The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Enhanced B-1 Cell Development, But Impaired IgG Antibody Responses in Mice Deficient in Secreted IgM
Abstract
The role of endogenous natural IgM in promoting the adaptive Ab response was investigated in newly constructed mutant mice in which B cells do not secrete IgM but still express surface IgM and IgD and undergo class switching to express other Ig isotypes. While the mutant mice had relatively normal numbers of conventional B (B-2) cells in all tissues examined, unexpectedly, B-1 cells in the peritoneum and spleen were approximately threefold more abundant. The elevated levels of B-1 cells were already detectable at 4 wk of age and were stably maintained throughout life. The levels of serum IgG2a, IgG3, and IgA were also elevated in the mutant mice at an early age. IgG2a response to a T cell-independent Ag was augmented, whereas IgG Ab responses to suboptimal doses of a T cell-dependent Ag were impaired. The latter defect was associated with fewer splenic germinal centers, impaired Ab affinity maturation, and less Ag trapping on follicular dendritic cells. Together, these findings demonstrate a physiologic role of natural IgM in the feedback regulation of B-1 cell development, the regulation of IgG2a production, and the promotion of efficient B-2 cell Ab responses.
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Cites
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Defective B cell development and function in Btk-deficient mice
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Cited by
Victora, G. D., & Nussenzweig, M. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075032 · Cited by 1,878
The double life of a B-1 cell: self-reactivity selects for protective effector functions
Baumgarth, N. (2011) · Nature Reviews Immunology · doi:10.1038/nri2901 · Cited by 969
The Role of Complement in the Development of Systemic Lupus Erythematosus
Manderson, A. P., Botto, M., & Walport, M. J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104549 · Cited by 538
Regulation of Antibody Responses via Antibodies, Complement, and Fc Receptors
Heyman, B. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.709 · Cited by 353
Role of B cells as antigen presenting cells
Rastogi, I., Jeon, D., Moseman, J. E., Muralidhar, A., Potluri, H. K., & McNeel, D. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.954936 · Cited by 352
Metadata
- Authors
- Boes, M., Esau, C., Fischer, M. B., Schmidt, T., Carroll, M., & Chen, J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-05
- Volume
- 160
- Issue
- 10
- Pages
- 4776-4787
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2109296554
- Cited by
- 323
- References
- 72
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Boes, M., Esau, C., Fischer, M. B., Schmidt, T., Carroll, M., & Chen, J. (1998). Enhanced B-1 Cell Development, But Impaired IgG Antibody Responses in Mice Deficient in Secreted IgM. The Journal of Immunology. https://doi.org/10.4049/jimmunol.160.10.4776
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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