Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

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Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

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X-inactivation profile reveals extensive variability in X-linked gene expression in females

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Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

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Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

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The aging immune system: primer and prospectus

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Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus

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Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals

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Toll-like receptor 7 (TLR7)–driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

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FcγRIV: A Novel FcR with Distinct IgG Subclass Specificity

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Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology

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Transcriptome and IgH Repertoire Analyses Show That CD11chi B Cells Are a Distinct Population With Similarity to B Cells Arising in Autoimmunity and Infection

Maul, R. W., Catalina, M. D., Kumar, V. V., Bachali, P., Grammer, A. C., Wang, S., Yang, W. W., Hasni, S., Ettinger, R., Lipsky, P. E., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.649458 · Cited by 32

Age/autoimmunity-associated B cells in inflammatory arthritis: An emerging therapeutic target

Li, Z., Cai, M.-L., Qin, Y., & Chen, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1103307 · Cited by 31

Dysregulation of humoral immunity in chronic infection

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Identification and Characterization of a Master Transcription Factor of Th1 Cells, T-bet, Within Flounder (Paralichthys olivaceus)

Tian, H., Xing, J., Tang, X., Chi, H., Sheng, X., & Zhan, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.704324 · Cited by 29

Type 1 helper T cells generate CXCL9/10-producing T-bet+ effector B cells potentially involved in the pathogenesis of rheumatoid arthritis

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Regulation of systemic autoimmunity and CD11c+ Tbet+ B cells by SWEF proteins

Manni, M., Ricker, E., & Pernis, A. B. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.05.010 · Cited by 28

The properties of the unique age-associated B cell subset reveal a shift in strategy of immune response with age

Swain, S. L., Kugler‐Umana, O., Kuang, Y., & Zhang, W. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.05.009 · Cited by 27

Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint

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Counteracting Immunosenescence—Which Therapeutic Strategies Are Promising?

Hieber, C., Grabbe, S., & Bros, M. (2023) · Biomolecules · doi:10.3390/biom13071085 · Cited by 30

Immunopathology and Immunosenescence, the Immunological Key Words of Severe COVID-19. Is There a Role for Stem Cell Transplantation?

Ligotti, M. E., Pojero, F., Accardi, G., Aiello, A., Caruso, C., Duro, G., & Candore, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.725606 · Cited by 26

Transient hepatic reconstitution of trophic factors enhances aged immunity

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CD19 + CD21lo/neg cells are increased in systemic sclerosis-associated interstitial lung disease

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Tfh cells and the germinal center are required for memory B cell formation & humoral immunity after ChAdOx1 nCoV-19 vaccination

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Role of B cells in immune‐related adverse events following checkpoint blockade

Dhodapkar, K. M., Duffy, A. M., & Dhodapkar, M. V. (2023) · Immunological Reviews · doi:10.1111/imr.13238 · Cited by 27

Malaria exposure drives both cognate and bystander human B cells to adopt an atypical phenotype

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B Cells Dynamic in Aging and the Implications of Nutritional Regulation

Yu, Y., Lu, C., Yu, W., Lei, Y., Sun, S., Liu, P., Bai, F., Chen, Y., & Chen, J. (2024) · Nutrients · doi:10.3390/nu16040487 · Cited by 29

Critical roles of chronic BCR signaling in the differentiation of anergic B cells into age-associated B cells in aging and autoimmunity

Imabayashi, K., Yada, Y., Kawata, K., Yoshimura, M., Iwasaki, T., Baba, A., Harada, A., Akashi, K., Niiro, H., & Baba, Y. (2025) · Science Advances · doi:10.1126/sciadv.adt8199 · Cited by 28

Mechanistic insights and biomarker discovery in immune cell aging and age-associated diseases

Upadhyay, P., Suhail, A., Khanal, P., & Kumar, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1637191 · Cited by 24

MZ B cells migrate in a T‐bet dependent manner and might contribute to the remission of collagen‐induced arthritis by the secretion of IL‐10

Huber, K., Sármay, G., & Kövesdi, D. (2016) · European Journal of Immunology · doi:10.1002/eji.201546248 · Cited by 24

Intragraft B cell differentiation during the development of tolerance to kidney allografts is associated with a regulatory B cell signature revealed by single cell transcriptomics

Guinn, M. T., Szuter, E. S., Yokose, T., Ge, J., Rosales, I. A., Chetal, K., Sadreyev, R. I., Cuenca, A. G., Kreisel, D., Sage, P. T., et al. (2023) · American Journal of Transplantation · doi:10.1016/j.ajt.2023.05.036 · Cited by 23

Exhaustion may not be in the human B cell vocabulary, at least not in malaria

Holla, P., Ambegaonkar, A. A., Sohn, H., & Pierce, S. K. (2019) · Immunological Reviews · doi:10.1111/imr.12809 · Cited by 22

Early multiple sclerosis activity associated with TBX21+CD21loCXCR3+ B cell expansion resembling EBV-induced phenotypes

SoRelle, E. D., Haukenfrers, E., Horn, G. Q., Jain, V., Giarraputo, J., Abramson, K., Hocke, E., Cooney, L. A., Harris, K. M., Zamvil, S. S., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.188543 · Cited by 21

Bystanders or not? Microglia and lymphocytes in aging and stroke

Chauhan, A., & Nguyen, J. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.360345 · Cited by 21

The transcriptional repressor Gfi1 prevents lupus autoimmunity by restraining TLR7 signaling

Desnues, B., Macedo, A. B., Ordoñez‐Rueda, D., Roussel‐Queval, A., MALISSEN, B., Bruhns, P., Malissen, M., & Alexopoulou, L. (2016) · European Journal of Immunology · doi:10.1002/eji.201646573 · Cited by 21

Mucosal delivery of ESX-1–expressing BCG strains provides superior immunity against tuberculosis in murine type 2 diabetes

Sathkumara, H. D., Muruganandah, V., Cooper, M. M., Field, M. A., Alim, M. A., Brosch, R., Ketheesan, N., Govan, B., Rush, C. M., Henning, L., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2003235117 · Cited by 21

The Potential Crosstalk Between the Brain and Visceral Adipose Tissue in Alzheimer’s Development

Nguyen, T. T., Hulme, J., Vo, T. K., & Vo, G. V. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03569-1 · Cited by 21

Estrogen, the Peripheral Immune System and Major Depression – A Reproductive Lifespan Perspective

Engler-Chiurazzi, E. B., Chastain, W. H., Citron, K. K., Lambert, L. E., Kikkeri, D. N., & Shrestha, S. S. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.850623 · Cited by 21

Therapeutic implications of the anergic/postactivated status of B cells in systemic lupus erythematosus

Dörner, T., Szelinski, F., Lino, A. C., & Lipsky, P. E. (2020) · RMD Open · doi:10.1136/rmdopen-2020-001258 · Cited by 20

Autoantibodies during infectious diseases: Lessons from malaria applied to COVID-19 and other infections

Rivera‐Correa, J., & Rodrı́guez, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.938011 · Cited by 18

Down syndrome: insights into autoimmune mechanisms

Khor, B., & Buckner, J. H. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-00970-0 · Cited by 19

Know Your ABC s: Discovery, Differentiation, and Targeting of T‐Bet+ B Cells

Winslow, G. M., & Levack, R. C. (2025) · Immunological Reviews · doi:10.1111/imr.13440 · Cited by 19

Aging-associated immune system changes in multiple myeloma: The dark side of the moon.

Visram, A., & Kourelis, T. (2021) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2021.100494 · Cited by 20

A Novel Model of Asymptomatic Plasmodium Parasitemia That Recapitulates Elements of the Human Immune Response to Chronic Infection

Fontana, M. F., Baccarella, A., Craft, J. F., Boyle, M. J., McIntyre, T. I., Wood, M. D., Thorn, K. S., Anidi, C. M., Bayat, A., Chung, M. R., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162132 · Cited by 18

Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections

Rivera‐Correa, J., Verdi, J., Sherman, J., Sternberg, J. M., Raper, J., & Rodrı́guez, A. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0009814 · Cited by 18

B cell primary immune responses

Shlomchik, M. J., & Weisel, F. J. (2019) · Immunological Reviews · doi:10.1111/imr.12756 · Cited by 17

Extrafollicular CD19lowCXCR5−CD11c− double negative 3 (DN3) B cells are significantly associated with disease activity in females with systemic lupus erythematosus

Chizzolini, C., Guéry, J., Noulet, F., Gruaz, L., Cénac, C., Frasca, L., Spoerl, D., Arlettaz, L., Horisberger, A., Ribi, C., et al. (2024) · Journal of Translational Autoimmunity · doi:10.1016/j.jtauto.2024.100252 · Cited by 17

Human Atypical B Cells. An Overview

Sanz, I. (2025) · Immunological Reviews · doi:10.1111/imr.70058 · Cited by 17

Fine-tuning of MEK signaling is pivotal for limiting B and T cell activation

Houde, N., Beuret, L., Bonaud, A., Fortier-Beaulieu, S.-P., Truchon-Landry, K., Aoidi, R., Pic, É., Alouche, N., Rondeau, V., Schlecht‐Louf, G., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110223 · Cited by 16

Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus

Baxter, R. M., Wang, C. S., Garcia‐Perez, J. E., Kong, D. S. H., Coleman, B. M., Larchenko, V., Schuyler, R. P., Jackson, C. L., Ghosh, T., Rudra, P., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1208282 · Cited by 15

Coordinated Regulation of Extrafollicular B Cell Responses by IL ‐12 and IFN γ

Elsner, R. A., & Shlomchik, M. J. (2025) · Immunological Reviews · doi:10.1111/imr.70027 · Cited by 16

Adipose Tissue B Cells Come of Age: The AABs of Fat Inflammation

Khan, S. M., Tsai, S. J., & Winer, D. A. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.007 · Cited by 15

Older Human B Cells and Antibodies

Dunn‐Walters, D. K., & O’Hare, J. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_21-1 · Cited by 14

Integrated systems immunology approach identifies impaired effector T cell memory responses as a feature of progression to severe dengue fever

Ioannidis, L. J., Studniberg, S. I., Eriksson, E. M., Suwarto, S., Denis, D., Liao, Y., Shi, W., Garnham, A. L., Sasmono, R. T., & Hansen, D. S. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-023-00916-4 · Cited by 14

A TNIP1-driven systemic autoimmune disorder with elevated IgG4

Medhavy, A., Athanasopoulos, V., Bassett, K., He, Y., Stanley, M., Tuipulotu, D. E., Cappello, J. Y., Brown, G. J., González-Figueroa, P., Turnbull, C., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01902-0 · Cited by 14

Mechanisms and strategies of immunosenescence effects on non-small cell lung cancer (NSCLC) treatment: A comprehensive analysis and future directions

Zhou, H., Zheng, Z., Fan, C., & Zhou, Z. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.01.001 · Cited by 15

Activated Peripheral Blood B Cells in Rheumatoid Arthritis and Their Relationship to Anti–Tumor Necrosis Factor Treatment and Response: A Randomized Clinical Trial of the Effects of Anti–Tumor Necrosis Factor on B Cells

Meednu, N., Barnard, J., Callahan, K., Coca, A., Marston, B. A., Thiele, R., Tabechian, D. A., Bolster, M. B., Curtis, J. R., Mackay, M. C., et al. (2021) · Arthritis & Rheumatology · doi:10.1002/art.41941 · Cited by 14

Adipose tissue microenvironments during aging: Effects on stimulated lipolysis

Camell, C. D. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2022.159118 · Cited by 16

Searching for the "X factor" in Sjögren's syndrome female predilection

Chatzis, L. G., Goules, A. V., & Tzioufas, A. G. (2021) · Clinical and Experimental Rheumatology · doi:10.55563/clinexprheumatol/88dyrn · Cited by 15

CD21lo/−CD27−IgM− Double-Negative B Cells Accumulate in the Joints of Patients With Antinuclear Antibody-Positive Juvenile Idiopathic Arthritis

Dirks, J., Fischer, J., Haase, G., Holl‐Wieden, A., Hofmann, C., Girschick, H. J., & Morbach, H. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.635815 · Cited by 12

Role of immunological disorders, endothelial dysfunction and hemostatic disorders in the genesis of arterial hypertension in the metabolic syndrome

Polozova, E. I., Пузанова, Е. В., & Александровна, С. А. (2020) · Medical Immunology (Russia) · doi:10.15789/1563-0625-roi-1926 · Cited by 12

Germinal-centre and extrafollicular B cell pathways in systemic lupus erythematosus

Zhu, Y. D., Castrillon, C. E., Akama‐Garren, E. H., & Carroll, M. C. (2026) · Nature Reviews Rheumatology · doi:10.1038/s41584-026-01365-7 · Cited by 13

Plasmodium chabaudi infection induces AID expression in transitional and marginal zone B cells

Wilmore, J. R., Maue, A. C., & Rochford, R. A. (2016) · Immunity Inflammation and Disease · doi:10.1002/iid3.134 · Cited by 11

Potential Relevance of B-cell Maturation Pathways in Defining the Cell(s) of Origin for Chronic Lymphocytic Leukemia

Ng, A. K. Y., & Chiorazzi, N. (2021) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2021.03.002 · Cited by 12

Immunologic and inflammatory consequences of SARS-CoV-2 infection and its implications in renal disease

Naiditch, H., Betts, M. R., Larman, H. B., Levi, M., & Rosenberg, A. Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1376654 · Cited by 10

The role of age-associated B cells in systemic lupus erythematosus

Su, Q. Y., Zheng, X., Han, X.-T., Li, Q., Gao, Y.-R., Zhang, S., & Li, X.-F. (2025) · Journal of Autoimmunity · doi:10.1016/j.jaut.2025.103433 · Cited by 12

The ligand interactions of B cell Siglecs are involved in the prevention of autoimmunity to sialylated self-antigens and in the quality control of signaling-competent B cells

Tsubata, T. (2023) · International Immunology · doi:10.1093/intimm/dxad030 · Cited by 10

The role of B lymphocyte subsets in nephrotic syndrome: functions, mechanisms, clinical significance and future perspectives

Liao, Y., Hu, H., Wan, Q., & Song, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1598197 · Cited by 9

From Steatosis to Immunosenescence: The Impact of Metabolic Dysfunction on Immune Aging in HIV and Non-HIV Populations

Acierno, C., Frontuto, M., Stefano, G. F. D., Erezanu, A., Limone, A., Morella, S., Picaro, F., Palazzo, D., & Gilio, M. (2025) · Biomedicines · doi:10.3390/biomedicines13102513 · Cited by 10

Deep Sequencing in Infectious Diseases: Immune and Pathogen Repertoires for the Improvement of Patient Outcomes

Burkholder, W. F., Newell, E. W., Poidinger, M., Chen, S. L., & Fink, K. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00593 · Cited by 9

Understanding the Heterogeneous Population of Age-Associated B Cells and Their Contributions to Autoimmunity and Immune Response to Pathogens

Kugler‐Umana, O., Devarajan, P., & Swain, S. L. (2020) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2020034934 · Cited by 10

Osteopontin and malaria: no direct effect on parasite growth, but correlation with P. falciparum-specific B cells and BAFF in a malaria endemic area

Mortazavi, S. E., Lugaajju, A., Kaddumukasa, M., Tijani, M. K., Kironde, F., & Persson, K. E. M. (2021) · BMC Microbiology · doi:10.1186/s12866-021-02368-y · Cited by 9

Radiation therapy induces immunosenescence mediated by p90RSK

Imanishi, M., Cheng, H., Kotla, S., Deswal, A. M., Le, N.-T., Chini, E. N., Ko, K. A., Samanthapudi, V. S. K., Lee, L.-L., Herrmann, J., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.988713 · Cited by 10

Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrowPreprint

Riedel, R., Addo, R., Ferreira‐Gomes, M., Heinz, G. A., Heinrich, F., Kummer, J., Greiff, V., Schulz, D., Klaeden, C., Cornelis, R., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/825224 · Cited by 9

Increased age-associated B cells in patients with acquired aplastic anemia correlate with IFN-γ

Solomou, E. E., Kattamis, A., Symeonidis, A. S., Sirinian, C., Salamaliki, C., Tzanoudaki, M., Diamantopoulos, P. T., Plakoula, E., Palassopoulou, M., Giannakoulas, N. C., et al. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023010109 · Cited by 8

The B cell response to both protein and nucleic acid antigens displayed on apoptotic cells are dependent on endosomal pattern recognition receptors

Garimella, M. G., He, C., Chen, G., Li, Q., Huang, X., & Karlsson, M. C. I. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102582 · Cited by 8

Innate Immune Receptors as Dynamic Modulators of Extrafollicular Autoimmune B Cell Response

Zhu, Y. D., Castrillon, C. E., & Carroll, M. C. (2025) · Immunological Reviews · doi:10.1111/imr.70005 · Cited by 7

‘-Omics’ shed light on B cells in lupus

Pernis, A. B., & Ivashkiv, L. B. (2019) · Nature Immunology · doi:10.1038/s41590-019-0446-6 · Cited by 7

B cells and atherosclerosis: A HIV perspective

Obare, L. M., Bonami, R. H., Doran, A. C., & Wanjalla, C. N. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31270 · Cited by 7

T-bet+CD11c+ age-associated B cells resist BLyS- and CD20-targeted ablation in murine lupus models

Knox, J. J., Scholz, J. L., Futeran, H., Cataliotti, S., & Cancro, M. P. (2025) · Journal of Autoimmunity · doi:10.1016/j.jaut.2025.103410 · Cited by 6

Deep Immunophenotyping and Clustering Identifies Biomarkers Predictive of Lymphoma in Primary Sjögren Disease

Marques, C., Régnier, P., Maciejewski‐Duval, A., de Vesvrotte, C. R., Vazquez, T., Montardi, C., Manoury, B., Dorgham, K., Comarmond, C., MEKINIAN, A., et al. (2025) · Arthritis & Rheumatology · doi:10.1002/art.43207 · Cited by 6

Thymic B cells in aging and autoimmune disease

Wedemeyer, S. A., & Griffith, A. V. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1595805 · Cited by 6

The multilayered identity of B cell memory

Glaros, V., Francis, N., & Kreslavsky, T. (2026) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01377-5 · Cited by 9

Switched CD21–/low B cells with an antigen-presenting phenotype in the infant thymus

Lundqvist, C., Camponeschi, A., Visentini, M., Telemo, E., Ekwall, O., & Mårtensson, I. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.11.019 · Cited by 6

Role of natural killer and B cell interaction in inducing pathogen specific immune responses

Tandel, N., Negi, S., Dalai, S. K., & Tyagi, R. K. (2023) · International Reviews of Immunology · doi:10.1080/08830185.2023.2172406 · Cited by 6

An EBV-associated atypical B cell signature in clinically isolated syndrome is implicated in progression of multiple sclerosisPreprint

SoRelle, E. D., Haukenfrers, E., Jain, V., Abramson, K., Hocke, E., Cooney, L. A., Harris, K. M., Zamvil, S. S., Gregory, S. G., & Luftig, M. A. (2023) · medRxiv · doi:10.1101/2023.02.26.23286433 · Cited by 6

The Influence of Heterochronic Non-Myeloablative Bone Marrow Transplantation on the Immune System, Frailty, General Health, and Longevity of Aged Murine Recipients

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Disparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Mice

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T-bet+ B cells Dominate the Peritoneal Cavity B Cell Response during Murine Intracellular Bacterial Infection

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Antigen in the Presence of DAMPs Induces Immunostimulatory Dendritic Cells to Promote Destructive Adaptive Immune Responses

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Gammaherpesvirus infection licenses age-associated B cells for pathogenicity in MS and EAEPreprint

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Aging induces Nlrp3 inflammasome dependent adipose B cell expansion to impair metabolic homeostasisPreprint

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Liver Is a Generative Site for the B Cell Response to Ehrlichia MurisPreprint

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A Spontaneous RAG1 Nonsense Mutation Unveils Naturally Occurring N-Terminal Truncated RAG1 Isoforms

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The effector function of mucosal associated invariant T cells alters with aging and is regulated by RORγt

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