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Newborns Develop a Th1-Type Immune Response to Mycobacterium bovis Bacillus Calmette-Guérin Vaccination
Open accessAbstract
Data obtained in animals indicate that neonatal immune responses are biased toward Th2. This could reduce the efficacy of vaccines against viral and mycobacterial diseases. The ability of human newborns to develop a Th1 immune response upon immunization has not been studied. Since the vaccine Mycobacterium bovis bacillus Calmette-Guérin (BCG) triggers a Th1-type response in adults, we investigated whether it induces a similar response in newborns and whether age at vaccination influences immunogenicity. We found that BCG vaccination at birth induces a memory Th1-type response of similar magnitude to that when given later in life. This study demonstrates that human newborns can be immunized against pathogens controlled by a Th1 immune response.
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Cited by
Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny
Kollmann, T. R., Kampmann, B., Mazmanian, S. K., Marchant, A., & Levy, O. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.009 · Cited by 478
Self-citationNewton, S. M., Brent, A. J., Anderson, S., Whittaker, E., & Kampmann, B. (2008) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(08)70182-8 · Cited by 480
Deficient IL-12(p35) Gene Expression by Dendritic Cells Derived from Neonatal Monocytes
Goriely, S., Vincart, B., Stordeur, P., Vekemans, J., Willems, F., Goldman, M., & De Wit, D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.2141 · Cited by 349
Early life: gut microbiota and immune development in infancy
Martin, R., Nauta, A., Ben Amor, K., Knippels, L., Knol, J., & Garssen, J. (2010) · Beneficial Microbes · doi:10.3920/bm2010.0027 · Cited by 338
Addressing parents’ concerns: do multiple vaccines overwhelm or weaken the infant's immune system?
Offit, P. A., Quarles, J., Gerber, M. A., Hackett, C. J., Marcuse, E. K., Kollman, T. R., Gellin, B. G., & Landry, S. (2002) · Pediatrics · doi:10.1542/peds.109.1.124 · Cited by 312
Metadata
- Authors
- Marchant, A., Goetghebuer, T., Ota, M. O., Wolfe, I., Ceesay, S. J., De Groote, D., Corrah, T., Bennett, S., Wheeler, J., Huygen, K., Aaby, P., McAdam, K. P. W. J., & Newport, M. J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-08
- Volume
- 163
- Issue
- 4
- Pages
- 2249-2255
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2132666683
- Cited by
- 404
- References
- 0
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Newborns Develop a Th1-Type Immune Response to Mycobacterium bovis Bacillus Calmette-Guérin Vaccination. https://app.cochat.ai/papers/10.4049/jimmunol.163.4.2249
- The paper
- Marchant, A., Goetghebuer, T., Ota, M. O., Wolfe, I., Ceesay, S. J., De Groote, D., Corrah, T., Bennett, S., Wheeler, J., Huygen, K., Aaby, P., McAdam, K. P. W. J., & Newport, M. J. (1999). Newborns Develop a Th1-Type Immune Response to Mycobacterium bovis Bacillus Calmette-Guérin Vaccination. The Journal of Immunology. https://doi.org/10.4049/jimmunol.163.4.2249
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
