Cited by 248T-cell and B-cell ImmunologySystemic Lupus Erythematosus ResearchImmune Response and Inflammation

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Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity

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Rubtsova, Kira, Rubtsov, Anatoly V, Cancro, Michael P, Marrack, Philippa·2015·The Journal of Immunology

DOI 10.4049/jimmunol.1501209PMC PMC4548292

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Abstract

A newly discovered B cell subset, age-associated B cells, expresses the transcription factor T-bet, has a unique surface phenotype, and accumulates progressively with age. Moreover, B cells with these general features are associated with viral infections and autoimmunity in both mice and humans. In this article, we review current understanding of the characteristics, origins, and functions of these cells. We also suggest that the protective versus pathogenic actions of these cells reflect appropriate versus aberrant engagement of regulatory mechanisms that control the Ab responses to nucleic acid–containing Ags.

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Authors: Rubtsova, K., Rubtsov, A. V., Cancro, M. P., & Marrack, P.
Affiliations: Howard Hughes Medical Institute (US)
University of Pennsylvania (US)
Corresponding author: Rubtsova, Kira
Marrack, Philippa
ORCID: Rubtsova, Kira
Cancro, Michael P
Marrack, Philippa
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2015-09-01
Volume: 195
Issue: 5
Pages: 1933-1937
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.1501209
PMC: PMC4548292
OpenAlex: W2120679720
Cited by: 246
References: 57
Citations by year: 2026: 21 · 2025: 27 · 2024: 11 · 2023: 22 · 2022: 28 · 2021: 32 · 2020: 25 · 2019: 33 · 2018: 17 · 2017: 19 · 2016: 10 · 2015: 1
FWCI: 1.47
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institute on Aging (R01AG-16841, R01AG016841)
National Institute of Allergy and Infectious Diseases (AI-18785, T32AI074491, R37AI018785, R56AI018785, R01AI118691, R01AI018785)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: age-associated B cells, T-bet, B cell differentiation, aging, autoimmunity, viral infection, antibody response, B-cell origin, protective immunity
MeSH terms: T-bet Transcription Factor, Aging, Animals, Humans, Inflammation, Signal Transduction, Autoimmunity, B-Lymphocyte Subsets, Models, Immunological, T-Box Domain Proteins, Mice

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Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity

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