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Microbial products induce autoimmune disease by an IL-12-dependent pathway
Abstract
The development and exacerbation of autoimmune diseases are associated with antecedent infectious illness. Microbial products such as LPS, bacterial DNA, or oligonucleotides containing an unmethylated cytosine-guanine dinucleotide have cytokine modulating properties. These products converted quiescent myelin basic protein-specific T cells into effector cells capable of transferring experimental allergic encephalomyelitis. The disease-promoting properties of the microbial products were solely dependent on their capacity to induce the production of IL-12.
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Citations
Cited by
CpG Motifs in Bacterial DNA and Their Immune Effects
Krieg, A. M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064842 · Cited by 2,573
Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483
DNA Vaccines: Immunology, Application, and Optimization
Gurunathan, S., Klinman, D. M., & Seder, R. A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.927 · Cited by 1,207
Self-citationImmunotherapeutic uses of CpG oligodeoxynucleotides
Klinman, D. M. (2004) · Nature Reviews Immunology · doi:10.1038/nri1329 · Cited by 1,012
Self-citationBode, C., Zhao, G., Steinhagen, F., Kinjo, T., & Klinman, D. M. (2011) · Expert Review of Vaccines · doi:10.1586/erv.10.174 · Cited by 891
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Metadata
- Authors
- Segal, B. M., Klinman, D. M., & Shevach, E. M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-06-01
- Volume
- 158
- Issue
- 11
- Pages
- 5087-5090
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1611703640
- Cited by
- 166
- References
- 0
- FWCI
- 15.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Microbial products induce autoimmune disease by an IL-12-dependent pathway. https://app.cochat.ai/papers/10.4049/jimmunol.158.11.5087
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- Segal, B. M., Klinman, D. M., & Shevach, E. M. (1997). Microbial products induce autoimmune disease by an IL-12-dependent pathway. The Journal of Immunology. https://doi.org/10.4049/jimmunol.158.11.5087
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