The DOI matches its Crossref record.
Effect of estradiol on cytokine secretion by proteolipid protein-specific T cell clones isolated from multiple sclerosis patients and normal control subjects
Abstract
The ability of estradiol (E2) to modulate the secretion of cytokines by CD4+ T cells was investigated using neuroantigen-specific T cell clones isolated from normal control subjects and patients with the demyelinating disease, multiple sclerosis. In the presence of E2, the majority of the tested clones showed a dose-dependent enhancement of Ag-stimulated IL-10 secretion. The secretion of IFN-γ was also enhanced, although the peak enhancement occurred at lower E2 concentrations and at lower magnitude than observed for IL-10. By contrast, the effect of E2 on Ag-stimulated secretion of TNF-αβ was biphasic, with enhancement occurring at low doses, and inhibition present at high concentrations. E2 had no effect on the secretion of IL-4 or TGF-beta. These data indicate that E2 is capable of modulating both pro- and anti-inflammatory activities of CD4+ T cells and thus has the potential to influence the outcome of CD4+ T cell-mediated immune responsiveness.
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Citations
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Self-citationKallaur, A. P., Oliveira, S. R., Simão, A. N. C., Alfieri, D. F., Flauzino, T., Lopes, J., de Carvalho Jennings Pereira, W. L., de Meleck Proença, C., Borelli, S. D., Kaimen-Maciel, D. R., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-9846-x · Cited by 75
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Metadata
- Authors
- Gilmore, W., Weiner, L. P., & Correale, J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-01-01
- Volume
- 158
- Issue
- 1
- Pages
- 446-451
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1605865008
- Cited by
- 316
- References
- 0
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- closed
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