The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Selective Retention of Activated CD8+ T Cells by the Normal Liver
Abstract
Activation-induced cell death resulting in peripheral deletion of CD8+ T cells is associated with the accumulation of large numbers of apoptotic T cells in the liver. The hypothesis that this accumulation results from the intrahepatic trapping of T cells from the circulating pool predicts that the liver should retain T cells, which subsequently undergo apoptosis. Here we test this prediction. Perfusion of the liver with lymphocyte mixtures showed retention of activated, but neither resting nor apoptosing, T cells. This trapping was selective for CD8+ cells and was mediated primarily by ICAM-1 constitutively expressed on sinusoidal endothelial cells and Kupffer cells. T cells trapped in the liver became apoptotic. The normal liver is therefore a “sink” for activated T cells.
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Cites
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The Liver as an Immunological Organ
Racanelli, V., & Rehermann, B. (2006) · Hepatology · doi:10.1002/hep.21060 · Cited by 1,377
Liver immunology and its role in inflammation and homeostasis
Robinson, M. W., Harmon, C., & O’Farrelly, C. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2016.3 · Cited by 1,151
Hepatic T cells and liver tolerance
Crispe, I. N. (2003) · Nature Reviews Immunology · doi:10.1038/nri981 · Cited by 661
Self-citationHomann, D., Teyton, L., & Oldstone, M. B. A. (2001) · Nature Medicine · doi:10.1038/90950 · Cited by 587
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Inhibition of T–Cell Responses by Hepatic Stellate Cells Via B7–H1-Mediated T–Cell Apoptosis in Mice
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Liver antigen-presenting cells
Crispe, I. N. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2010.10.005 · Cited by 262
Self-citationAntigen-Specific Primary Activation of CD8+ T Cells Within the Liver
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LPS signaling enhances hepatic fibrogenesis caused by experimental cholestasis in mice
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Human Hepatic Stellate Cells Inhibit T-Cell Response Through B7-H1 Pathway
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Kremer, K. N., Khammash, H. A., Miranda, A. M., Rutt, L. N., Twardy, S. M., Anton, P. E., Campbell, M. L., Garza-Ortiz, C., Orlicky, D. J., Pelanda, R., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1497788 · Cited by 19
Metadata
- Authors
- Mehal, W. Z., Juedes, A. E., & Crispe, I. N.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-09
- Volume
- 163
- Issue
- 6
- Pages
- 3202-3210
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1588051227
- Cited by
- 254
- References
- 2
- FWCI
- 4.91
- Type
- journal article
- Language
- en
- Open access
- closed
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