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Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells.
Abstract
The interaction between human endothelial cells and leukocytes during immunologic and inflammatory responses is in part mediated through the release of soluble mediators. We report that cultured human umbilical vein endothelial cells secrete IL-6 when stimulated with LPS. This effect was inhibited by polymyxin-B. The monokines IL-1 and TNF-alpha were also potent inducers of IL-6, whereas lymphotoxin was only effective at much higher concentrations. Endothelial cell supernatant IL-6 was active as hybridoma-plasmacytoma growth factor and as B-cell stimulating factor. Endothelial IL-6 activity was neutralized by a specific anti-IL-6 antibody and by immunoprecipitation it was shown to be identical in size to human fibroblast-derived IL-6. As IL-6 is possibly an important regulator of host defense responses, production of this cytokine by endothelial cells may contribute to the pathogenesis of various inflammatory and immunologic diseases.
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Citations
Cited by
Interleukin-6 and the acute phase response
Heinrich, P. C., Castell, J. V., & Andus, T. (1990) · Biochemical Journal · doi:10.1042/bj2650621 · Cited by 2,734
Interleukin-6 and its receptor: a paradigm for cytokines
Kishimoto, T., Akira, S., & Taga, T. (1992) · Science · doi:10.1126/science.1411569 · Cited by 665
Self-citationIL-6 increases endothelial permeability in vitro
Maruo, N. (1992) · Endocrinology · doi:10.1210/en.131.2.710 · Cited by 386
Vince, G. S., Starkey, P. M., Austgulen, R., Kwiatkowski, D., & Redman, C. W. G. (1995) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1995.tb09020.x · Cited by 381
Loppnow, H., & Libby, P. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114498 · Cited by 375
Metadata
- Authors
- Jirik, F. R., Podor, T. J., Hirano, T., Kishimoto, T., Loskutoff, D. J., Carson, D. A., & Lotz, M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1989-01-01
- Volume
- 142
- Issue
- 1
- Pages
- 144-147
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1501935155
- Cited by
- 459
- References
- 0
- FWCI
- 21.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jirik, F. R., Podor, T. J., Hirano, T., Kishimoto, T., Loskutoff, D. J., Carson, D. A., & Lotz, M. (1989). Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.142.1.144
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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