The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.
Antigen-Reactive T Cell Enrichment for Direct, High-Resolution Analysis of the Human Naive and Memory Th Cell Repertoire
Abstract
Ag-specific CD4+ T cells orchestrating adaptive immune responses are crucial for the development of protective immunity, but also mediate immunopathologies. To date, technical limitations often prevented their direct analysis. In this study, we report a sensitive flow cytometric assay based on magnetic pre-enrichment of CD154+ T cells to visualize rare Ag-reactive naive and memory Th cells directly from human peripheral blood. The detection limit of ∼1 cell within 105–106 permitted the direct enumeration and characterization of auto-, tumor-, or neo-Ag–reactive T cells within the naive and even memory CD4+ T cell repertoire of healthy donors. Furthermore, the analysis of high target cell numbers after pre-enrichment of rare Ag-specific T cells from large blood samples dramatically improved the identification of small subpopulations. As exemplified in this work, the dissection of the Ag-specific memory responses into small cytokine-producing subsets revealed great heterogeneity between pathogens, but also pathogen-related microsignatures refining Th cell subset classification. The possibility to directly analyze CD4+ T cells reactive against basically any Ag of interest at high resolution within the naive and memory repertoire will open up new avenues to investigate CD4+ T cell–mediated immune reactions and their use for clinical diagnostics.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“CD154 + cells were magnetically enriched from 25 to 50 million PBMCs to detect T cells at low frequencies (detection limit = 1 in 10 6 ). 4,42”
From Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases (2024) · cites this paper as [42]
Citations
Cites
Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., & Napolitani, G. (2007) · Nature Immunology · doi:10.1038/ni1467 · Cited by 1,828
Dzionek, A., Fuchs, A., Schmidt, P., Cremer, S., Zysk, M., Miltenyi, S., Buck, D., & Schmitz, J. (2000) · Journal of Immunology · doi:10.4049/jimmunol.165.11.6037 · Cited by 1,433
Moon, J. J., Chu, H., Pepper, M., McSorley, S. J., Jameson, S. C., Kedl, R. M., & Jenkins, M. K. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.007 · Cited by 977
Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β
Zielinski, C. E., Mele, F., Aschenbrenner, D., Jarrossay, D., Ronchi, F., Gattorno, M., Monticelli, S., Lanzavecchia, A., & Sallusto, F. (2012) · Nature · doi:10.1038/nature10957 · Cited by 919
Newell, E. W., Sigal, N., Bendall, S. C., Nolan, G. P., & Davis, M. M. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.002 · Cited by 555
Rongvaux, A., Shea, R. J., Mulks, M. H., Gigot, D., Urbain, J., Léo, O., & Andris, F. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200211)32:11 · Cited by 551
Direct access to CD4+ T cells specific for defined antigens according to CD154 expression
Frentsch, M., Arbach, O., Kirchhoff, D., Moewes, B., Worm, M., Rothe, M., Scheffold, A., & Thiel, A. (2005) · Nature Medicine · doi:10.1038/nm1292 · Cited by 475
Self-citationWölfl, M., Kuball, J. H. E., Ho, W., Nguyen, H., Manley, T. J., Bleakley, M., & Greenberg, P. D. (2007) · Blood · doi:10.1182/blood-2006-11-056168 · Cited by 450
Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection
Obar, J. J., Khanna, K. M., & Lefrançois, L. (2008) · Immunity · doi:10.1016/j.immuni.2008.04.010 · Cited by 449
Novak, E. J., Liu, A. W., Nepom, G. T., & Kwok, W. W. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8476 · Cited by 376
Flagged first, then by citations
1 of the 38 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–174 of 174
Biomarkers for antigen immunotherapy in allergy and type 1 diabetes
Odegard, J., Nepom, G. T., & Wambre, E. R. (2015) · Clinical Immunology · doi:10.1016/j.clim.2015.05.023 · Cited by 15
Page, L., Weis, P., Müller, T., Dittrich, M. T., Lazariotou, M., Dragan, M., Waaga-Gasser, A. M., Helm, J., Dandekar, T., Einsele, H., et al. (2018) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2018.09.002 · Cited by 17
Michel, M., Gomez, C., Sérémé, Y., Gouitaa, M., Chartier, C., Blanchard, P., Pinchemel, S., Cassagne, C., Ranque, S., Mège, J., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03149 · Cited by 15
CD154 Expression Indicates T Cell Activation Following Tetanus Toxoid Vaccination of Horses
Schnabel, C. L., Fletemeyer, B., Lübke, S., Marti, E., Wagner, B., & Alber, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.805026 · Cited by 14
Eschenhagen, P. N., Bächer, P., Grehn, C., Mainz, J. G., Scheffold, A., & Schwarz, C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1180826 · Cited by 14
Self-citationDetermining T-cell specificity to understand and treat disease
Hadrup, S. R., & Newell, E. W. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0143-4 · Cited by 15
Moskovljevic, M., Dragoni, F., Nathan L. Board, Wu, F., Lai, J., Zhang, H., White, J. R., Hoh, R., Lynn, K., Tebas, P., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.11.002 · Cited by 17
Human Immune Monitoring Techniques during Food Allergen Immunotherapy
Rust, B. J., & Wambre, E. R. (2017) · Current Allergy and Asthma Reports · doi:10.1007/s11882-017-0689-y · Cited by 13
Frequencies and TCR Repertoires of Human 2,4,6-Trinitrobenzenesulfonic Acid-specific T Cells
Curato, C., Aparicio‐Soto, M., Riedel, F., Wehl, I., Basaran, A., Abbas, A., Thierse, H., Luch, A., & Siewert, K. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.827109 · Cited by 13
Peptide immunotherapy in experimental autoimmune encephalomyelitis
Anderton, S. M. (2015) · Biomedical Journal · doi:10.4103/2319-4170.158510 · Cited by 13
CD4+ Th immunogenicity of the Ascaris spp. secreted products
Ebner, F., Morrison, E., Bertazzon, M., Midha, A., Hartmann, S., Freund, C., & Álvaro‐Benito, M. (2020) · npj Vaccines · doi:10.1038/s41541-020-0171-z · Cited by 12
Kapłonek, P., Yao, L., Reppe, K., Voß, F., Kohler, T. P., Ebner, F., Schäfer, A., Blohm, U., Priegue, P., Bräutigam, M., et al. (2022) · Vaccine · doi:10.1016/j.vaccine.2021.12.068 · Cited by 11
Kar, R., Chattopadhyay, S., Sharma, A., Sharma, K. M. T. K., Sinha, S., Arimbasseri, G. A., & Patil, V. S. (2024) · Immunology · doi:10.1111/imm.13783 · Cited by 11
Vandamme, C., Rytkönen-Nissinen, M. A., Lönnberg, T., Randell, J. T., Harvima, R. J., Kinnunen, T. T., & Virtanen, T. I. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.11.018 · Cited by 11
Wurster, S., Weis, P., Page, L., Helm, J., Lazariotou, M., Einsele, H., & Ullmann, A. J. (2017) · Mycoses · doi:10.1111/myc.12643 · Cited by 11
Environmentally driven immune imprinting protects against allergy
Erickson, S. A., Lauring, B., Cullen, J. L., & Medzhitov, R. M. (2026) · Nature · doi:10.1038/s41586-025-10001-5 · Cited by 12
Weis, P., Helm, J., Page, L., Lauruschkat, C. D., Lazariotou, M., Einsele, H., Loeffler, J., Ullmann, A. J., & Wurster, S. (2019) · Medical Mycology · doi:10.1093/mmy/myz038 · Cited by 10
Kusnadi, A., Ramírez-Suástegui, C., Fajardo, V., Chee, S., Meckiff, B. J., Simon, H. A., Pelosi, E., Seumois, G., Ay, F., Vijayanand, P., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.09.194027 · Cited by 10
Wang, J., Zhan, M., Zhai, Y., Wang, S., Gu, F., Zhao, Z., Zhang, Z., Li, Y., Dong, X., Zhang, Y., et al. (2024) · Clinical & Experimental Immunology · doi:10.1093/cei/uxae022 · Cited by 9
Schmidt, S., Ebner, F., Rosen, K., Kniemeyer, O., Brakhage, A. A., Löffler, J., Seif, M., Springer, J., Schlosser, J., Scharek‐Tedin, L., et al. (2020) · European Journal of Immunology · doi:10.1002/eji.201948524 · Cited by 11
Self-citationHansen, B.-T., Bächer, P., Eiz‐Vesper, B., Heckl, S. M., Klapper, W., Koch, K., Maecker‐Kolhoff, B., Baldus, C. D., & Fransecky, L. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.727814 · Cited by 9
Human memory CD4+ T cell response to the major dog allergen Can f 5, prostatic kallikrein
Kailaanmäki, A., Kinnunen, T. T., Rönkä, A., Rytkönen-Nissinen, M. A., Lidholm, J., Mattsson, L.-Å., Randell, J. T., & Virtanen, T. I. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12694 · Cited by 8
Rodriguez‐Sillke, Y., Visekruna, A., Glauben, R., Siegmund, B., & Steinhoff, U. (2021) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2021.151493 · Cited by 8
Insights into the Role of Commensal-Specific T Cells in Intestinal Inflammation
Gehlhaar, A., Inala, A., Llivichuzhca-Loja, D., Silva, T. N., Adegboye, C., O’Connell, A. E., & Konnikova, L. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s288288 · Cited by 8
Wang, X., Jiang, K., Xing, W., Xin, Q., Hu, Q., Wu, S., Sun, Z., Hou, H., Yi, R., & Wang, F. (2025) · Journal of Infection · doi:10.1016/j.jinf.2025.106449 · Cited by 7
Mura, M., Chaudhury, S., Farooq, F., Duncan, E. H., Beck, K., & Bergmann‐Leitner, E. S. (2020) · MethodsX · doi:10.1016/j.mex.2020.101005 · Cited by 7
Mechanistic and Biomarker Studies to Demonstrate Immune Tolerance in Multiple Sclerosis
Docampo, M. J., Lutterotti, A., Sospedra, M., & Martinꝉ, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.787498 · Cited by 7
Phenotyping of Adaptive Immune Responses in Inflammatory Diseases
Humrich, J. Y., Bernardes, J. P., Ludwig, R. J., Klatzmann, D., & Scheffold, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604464 · Cited by 7
Self-citationIbáñez, J., Fendel, R., Lorenz, F.-R., Bayon, P. G., Brückner, S., Esen, M., Sulyok, M., Sulyok, Z., Borrmann, S., Bächer, P., et al. (2022) · npj Vaccines · doi:10.1038/s41541-022-00473-1 · Cited by 8
Self-citationMorgan, N. N., & Mannon, P. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000918 · Cited by 6
Rodriguez‐Sillke, Y., Schümann, M., Lissner, D., Branchi, F., Proft, F. N., Steinhoff, U., Siegmund, B., & Glauben, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098153 · Cited by 6
Clinical Relevance of Fungi in Cystic Fibrosis
Schwarz, C. (2023) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0042-1759882 · Cited by 5
Yang, J., Jing, L., James, E. A., Gebe, J. A., Koelle, D. M., & Kwok, W. W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02811 · Cited by 5
How can the latest technologies advance cell therapy manufacturing?
Scheffold, A. (2014) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000133 · Cited by 5
Self-citationMartini, G. R., Hofmann, P., Kamps, A.-K., Weichberger, A., Tikhonova, E., Conroy, A., Pan, X., Namuch, D. M., Rathjens, L., Bergfeld, A., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.06.013 · Cited by 5
Self-citationMahdy, A. K. H., ElAbd, H., Prinzensteiner, M., Jebens, H., Sivickis, K., Bächer, P., Vogl, T. J., Poyet, M., & Franke, A. (2026) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjag015 · Cited by 4
Ishina, I. A., Kurbatskaia, I. N., Mamedov, A. E., Shramova, E. I., Deyev, S. M., Nurbaeva, K. S., Rubtsov, Y. P., Belogurov, A. A., Gabibov, A. G., & Zakharova, M. Y. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1341685 · Cited by 5
Chemical-Specific T Cell Tests Aim to Bridge a Gap in Skin Sensitization Evaluation
Fritsch, N., Aparicio‐Soto, M., Curato, C., Riedel, F., Thierse, H., Luch, A., & Siewert, K. (2024) · Toxics · doi:10.3390/toxics12110802 · Cited by 4
Elst, J., Mertens, C. H., Houdt, M. V., van der Poorten, M. M., Gasse, A. L. V., Toscano, A., Beyens, M. M. J., Yerly, D., Hagendorens, M. M., Sabato, V., et al. (2025) · Allergy · doi:10.1111/all.16548 · Cited by 4
Baker, S. M., Settles, E. W., Celona, K. R., Shannon, A. B., Davitt, C., Hall, K., Jain, A., de Assis, R. R., Gregory, A. E., Felgner, P. L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67213-6 · Cited by 3
Narrowing Down Key Players in Autoimmunity via Single‐Cell Multiomics
Gjurgjaj, A., & Conde, C. D. (2025) · European Journal of Immunology · doi:10.1002/eji.202451233 · Cited by 5
Tools and Methods for Identification and Analysis of Rare Antigen-Specific T Lymphocytes
Martin, S. F., Schmucker, S. S., & Richter, A. (2013) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-0348-0726-5_6 · Cited by 3
Dietary and commensal yeasts drive aberrant T cell responses in Crohn’s disease
(2023) · Nature Medicine · doi:10.1038/s41591-023-02559-2 · Cited by 2
An autoreactive T cell’s perception of a land of plenty
Korn, T. (2024) · Immunity · doi:10.1016/j.immuni.2024.09.005 · Cited by 2
Role of human antigen-specific T cells in tolerance and IgE-mediated allergic reactions to food
López‐Fandiño, R. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1595696 · Cited by 2
Tattoos – mehr als nur kolorierte Haut? Auf der Suche nach Tattoo‐Allergenen
Weiß, K. T., Schreiver, I., Siewert, K., Luch, A., Haslböck, B., Berneburg, M., & Bäumler, W. (2021) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.14436_g · Cited by 2
Mapping of class II HLA restriction of SepSecS-specific CD4 T-cell epitopes in autoimmune hepatitis
Guinebretière, T., Garcia, A., Dong, C., Bernier, L., Huchet, V., Gavlovsky, P.-J., Gil, L., Ado, S., David, L., Chevalier, C., et al. (2026) · JHEP Reports · doi:10.1016/j.jhepr.2026.101952 · Cited by 1
IMMUNOPATHOGENESIS OF MYASTHENIA GRAVIS (REVIEW)
Gasymly, E. D. (2018) · The Russian Archives of Internal Medicine · doi:10.20514/2226-6704-2018-8-3-176-185 · Cited by 2
(2017) · Pediatric Pulmonology · doi:10.1002/ppul.23839 · Cited by 1
CD4+ T Cell Epitope Identification from Complex Parasite Antigen Mixtures
Álvaro‐Benito, M., Ebner, F., Bertazzon, M., & Morrison, E. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3239-0_6 · Cited by 1
Respiratory Fungal Infections in Cystic Fibrosis: Diagnostic and Therapeutic Challenges
Schwarz, C., Mainz, J. G., Romanowska, E., Rosseau, S., Schuette, H., Martin–Souto, L., Ramirez‐Garcia, A., & Eschenhagen, P. N. (2023) · Current Fungal Infection Reports · doi:10.1007/s12281-023-00467-z · Cited by 1
Maksymowych, W. P., van der Heijde, D. M. F. M., Dougados, M., Sieper, J., Braun, J., Citera, G., Miceli‐Richard, C., Wei, J. C., Pedersen, R., Bonin, R., et al. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2014-eular.1138 · Cited by 1
Elias, G., Meysman, P., Bartholomeus, E., Neuter, N. D., Keersmaekers, N., Suls, A., Jansens, H., Souquette, A. H., Reu, H. D., Emonds, M., et al. (2021) · eLife · doi:10.7554/elife.68388.sa2 · Cited by 1
Cognate Antigen Engagement Induces HIV-1 Expression In CD4 + T Cells From People On Long-Term ARTPreprint
Moskovljevic, M., Dragoni, F., Nathan L. Board, Wu, F., Lai, J., Zhang, H., White, J. R., Hoh, R., Lynn, K., Tebas, P., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.27.582096 · Cited by 1
Lücken im regulatorischen T‑Zell-Schutzschild erzeugen Immunpathologien
Bächer, P. (2018) · Zeitschrift für Rheumatologie · doi:10.1007/s00393-018-0554-y
Functional Assessment of T Cells
Moschopoulos, C. D., Berger, T., & Skevaki, C. L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818731-9.00151-8
Application of CRISPR-Based Technology in Medical Research and Disease Treatment
Zhang, Z., Wang, P., & Liu, J. (2022) · Springer eBooks · doi:10.1007/978-981-16-8504-0_4
Association of Interleukin 17 in Antifungal Insusceptibility: The Systematic Review and Metaanalysis
Dabukke, Y. J. S. (2022) · Pakistan Journal of Medical and Health Sciences · doi:10.53350/pjmhs221611210
Prlic, M. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736023649.793563391
Daëron, M. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738132258.793576895
Yu, J., & Park, H.-S. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734151230.793552591
Patil, V. S., Kar, R., Chattopadhyay, S., Sharma, A., Sharma, K. M. T. K., Sinha, S., & Arimbasseri, G. A. (2023) · doi:10.22541/au.169735638.81514076/v1
Veränderte T-Zell-Reaktion gegen Hefepilze bei chronischer Darmentzündung
Martini, G. R., & Bächer, P. (2024) · BIOspektrum · doi:10.1007/s12268-024-2148-3
Kraft, M., Saleh, S., Heine, G., Scheffold, A., Bächer, P., & Worm, M. (2024) · Clinical & Experimental Allergy · doi:10.1111/cea.14606
Self-citationHoffmann, J., Machule, M.-L., Kreye, J., Stöffler, L., Körtvelyessy, P., Buthut, M., Rößling, R., Bächer, P., Scheffold, A., & Prüß, H. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00516-w
Self-citationManfroi, B., & Fillatreau, S. (2025) · médecine/sciences · doi:10.1051/medsci/2025102
Lindelauf, C. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.22012093
Ebo, D. G., Mertens, C., Houdt, M. V., Toscano, A., Beyens, M., Hagendorens, M. M., Yerly, D., Sabato, V., Hausmann, O., & Elst, J. (2025) · Revue française d'allergologie · doi:10.1016/j.reval.2025.104634
Haag, L.-M., Müller, M., Ziegler, J., Lehmann, M., Hecker, J., Glauben, R., Heimesaat, M. M., Compton, F., & Siegmund, B. (2025) · Gut Pathogens · doi:10.1186/s13099-025-00770-9
Kocher, K., Drost, F., Schülein, C., Spriewald, B. M., Schubert, B., & Schober, K. (2026) · iScience · doi:10.1016/j.isci.2026.116175 · Cited by 2
Aquaporin-4–Specific T Cell Responses in NMOSD Revealed by mRNA-Engineered Dendritic CellsPreprint
Pauly, V., Hastermann, M., Paul, F., Garner, C. C., Cestari, S., Schmitz, D., Klotzsch, E., & Strempel, N. U. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.05.730365
Lindelauf, C., Jiang, Q., Koning, F., Jong, A. E. V. D. M., van Unen, V., & Pascutti, M. F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.29.685441
Lazzaro, S., Leroux-Roels, G. G., Janetzki, S., Salaun, B., Cook, L. E., Franke, K., Poschke, I. C., Bunse, L., Welters, M. J. P., Fehlings, M., et al. (2026) · Nature Protocols · doi:10.1038/s41596-026-01453-8 · Cited by 1
Metadata
- Authors
- Bacher, P., Schink, C., Teutschbein, J., Kniemeyer, O., Assenmacher, M., Brakhage, A. A., & Scheffold, A.
- Affiliations
- Miltenyi Biotec , 51429 Bergisch Gladbach,
- Miltenyi Biotec (Germany) (DE)
- Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) (DE)
- Jena University Hospital (DE)
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Schink, Christian
- Assenmacher, Mario
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-04
- Volume
- 190
- Issue
- 8
- Pages
- 3967-3976
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2100544695
- Cited by
- 173
- References
- 38
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 14 · 2023: 11 · 2022: 19 · 2021: 20 · 2020: 23 · 2019: 14 · 2018: 16 · 2017: 11 · 2016: 5 · 2015: 12 · 2014: 7 · 2013: 3
- FWCI
- 4.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- antigen-specific T cells, CD4+ T cells, naive T cells, memory T cells, CD154, flow cytometry assay, T cell receptor repertoire, neoantigens, peripheral blood
- MeSH terms
- Antigen-Antibody Reactions, Antigen-Presenting Cells, Aspergillus fumigatus, Cell Differentiation, Cell Line, Clone Cells, T-Lymphocytes, Helper-Inducer, Humans, Immunologic Memory, T-Lymphocyte Subsets, Antigen Presentation, CD4 Lymphocyte Count, Epitopes, T-Lymphocyte
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review