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Host-Microbiota Interactions Shape Local and Systemic Inflammatory Diseases
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Recent advances in understanding how the mammalian immune system and intestinal microbiota functionally interact have yielded novel insights for human health and disease. Modern technologies to quantitatively measure specific members and functional characteristics of the microbiota in the gastrointestinal tract, along with fundamental and emerging concepts in the field of immunology, have revealed numerous ways in which host-microbiota interactions proceed beneficially, neutrally, or detrimentally for mammalian hosts. It is clear that the gut microbiota has a strong influence on the shape and quality of the immune system; correspondingly, the immune system guides the composition and localization of the microbiota. In the following review, we examine the evidence that these interactions encompass homeostasis and inflammation in the intestine and, in certain cases, extraintestinal tissues. Lastly, we discuss translational therapies stemming from research on host-microbiota interactions that could be used for the treatment of chronic inflammatory diseases.
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“Notably, the microbiota orchestrates the local immune system in the intestine (67), and shapes immune and non-immune cells located in distal sites and acting systemically (68, 69).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [67]
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Metadata
- Authors
- Grigg, J. B., & Sonnenberg, G. F.
- Affiliations
- Weill Cornell Medicine (US)
- Corresponding author
- Sonnenberg, Gregory F
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-01
- Volume
- 198
- Issue
- 2
- Pages
- 564-571
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- PMC
- PMC5228396
- OpenAlex
- W2577439289
- Cited by
- 130
- References
- 124
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 19 · 2023: 21 · 2022: 14 · 2021: 17 · 2020: 21 · 2019: 9 · 2018: 9 · 2017: 11
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Crohn's and Colitis Foundation of America
- American Asthma Foundation
- Crohn's and Colitis Foundation
- Searle Scholars Program
- National Institutes of Health (DP5OD012116)
- National Institute of Allergy and Infectious Diseases (U01AI095608, R01AI123368)
- National Institute of Diabetes and Digestive and Kidney Diseases (R21DK110262)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- host-microbiota interactions, gut microbiota, intestinal inflammation, systemic inflammation, immune system, microbiota composition, immune homeostasis, chronic inflammatory diseases, microbiota-based therapy
- MeSH terms
- Gastrointestinal Microbiome, Animals, Homeostasis, Humans, Immune System, Inflammation
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