The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Effects of Aging, Cytomegalovirus Infection, and EBV Infection on Human B Cell Repertoires
Open accessAbstract
Elderly humans show decreased humoral immunity to pathogens and vaccines, yet the effects of aging on B cells are not fully known. Chronic viral infection by CMV is implicated as a driver of clonal T cell proliferations in some aging humans, but whether CMV or EBV infection contributes to alterations in the B cell repertoire with age is unclear. We have used high-throughput DNA sequencing of IGH gene rearrangements to study the BCR repertoires over two successive years in 27 individuals ranging in age from 20 to 89 y. Some features of the B cell repertoire remain stable with age, but elderly subjects show increased numbers of B cells with long CDR3 regions, a trend toward accumulation of more highly mutated IgM and IgG Ig genes, and persistent clonal B cell populations in the blood. Seropositivity for CMV or EBV infection alters B cell repertoires, regardless of the individual’s age: EBV infection correlates with the presence of persistent clonal B cell expansions, whereas CMV infection correlates with the proportion of highly mutated Ab genes. These findings isolate effects of aging from those of chronic viral infection on B cell repertoires and provide a baseline for understanding human B cell responses to vaccination or infectious stimuli.
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Citations
Cites
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B‐cell diversity decreases in old age and is correlated with poor health status
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“Changes in serum Ab production, including decreases in vaccine-specific Abs, and decreased isotype switching associated with lower expression of activation-induced cytidine deaminase in B cells also have been described previously (8, 10, 14).”
BackgroundSasaki, S., Sullivan, M., Narvaez, C. F., Holmes, T. H., Furman, D., Zheng, N.-Y., Nishtala, M., Wrammert, J., Smith, K., James, J. A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57834 · Cited by 300
Self-citationRegulation of Aged Humoral Immune Defense against Pneumococcal Bacteria by IgM Memory B Cell
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Effects of aging on B cell function
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Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans
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Thyroid autoimmunity and aging
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Cited by
Elements of cancer immunity and the cancer–immune set point
Chen, D. S., & Mellman, I. (2017) · Nature · doi:10.1038/nature21349 · Cited by 5,352
Chronic inflammation in the etiology of disease across the life span
Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0675-0 · Cited by 4,915
Self-citationSayed, N., Huang, Y., Nguyen, K., Krejciova-Rajaniemi, Z., Grawe, A. P., Gao, T., Tibshirani, R., Hastie, T., Alpert, A., Cui, L., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00082-y · Cited by 572
Self-citationTowards error-free profiling of immune repertoires
Shugay, M., Britanova, O. V., Merzlyak, E. M., Turchaninova, M. A., Mamedov, I. Z., Tuganbaev, T. R., Bolotin, D. A., Staroverov, D. B., Putintseva, E. V., Plevova, K., et al. (2014) · Nature Methods · doi:10.1038/nmeth.2960 · Cited by 428
Furman, D., Chang, J., Lartigue, L., Bolen, C. R., Haddad, F., Gaudilliere, B., Ganio, E. A., Fragiadakis, G. K., Spitzer, M. H., Douchet, I., et al. (2017) · Nature Medicine · doi:10.1038/nm.4267 · Cited by 389
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Metadata
- Authors
- Wang, C., Liu, Y., Xu, L. T., Jackson, K. J. L., Roskin, K. M., Pham, T. D., Laserson, J., Marshall, E. L., Seo, K., Lee, J.-Y., Furman, D., Koller, D., Dekker, C. L., Davis, M. M., Fire, A. Z., & Boyd, S. D.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-01
- Volume
- 192
- Issue
- 2
- Pages
- 603-611
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2157203934
- Cited by
- 183
- References
- 10
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, C., Liu, Y., Xu, L. T., Jackson, K. J. L., Roskin, K. M., Pham, T. D., Laserson, J., Marshall, E. L., Seo, K., Lee, J.-Y., Furman, D., Koller, D., Dekker, C. L., Davis, M. M., Fire, A. Z., & Boyd, S. D. (2014). Effects of Aging, Cytomegalovirus Infection, and EBV Infection on Human B Cell Repertoires. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1301384
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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