Loss of CD28 expression on T lymphocytes: A marker of replicative senescence

A Theory of Self-Nonself Discrimination

Bretscher, P., & Cohn, M. (1970) · Science · doi:10.1126/science.169.3950.1042 · Cited by 1,755 · see citing works

The B7 and CD28 receptor families

June, C. H., Bluestone, J. A., Nadler, L. M., & Thompson, C. B. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90080-9 · Cited by 1,296 · see citing works

Telomere loss: mitotic clock or genetic time bomb?

Harley, C. B. (1991) · Mutation Research/DNAging · doi:10.1016/0921-8734(91)90018-7 · Cited by 1,139 · see citing works

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

Tough, D. F., Borrow, P., & Sprent, J. (1996) · Science · doi:10.1126/science.272.5270.1947 · Cited by 1,081 · see citing works

Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy".

Posnett, D. N., Sinha, R., Kabak, S., & Russo, C. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.2.609 · Cited by 761 · see citing works

Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.

Vaziri, H., Schächter, F., Uchida, I. A., Wei, L., Zhu, X., Effros, R. B., Cohen, D., & Harley, C. (1993) · PubMed · Cited by 734 · see citing works

Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression

Smith, J. R., & Pereira-Smith, O. M. (1996) · Science · doi:10.1126/science.273.5271.63 · Cited by 547 · see citing works

Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis

Effros, R. B., Allsopp, R., Chiu, C.-P., Hausner, M. A., Hirji, K., Wang, L., Harley, C. B., Villeponteau, B., West, M. D., & Giorgi, J. V. (1996) · AIDS · doi:10.1097/00002030-199607000-00001 · Cited by 457 · see citing works

Regulated expression of telomerase activity in human T lymphocyte development and activation.

Weng, N., Levine, B. L., June, C. H., & Hodes, R. J. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2471 · Cited by 403 · see citing works

CD28- T lymphocytes. Antigenic and functional properties

Azuma, M., Phillips, J. H., & Lanier, L. L. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.4.1147 · Cited by 392 · see citing works

Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence

Effros, R. B., Boucher, N., Porter, V., Zhu, X., Spaulding, C., Walford, R. L., Kronenberg, M., Cohen, D., & Schächter, F. (1994) · Experimental Gerontology · doi:10.1016/0531-5565(94)90073-6 · Cited by 377 · see citing works

Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts

Monteiro, J., Batliwalla, F., Ostrer, H., & Gregersen, P. K. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.10.3587 · Cited by 376 · see citing works

Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?

Effros, R. B., & Pawelec, G. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01079-7 · Cited by 336 · see citing works

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

Beverly, B., Kang, S., Lenardo, M. J., & Schwartz, R. H. (1992) · International Immunology · doi:10.1093/intimm/4.6.661 · Cited by 333 · see citing works

Mechanism of Telomerase Induction during T Cell Activation

Bodnar, A. G., Kim, N. W., Effros, R. B., & Chiu, C. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0299 · Cited by 285 · see citing works

Generation of both cross-reactive and virus-specific T-cell populations after immunization with serologically distinct influenza A viruses.

Effros, R. B., Doherty, P. C., Gerhard, W., & Bennink, J. R. (1977) · The Journal of Experimental Medicine · doi:10.1084/jem.145.3.557 · Cited by 280 · see citing works

Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen).

Hara, T., Fu, S. M., & Hansen, J. A. (1985) · The Journal of Experimental Medicine · doi:10.1084/jem.161.6.1513 · Cited by 280 · see citing works

Anergy and apoptosis in CD8+ T cells from HIV-infected persons.

Lewis, D. E., Tang, D. S. N., Adu-Oppong, A., Schober, W. D., & Rodgers, J. R. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.1.412 · Cited by 234 · see citing works

Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections.

Selin, L. K., Vergilis, K., Welsh, R. M., & Nahill, S. R. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2489 · Cited by 211 · see citing works

Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion.

Shimizu, Y., van Seventer, G. A., Ennis, E. A., Newman, W., Horgan, K. J., & Shaw, S. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.2.577 · Cited by 190 · see citing works

Recruitment and proliferation of CD8+ T cells in respiratory virus infections.

Tripp, R. A., Hou, S., McMickle, A., Houston, J., & Doherty, P. C. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.11.6013 · Cited by 127 · see citing works

Human T lymphocytes possess a limited in vitro life span

Perillo, N. L., Walford, R. L., Newman, M. A., & Effros, R. B. (1989) · Experimental Gerontology · doi:10.1016/0531-5565(89)90009-0 · Cited by 120 · see citing works

Immunosenescence: ageing of the immune system

Pawelec, G., Adibzadeh, M., Pohla, H., & Schaudt, K. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80017-4 · Cited by 115 · see citing works

The T cell in the ageing individual1This article is based on a presentation to the First International Conference on Aging and Immunology, Bethesda, MD, 16–19 June, 1996.1

Pawelec, G., Adibzadeh, M., Solana, R., & Beckman, I. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01812-x · Cited by 109 · see citing works

Reference Intervals for Human Peripheral Blood Lymphocyte Subpopulations from ‘Healthy’ Young and Aged Subjects

Stulnig, T. M., Maczek, C., Böck, G., Majdic, O., & Wick, G. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000237155 · Cited by 81 · see citing works

Stress Response of Senescent T Lymphocytes Reduced hsp70 Is Independent of the Proliferative Block

Effros, R. B., Zhu, X., & Walford, R. L. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.2.b65 · Cited by 72 · see citing works

Effect of age on lymphocyte proliferation

McCarron, M., Osborne, Y., Story, C. J., Dempsey, J. L., Turner, D. R., & Morley, A. A. (1987) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(87)90041-8 · Cited by 68 · see citing works

Long-term culture of monoclonal human T lymphocytes: models for immunosenescence?

Adibzadeh, M., Pohla, H., Rehbein, A., & Pawelec, G. (1995) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(95)01625-a · Cited by 64 · see citing works

The in vitro senescence of human T lymphocytes: Failure to divide is not associated with a loss of cytolytic activity or memory T cell phenotype

Perillo, N. L., Naeim, F., Walford, R. L., & Effros, R. B. (1993) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(93)90121-7 · Cited by 63 · see citing works

Long-Term in vitro Growth of Human T Cell Clones: Can Postmitotic ‘Senescent’ Cell Populations Be Defined?

Grubeck‐Loebenstein, B., Lechner, H., & Trieb, K. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000236671 · Cited by 58 · see citing works

CD28:B7 interactions promote T cell adhesion

Turcovski‐Corrales, S. M., Fenton, R. G., Peltz, G., & Taub, D. D. (1995) · European Journal of Immunology · doi:10.1002/eji.1830251115 · Cited by 31 · see citing works

Enhanced frequency of spontaneous B cell lines from Epstein-Barr virus (EBV) seropositive donors 80 years and older

Rangan, S. R. S., & Armatis, P. E. (1991) · Experimental Gerontology · doi:10.1016/0531-5565(91)90072-t · Cited by 7 · see citing works

The aging of the immune system

Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908 · see citing works

Causes, consequences, and reversal of immune system aging

Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64096 · Cited by 793 · see citing works

CD28 extinction in human T cells: altered functions and the program of T‐cell senescence

Vallejo, A. N. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00256.x · Cited by 435 · see citing works

Leukocyte Telomere Length in Major Depression: Correlations with Chronicity, Inflammation and Oxidative Stress - Preliminary Findings

Wolkowitz, O. M., Mellon, S. H., Epel, E. S., Lin, J., Dhabhar, F. S., Su, Y., Reus, V. I., Rosser, R., Burke, H. M., Kupferman, E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017837 · Cited by 421 · see citing works

Telomere shortening in T cells correlates with Alzheimer's disease status

Panossian, L. A. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00043-x · Cited by 409 · see citing works

Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation☆

Spaulding, C., Guo, W., & Effros, R. B. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00033-9 · Cited by 258 · see citing works

The aging of the immune system

Grubeck-Loebenstein, B., & Wick, G. (2002) · Advances in immunology · doi:10.1016/s0065-2776(02)80017-7 · Cited by 232 · see citing works

Telomere Erosion and Senescence in Human Articular Cartilage Chondrocytes

Martin, J. A., & Buckwalter, J. A. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.4.b172 · Cited by 232 · see citing works

Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates

Messaoudi, I., Warner, J., Fischer, M. B., Park, B., Hill, B. J., Mattison, J. A., Lane, M. A., Roth, G. S., Ingram, D. K., Picker, L. J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606661103 · Cited by 225 · see citing works

T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection

Vallejo, A. N., Weyand, C. M., & Goronzy, J. J. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.01.002 · Cited by 223 · see citing works

Modulation of CD28 Expression: Distinct Regulatory Pathways During Activation and Replicative Senescence

Vallejo, A. N., Brandes, J. C., Weyand, C. M., & Goronzy, J. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.11.6572 · Cited by 209 · see citing works

Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation.

Goronzy, J. J., & Weyand, C. M. (2003) · Arthritis Research · doi:10.1186/ar974 · Cited by 199 · see citing works

Survival, Persistence, and Progressive Differentiation of Adoptively Transferred Tumor-Reactive T Cells Associated with Tumor Regression

Huang, J., Khong, H. T., Dudley, M. E., El‐Gamil, M., Li, Y. F., Rosenberg, S. A., & Robbins, P. F. (2005) · Journal of Immunotherapy · doi:10.1097/01.cji.0000158855.92792.7a · Cited by 192 · see citing works

Immunosenescence and Immunogenetics of Human Longevity

Ostan, R., Bucci, L., Capri, M., Salvioli, S., Scurti, M., Pini, E., Monti, D., & Franceschi, C. (2008) · NeuroImmunoModulation · doi:10.1159/000156466 · Cited by 188 · see citing works

Aging is associated with increased regulatory T ‐cell function

Garg, S. K., Delaney, C. E., Toubai, T., Ghosh, A. K., Reddy, P. R., Banerjee, R. V., & Yung, R. L. (2013) · Aging Cell · doi:10.1111/acel.12191 · Cited by 184 · see citing works

Rheumatoid arthritis

Goronzy, J. J., & Weyand, C. M. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00245.x · Cited by 175 · see citing works

The unmet need in the elderly: Designing new influenza vaccines for older adults

McElhaney, J. E. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.04.019 · Cited by 168 · see citing works

The Role of Stress Factors during Aging of the Immune System

Bauer, M. E., Jeckel, C. M. M., & Luz, C. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03966.x · Cited by 167 · see citing works

Immunosenescence, autoimmunity, and rheumatoid arthritis

Weyand, C. M., Fulbright, J. W., & Goronzy, J. J. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00090-1 · Cited by 161 · see citing works

HIV infection induces age-related changes to monocytes and innate immune activation in young men that persist despite combination antiretroviral therapy

Hearps, A. C., Maisa, A., Cheng, W., Angelovich, T. A., Lichtfuss, G. F., Palmer, C. S., LANDAY, A. L., Jaworowski, A., & Crowe, S. M. (2012) · AIDS · doi:10.1097/qad.0b013e328351f756 · Cited by 159 · see citing works

Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection

Files, J. K., Boppana, S., Perez, M. D., Sarkar, S., Lowman, K. E., Qin, K., Sterrett, S., Carlin, E., Bansal, A., Sabbaj, S., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci140491 · Cited by 155 · see citing works

Age-associated decrease in virus-specific CD8+ T lymphocytes during primary influenza infection

Po, J. L., Gardner, E. M., Anaraki, F., Katsikis, P. D., & Murasko, D. M. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00010-6 · Cited by 143 · see citing works

Role of CD8 T Cell Replicative Senescence in Human Aging and in HIV-mediated Immunosenescence.

Dock, J., & Effros, R. B. (2011) · Europe PMC (PubMed Central) · Cited by 137 · see citing works

CX3CR1 drives cytotoxic CD4+CD28− T cells into the brain of multiple sclerosis patients

Broux, B., Pannemans, K., Zhang, X., Markovic‐Plese, S., Broekmans, T., Eijnde, B. O., Wijmeersch, B. V., Somers, V. A., Geusens, P., van der Pol, S. M. A., et al. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.11.006 · Cited by 137 · see citing works

Signaling pathways in aged T cells – A reflection of T cell differentiation, cell senescence and host environment

Goronzy, J. J., Li, G., Yu, M., & Weyand, C. M. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.003 · Cited by 134 · see citing works

Lymphocyte subset patterns and cytokine production in Alzheimer's disease patients

Speciale, L., Calabrese, E., Saresella, M., Tinelli, C., Mariani, C., Sanvito, L., Longhi, R., & Ferrante, P. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.05.020 · Cited by 122 · see citing works

Telomeres and immunological diseases of aging.

Andrews, N. P., Fujii, H., Goronzy, J. J., & Weyand, C. M. (2010) · Gerontology · doi:10.1159/000268620 · Cited by 108 · see citing works

Increased cytotoxic T cells with effector phenotype in aplastic anemia and myelodysplasia

Kook, H., Zeng, W., Chen, G., Kirby, M., Young, N. S., & Maciejewski, J. P. (2001) · Experimental Hematology · doi:10.1016/s0301-472x(01)00736-6 · Cited by 114 · see citing works

The Single-Cell Phenotypic Identity of Human CD8+ and CD4+ T Cells

Brummelman, J., Pilipow, K., & Lugli, E. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.007 · Cited by 110 · see citing works

Convergence of Innate and Adaptive Immunity during Human Aging

Pereira, B. I., & Akbar, A. N. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00445 · Cited by 106 · see citing works

CD58/CD2 Is the Primary Costimulatory Pathway in Human CD28−CD8+ T Cells

Leitner, J., Herndler-Brandstetter, D., Zlabinger, G. J., Grubeck-Loebenstein, B., & Steinberger, P. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401917 · Cited by 104 · see citing works

Rejection and recipient age

BRADLEY, B. A. (2002) · Transplant Immunology · doi:10.1016/s0966-3274(02)00058-8 · Cited by 95 · see citing works

FOXO1 constrains activation and regulates senescence in CD8 T cells

Delpoux, A., Marcel, N., Michelini, R. H., Katayama, C. D., Allison, K. A., Glass, C. K., Quiñones‐Parra, S. M., Murre, C., Loh, L., Kedzierska, K., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108674 · Cited by 86 · see citing works

Telomere Shortening and Decreased Replicative Potential, Contrasted by Continued Proliferation of Telomerase-Positive CD8+CD28lo T Cells in Patients with Systemic Lupus Erythematosus

Honda, M., Mengesha, E., Albano‐Aluquin, S., Nichols, W. S., Wallace, D. J., Al, M., Klinenberg, J. R., & Linker‐Israeli, M. (2001) · Clinical Immunology · doi:10.1006/clim.2001.5023 · Cited by 90 · see citing works

Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors

Pita‐López, M. L., Gayoso, I., DelaRosa, O., Casado, J. G., Alonso, C., Muñoz-Gomáriz, E., Tarazona, R., & Solana, R. (2009) · Immunity & Ageing · doi:10.1186/1742-4933-6-11 · Cited by 86 · see citing works

Vα24+ NKT cells are decreased in elderly humans

DelaRosa, O., Tarazona, R., Casado, J. G., Alonso, C., Ostos, B., Peña, J., & Solana, R. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00186-3 · Cited by 86 · see citing works

Distinct categories of immunologic changes in frail elderly

Fahey, J. L., Schnelle, J. F., Boscardin, W. J., Thomas, J. K., Gorre, M. E., Aziz, N., Sadeghi, H. M., & Nishanian, P. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00094-4 · Cited by 84 · see citing works

Postmenopausal changes in production of type 1 and type 2 cytokines and the effects of hormone replacement therapy

Deguchi, K., Kamada, M., Irahara, M., Maegawa, M., Yamamoto, S., Ohmoto, Y., Murata, K., Yasui, T., Yamano, S., & Aono, T. (2001) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-200107000-00008 · Cited by 82 · see citing works

Complexity of Anti‐immunosenescence Strategies in Humans

Capri, M., Monti, D., Salvioli, S., Lescai, F., Pierini, M., Altilia, S., Sevini, F., Valensin, S., Ostan, R., Bucci, L., et al. (2006) · Artificial Organs · doi:10.1111/j.1525-1594.2006.00295.x · Cited by 81 · see citing works

Ectopic Human Telomerase Catalytic Subunit Expression Maintains Telomere Length But Is Not Sufficient for CD8+ T Lymphocyte Immortalization

Migliaccio, M., Amacker, M., Just, T., Reichenbach, P., Valmori, D., Cerottini, J., Romero, P. J., & Nabholz, M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.9.4978 · Cited by 78 · see citing works

Costimulatory mechanisms in the elderly

Effros, R. B. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00503-4 · Cited by 79 · see citing works

Mass Cytometry Analysis Reveals that Specific Intratumoral CD4+ T Cell Subsets Correlate with Patient Survival in Follicular Lymphoma

Yang, Z., Kim, H. J., Villasboas, J. C., Price-Troska, T. L., Jalali, S., Wu, H., Luchtel, R. A., Polley, M. C., Novak, A. J., & Ansell, S. M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.085 · Cited by 77 · see citing works

IL-15 Amplifies the Pathogenic Properties of CD4+CD28− T Cells in Multiple Sclerosis

Broux, B., Mizee, M. R., Vanheusden, M., van der Pol, S. M. A., van Horssen, J., Wijmeersch, B. V., Somers, V. A., de Vries, H. E., Stinissen, P., & Hellings, N. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401547 · Cited by 76 · see citing works

Epigenomic drivers of immune dysfunction in aging

Keenan, C. R., & Allan, R. S. (2018) · Aging Cell · doi:10.1111/acel.12878 · Cited by 76 · see citing works

CD8 T cells expressing NK associated receptors are increased in melanoma patients and display an effector phenotype

Casado, J. G., Soto, R., DelaRosa, O., Peralbo, E., Muñoz-Villanueva, M. C., Rioja, L. F., Peña, J., Solana, R., & Tarazona, R. (2005) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-005-0682-5 · Cited by 76 · see citing works

Phenotypic and functional T-cell aging in rhesus macaques (Macaca mulatta): differential behavior of CD4 and CD8 subsets

Janković, V., Messaoudi, I., & Nikolich‐Žugich, J. (2003) · Blood · doi:10.1182/blood-2003-03-0927 · Cited by 75 · see citing works

Premature aging of the immune system in children with juvenile idiopathic arthritis

Prelog, M., Schwarzenbrunner, N., Sailer‐Höck, M., Kern, H., Klein‐Franke, A., Ausserlechner, M. J., Koppelstaetter, C., Brunner, A., Duftner, C., Dejaco, C., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23599 · Cited by 74 · see citing works

CD8+CD28– T cells: Certainties and uncertainties of a prevalent human T‐cell subset

Arosa, F. A. (2002) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2002.01057.x · Cited by 73 · see citing works

Daidzein Prevents the Increase in CD4+CD28null T Cells and B Lymphopoesis in Ovariectomized Mice: A Key Mechanism for Anti-Osteoclastogenic Effect

Tyagi, A. M., Srivastava, K., Sharan, K., Yadav, D. K., Maurya, R., & Singh, D. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021216 · Cited by 73 · see citing works

Age-associated inflammation connects ras-induced senescence to stem cell dysfunction and epidermal malignancy

Golomb, L., Sagiv, A., Pateras, I. S., Maly, A., Krizhanovsky, V, Gorgoulis, V. G., Oren, M., & Ben-Yehuda, A. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2015.21 · Cited by 71 · see citing works

Time-restricted feeding influences immune responses without compromising muscle performance in older men

Gasmi, M., Sellami, M., Denham, J., Padulo, J., Kuvačić, G., Selmi, W., & Khalıfa, R. (2018) · Nutrition · doi:10.1016/j.nut.2017.12.014 · Cited by 68 · see citing works

Proliferation and apoptosis of human CD8+CD28+ and CD8+CD28− lymphocytes during aging

Brzezińska, A., Magalska, A., Szybińska, A., & Sikora, E. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.09.026 · Cited by 69 · see citing works

Cytomegalovirus infection exacerbates autoimmune mediated neuroinflammation

Vanheusden, M., Broux, B., Welten, S. P. M., Peeters, L. M., Panagioti, E., Wijmeersch, B. V., Somers, V. A., Stinissen, P., Arens, R., & Hellings, N. (2017) · Scientific Reports · doi:10.1038/s41598-017-00645-3 · Cited by 60 · see citing works

Oligoclonal expansions in the CD8+CD28− T cells largely explain the shorter telomeres detected in this subset:

Batliwalla, F., Rufer, N., Lansdorp, P. M., & Gregersen, P. K. (2000) · Human Immunology · doi:10.1016/s0198-8859(00)00157-9 · Cited by 59 · see citing works

Human chondrocyte senescence and osteoarthritis

Martin, J. A., & Buckwalter, J. A. (2002) · Biorheology · doi:10.1177/0006355x2002039001002017 · Cited by 56 · see citing works

Premature T cell senescence in Ovx mice is inhibited by repletion of estrogen and medicarpin: a possible mechanism for alleviating bone loss

Tyagi, A. M., Srivastava, K., Kureel, J., Kumar, A., Raghuvanshi, A. S., Yadav, D., Maurya, R., Goel, A., & Singh, D. R. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1650-x · Cited by 53 · see citing works

T-Cells in Multiple Sclerosis

Severson, C., & Hafler, D. A. (2009) · Results and problems in cell differentiation · doi:10.1007/400_2009_12 · Cited by 55 · see citing works

Age associated decline in CD25 and CD28 expression correlate with an increased susceptibility to CD95 mediated apoptosis in T cells

Dennett, N. S., Bárcia, R. N., & McLeod, J. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00193-0 · Cited by 55 · see citing works

Major reduction of NKT cells in patients with severe COVID-19 pneumonia

Zingaropoli, M. A., Perri, V., Pasculli, P., Dezza, F. C., Nijhawan, P., Savelloni, G., Torre, G. L., D’Agostino, C., Mengoni, F., Lichtner, M., et al. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108630 · Cited by 53 · see citing works

Transient Increase in the Levels of T-Helper 1 Cytokines in Postmenopausal Women and the Effects of Hormone Replacement Therapy

Kamada, M., Irahara, M., Maegawa, M., Ohmoto, Y., Murata, K., Yasui, T., Yamano, S., & Aono, T. (2001) · Gynecologic and Obstetric Investigation · doi:10.1159/000052948 · Cited by 53 · see citing works

Involvement of steroids and cytochromes P450 species in the triggering of immune defenses

Morfin, R. F. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00025-0 · Cited by 49 · see citing works

Age-related changes of signal transduction in T cells

Hirokawa, K. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00067-9 · Cited by 49 · see citing works

Shortening of telomeres: Evidence for replicative senescence of T cells derived from patients with Wegener's granulomatosis

Vogt, S., Iking‐Konert, C., Hug, F., Andrássy, K., & Hänsch, G. M. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00037.x · Cited by 48 · see citing works

Functional Unresponsiveness and Replicative Senescence of Myeloid Leukemia Antigen–specific CD8+ T Cells After Allogeneic Stem Cell Transplantation

Beatty, G. L., Smith, J. S., Reshef, R., Patel, K. P., Colligon, T. A., Vance, B. A., Frey, N. V., Johnson, F. B., Porter, D. L., & Vonderheide, R. H. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-3332 · Cited by 45 · see citing works

Poor survival in glioblastoma patients is associated with early signs of immunosenescence in the CD4 T-cell compartment after surgery

Fornara, O., Odeberg, J., Wolmer Solberg, N., Tammik, C., Skarman, P., Peredo, I., Stragliotto, G., Rahbar, A., & Söderberg-Nauclér, C. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1036211 · Cited by 45 · see citing works

Aging-associated subpopulations of human CD8+ T-lymphocytes identified by their CD28 and CD57 phenotypes

Onyema, O. O., Njemini, R., Forti, L. N., Bautmans, I., Aerts, J. L., Waele, M. D., & Mets, T. F. (2015) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2015.08.007 · Cited by 45 · see citing works

Long-term immunological memory against viruses

Effros, R. B. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00207-4 · Cited by 45 · see citing works

Tumor Necrosis Factor-α and CD80 Modulate CD28 Expression through a Similar Mechanism of T-cell Receptor-independent Inhibition of Transcription

Lewis, D. E., Merched-Sauvage, M., Goronzy, J. J., Weyand, C. M., & Vallejo, A. N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402194200 · Cited by 45 · see citing works

Pulmonary Impairment after Respiratory Viral Infections Is Associated with High Mortality in Allogeneic Hematopoietic Cell Transplant Recipients

Sheshadri, A., Chemaly, R. F., Alousi, A. M., Shah, P., Rondón, G., Bashoura, L., Kmeid, J., Azzi, J. M., Blanco, D., Kaous, M., et al. (2018) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2018.11.022 · Cited by 42 · see citing works

PBMC telomerase activity, but not leukocyte telomere length, correlates with hippocampal volume in major depression

Wolkowitz, O. M., Mellon, S. H., Lindqvist, D., Epel, E. S., Blackburn, E. H., Lin, J., Reus, V. I., Burke, H., Rosser, R., Mahan, L., et al. (2015) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2015.01.007 · Cited by 41 · see citing works

Characterization of Donor Variability for γδ T Cell ex vivo Expansion and Development of an Allogeneic γδ T Cell Immunotherapy

Burnham, R. E., Zoine, J. T., Story, J. Y., Garimalla, S., Gibson, G. C., Rae, A. J., Williams, E., Bixby, L. M., Archer, D. R., Doering, C. B., et al. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.588453 · Cited by 41 · see citing works

Functionally Diverse NK-Like T Cells Are Effectors and Predictors of Successful Aging

Michel, J. J., Griffin, P. C., & Vallejo, A. N. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00530 · Cited by 41 · see citing works

Phenotypic Evidence of T Cell Exhaustion and Senescence During Symptomatic Plasmodium falciparum Malaria

Frimpong, A., Kusi, K. A., Adu‐Gyasi, D., Amponsah, J. A., Ofori, M. F., & Ndifon, W. O. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01345 · Cited by 41 · see citing works

Simultaneous flow cytometric analysis of two cell surface markers, telomere length, and DNA content

Schmid, I., Dagarag, M. D., Hausner, M. A., Matud, J. L., Just, T., Effros, R. B., & Jamieson, B. D. (2002) · Cytometry · doi:10.1002/cyto.10163 · Cited by 40 · see citing works

Lymphocyte activation in response to melanoma: interaction of NK-associated receptors and their ligands

Solana, R., Casado, J. G., Delgado, E., DelaRosa, O., Marín, J., Durán, E., Pawelec, G., & Tarazona, R. (2006) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-006-0141-y · Cited by 40 · see citing works

Shifts in subsets of CD8+ T-cells as evidence of immunosenescence in patients with cancers affecting the lungs: an observational case-control study

Onyema, O. O., Decoster, L., Njemini, R., Forti, L. N., Bautmans, I., Waele, M. D., & Mets, T. F. (2015) · BMC Cancer · doi:10.1186/s12885-015-2013-3 · Cited by 38 · see citing works

Lack of CD28 expression on HIV‐specific cytotoxic T lymphocytes is associated with disease progression

Gamberg, J., Pardoe, I. U., Bowmer, M. I., Howley, C., & Grant, M. D. (2004) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2004.01204.x · Cited by 38 · see citing works

A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma

Pilcher, W., Yao, L., Gonzalez‐Kozlova, E., Pita-Juárez, Y. H., Karagkouni, D., Acharya, C. R., Michaud, M. E., Hamilton, M., Nanda, S., Song, Y., et al. (2026) · Nature Cancer · doi:10.1038/s43018-025-01072-4 · Cited by 42 · see citing works

Protective Immunity to Cytomegalovirus (CMV) Retinitis in AIDS Is Associated with CMV‐Specific T Cells That Express Interferon‐γ and Interleukin‐2 and Have a CD8+Cell Early Maturational Phenotype

Sinclair, E., Tan, Q. X., Sharp, M., Girling, V., Poon, C., Natta, M. L. V., Jabs, D. A., Inokuma, M. S., Maecker, H. T., Bredt, B. M., et al. (2006) · The Journal of Infectious Diseases · doi:10.1086/508997 · Cited by 36 · see citing works

Immunophenotyping and T-cell proliferative capacity in a healthy aged population

Peres, A., Bauer, M. E., da Cruz, I. B. M., Nardi, N. B., & Chies, J. A. B. (2003) · Biogerontology · doi:10.1023/a:1026282917406 · Cited by 35 · see citing works

Effect of hormone replacement therapy on post-menopausal changes of lymphocytes and T cell subsets

Kamada, M., Irahara, M., Maegawa, M., Yasui, T., Takeji, T., Yamada, M., Tezuka, M., Kasai, Y., & Aono, T. (2000) · Journal of Endocrinological Investigation · doi:10.1007/bf03343741 · Cited by 34 · see citing works

T Cell Replicative Senescence Pleiotropic Effects on Human Aging

Effros, R. B. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.022 · Cited by 33 · see citing works

Immune Pathophysiology of Aplastic Anemia

Nakao, S., Feng, X., & Sugimori, C. (2005) · International Journal of Hematology · doi:10.1532/ijh97.05116 · Cited by 31 · see citing works

T Lymphocytes from Chagasic Patients Are Activated but Lack Proliferative Capacity and Down-Regulate CD28 and CD3ζ

Giraldo, N. A., Bolaños, N. I., Cuéllar, A., Roa, N. L., Cucunubá, Z. M., Rosas, F., Velasco, V. M., Puerta, C. J., & González, J. M. (2013) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002038 · Cited by 31 · see citing works

Immune Activation, Immunosenescence, and Osteoprotegerin as Markers of Endothelial Dysfunction in Subclinical HIV-Associated Atherosclerosis

D’Abramo, A., Zingaropoli, M. A., Oliva, A., D’Agostino, C., Moghazi, S. A., Luca, G. D., Iannetta, M., Mastroianni, C. M., & Vullo, V. (2014) · Mediators of Inflammation · doi:10.1155/2014/192594 · Cited by 29 · see citing works

The frequency of differentiated CD3+CD27-CD28- T cells predicts response to CART cell therapy in diffuse large B-cell lymphoma

Worel, N., Grabmeier‐Pfistershammer, K., Kratzer, B., Schlager, M., Tanzmann, A., Rottal, A., Körmöczi, U., Porpaczy, E. A., Staber, P. B., Skrabs, C., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1004703 · Cited by 30 · see citing works

Immune pathophysiology of aplastic anemia

Maciejewski, J. P., Risitano, A. M., Kook, H., Zeng, W., Chen, G., & Young, N. S. (2002) · International Journal of Hematology · doi:10.1007/bf03165246 · Cited by 29 · see citing works

Aging- and Tumor-Mediated Increase in CD8+CD28− T Cells Might Impose a Strong Barrier to Success of Immunotherapy in Glioblastoma

Huff, W. X., Bam, M., Shireman, J. M., Kwon, J. H., Song, L., Newman, S., Cohen‐Gadol, A., Shapiro, S., Jones, T., Fulton, K., et al. (2021) · ImmunoHorizons · doi:10.4049/immunohorizons.2100008 · Cited by 28 · see citing works

Single-cell transcriptomics of peripheral blood in the aging mouse

Teo, Y. V., Hinthorn, S. J., Webb, A. E., & Neretti, N. (2023) · Aging · doi:10.18632/aging.204471 · Cited by 28 · see citing works

Future Directions

Fitzpatrick, M. E., Crothers, K. A., & Morris, A. M. (2013) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2013.01.010 · Cited by 28 · see citing works

CD28−CD8+ T cells do not contain unique clonotypes and are therefore dispensable

Weinberger, B., Welzl, K., Herndler‐Brandstetter, D., Parson, W., & Grubeck‐Loebenstein, B. (2009) · Immunology Letters · doi:10.1016/j.imlet.2009.08.008 · Cited by 26 · see citing works

Mapping the interplay between NK cells and HIV: therapeutic implications

Anderko, R. R., & Mailliard, R. B. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiac007 · Cited by 25 · see citing works

Phosphorylation and coupling of ζ-chains to activated T-cell receptor (TCR)/CD3 complexes from peripheral blood T-cells of elderly humans

Whisler, R. L., Karanfilov, C. I., Newhouse, Y. G., Fox, C. C., Lakshmanan, R. R., & Beiqing, L. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00084-0 · Cited by 26 · see citing works

Immunosenescence and juvenile idiopathic arthritis.

Mayerl, C., & Prelog, M. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2010.02.015 · Cited by 25 · see citing works

Maternal cigarette smoking and its effect on neonatal lymphocyte subpopulations and replication

Almanzar, G., Eberle, G., Lassacher, A., Specht, C., Koppelstaetter, C., Heinz-Erian, P., Trawöger, R., Bernhard, D., & Prelog, M. (2013) · BMC Pediatrics · doi:10.1186/1471-2431-13-57 · Cited by 24 · see citing works

Impact of immunological aging on T cell-mediated therapies in older adults with multiple myeloma and lymphoma

Ullrich, F., Bröckelmann, P. J., Turki, A. T., Khan, A., Chiru, E.-D., Vetter, M. H. F., von Tresckow, B., Wirth, R., Córdoba, R., Ortiz‐Maldonado, V., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009462 · Cited by 24 · see citing works

T cell immunosenescence, hypertension, and arterial stiffness

Yu, H. T., & Shin, E. (2014) · Epidemiology and Health · doi:10.4178/epih/e2014005 · Cited by 22 · see citing works

Selective T cell receptor decrease in peripheral blood T lymphocytes of patients with polymyalgia rheumatica and giant cell arteritis

López‐Hoyos, M., Bartolome-Pacheco, M. J., Blanco, R., Rodriguez-Valverde, V., & Martinez-Taboada, V. M. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.005900 · Cited by 22 · see citing works

CD8 T-cell immune phenotype of successful aging

Hsu, H. C., Scott, D. K., Zhang, P., Zhou, J., Yang, P. A., Wu, Q., Schroeder, H. W., Gerald, L. B., Ravussin, É., & Jazwinski, S. M. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.10.001 · Cited by 22 · see citing works

CTLA4-Ig prolongs graft survival specifically in young but not old mice

Heinbokel, T., Quante, M., Iske, J., Nian, Y., Maenosono, R., Minami, K., Liu, Y., Azuma, H., Elkhal, A., & Tullius, S. G. (2020) · American Journal of Transplantation · doi:10.1111/ajt.16218 · Cited by 21 · see citing works

CD28 extinction in human T cells: altered functions and the program of T‐cell senescence

Vallejo, A. N. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00256.x · Cited by 435 · see citing works

Maintaining CD28 expression prevents replicative senescence in human CD 8 T cells (50.23)

Parish, S. T., Wu, J. D., & Effros, R. B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.184.supp.50.23

Costimulatory mechanisms in the elderly

Effros, R. B. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00503-4 · Cited by 79 · see citing works

Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation☆

Spaulding, C., Guo, W., & Effros, R. B. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00033-9 · Cited by 258 · see citing works

Sustained CD28 Expression Delays Multiple Features of Replicative Senescence in Human CD8 T Lymphocytes

Parish, S. T., Wu, J. E., & Effros, R. B. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9449-7 · Cited by 85 · see citing works