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Cited by 411

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1β Production

Haneklaus, Moritz, Gerlic, Motti, Kurowska-Stolarska, Mariola, Rainey, Ashleigh-Ann, Pich, Dagmar, McInnes, Iain B, Hammerschmidt, Wolfgang, O’Neill, Luke A J, Masters, Seth L·2012·The Journal of Immunology
DOI 10.4049/jimmunol.1200312
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Abstract

Although microRNA (miRNA) regulation of TLR signaling is well established, this has not yet been observed for NLR proteins or the inflammasomes they form. We have now validated a highly conserved miR-223 target site in the NLRP3 3′-untranslated region. miR-223 expression decreases as monocytes differentiate into macrophages, whereas NLRP3 protein increases during this time. However, overexpression of miR-223 prevents accumulation of NLRP3 protein and inhibits IL-1β production from the inflammasome. Virus inhibition of the inflammasome is an emerging theme, and we have also identified an EBV miRNA that can target the miR-223 binding site in the NLRP3 3′-untranslated region. Furthermore, this virus miRNA can be secreted from infected B cells via exosomes to inhibit the NLRP3 inflammasome in noninfected cells. Therefore, we have identified both the first endogenous miRNA that limits NLRP3 inflammatory capacity during myeloid cell development and also a viral miRNA that takes advantage of this, limiting inflammation for its own purposes.

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Research works printed but not linked: 12

  1. O’Neill, 2011, MicroRNAs: the fine-tuners of Toll-like receptor signalling, Nat. Rev. Immunol., 11, 163, 10.1038/nri2957 · DOI · Paper page
  2. Bauernfeind, 2009, Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression, J. Immunol., 183, 787, 10.4049/jimmunol.0901363 · DOI · Paper page
  3. Mathonnet, 2007, MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F, Science, 317, 1764, 10.1126/science.1146067 · DOI · Paper page
  4. Guarda, 2011, Differential expression of NLRP3 among hematopoietic cells, J. Immunol., 186, 2529, 10.4049/jimmunol.1002720 · DOI · Paper page
  5. Johnnidis, 2008, Regulation of progenitor cell proliferation and granulocyte function by microRNA-223, Nature, 451, 1125, 10.1038/nature06607 · DOI · Paper page
  6. Pegtel, 2010, Functional delivery of viral miRNAs via exosomes, Proc. Natl. Acad. Sci. USA, 107, 6328, 10.1073/pnas.0914843107 · DOI · Paper page
  7. Savina, 2003, Exosome release is regulated by a calcium-dependent mechanism in K562 cells, J. Biol. Chem., 278, 20083, 10.1074/jbc.M301642200 · DOI · Paper page
  8. Ichinohe, 2010, Influenza virus activates inflammasomes via its intracellular M2 ion channel, Nat. Immunol., 11, 404, 10.1038/ni.1861 · DOI · Paper page
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Metadata

Authors
Haneklaus, M., Gerlic, M., Kurowska-Stolarska, M., Rainey, A.-A., Pich, D., McInnes, I. B., Hammerschmidt, W., O’Neill, L. A. J., & Masters, S. L.
Affiliations
  • Inflammation Research Group and Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin , Dublin 4,
  • Inflammation Division, The Walter and Eliza Hall Institute , Melbourne, Victoria 3052,
  • Institute of Infection, Immunity and Inflammation, University of Glasgow , Glasgow G12 8TA,
  • Department of Gene Vectors, Helmholtz Center Munich , Munich 81377,
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2012-10
Volume
189
Issue
8
Pages
3795-3799
ISSN
  • 0022-1767
  • 1550-6606
DOI
10.4049/jimmunol.1200312
Cited by
411
References
4
Language
en
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)

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CoChat. (2026). Citation check: Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1β Production. https://app.cochat.ai/papers/10.4049/jimmunol.1200312
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Haneklaus, M., Gerlic, M., Kurowska-Stolarska, M., Rainey, A.-A., Pich, D., McInnes, I. B., Hammerschmidt, W., O’Neill, L. A. J., & Masters, S. L. (2012). Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1β Production. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1200312

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.