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Cited by 386

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

IL-6 increases endothelial permeability in vitro

Maruo, N.·1992·Endocrinology
DOI 10.1210/en.131.2.710
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Abstract

The effect of interleukin 6 (IL-6) on endothelial permeability was examined by measuring fluorescein isothiocyanate-labeled albumin flux across an endothelial cell monolayer. Bovine vascular endothelial cells (BVEC) were cultured up to confluency on collagen-coated polycarbonate micropore filters and then the filters were mounted on modified Boyden chambers. Treatment of the BVEC with IL-6 at 100 ng/ml for 21 h caused a remarkable increase in the permeability of fluorescein isothiocyanate-labeled albumin across the endothelial monolayer. This effect of IL-6 was concentration dependent, in the range from 10-200 ng/ml of IL-6. The effect of IL-6 was also time dependent, the maximal level being reached at 21 h from the beginning of the treatment. This stimulatory effect of IL-6 on albumin clearance was completely abolished by the addition of anti-IL-6 antibody. Light microscopic observation of a cross-section of a monolayer showed that the IL-6-induced increase in the permeability was correlated with changes in cell shape and rearrangement of intracellular actin fibers. IL-6 did not show any cytotoxicity toward or growth inhibition of endothelial cells, even at more than 200 ng/ml. The enhancing effect of IL-6 on the increase in the permeability was reversible; when IL-6 was removed by a medium change and the cells were incubated for a further 24 h without IL-6, the permeability was restored to the control level. These results suggest that IL-6 can induce an increase in endothelial permeability in vitro by rearranging actin filaments and by changing the shape of endothelial cells.

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Metadata

Authors
Maruo, N.
Venue
Endocrinology
Publisher
The Endocrine Society
Published
1992-08-01
Volume
131
Issue
2
Pages
710-714
ISSN
0013-7227 (ISSN-L)
DOI
10.1210/en.131.2.710
OpenAlex
W1974400821
Cited by
386
References
9
FWCI
6.17
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: IL-6 increases endothelial permeability in vitro. https://app.cochat.ai/papers/10.1210/en.131.2.710
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Maruo, N. (1992). IL-6 increases endothelial permeability in vitro. Endocrinology. https://doi.org/10.1210/en.131.2.710

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