Lineage Structure of the Human Antibody Repertoire in Response to Influenza Vaccination
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High-throughput sequencing suggests age-related differences in the changes in the human antibody repertoire after influenza vaccination.
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Elderly individuals have decreased numbers of B-cell lineages but increased pre-vaccination mutation load in their repertoire, resulting in a less efficient response, and lineage diversity is greatly reduced compared with young individuals.
“Moreover, elderly individuals have decreased numbers of B-cell lineages but increased pre-vaccination mutation load in their repertoire, resulting in a less efficient response, and the diversity of the lineages is thus greatly reduced as compared with that in young individuals [131].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [131]
Poor immune responses account for diminished efficacy of vaccines.
“Furthermore, poor immune responses account for diminished efficacy of vaccines [82,85].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [82]
As age advances, the immune system undergoes profound remodelling and decline, with major impact on health and survival.
“As age advances, the immune system undergoes profound remodelling and decline, with major impact on health and survival [81,82].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [82]
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- Authors
- Jiang, N., He, J., Weinstein, J. A., Penland, L., Sasaki, S., He, X.-S., Dekker, C. L., Zheng, N.-Y., Huang, M., Sullivan, M., Wilson, P. C., Greenberg, H. B., Davis, M. M., Fisher, D. S., & Quake, S. R.
- Affiliations
- Stanford Medicine (US)
- Stanford University (US)
- VA Palo Alto Health Care System (US)
- University of Chicago (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Jiang, Ning
- He, Jiankui
- Weinstein, Joshua A.
- Quake, Stephen R.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2013-02-06
- Volume
- 5
- Issue
- 171
- Pages
- 171ra19-171ra19
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3699344
- OpenAlex
- W2097816699
- Cited by
- 335
- References
- 30
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 16 · 2023: 13 · 2022: 21 · 2021: 26 · 2020: 33 · 2019: 30 · 2018: 23 · 2017: 33 · 2016: 39 · 2015: 39 · 2014: 31 · 2013: 17
- FWCI
- 23.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (UL1TR001085)
- National Institute on Aging (K99AG040149)
- National Institute of Allergy and Infectious Diseases (U19AI090019, U19AI057229)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- human antibody repertoire, influenza vaccination, immunogenomics, clonal architecture, somatic hypermutation, age-related immune decline, isotype distribution, long-read sequencing
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Antibodies, Viral, Child, Humans, Immunoglobulin M, Immunoglobulin Isotypes, Influenza, Human, Middle Aged, Mutation, Phylogeny, Vaccination, Genetic Variation, Cluster Analysis, Somatic Hypermutation, Immunoglobulin, Young Adult
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