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CpG DNA as a vaccine adjuvant

Open access
Bode, Christian, Zhao, Gan, Steinhagen, Folkert, Kinjo, Takeshi, Klinman, Dennis M·2011·Expert Review of Vaccines
DOI 10.1586/erv.10.174
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Abstract

Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs trigger cells that express Toll-like receptor 9 (including human plasmacytoid dendritic cells and B cells) to mount an innate immune response characterized by the production of Th1 and proinflammatory cytokines. When used as vaccine adjuvants, CpG ODNs improve the function of professional antigen-presenting cells and boost the generation of humoral and cellular vaccine-specific immune responses. These effects are optimized by maintaining ODNs and vaccine in close proximity. The adjuvant properties of CpG ODNs are observed when administered either systemically or mucosally, and persist in immunocompromised hosts. Preclinical studies indicate that CpG ODNs improve the activity of vaccines targeting infectious diseases and cancer. Clinical trials demonstrate that CpG ODNs have a good safety profile and increase the immunogenicity of coadministered vaccines.

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Metadata

Authors
Bode, C., Zhao, G., Steinhagen, F., Kinjo, T., & Klinman, D. M.
Venue
Expert Review of Vaccines
Publisher
Informa UK Limited
Published
2011-04
Volume
10
Issue
4
Pages
499-511
ISSN
  • 1476-0584 (ISSN-L)
  • 1744-8395
DOI
10.1586/erv.10.174
OpenAlex
W2110223801
Cited by
891
References
10
FWCI
18.78
Type
journal article
Language
en
Open access
green

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Bode, C., Zhao, G., Steinhagen, F., Kinjo, T., & Klinman, D. M. (2011). CpG DNA as a vaccine adjuvant. Expert Review of Vaccines. https://doi.org/10.1586/erv.10.174

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