12401 · Cited by 26
Peda, J. D., Salah, S. M., Wallace, D. P., Fields, P. E., Grantham, C. J., Fields, T. A., & Swenson-Fields, K. I. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.024745 · Cited by 26
“Macrophage-induced proliferation of myoblasts has been shown to require IL-10 stimulation, whereas the proliferation of myoblasts is not altered by IL-10 alone (Deng et al., 2012).”
Martin, K. S., Virgilio, K. M., Peirce, S., & Blemker, S. (2016) · Cells Tissues Organs · doi:10.1159/000443635 · Cited by 18
Myeloid cell diversification during regenerative inflammation: Lessons from skeletal muscle
Patsalos, A., Tzerpos, P., Wei, X., & Nagy, L. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.05.005 · Cited by 28
“We and others have systematically profiled and identified regulatory and effector mechanisms of muscle-infiltrating macrophages using a sterile muscle injury model in mice injured by cardiotoxin [115, 121,29,73].”
BackgroundZheng, Y., Tan, X., & Cao, S. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01175-3 · Cited by 28
“Thus, there is a positive feedback loop between IL-10 and CD163 (Deng et al.”
BackgroundImpact of 12-s Rule on Performance and Muscle Damage of Baseball Pitchers.
Yang, S.-C., Wang, C.-C., Lee, S.-D., Lee, Y.-C., Chan, K.-H., Chen, Y.-L., Fogt, D., & Kuo, C.-H. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001048 · Cited by 18
Osteocyte secreted factors inhibit skeletal muscle differentiation
Wood, C. L., Pajevic, P. D., & Gooi, J. H. (2017) · Bone Reports · doi:10.1016/j.bonr.2017.02.007 · Cited by 24
“Il-10 and M-CSF promote a macrophage phenotype involved in the regeneration of atrophied muscle (Keeling et al., 2013; Deng et al., 2012) and MIG and MIP-1a promote myoblast proliferation (Ge et al.”
BackgroundMarchildon, F., Fu, D., Lala-Tabbert, N., & Wiper‐Bergeron, N. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.4 · Cited by 26
Dysferlinopathy Promotes an Intramuscle Expansion of Macrophages with a Cyto-Destructive Phenotype
Baek, J.-H., Many, G. M., Evesson, F. J., & Kelley, V. R. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.02.011 · Cited by 23
Gallardo, F. S., Córdova-Casanova, A., & Brandan, E. (2021) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-021-00610-w · Cited by 27
“Accordingly, IL-10 induces activation of M2-MPs, while IL-10 mutant mice experience reduced regeneration capacity associated with increased number of necrotic fibers (Deng et al. 2012), confirming the importance of IL-10 in promoting skeletal muscle regeneration by regulating the MP subtype population.”
BackgroundMechanisms of Interleukin-10-Mediated Immunosuppression in Viral Infections
Guo, Z., He, Q., Zhang, Y., Li, Y., & Zhang, Z. (2025) · Pathogens · doi:10.3390/pathogens14100989 · Cited by 30
“The shift from M1 to M2 is essential for reducing inflammation and reestablishing tissue balance [118,119].”
Adipose‐derived stem cells delay muscle atrophy after peripheral nerve injury in the rodent model
Schilling, B. K., Schusterman, M. A., Kim, D. Y., Repko, A. J., Klett, K. C., Christ, G. J., & Marra, K. G. (2019) · Muscle & Nerve · doi:10.1002/mus.26432 · Cited by 23
“has been shown to significantly impair the muscle healing cascade.(40) The Empty Defect appeared to have the most prevalence of iNOS amongst any of the conditions (Figure 5a), potentially suggestive of a degenerative environment.”
BackgroundFerrara, P. J., Yee, E. M., Petrocelli, J. J., Fix, D. K., Hauser, C. T., de Hart, N. M. M. P., Mahmassani, Z. S., Reidy, P. T., O’Connell, R. M., & Drummond, M. J. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00374.2022 · Cited by 23
Ahmed, A., Dolasia, K., & Mukhopadhyay, S. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1602065 · Cited by 23
“Also, rPPE18 was found to be a potent inducer of arginase-1 and IL-10, markers for M2 macrophages.”
BackgroundInfluentialKodani, M., Fukui, H., Tomita, T., Oshima, T., Watari, J., & Miwa, H. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8926 · Cited by 23
Tawfik, V. L., Quarta, M., Paine, P., Forman, T. E., Pajarinen, J., Takemura, Y., Goodman, S. B., Rando, T. A., & Clark, J. D. (2019) · The Journal of Physiology · doi:10.1113/jp278991 · Cited by 23
“It is therefore possible that too early a resolution of the post-traumatic inflammatory state is actually detrimental to muscle regeneration because of alteration in cytokines, such as interleukin-10, which promote muscle growth and regeneration through immunomodulatory mechanisms (Tidball & Villalta, 2010; Deng et al…”
BackgroundMa, L., Nidadavolu, L. S., Yang, H., Langdon, J., Westbrook, R., Tsui, B. M. W., Lee, T.-S., Hinson, J., Ling, S., Marx-Rattner, R., et al. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa156 · Cited by 23
Welc, S. S., Wehling‐Henricks, M., Antoun, J., Ha, T. T., Tous, I., & Tidball, J. G. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000247 · Cited by 23
“thermore, diminishing expression of these regulators of M2-biased macrophage phenotype in injured or diseased muscle causes impaired muscle repair and retarded muscle growth (8, 21, 23), which emphasizes the functional importance of intramuscular macrophages biased to an M2-biased phenotype.”
BackgroundResultInfluentialWestman, A. M., Peirce, S. M., Christ, G. J., & Blemker, S. S. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008937 · Cited by 23
Chevalier, F. P., Arnaud, D., Hénault, E., Guillevic, O., Siñeriz, F., Ponsen, A.-C., Papy-García, D., Barritault, D., Letourneur, D., Uzan, G., et al. (2015) · European Cells and Materials · doi:10.22203/ecm.v030a05 · Cited by 22
Fujita, N., Ono, M., Tomioka, T., & Deie, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115685 · Cited by 23
Myeloid Cell Responses to Contraction-induced Injury Differ in Muscles of Young and Old Mice
Sloboda, D. D., Brown, L. A., & Brooks, S. V. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly086 · Cited by 22
Towards advanced wound regeneration
Man, E., & Hoskins, C. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105360 · Cited by 27
Cañellas, L. R., Martínez, S. G., Aguiló, A., & Tauler, P. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00375-4 · Cited by 28
Supplementary Materials and Methods
Groenendijk, F. H., Zwart, W. T., Floore, A. N., Akbari, S., & Bernards, R. (2013) · Cited by 22
Bartolacci, J. G., Behun, M. N., Warunek, J., Li, T., Sahu, A., Dwyer, G. K., Lucas, A., Rong, J., Ambrosio, F., Turnquist, H. R., et al. (2024) · npj Regenerative Medicine · doi:10.1038/s41536-024-00346-2 · Cited by 22
“The temporal switch from M1-like to M2-like macrophages is required for functional muscle repair 7,11 , and a failure to transition has been associated with delayed healing 9 .”
Crossland, B. W., Rigby, B. R., Duplanty, A. A., King, G. A., Juma, S., Levine, N. A., Clark, C., Ramirez, K. P., & Varone, N. L. (2022) · Healthcare · doi:10.3390/healthcare10061133 · Cited by 22
“The primary function of IL-10 is to regulate and ultimately stop the inflammatory response across several cell types, and it may also enhance myogenesis [69,70].”
BackgroundTofu-Incorporated Hydrogels for Potential Bone Regeneration
Huang, K., Gu, Z., & Wu, J. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01997 · Cited by 22
Potential Importance of Immune System Response to Exercise on Aging Muscle and Bone
Cornish, S. M., Chilibeck, P. D., & Candow, D. G. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00596-1 · Cited by 22
Immune System of Dental Pulp in Inflamed and Normal Tissue
Sarfi, S., Azaryan, E., & Naseri, M. (2024) · DNA and Cell Biology · doi:10.1089/dna.2024.0044 · Cited by 21
“…transition from M1-to M2-dominant, suggesting that the M1-to-M2 transition of MQs plays an important role in creating a favorable microenvironment necessary for dental pulp tissue regeneration (Deng et al., 2012; Gu et al., 2019; Rostoker et al., 2013; Yuan et al., 2015; Zaky et al., 2021) (Fig.”
Hong, M., Han, I., Choi, I., Cha, N., Kim, W., Kim, S. K., & Bae, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063188 · Cited by 21
“IL-10 has been shown to regulate the switch between M1 and M2 macrophages [12].”
BackgroundCorr, L. D., Field, A., Pufal, D., Clifford, T., Harper, L. D., & Naughton, R. J. (2021) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-021-00319-8 · Cited by 19
“It should be noted that the inflammatory process is necessary for skeletal muscle adaptation, and by blunting the initial pro-inflammatory phase, it is possible that the muscle regenerative phase can be impaired [73].”
BackgroundMinari, A. L. A., & dos Santos, R. V. T. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00038.2021 · Cited by 21
Macrophage Regulation of Muscle Regrowth From Disuse in Aging
Reidy, P. T., Dupont‐Versteegden, E. E., & Drummond, M. J. (2019) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000201 · Cited by 20
“Indeed, depletion of circulating monocytes (13), all macrophages (11), or cytokines regulating macrophage function (12,15) impair muscle recovery after disuse in young adult mice.”
BackgroundDablainville, V., Mornas, A., Normand‐Gravier, T., Al‐Mulla, M., Papakostas, E., Olory, B. C. R., Fermín, T. M., Zampeli, F., Nader, N., Alhammoud, M., et al. (2025) · The Journal of Physiology · doi:10.1113/jp287777 · Cited by 23
“Anti-inflammatory processes are largely affected by IL-10 expression, which is particularly upregulated during the late inflammatory phase (Deng et al., 2012; Tidball, 2017).”
Exercise Restores Hypothalamic Health in Obesity by Reshaping the Inflammatory Network
Guardia, L. D., & Codella, R. (2023) · Antioxidants · doi:10.3390/antiox12020297 · Cited by 25
“This cooperative activity is further supported by the evidence that exercise-induced muscle IL-6 exerts a systemic anti-inflammatory response through bosting systemic IL-10 increase [18,83,84].”
BackgroundRevolutionizing bone defect healing: the power of mesenchymal stem cells as seeds
Zhang, Y., Fan, M., & Zhang, Y. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1421674 · Cited by 23
Liu, X., Zeng, Z., Zhao, L., Xiao, W., & Chen, P. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5625 · Cited by 20
Diniz, T. A., Aquino‐Junior, J. C. J., Mosele, F. C., Cabral‐Santos, C., de Lima, E. A., Teixeira, A. A. D. S., Lira, F. S., & Neto, J. C. R. (2019) · Cytokine · doi:10.1016/j.cyto.2019.03.009 · Cited by 20
Minari, A. L. A., Oyama, L., & Santos, R. V. D. D. (2015) · Inflammation · doi:10.1007/s10753-014-0024-x · Cited by 19
Jin, T., Yu, H. W., Wang, D., Zhang, H., Zhang, B., Quezada, H. C., Zhu, J., & Zhu, W. (2016) · Immunology Letters · doi:10.1016/j.imlet.2016.01.004 · Cited by 19
“However, BBIC can enhance IL-10 production both in the nfiltrating cells of PNS and macrophages in the present study, hile IL-10 itself can promote M1 to M2 transition [8].”
BackgroundNihei, J. S., Cardillo, F., dos‐Santos, W. L. C., Pontes–de-Carvalho, L., & Mengel, J. (2014) · European Journal of Microbiology and Immunology · doi:10.1556/eujmi.4.2014.2.6 · Cited by 18
“A protective role of this kind from TNF-α-induced apoptosis has already been suggested for IL-10 in heart and striated muscle cells [32–35].”
BackgroundGrabowska, I., Zimowska, M., Maciejewska, K., Jablonska, Z., Bazga, A., Ozieblo, M., Stremińska, W., Bem, J., Brzóska, E., & Ciemerych, M. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133313 · Cited by 18
“, by infiltrated monocytes/macrophages [69–71] and IL‐ 10—an anti‐inflammatory cytokine that regulates changes in macrophage phenotype [72] and improves skeletal muscle regeneration [73,74].”
BackgroundKhan, M. A., Ashoor, G. A., Shamma, T., Alanazi, F., Altuhami, A., Kazmi, S., Ahmed, H. A., Assiri, A. M., & Broering, D. C. (2021) · Cells · doi:10.3390/cells10051248 · Cited by 17
Differential Macrophage Responses to Gold Nanostars and Their Implication for Cancer Immunotherapy
Kenry, K., Eschle, B. K., Andreiuk, B., Gokhale, P. C., & Mitragotri, S. (2022) · Advanced Therapeutics · doi:10.1002/adtp.202100198 · Cited by 17
Hymel, L. A., Anderson, S. E., Turner, T., York, W. Y., Zhang, H., Liversage, A. R., Lim, H. S., Qiu, P., Mortensen, L. J., Jang, Y. C., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-04790-6 · Cited by 15
“The transition to an anti-in fl ammatory, interleukin (IL)-10 and transforming growth factor (TGF)- β rich environment corresponds with both a transition to M2 macrophages around 4 – 7 days post injury 8,9 as well as the differentiation and growth stages of myogenesis 10 .”
Decades Long Involvement of THP-1 Cells as a Model for Macrophage Research: A Comprehensive Review
Sharma, P., Venkatachalam, K., & Binesh, A. (2024) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/0118715230294413240415054610 · Cited by 16
de Carvalho, S. C., Matsumura, C. Y., Neto, H. S., & Marques, M. J. (2017) · Cytokine · doi:10.1016/j.cyto.2017.12.006 · Cited by 17
“IL10 is associated to reduced muscular dystrophy [39] and to promotion of muscle regeneration [39,40] and this may be consistent with the present observation that plasma IL-10 is decreased in the mdx mice, which correlates to morphological and molecular studies showing that skeletal muscles from mdx mice show poor reg…”
ResultFix, D. K., Mahmassani, Z. S., Petrocelli, J. J., de Hart, N. M. M. P., Ferrara, P. J., Painter, J. S., Nistor, G., Lane, T. E., Keirstead, H. S., & Drummond, M. J. (2021) · GeroScience · doi:10.1007/s11357-021-00423-0 · Cited by 18
Philippou, A., Tryfonos, A., Theos, A., Nezos, A., Halapas, A., Maridaki, M., & Koutsilieris, M. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06412-y · Cited by 15
“, whether the inflammation will be resolved with scar formation or muscle cell replacement [12, 17].”
BackgroundMonitoring regulatory T cells as a prognostic marker in lung transplantation
Khan, M. A., Lau, C. L., & Krupnick, A. S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1235889 · Cited by 16
“In addition to limiting collateral tissue damage caused by uncontrolled immune responses, IL-10 helps maintain the regulatory microenvironment by upregulating TSG-6, M2 macrophages, and, tolerogenic dendritic cells (DC-10), antigenspecific T regulatory type 1 (Tr1), while suppressing Th1/Th17 effector immunity (65, 67…”
BackgroundBiomarkers in Endurance Exercise: Individualized Regulation and Predictive Value
Hacker, S., Keck, J., Reichel, T., Eder, K., Ringseis, R., Krüger, K., & Krüger, B. (2023) · Translational Sports Medicine · doi:10.1155/2023/6614990 · Cited by 16
“Due to its secondary release to an infammatory stimulus, IL-10 might be less directly related to recovery than the other markers [26].”
BackgroundCytokine Mediated Control of Muscle Stem Cell Function
Joanisse, S., & Parise, G. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-27511-6_2 · Cited by 17
Hymel, L. A., Ogle, M. E., Anderson, S. E., Emeterio, C. L. S., Turner, T., York, W. Y., Liu, A. Y., Olingy, C. E., Sridhar, S., Lim, H. S., et al. (2020) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37053 · Cited by 16
Peroxiredoxin2 Deficiency Aggravates Aging-Induced Insulin Resistance and Declines Muscle Strength
Cha, H.-N., Park, S., Dan, Y., Kim, J., & Park, S. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly113 · Cited by 16
The inflammatory response, a mixed blessing for muscle homeostasis and plasticity
Bouredji, Z., Argaw, A., & Frenette, J. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1032450 · Cited by 19
“favoring the switch of macrophages to anti-inflammatory M2 macrophages during muscle repair and regeneration (Deng et al., 2012).”
BackgroundWhole Body Periodic Acceleration Improves Muscle Recovery after Eccentric Exercise
Lopez, J. R., Mijares, A., Kolster, J., Henríquez‐Olguín, C., Zhang, R., Altamirano, F. J., & Adams, J. A. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000932 · Cited by 15
de Carvalho, S. C., Hindi, S. M., Kumar, A., & Marques, M. J. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2640-x · Cited by 15
Komori, T., & Morikawa, Y. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102686 · Cited by 15
Autophagy in Muscle Regeneration: Mechanisms, Targets, and Therapeutic Perspective
Chu, Y., Yuan, X., Tao, Y., Yang, B. T., & Luo, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252211901 · Cited by 19
Turiel, G., Desgeorges, T., Masschelein, E., Fan, Z., Lussi, D., Capelle, C., Bernardini, G., Ardicoglu, R., Schönberger, K., Birrer, M., et al. (2025) · Nature Cardiovascular Research · doi:10.1038/s44161-025-00709-y · Cited by 15
Effects of peritoneal macrophage autophagy on the immune function of sepsis mice.
Zhang, D.-L., Zhang, S., Cheng, Q. H., Wu, F., Wu, J., Zhang, J., Dong, J.-T., Zhu, H., Zhang, S., Wu, Q., et al. (2017) · Europe PMC (PubMed Central) · Cited by 14
Kazmi, S., Khan, M. A., Shamma, T., Altuhami, A., Ahmed, H. A., Assiri, A. M., & Broering, D. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031269 · Cited by 14
Macrophage activation in response to shape memory polymer f oam‐coated aneurysm occlusion devices
Chau, S. M., Herting, S. M., Noltensmeyer, D. A., Ahmed, H., Maitland, D. J., & Raghavan, S. A. (2022) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.35015 · Cited by 14
Zebrafish Models for Skeletal Muscle Senescence: Lessons from Cell Cultures and Rodent Models
Ichii, S., Matsuoka, I., Okazaki, F., & Shimada, Y. (2022) · Molecules · doi:10.3390/molecules27238625 · Cited by 15
“Il-10 induces a switch from the M1 to the M2 phenotype of macrophages that migrate to damaged skeletal muscle; M2 macrophages are required for normal muscle growth and regeneration [93].”
BackgroundWashio, K., Kobayashi, M., Saito, N., Amagasa, M., & Kitamura, H. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/349751 · Cited by 14
Sun, K.-T., Cheung, K., Au, S. W., Yeung, S. S., & Yeung, E. W. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00999 · Cited by 14
Stem cells in skeletal muscle growth and regeneration in amniotes and teleosts: Emerging themes
Ruparelia, A. A., Ratnayake, D., & Currie, P. D. (2019) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.365 · Cited by 15
Skeletal Muscle Is an Early Site of Zika Virus Replication and Injury, Which Impairs Myogenesis
Gavino-Leopoldino, D., Figueiredo, C. M., Barcellos, L. G., da Silva, M. O. L., Araújo, S. M. B., Neris, R. L. S., Miranda, L. D., Ladislau, L., Benjamim, C. F., Poian, A. T. D., et al. (2021) · Journal of Virology · doi:10.1128/jvi.00904-21 · Cited by 14
“The primer sequences were as follows: IL-6 (FW, 59-TTCTTGGGACTGATGCTGGTG-39; REV, 5-CAGAATTGCCATTGCACACTC-39), MCP-1 (FW, 59-GTCCCCAGCTCAAGGAGTAT-39; REV, 59-CCTACTTCTTCTCTGGGTTG-39), RANTES (FW, 59- GTGCCCACGTCAAGGAGTAT-39; REV, 59-CCTACTTCTTCTCTGGGTTG-39), TNF (FW, 59-CCTCACACTC AGATCATCTTCTCA-39; REV, 59-TGGTTGTCTT…”
BackgroundInfluentialOrthogonalized human protease control of secreted signals
Aldrete, C. A., Call, C. C., Sant’Anna, L. E., Vlahos, A. E., Pei, J., Cong, Q., & Gao, X. J. (2025) · Nature Chemical Biology · doi:10.1038/s41589-024-01831-x · Cited by 14
“IL-6 and IL-10 were reported to promote muscle regeneration at 10 ng ml −1 , within the detection range of their respective reporter cells 51,52 .”
Myogenic Satellite Cells: Biological Milieu and Possible Clinical Applications
Said, R. S., Mustafa, A., Asfour, H. A., & Shaqour, E. I. (2016) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2017.1.11 · Cited by 13
Modulation of Macrophage Polarization by Phospholipids on the Surface of Titanium
Quan, H., Kim, Y., Wu, L., Park, H. C., & Yang, H. (2020) · Molecules · doi:10.3390/molecules25112700 · Cited by 13
“IL-10 also changed macrophage phenotype that promoted muscle regeneration [10].”
BackgroundImpaired Skeletal Muscle Development and Regeneration in Transglutaminase 2 Knockout Mice
Budai, Z., Al‐Zaeed, N., Szentesi, P., Halász, H., Csernoch, L. J., Szondy, Z., & Sarang, Z. (2021) · Cells · doi:10.3390/cells10113089 · Cited by 13
“M2-like M φ s secrete anti-inflammatory cytokines and lipids, such as IL-10 and resolvins, to suppress inflammation [5,6].”
BackgroundSugihara, H., MIYAJI, K., Yamanouchi, K., Matsuwaki, T., & Nishihara, M. (2017) · Journal of Veterinary Medical Science · doi:10.1292/jvms.17-0638 · Cited by 12
“As the process of muscle regeneration advances, they switch their phenotype, named M2 macrophages, to repress inflammation and begin to secrete anti-inflammatory cytokines like TGF-β and IL-10 [1, 8].”
BackgroundBenefits and pathologies associated with the inflammatory response
Singh, P., & Chazaud, B. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112905 · Cited by 15
Macrophage immunometabolism: emerging targets for regrowth in aging muscle
Fennel, Z. J., O’Connell, R. M., & Drummond, M. J. (2025) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00403.2024 · Cited by 13
Long, S. R., Shang, W. X., Zhang, H. R., Jiang, M., Wang, J. J., Liu, R. D., Wang, Z. Q., Cui, J. H., & Sun, H. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111320 · Cited by 11
Metadata
- Authors
- Deng, B., Wehling-Henricks, M., Villalta, S. A., Wang, Y., & Tidball, J. G.
- Affiliations
- University of California, Los Angeles (US)
- Department of Integrative Biology and Physiology, University of California , Los Angeles, Los Angeles, CA 90095
- Corresponding author
- Deng, Bo
- Wang, Ying
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-10-01
- Volume
- 189
- Issue
- 7
- Pages
- 3669-3680
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- PMC
- PMC3448810
- OpenAlex
- W2153554828
- Cited by
- 472
- References
- 68
- Citations by year
- 2026: 24 · 2025: 25 · 2024: 26 · 2023: 33 · 2022: 43 · 2021: 40 · 2020: 41 · 2019: 44 · 2018: 32 · 2017: 43 · 2016: 43 · 2015: 28 · 2014: 27 · 2013: 22 · 2012: 1
- FWCI
- 9.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Muscular Dystrophy Association (157881)
- National Institutes of Health (R01 AR/AG054451)
- National Institute on Aging (R01 AR/AG054451)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR047855, R01AR054451, R01AR047721)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Keywords
- IL-10, muscle regeneration, muscle growth, macrophage polarization, M2 macrophages, M1 macrophages, Th1/Th2 shift, muscle damage, myogenesis, myoblast proliferation, arginase-1, CD163, myogenin, MyoD, MCP-1, TNF-α, interleukin-6
- MeSH terms
- Animals, Female, Macrophages, Mice, Inbred C57BL, Regeneration, Up-Regulation, Immunophenotyping, Cytokines, Interleukin-10, Mice, Knockout, Th1 Cells, Th2 Cells, Muscle, Skeletal, Cell Enlargement, Cell Proliferation, Mice, Mice, 129 Strain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
