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BDCA-2, BDCA-3, and BDCA-4: Three Markers for Distinct Subsets of Dendritic Cells in Human Peripheral Blood

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Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

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Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes

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Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis

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Direct access to CD4+ T cells specific for defined antigens according to CD154 expression

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Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities

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Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection

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MHC class II tetramers identify peptide-specific human CD4+ T cells proliferating in response to influenza A antigen

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Identification of preexisting adaptive immunity to Cas9 proteins in humans

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Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

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Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19

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Guidelines for the use of flow cytometry and cell sorting in immunological studies *

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Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

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Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans

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Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation

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Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans

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Low-Avidity CD4+ T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19

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Functional heterogeneity of human memory CD4 + T cell clones primed by pathogens or vaccines

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Gut Mycobiota in Immunity and Inflammatory Disease

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Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8 + T cells

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Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma

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Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B 100 –Reactive CD4 + T-Regulatory Cells

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Flow-cytometric analysis of rare antigen-specific T cells

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Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease

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Antigen-specific expansion of human regulatory T cells as a major tolerance mechanism against mucosal fungi

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Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic TH1 cell responses in Crohn’s disease

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Human Microbiota Flagellins Drive Adaptive Immune Responses in Crohn’s Disease

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SCT for severe autoimmune diseases: consensus guidelines of the European Society for Blood and Marrow Transplantation for immune monitoring and biobanking

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T cells specific for post-translational modifications escape intrathymic tolerance induction

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Interleukin-17 in Antifungal Immunity

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Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes

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Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis

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Expanding Role of T Cells in Human Autoimmune Diseases of the Central Nervous System

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Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases

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Efficient Culture of Human Naive and Memory B Cells for Use as APCs

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A Mechanistic, Multiscale Mathematical Model of Immunogenicity for Therapeutic Proteins: Part 1—Theoretical Model

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Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs

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Proteome Analysis Reveals the Conidial Surface Protein CcpA Essential for Virulence of the Pathogenic Fungus Aspergillus fumigatus

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Pulmonary immune responses against Aspergillus fumigatus are characterized by high frequencies of IL-17 producing T-cells

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Identification of Immunogenic Antigens from Aspergillus fumigatus by Direct Multiparameter Characterization of Specific Conventional and Regulatory CD4+ T Cells

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Resolving SARS-CoV-2 CD4+ T cell specificity via reverse epitope discovery

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The effect of regulatory T cells on tolerance to airborne allergens and allergen immunotherapy

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Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

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Activation and Induction of Antigen-Specific T Follicular Helper Cells Play a Critical Role in Live-Attenuated Influenza Vaccine-Induced Human Mucosal Anti-influenza Antibody Response

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The renaissance of oral tolerance: merging tradition and new insights

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Chronic cat allergen exposure induces a TH2 cell–dependent IgG4 response related to low sensitization

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A Novel HLA–DRB1*10:01–Restricted T Cell Epitope From Citrullinated Type II Collagen Relevant to Rheumatoid Arthritis

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Fungus-Specific CD4+ T Cells for Rapid Identification of Invasive Pulmonary Mold Infection

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FB5P-seq: FACS-Based 5-Prime End Single-Cell RNA-seq for Integrative Analysis of Transcriptome and Antigen Receptor Repertoire in B and T Cells

Attaf, N., Cervera-Marzal, I., Dong, C., Gil, L., Renand, A., Spinelli, L., & Milpied, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00216 · Cited by 45

The pre-exposure SARS-CoV-2-specific T cell repertoire determines the quality of the immune response to vaccination

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Nuclear antigen–reactive CD4+ T cells expand in active systemic lupus erythematosus, produce effector cytokines, and invade the kidneys

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Antigen-specificity measurements are the key to understanding T cell responses

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Adoptive transfer of Aspergillus-specific T cells as a novel anti-fungal therapy for hematopoietic stem cell transplant recipients: Progress and challenges

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Single-Cell Transcriptomic Analysis of SARS-CoV-2 Reactive CD4 + T CellsPreprint

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Role of the adaptive immune system in atherosclerosis

Ley, K. F. (2020) · Biochemical Society Transactions · doi:10.1042/bst20200602 · Cited by 46

Antigen-specific immunotherapies for autoimmune disease

Buckner, J. H. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01201-w · Cited by 41

Antigen-Specificity in the Thymic Development and Peripheral Activity of CD4+FOXP3+ T Regulatory Cells

Pohar, J., Simon, Q., & Fillatreau, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01701 · Cited by 39

Tattoos – more than just colored skin? Searching for tattoo allergens

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Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through ‘reverse phenotyping’

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New technologies for monitoring human antigen-specific T cells and regulatory T cells by flow-cytometry

Bächer, P., & Scheffold, A. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.04.005 · Cited by 38

Invasive Pulmonary Fungal Infections in Cystic Fibrosis

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Resolvin E1 Regulates Th17 Function and T Cell Activation

Öner, F., Álvarez, C., Yaghmoor, W., Stephens, D. N., Hastürk, H., Fıratlı, E., & Kantarcı, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.637983 · Cited by 40

T cell responses to control fungal infection in an immunological memory lens

Sharma, J., Mudalagiriyappa, S., & Nanjappa, S. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.905867 · Cited by 39

A Review on T Cell Epitopes Identified Using Prediction and Cell-Mediated Immune Models for Mycobacterium tuberculosis and Bordetella pertussis

Tian, Y., Antunes, R. D. S., Sidney, J., Arlehamn, C. S. L., Grifoni, A., Dhanda, S. K., Paul, S., Peters, B., Weiskopf, D., & Sette, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02778 · Cited by 36

Distinct trajectories distinguish antigen-specific T cells in peanut-allergic individuals undergoing oral immunotherapy

Calise, J., DeBerg, H. A., Garabatos, N., Khosa, S., Bajzik, V., Calderon, L. B., Aldridge, K., Rosasco, M. G., Ferslew, B. C., Zhu, T., et al. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.03.020 · Cited by 34

Clinical-scale isolation of the total Aspergillus fumigatus–reactive T–helper cell repertoire for adoptive transfer

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T cell immunity to commensal fungi

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Jug r 2–reactive CD4+ T cells have a dominant immune role in walnut allergy

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Autoreactive T cell receptors with shared germline-like α chains in type 1 diabetes

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Pathogen-Reactive T Helper Cell Analysis in the Pig

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TCRs with segment TRAV9‐2 or a CDR3 histidine are overrepresented among nickel‐specific CD4+ T cells

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Specificity of Adaptive Immune Responses in Central Nervous System Health, Aging and Diseases

Rickenbach, C., & Gericke, C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.806260 · Cited by 33

Bystander responses impact accurate detection of murine and human antigen-specific CD8+ T cells

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Distinct editing functions of natural HLA-DM allotypes impact antigen presentation and CD4+ T cell activation

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The long term vaccine‐induced anti‐SARS‐CoV‐2 immune response is impaired in quantity and quality under TNFα blockade

Geisen, U. M., Rose, R., Neumann, F., Ciripoi, M., Vullriede, L., Reid, H. M., Berner, D. K., Bertoglio, F., Hoff, P., Hust, M., et al. (2022) · Journal of Medical Virology · doi:10.1002/jmv.28063 · Cited by 27

Antigen specificity and cross-reactivity drive functionally diverse anti–Aspergillus fumigatus T cell responses in cystic fibrosis

Schwarz, C., Eschenhagen, P. N., Schmidt, H., Hohnstein, T., Iwert, C., Grehn, C., Roehmel, J. F., Steinke, E., Stahl, M., Lozza, L., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci161593 · Cited by 29

Cell population identification using fluorescence-minus-one controls with a one-class classifying algorithm

Feher, K., Kirsch, J., Radbruch, A., Chang, H., & Kaiser, T. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu575 · Cited by 28

Development and Validation of a Bordetella pertussis Whole‐Genome Screening Strategy

Antunes, R. D. S., Quiambao, L. G., Sutherland, A., Soldevila, F., Dhanda, S. K., Armstrong, S. K., Brickman, T. J., Merkel, T. J., Peters, B., & Sette, A. (2020) · Journal of Immunology Research · doi:10.1155/2020/8202067 · Cited by 28

Immunoproteomics of Aspergillus for the development of biomarkers and immunotherapies

Kniemeyer, O., Ebel, F., Krüger, T., Bächer, P., Scheffold, A., Luo, T., Straßburger, M., & Brakhage, A. A. (2016) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201600053 · Cited by 26

Developmental induction of human T-cell responses against Candida albicans and Aspergillus fumigatus

Vogel, K., Pierau, M., Arra, A., Lampe, K., Schlueter, D., Arens, C., & Brunner-Weinzierl, M. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-35161-5 · Cited by 27

Emerging Fungal Threats in Cystic Fibrosis

Schwarz, C., Eschenhagen, P. N., & Bouchara, J. (2021) · Mycopathologia · doi:10.1007/s11046-021-00574-w · Cited by 27

Decreased inflammatory cytokine production of antigen-specific CD4+ T cells in NMDA receptor encephalitis

Dao, L., Machule, M.-L., Bächer, P., Hoffmann, J., Ly, L.-T., Wegner, F., Scheffold, A., & Prüß, H. (2021) · Journal of Neurology · doi:10.1007/s00415-020-10371-y · Cited by 24

Vaccine-Induced Cellular Immunity against Bordetella pertussis: Harnessing Lessons from Animal and Human Studies to Improve Design and Testing of Novel Pertussis Vaccines

Saso, A., Kampmann, B., & Roetynck, S. (2021) · Vaccines · doi:10.3390/vaccines9080877 · Cited by 24

Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon hepatitis B vaccination

Elias, G., Meysman, P., Bartholomeus, E., Neuter, N. D., Keersmaekers, N., Suls, A., Jansens, H., Souquette, A. H., Reu, H. D., Emonds, M., et al. (2022) · eLife · doi:10.7554/elife.68388 · Cited by 26

Strategies for clinical trials in type 1 diabetes

Ehlers, M. R. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2016.03.008 · Cited by 25

Antigen-specific regulatory T-cell responses against aeroantigens and their role in allergy

Bächer, P., & Scheffold, A. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0038-z · Cited by 24

T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis

Ramien, C., Yusko, E. C., Engler, J. B., Gamradt, S., Patas, K., Schweingruber, N., Willing, A., Rosenkranz, S. C., Diemert, A., Harrison, A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.025 · Cited by 24

Competitive fungal commensalism mitigates candidiasis pathology

Kralova, J. S., Donic, C., Dassa, B., Livyatan, I., Jansen, P. M., Ben‐Dor, S., Fidel, L., Trzebanski, S., Narunsky-Haziza, L., Asraf, O., et al. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20231686 · Cited by 23

Mould‐reactive T cells for the diagnosis of invasive mould infection—A prospective study

Steinbach, A., Cornely, O. A., Wisplinghoff, H., Schauss, A. C., Vehreschild, J. J., Rybniker, J., Hamprecht, A. G., Richter, A., Bächer, P., Scheffold, A., et al. (2019) · Mycoses · doi:10.1111/myc.12919 · Cited by 22

Bioanalysis of Adeno-Associated Virus Gene Therapy Therapeutics: Regulatory Expectations

Gorovits, B., Marshall, J.-C. A., Smith, J., Whiteley, L. O., & Neubert, H. (2019) · Bioanalysis · doi:10.4155/bio-2019-0135 · Cited by 21

Antigen-specific T cells and autoimmunity

Rojas, M., Acosta‐Ampudia, Y., Heuer, L. S., Zang, W., Monsalve, D. M., Ramı́rez-Santana, C., Anaya, J., Ridgway, W. M., Ansari, A. A., & Gershwin, M. E. (2024) · Journal of Autoimmunity · doi:10.1016/j.jaut.2024.103303 · Cited by 25

T helper 2 response in allergic bronchopulmonary aspergillosis is not driven by specific Aspergillus antigens

Jolink, H., de Boer, R., Willems, L., van Dissel, J. T., Falkenburg, J. H. F., & Heemskerk, M. H. M. (2015) · Allergy · doi:10.1111/all.12688 · Cited by 21

Analysis of the functional WT 1‐specific T‐cell repertoire in healthy donors reveals a discrepancy between CD 4+ and CD 8+ memory formation

Schmied, S., Emma Gostick, D., Price, D. A., Abken, H., Assenmacher, M., & Richter, A. (2015) · Immunology · doi:10.1111/imm.12472 · Cited by 20

T-cell epitope discovery and single-cell technologies to advance food allergy research

Lewis, S. A., & Peters, B. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.10.025 · Cited by 19

Activation-induced surface proteins in the identification of antigen-responsive CD4 T cells

Elias, G., Ogunjimi, B., & Tendeloo, V. F. V. (2019) · Immunology Letters · doi:10.1016/j.imlet.2019.12.006 · Cited by 19

Fungus-Specific CD4 T Cells as Specific Sensors for Identification of Pulmonary Fungal Infections

Scheffold, A., Schwarz, C., & Bächer, P. (2017) · Mycopathologia · doi:10.1007/s11046-017-0229-2 · Cited by 20

Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting

Murray, C., Miwa, H., Dhar, M., Park, D. E., Pao, E., Martinez, J., Kaanumalle, S., Loghin, E., Graf, J. F., Rhaddassi, K., et al. (2018) · Lab on a Chip · doi:10.1039/c8lc00518d · Cited by 19

Editorial: Precision Medicine in Chronic Inflammation

Distler, O., Ludwig, R. J., Niemann, S., Riemekasten, G., & Schreiber, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.770462 · Cited by 19

Single cell profiling of circulating autoreactive CD4 T cells from patients with autoimmune liver diseases suggests tissue imprinting

Cardon, A., Guinebretière, T., Dong, C., Gil, L., Ado, S., Gavlovsky, P.-J., Braud, M., Danger, R., Schultheiß, C., Doméné, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56363-2 · Cited by 25

The role of A Disintegrin and Metalloproteinase (ADAM)-10 in T helper cell biology

Sezin, T., Selvakumar, B., & Scheffold, A. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.119192 · Cited by 18

Crohn’s Disease Patients Uniquely Contain Inflammatory Responses to Flagellin in a CD4 Effector Memory Subset

Morgan, N. N., Duck, L. W., Wu, J., Rujani, M., Thomes, P. G., Elson, C. O., & Mannon, P. (2022) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izac146 · Cited by 18

Anti-fungal T cell responses in the lung and modulation by the gut-lung axis

Scheffold, A., & Bächer, P. (2020) · Current Opinion in Microbiology · doi:10.1016/j.mib.2020.06.006 · Cited by 18

Resident memory CD4 + T lymphocytes mobilize from bone marrow to contribute to a systemic secondary immune reaction

Cendón, C., Du, W., Durek, P., Liu, Y., Alexander, T., Serene, L. G., Yang, X., Gasparoni, G., Salhab, A., Nordström, K. J. V., et al. (2022) · European Journal of Immunology · doi:10.1002/eji.202149726 · Cited by 18

Candida-Reactive T Cells for the Diagnosis of Invasive Candida Infection—A Prospective Pilot Study

Koehler, F. C., Cornely, O. A., Wisplinghoff, H., Schauss, A. C., Salmanton‐García, J., Ostermann, H., Ziegler, M., Bächer, P., Scheffold, A., Alex, R., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01381 · Cited by 17

Identification and characterization of antigen-specific CD4+ T cells targeting renally expressed antigens in human lupus nephritis with two independent methods

Tesch, S., Abdirama, D., Grießbach, A., Brand, H., Goerlich, N., Humrich, J. Y., Bächer, P., Hiepe, F., Riemekasten, G., & Enghard, P. (2020) · Scientific Reports · doi:10.1038/s41598-020-78223-3 · Cited by 16

In Vitro Monitoring of Human T Cell Responses to Skin Sensitizing Chemicals—A Systematic Review

Aparicio‐Soto, M., Curato, C., Riedel, F., Thierse, H., Luch, A., & Siewert, K. (2021) · Cells · doi:10.3390/cells11010083 · Cited by 16

Mycobacterium tuberculosis-specific CD4 T-cell scoring discriminates tuberculosis infection from disease

Mantei, A., Meyer, T., Schürmann, M., Beßler, C., Bias, H., Krieger, D., Bauer, T. T., Bächer, P., Helmuth, J., Volk, H., et al. (2022) · European Respiratory Journal · doi:10.1183/13993003.01780-2021 · Cited by 16

Flow Cytometric Characterization of Human Antigen-Reactive T-Helper Cells

Saggau, C., Scheffold, A., & Bächer, P. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1311-5_12 · Cited by 16

A high-sensitivity detection system for monitoring of rare antigen specific naive and memory T helper cells (58.6)

Bächer, P., Schink, C., Teutschbein, J., Kniemeyer, O., Assenmacher, M., Brakhage, A. A., Schmitz, J., & Scheffold, A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.188.supp.58.6

Flow Cytometric Characterization of Human Antigen-Reactive T-Helper Cells

Saggau, C., Scheffold, A., & Bächer, P. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1311-5_12 · Cited by 16

Direct access to CD4+ T cells specific for defined antigens according to CD154 expression

Frentsch, M., Arbach, O., Kirchhoff, D., Moewes, B., Worm, M., Rothe, M., Scheffold, A., & Thiel, A. (2005) · Nature Medicine · doi:10.1038/nm1292 · Cited by 475

Flow-cytometric analysis of rare antigen-specific T cells

Bacher, P., & Scheffold, A. (2013) · Cytometry Part A · doi:10.1002/cyto.a.22317 · Cited by 155

On-Chip Activation and Subsequent Detection of Individual Antigen-Specific T Cells

Song, Q., Han, Q., Bradshaw, E. M., Kent, S. C., Raddassi, K., Nilsson, B., Nepom, G. T., Hafler, D. A., & Love, J. C. (2009) · Analytical Chemistry · doi:10.1021/ac9024363 · Cited by 31