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Cited by 356

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Impaired Allostimulatory Capacity of Peripheral Blood Dendritic Cells Recovered from Hepatitis C Virus-Infected Individuals

Open access
Kanto, Tatsuya, Hayashi, Norio, Takehara, Tetsuo, Tatsumi, Tomohide, Kuzushita, Noriyoshi, Ito, Akihiko, Sasaki, Yutaka, Kasahara, Akinori, Hori, Masatsugu·1999·The Journal of Immunology
DOI 10.4049/jimmunol.162.9.5584
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Abstract

In hepatitis C virus (HCV) infection, Th responses are implicated in the pathogenesis of liver disease. The dendritic cell (DC) is the most potent activator of CD4 T cells for supporting Th1 differentiation. To clarify the roles of DC of HCV-infected individuals in the development of CD4 T cell responses, we generated peripheral DC with GM-CSF and IL-4 from 24 chronic hepatitis C patients and 14 healthy donors. We then compared their potentials for stimulating allogeneic CD4 T cells, autologous CD4 T cells against influenza A or HCV core Ags, and cytokine production. The DC from the patients (HCV-DC) expressed lower degrees of CD86 than DC from the donors (N-DC), whereas no difference was found in the HLA molecules and other costimulators. HCV-DC stimulated allogeneic T cells less than N-DC; however, influenza A- or core-pulsed HCV-DC retained the potentials for autologous T cell proliferation. In allogeneic DC/T cell cultures, the IFN-γ levels with HCV-DC were lower than those with N-DC, which may be related to the low expressions of IL-12 p35 and p40 transcripts in HCV-DC. The stimulation with LPS disclosed that HCV-DC is less potent in IL-12 p70 production than N-DC. In the autologous cultures, the pulsing of the Ags to HCV-DC increased the IL-12 p40 and IFN-γ production and up-regulated the transcription of both IL-12 subunits. Exogenous IL-2 or IL-12 restored the low allogeneic T cell proliferation with HCV-DC in a dose-dependent manner. Therefore, low expression of CD86 and/or IL-12 is crucially involved in the low allostimulatory capacity of HCV-DC. Low IL-12 and low IFN-γ milieu with HCV-DC on encounters with alloantigens may impede Th1 polarization.

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Metadata

Authors
Kanto, T., Hayashi, N., Takehara, T., Tatsumi, T., Kuzushita, N., Ito, A., Sasaki, Y., Kasahara, A., & Hori, M.
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
1999-05-01
Volume
162
Issue
9
Pages
5584-5591
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.162.9.5584
OpenAlex
W1633418194
Cited by
356
References
40
FWCI
4.70
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Impaired Allostimulatory Capacity of Peripheral Blood Dendritic Cells Recovered from Hepatitis C Virus-Infected Individuals. https://app.cochat.ai/papers/10.4049/jimmunol.162.9.5584
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Kanto, T., Hayashi, N., Takehara, T., Tatsumi, T., Kuzushita, N., Ito, A., Sasaki, Y., Kasahara, A., & Hori, M. (1999). Impaired Allostimulatory Capacity of Peripheral Blood Dendritic Cells Recovered from Hepatitis C Virus-Infected Individuals. The Journal of Immunology. https://doi.org/10.4049/jimmunol.162.9.5584

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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