Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891

Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

Wherry, E. J., Ha, S.-J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.006 · Cited by 2,103

X-inactivation profile reveals extensive variability in X-linked gene expression in females

Carrel, L., & Willard, H. F. (2005) · Nature · doi:10.1038/nature03479 · Cited by 2,097

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

Leadbetter, E. A., Rifkin, I. R., Hohlbaum, A. M., Beaudette-Zlatanova, B. C., Shlomchik, M. J., & Marshak‐Rothstein, A. (2002) · Nature · doi:10.1038/416603a · Cited by 1,929

Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

Wherry, E. J., Ha, S., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.11.006 · Cited by 1,355

The aging immune system: primer and prospectus

Miller, R. A. (1996) · Science · doi:10.1126/science.273.5271.70 · Cited by 1,165

Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus

Christensen, S. R., Shupe, J., Nickerson, K., Kashgarian, M., Flavell, R. A., & Shlomchik, M. J. (2006) · Immunity · doi:10.1016/j.immuni.2006.07.013 · Cited by 1,090

Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals

Moir, S. L., Ho, J., Malaspina, A., Wang, W., DiPoto, A. C., O’Shea, M. A., Roby, G. A., Kottilil, S., Arthos, J. A., Proschan, M. A., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072683 · Cited by 894

Toll-like receptor 7 (TLR7)–driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

Rubtsov, A. V., Rubtsova, K., Fischer, A., Meehan, R. T., Gillis, J. Z., Kappler, J. W., & Marrack, P. (2011) · Blood · doi:10.1182/blood-2011-01-331462 · Cited by 808

FcγRIV: A Novel FcR with Distinct IgG Subclass Specificity

Nimmerjahn, F., Bruhns, P., Horiuchi, K., & Ravetch, J. V. (2005) · Immunity · doi:10.1016/j.immuni.2005.05.010 · Cited by 672

Inflammatory CD11c+ B Cells Induced by the TREM2 Signal Accelerate Sepsis Development

Ming, S., Chen, Z., Yang, J., Liu, J., Liu, X., Yang, L., Tan, Z., Zhou, H., Wu, Y., & Huang, X. (2025) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaf112 · Cited by 1

Peripheral T-cell subset activation in NMDAR encephalitis: Insights into pathogenesis and biomarker potential for disease monitoring

Wang, M., Wang, J., Zhai, J., He, Y., Ma, Y., Wang, Z., Ren, Y. D., Ying, B., Zhou, D., & Li, J. (2025) · Clinical Immunology · doi:10.1016/j.clim.2025.110506 · Cited by 1

Increased Fascin1 and Pak1 Expressions Enhance Age‐Associated B‐Cell Actin Cytoskeleton Remodeling and Motility

Fujiwara, M., Kondo, R., Sugiyama, Y., Maruyama, M., & Nishikimi, A. (2025) · Cell Biochemistry and Function · doi:10.1002/cbf.70090 · Cited by 1

Identification of Histone Deacetylase Inhibitor Targeting Type I Interferon and B Cell Abnormalities in Systemic Lupus Erythematosus

Hirayama, T., Konaka, H., Kato, Y., Shibahara, T., Nishizawa, C., Tsujimoto, K., Park, J., Itotagawa, E., Jo, T., Nishide, M., et al. (2025) · Arthritis & Rheumatology · doi:10.1002/art.43434 · Cited by 1

The impact of growth hormone (GH) on immunosenescence: exploring the role of B and T cells

Bashir, B., van Hoolwerff, M., Benencia, F., Duran‐Ortiz, S., List, E. O., Kopchick, J. J., & Berryman, D. E. (2026) · Pituitary · doi:10.1007/s11102-025-01632-y · Cited by 2

The exposome-autoimmunity axis: environmental xenobiotics, gut dysbiosis, and potential pathways to immunosenescence

Daşdemir, F. O., Sari, M. F., Aktaş, B., & Kocazeybek, B. S. (2026) · Food and Chemical Toxicology · doi:10.1016/j.fct.2026.116331 · Cited by 1

Unraveling the syndrome of age-associated diseases: Common pathways and novel therapeutic strategies

Mertelsmann, R. H., Faletti, L. E., & Zirlik, K. (2019) · Journal of Science Humanities and Arts - JOSHA · doi:10.17160/josha.6.2.539 · Cited by 1

Pattern of Tumor-Infiltrating Lymphocytes in Mixed Epithelial and Stromal Tumor of the Kidney: A Review of Five Cases

Lee, H. W., Lee, H., Park, C., Oh, W. J., Kim, T. J., Kwon, G. Y., & Seo, S. I. (2021) · Cells · doi:10.3390/cells10040917 · Cited by 1

In Systemic Sclerosis Patients, Peripheral Blood CD21low B Cells and Serum IL-4 and IL-21 Influence Joint Involvement

Pellicano, C., Colalillo, A., Carnazzo, V., Redi, S., Basile, V., Marino, M., Basile, U., & Rosato, E. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13091334 · Cited by 1

The Role of B Lymphocyte Subsets in Adipose Tissue Development, Metabolism, and Aging

Fernandez, N. C., & Shinoda, K. (2022) · Comprehensive physiology · doi:10.1002/j.2040-4603.2022.tb00243.x · Cited by 1

What's atypical about human B cells after allogeneic stem cell transplantation?

Bracken, S. J., Poe, J. C., & Sarantopoulos, S. (2025) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiaf048 · Cited by 1

Immune Aging, Autoimmunity, and Autoinflammation

Watad, ‬., McGonagle, D., Sellami, M., Amital, H., & Bragazzi, N. L. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_439-1 · Cited by 1

PLCγ2 deficiency compromises systemic immune tolerance and erodes myelin homeostasis while enhancing oxidative metabolism in the mouse brain

Gutierrez-Kuri, E., Marie Garcia-Rogers, J. L., Perez, J., Smith, S., Kenwood, M. R., Archuleta, K. S., Xiao, Y., Campos, G., Barannikov, S., Wang, H., et al. (2026) · doi:10.64898/2026.07.13.738356

Structure and Derivation of Autoantibodies

Sanz, I., Jenks, S. A., & Cashman, K. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47927-1.00026-8

Immunization With Recombinant Myelin Oligodendrocyte Glycoprotein Identifies Autoreactive T Cells As A Limiting Factor In Autoreactive Germinal Center Maintenance

Jain, R. W. (2018) · Scholarship@Western (Western University)

Immune regulation by mimethyl fumarate (DMF) in relapsing-remitting multiple sclerosis patients

Diaz, G. M. (2020) · Research Publications (Maastricht University) · doi:10.26481/dis.20201015gmd

Characteristics of the Immunoresponse in Elderly People and Autoimmunity

Moskalets, O. V. (2020) · Advances in Gerontology · doi:10.1134/s2079057020040153

Uncontrolled CD21 low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpointPreprint

Masle‐Farquhar, E., Peters, T. J., Miosge, L. A., Parish, I. A., Weigel, C., Oakes, C. C., Reed, J. H., & Goodnow, C. C. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.01.450650

The IgE production is initially induced in subcutaneous fat and depends on extrafollicular B cellsPreprint

Chudakov, D. B., Fattakhova, G. V., Konovalova, M. V., Tsaregorodtseva, D. S., Shevchenko, M. A., Kotsareva, O. D., Sergeev, A. A., & Svrshcehvskaya, E. V. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.18.456888

Immune Aging, Autoimmunity, and Autoinflammation

Watad, ‬., McGonagle, D., Sellami, M., Amital, H., & Bragazzi, N. L. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_439

B Cell Repertoire Changes in Mouse Models of Aging

Scholz, J. L., Hao, Y., Quinn, W. J., & Cancro, M. P. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_20-1

B Cell Repertoire Changes in Mouse Models of Aging

Scholz, J. L., Hao, Y., Quinn, W. J., & Cancro, M. P. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_20

B cells as multifactorial players in multiple sclerosis pathogenesis

Claes, N. (2016) · Research Publications (Maastricht University) · doi:10.26481/dis.20160616nc · Cited by 1

Increased of Fascin1 and Pak1 expression enhances age-associated B cell actin cytoskeleton remodelingPreprint

Fujiwara, M., Kondo, R., Sugiyama, Y., Maruyama, M., & Nishikimi, A. (2023) · Research Square · doi:10.21203/rs.3.rs-2659669/v1

Tribute to Mike Cancro – Former editor-in-chief at Cellular Immunology

Fillatreau, S., & Hao, Y. (2025) · Cellular Immunology · doi:10.1016/j.cellimm.2025.104973

T Follicular Helper (Tfh) Cells are a Distinct CD4 T Helper Subset

Hirsch, E. S., Brimmer, K. E., & Weinstein, J. S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-824465-4.00281-7

Additional file 10 of Single-cell resolution landscape of equine peripheral blood mononuclear cells reveals diverse cell types including T-bet+ B cells

Patel, R. S., Tomlinson, J. E., Divers, T. J., Van de Walle, G. R., & Rosenberg, B. R. (2021) · Figshare · doi:10.6084/m9.figshare.13632821

Additional file 1 of Single-cell resolution landscape of equine peripheral blood mononuclear cells reveals diverse cell types including T-bet+ B cells

Patel, R. S., Tomlinson, J. E., Divers, T. J., Van de Walle, G. R., & Rosenberg, B. R. (2021) · Figshare · doi:10.6084/m9.figshare.13632824

Additional file 2 of Integrated systems immunology approach identifies impaired effector T cell memory responses as a feature of progression to severe dengue fever

Ioannidis, L. J., Studniberg, S. I., Eriksson, E. M., Suwarto, S., Denis, D., Liao, Y., Shi, W., Garnham, A. L., Sasmono, R. T., & Hansen, D. S. (2023) · Figshare · doi:10.6084/m9.figshare.22631488

Additional file 3 of Integrated systems immunology approach identifies impaired effector T cell memory responses as a feature of progression to severe dengue fever

Ioannidis, L. J., Studniberg, S. I., Eriksson, E. M., Suwarto, S., Denis, D., Liao, Y., Shi, W., Garnham, A. L., Sasmono, R. T., & Hansen, D. S. (2023) · Figshare · doi:10.6084/m9.figshare.22631491

Additional file 1 of Integrated systems immunology approach identifies impaired effector T cell memory responses as a feature of progression to severe dengue fever

Ioannidis, L. J., Studniberg, S. I., Eriksson, E. M., Suwarto, S., Denis, D., Liao, Y., Shi, W., Garnham, A. L., Sasmono, R. T., & Hansen, D. S. (2023) · Figshare · doi:10.6084/m9.figshare.22631485

Origine et spécificité de la réponse autoimmune au cours de la thrombopénie immunologique de l'adulte

Crickx, É. (2019) · theses.fr (ABES) · doi:10.70675/fc2288fczc4f4z4701zbe17ze5812ccfba3d

Signature moléculaire des lymphocytes B régulateurs en physiologie et en pathologie

Grasseau, A. (2020) · doi:10.70675/8cd4f580za2b1z4a35z8c3fz199055e7f4b3

Contribution of innate and adaptive immune mechanisms to anti-HLA donor-specific antibody generation and triggered injury after kidney transplantation

Bailly, É. (2023) · theses.fr (ABES) · doi:10.70675/eb42531fz3b1az442az8f36ze9f4e6fa13e7

Microenvironnement immunitaire du cancer de l'ovaire : évolution sous chimio/immunothérapie néoadjuvante, caractérisation de l'hétérogénéité et rôle des cellules sécrétrices d'anticorps

Saux, O. L. (2022) · theses.fr (ABES) · doi:10.70675/01d898eaz0069z4b67z9b50z64b863171422

Defective inducible T cell costimulator signalling drives neuropilin-1hi CD4+ T cell-mediated non-germinal centre B cell activation via impaired regulatory T cell maintenance in a lupus model

Kang, S., Kim, D. E., Kim, N. D., Eunju, O., Yoon, H. J., Joo, Y., Hong, S., & Kim, K. S. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01756-6

Age-associated B-cells across the rheumatoid arthritis continuum: from early immunopathogenesis to comorbidities

Miranda-Prieto, D., Suárez, A., & Rodríguez‐Carrio, J. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1812225

Respiratory Microbiome Remodeling in Aging: Implications for Immunosenescence and Therapeutic Intervention

Jung, S.-M., Sunwoo, W., & Son, Y. M. (2026) · Immune Network · doi:10.4110/in.2026.26.e23

Multimodal computational framework identifies B cell convergence in autoimmunity and ageingPreprint

Lou, H., Zhang, M., Zhang, B. Y., Lu, Q., Zheng, J.-Q., & Cao, X. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.29.735110

Immunosenescence modulates radiation-induced anti-tumor immunity: implications for personalized immuno-oncology

Arnold, C. R., Mangesius, J., Weinberger, B., Portnaia, I., Santacroce, A., Ganswindt, U., & Muacevic, A. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1888282

Senescence of the immune system in SLE: Pathogenic mechanisms and therapeutic implications

Jiang, X., Liang, Z., Zhao, C., Li, F., Su, Q., Wang, Y., Zhang, S., & Cheng, T. (2026) · Autoimmunity Reviews · doi:10.1016/j.autrev.2026.104152

Single-cell multi-omics reveals circulating B cell heterogeneity across diverse disease contexts

Gan, R., & Zhong, Y. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1897676

Chronic TLR7 activation promotes expansion of activated CD11c+ double-negative B cells and autoreactive humoral responses in lupus-like autoimmunity

Ferreyra, F. N., Almada, L., Martinez, M. S., Chocobar, Y. A., Motrich, R. D., Mackern‐Oberti, J. P., Gruppi, A., & Rivero, V. E. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1920764

Multimodal computational framework resolves B cell maturation in autoimmunity and ageing

Lou, H., Zhang, M., Zhang, B., Lu, Q., Zheng, J., & Cao, X. (2026) · Journal of Autoimmunity · doi:10.1016/j.jaut.2026.103609

Activation of Anergic B Cells During Development of Autoimmunity

Mansoor, M., Hilliard, B. K., & Smith, M. J. (2026) · Immunological Reviews · doi:10.1111/imr.70175

Sex and age differences in antibody responses to seasonal influenza vaccination are mediated by estrogenic upregulation of NF-κB and TNF signaling in B cells

Park, H.-S., Yin, A., Zhou, W., Wenstedt, E. F. E., Jedlicka, A., Dziedzic, A., Werner, A., Fenstermacher, K., Li, H., Shea, P. J., et al. (2026) · mBio · doi:10.1128/mbio.01435-26 · Cited by 2

B Lymphocytes in Acute Ischemic Stroke: From Immune Tolerance to Neuroprotection and Autoimmunity

Zouali, M. (2026) · European Journal of Neuroscience · doi:10.1111/ejn.70707

Immune memory to COVID-19 vaccines

Crotty, S., Sette, A., & Weiskopf, D. (2023) · ImmPort · doi:10.21430/m3cppwclw4

Age‐associated B cells: key mediators of both protective and autoreactive humoral responses

Naradikian, M. S., Hao, Y., & Cancro, M. P. (2015) · Immunological Reviews · doi:10.1111/imr.12380 · Cited by 157

Coming of age: the formation and function of age-associated B cells

Rui, K., Che, N., Ma, K., Zou, H., Xiao, F., & Lu, L. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01143-z · Cited by 10

Signals that drive T-bet expression in B cells

Myles, A., Gearhart, P. J., & Cancro, M. P. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.09.004 · Cited by 53

Understanding the Heterogeneous Population of Age-Associated B Cells and Their Contributions to Autoimmunity and Immune Response to Pathogens

Kugler‐Umana, O., Devarajan, P., & Swain, S. L. (2020) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2020034934 · Cited by 10

Age (autoimmunity) associated B cells (ABCs) and their relatives

Phalke, S., & Marrack, P. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.09.007 · Cited by 57