The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Modulation of CD28 Expression: Distinct Regulatory Pathways During Activation and Replicative Senescence
Open accessAbstract
The costimulatory molecule CD28 has a restricted tissue distribution and is expressed on T cells and some plasmacytoma cells. Although CD28 is constitutively expressed, its expression is transiently down-regulated following T cell activation and declines progressively with in vitro senescence. In vivo, CD8+ T cells and, less frequently, CD4+ T cells may completely lose CD28 surface expression during chronic infections and with aging. This correlates with changes of nuclear protein-binding activities to two motifs, site α and β, within the CD28 minimal promoter. Both α- and β-bound complexes are found only in lymphoid tissues, in CD28+ T cells, and in some transformed B cells. These complexes are coordinately expressed except during replicative senescence, which is characterized by the down-modulation of site β- but not site α-binding activities. In contrast, T cell activation induces a parallel decline in both site α- and β-binding activities. CD4+ and CD8+ T cells differ in their β-binding profiles, which may explain the more pronounced down-regulation of CD28 in senescent CD8+ T cells. In vivo expanded CD4+CD28null and CD8+CD28null T cells uniformly lack α- and β-bound complexes, resembling the pattern seen in chronically activated cells and not of senescent cells.
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Cites
CD28/B7 SYSTEM OF T CELL COSTIMULATION
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CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics
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“Loss of CD28 expression on T lymphocytes has been proposed to be a marker of replicative senescence ( 14 , 15).”
BackgroundInfluentialMonteiro, J., Batliwalla, F., Ostrer, H., & Gregersen, P. K. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.10.3587 · Cited by 376
Expansion of cytotoxic CD8 + CD28 − T cells in healthy ageing people, including centenarians
FAGNONI, F. F., VESCOVINI, R., MAZZOLA, M., BOLOGNA, G., NIGRO, E., LAVAGETTO, G., FRANCESCHI, C., PASSERI, M., & SANSONI, P. (1996) · Immunology · doi:10.1046/j.1365-2567.1996.d01-689.x · Cited by 362
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Self-citationLoss of CD28 expression on T lymphocytes: A marker of replicative senescence
Effros, R. B. (1997) · Developmental & Comparative Immunology · doi:10.1016/s0145-305x(97)00027-x · Cited by 175
CD28: a signalling perspective
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Cited by
Brenchley, J. M., Karandikar, N. J., Betts, M. R., Ambrozak, D. R., Hill, B. J., Crotty, L. E., Casazza, J. P., Kuruppu, J., Migueles, S. A., Connors, M., et al. (2003) · Blood · doi:10.1182/blood-2002-07-2103 · Cited by 1,073
Spatial map of human T cell compartmentalization and maintenance over decades of life
Thome, J. J. C., Yudanin, N., Ohmura, Y., Kubota, M., Grinshpun, B., Sathaliyawala, T., Kato, T., Lerner, H., Shen, Y., & Farber, D. L. (2014) · Cell · doi:10.1016/j.cell.2014.10.026 · Cited by 587
T cell subset-specific susceptibility to aging
Czesnikiewicz-Guzik, M., Lee, W.-W., Cui, D., Hiruma, Y., Lamar, D. L., Yang, Z.-Z., Ouslander, J. G., Weyand, C. M., & Goronzy, J. J. (2008) · Clinical Immunology · doi:10.1016/j.clim.2007.12.002 · Cited by 478
Self-citationCD28 extinction in human T cells: altered functions and the program of T‐cell senescence
Vallejo, A. N. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00256.x · Cited by 431
Self-citationGoronzy, J. J., Fulbright, J. W., Crowson, C. S., Poland, G. A., O'Fallon, W. M., & Weyand, C. M. (2001) · Journal of Virology · doi:10.1128/jvi.75.24.12182-12187.2001 · Cited by 402
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Metadata
- Authors
- Vallejo, A. N., Brandes, J. C., Weyand, C. M., & Goronzy, J. J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-06-01
- Volume
- 162
- Issue
- 11
- Pages
- 6572-6579
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2160352261
- Cited by
- 209
- References
- 9
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vallejo, A. N., Brandes, J. C., Weyand, C. M., & Goronzy, J. J. (1999). Modulation of CD28 Expression: Distinct Regulatory Pathways During Activation and Replicative Senescence. The Journal of Immunology. https://doi.org/10.4049/jimmunol.162.11.6572
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